KEGG   ORTHOLOGY: K00320
Entry
K00320                      KO                                     
Symbol
mer
Name
5,10-methylenetetrahydromethanopterin reductase [EC:1.5.98.2]
Pathway
map00680  Methane metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00567  Methanogenesis, CO2 => methane
Reaction
R04464  5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00320  mer; 5,10-methylenetetrahydromethanopterin reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.98  With other, known, physiological acceptors
    1.5.98.2  5,10-methylenetetrahydromethanopterin reductase
     K00320  mer; 5,10-methylenetetrahydromethanopterin reductase
Other DBs
COG: COG2141
GO: 0018537
Genes
ZAL: AZF00_03740
HALC: EY643_08545
KIM: G3T16_19900
PSPW: BJG93_33595
DOE: DENOEST_1262
DENI: B9N43_02520
BIC: LMTR13_24555 LMTR13_24680
BRAZ: LRP30_33355 LRP30_33475
RPB: RPB_4412 RPB_4431
NRE: BES08_26800
SWI: Swit_0724
SPHD: HY78_07885 HY78_23075
RDI: CMV14_12235
SPKC: KC8_06245
SBIN: SBA_ch2_0970
SYB: TZ53_18460
SBD: ATN00_17390 ATN00_17485
SPMI: K663_17326 K663_17801
SPHT: K426_23754 K426_23849
SHYD: CJD35_15390 CJD35_15495
SUFL: FIL70_06830 FIL70_06930 FIL70_11560
SPRS: EGM87_05490
CMAN: A9D14_14795
KHA: IFJ82_10875
STI: Sthe_2316 Sthe_2879
MICA: P0L94_12400
ERZ: ER308_02385 ER308_09985 ER308_12970 ER308_13090
MPA: MAP_0675
MAO: MAP4_3189
MAVI: RC58_15805
MAVU: RE97_15835
MAV: MAV_1930 MAV_5061
MIT: OCO_13230 OCO_25030 OCO_39800
MIA: OCU_13700 OCU_24900 OCU_39700
MID: MIP_00259 MIP_03465 MIP_05993
MYO: OEM_23460
MCHI: AN480_12585 AN480_20895
MIR: OCQ_23580 OCQ_28210 OCQ_29400 OCQ_40880
MMAL: CKJ54_11345
MSER: MTY59_40720
MSA: Mycsm_03546 Mycsm_04592 Mycsm_06787 Mycsm_06803
MMC: Mmcs_3824
MKM: Mkms_3898
MJL: Mjls_3810 Mjls_4047
MMM: W7S_08445 W7S_12080 W7S_19830
MYV: G155_01495 G155_03345 G155_28015
MYE: AB431_15950
MDX: BTO20_10285 BTO20_23080 BTO20_34590
MFJ: MFLOJ_08070 MFLOJ_18720 MFLOJ_23560 MFLOJ_42820 MFLOJ_56420
MSTO: MSTO_09290 MSTO_20260 MSTO_27520 MSTO_46930
MSIM: MSIM_14700
MXE: MYXE_08020(hmd)
MPAG: C0J29_20060
MGOR: H0P51_10265
MCOO: MCOO_10090
MSEO: MSEO_32410
MHEK: JMUB5695_00830(fgd)
MBRD: MBRA_11340
MMAM: K3U93_09515
MPAA: MKK62_12720
MWU: PT015_06220
MYW: BVC93_04905 BVC93_07250
MYJ: BCA37_04835
MSM: MSMEG_2103 MSMEG_2456 MSMEG_3445
MSG: MSMEI_2056 MSMEI_2395 MSMEI_3365
MSB: LJ00_10475 LJ00_12225 LJ00_17140
MSN: LI99_10475 LI99_12225 LI99_17145
MSH: LI98_10475 LI98_12230 LI98_17150
MVA: Mvan_0261 Mvan_4259
MGI: Mflv_0410
MSP: Mspyr1_03440
MCB: Mycch_0231
MNE: D174_03035
MYN: MyAD_02965
MFT: XA26_03220 XA26_06010 XA26_56620
MPHL: MPHLCCUG_03824
MVQ: MYVA_0266 MYVA_2357 MYVA_4061
MLL: B1R94_12750 B1R94_16695
MRH: MycrhN_3896
MTHN: 4412656_00262 4412656_03260(fgd1_4)
MHAS: MHAS_00010(fgd1_1)
MDU: MDUV_19340 MDUV_30540 MDUV_40590
MCHT: MCHIJ_11280(hmd_2)
MAUU: NCTC10437_00266 NCTC10437_02307(fgd1_5) NCTC10437_04003 NCTC10437_05699
MMAG: MMAD_05430
MMOR: MMOR_05480 MMOR_22830 MMOR_28450(hmd) MMOR_42210
MAIC: MAIC_27490
MALV: MALV_21310 MALV_28120 MALV_30900 MALV_32630
MTY: MTOK_12730 MTOK_26490 MTOK_30960
MPSC: MPSYJ_06270
MARZ: MARA_16780 MARA_35350 MARA_40190
MGAD: MGAD_45740 MGAD_56050
MHEV: MHEL_32200 MHEL_51230
MANY: MANY_24330(hmd) MANY_41960
MAUB: MAUB_13640 MAUB_36340 MAUB_37910
MPOF: MPOR_08040 MPOR_27800
MPHU: MPHO_32370 MPHO_33950
MMUC: C1S78_001170 C1S78_001810 C1S78_018685
MMAT: MMAGJ_54430
MBOK: MBOE_17960 MBOE_50810
MFG: K6L26_28525
MSEI: MSEDJ_16290
MGO: AFA91_08815 AFA91_27215 AFA91_32745
MSEN: K3U95_03240
MPAE: K0O64_15015
MRF: MJO55_01245
MDF: K0O62_17150
MCRO: MI149_16010
MGRO: FZ046_08030 FZ046_16835
MAUS: JN090_18635
MBUG: MU0053_001369
MYQ: TUM20985_28380 TUM20985_53710
MYH: QU592_03520 QU592_11590
MPAT: MPNTM1_00935
MKR: MKOR_28420
MTER: 4434518_02913 4434518_02982
MMIN: MMIN_35190
MHIB: MHIB_00990(hmd)
MHER: K3U94_10745
MVM: MJO54_10775
MKK: MU0083_002151
NBR: O3I_022250
NNO: NONO_c47850 NONO_c58860
NSL: BOX37_14070
NOZ: DMB37_02885
NWL: NWFMUON74_53980 NWFMUON74_57790
NTC: KHQ06_23305
NYA: LTV02_02545
NYU: D7D52_02180
NVU: V7968_29955
ROA: Pd630_LPD12069
RRT: 4535765_00819
RKO: JWS14_25785 JWS14_43070 JWS14_45920
ROZ: CBI38_22735
RPSK: JWS13_43360
RHJS: OYT95_22340
RHZQ: GO592_11305
GBR: Gbro_3836
GPO: GPOL_c36980
GOR: KTR9_3774
GOQ: ACH46_18365
GTA: BCM27_19765
GOC: CXX93_05420
GRU: GCWB2_11310(fgd4) GCWB2_12090(ssuD) GCWB2_19375
GOM: D7316_01986 D7316_02156(fgd2_4)
GAV: C5O27_08760
GOD: GKZ92_18305 GKZ92_19915
GOS: QAD21_18700
GOJ: GR168_18065
GAM: GII34_07275
GJI: H1R19_18105
GHN: MVF96_18700
GAMI: IHQ52_22285
DIZ: CT688_02325
DPC: A6048_02280
SGB: WQO_00840
SFI: SFUL_290
SCB: SCAB_88981
SSX: SACTE_5139
SVL: Strvi_3235
SRC: M271_09195
SMAL: SMALA_8438
SCW: TU94_30975
SXI: SXIM_17420
STRC: AA958_24575
SPRI: SPRI_3761 SPRI_6783
SLE: sle_06190(sle_06190)
SCLF: BB341_28080
SLS: SLINC_0648
SNR: SNOUR_24160
SALU: DC74_6554
SALL: SAZ_34125
SVU: B1H20_00460
SGE: DWG14_02663(fgd2_1)
SQZ: FQU76_28675
SAST: CD934_00975
SFY: GFH48_04670
SBY: H7H31_03885
STSU: B7R87_28850
SCOE: CP976_04140
SBAT: G4Z16_14350
SHAR: HUT13_11085
SFEU: IM697_21740
SVD: CP969_02205
SCAL: I6J39_00585
SLF: JEQ17_44815
SDEC: L3078_04100
SLON: LGI35_42285
SANT: QR300_07695
SOV: QZH56_33460
SCOA: QU709_44345
STRZ: OYE22_03725
KBU: Q4V64_26565
SARM: DVA86_22795
STRL: HEP84_45755
STSD: HEP87_54900 HEP87_55015 HEP87_62345
STBR: ABDE16_25735
STRI: C7M71_029915
YIA: LO772_01055
MIO: AOA12_21255
MCW: A8L33_00440
MLV: CVS47_00302 CVS47_02477 CVS47_02481
MINV: T9R20_04950
MALP: QSU92_04000 QSU92_04370
RTN: A6122_0692
RRY: C1O28_02305
RIA: C7V51_08830
RFS: C1I64_01265
RTE: GSU10_11605
AGM: DCE93_00245
CART: PA27867_2020
CRY: B7495_09995
MYL: C3E77_14575
SALA: ESZ53_01560
AGG: C1N71_12800
AGX: AGREI_0926
BCV: Bcav_0157 Bcav_1677
BEI: GCM100_01690
IDO: I598_2061(fgd1_2)
CET: B8281_01045 B8281_02715
CCEU: CBR64_09100 CBR64_10955
SKE: Sked_00690
CFL: Cfla_3359
CFI: Celf_0191
CEZ: CBP52_12925
CELZ: E5225_00855 E5225_03090
CEJ: GC089_00780
CELH: GXP71_17345
CIRA: LFM56_01045
CDON: KKR89_14295
OEK: FFI11_002680
PSEI: GCE65_14670
KNO: V6K52_04010
ORZ: FNH13_06330
OFA: NF556_13630
SERW: FY030_06825
HALT: IM660_01200
RHAL: LQF10_01040
RSUA: LQF12_00805
DCP: RN607_11955
MICG: GJV80_12635
NCA: Noca_0856 Noca_1630
NDK: I601_3217
NOY: EXE57_05580
NANO: G5V58_00785 G5V58_03785
NARO: CFH99_04900
NBI: SHK19_16410
NOF: MF408_12615
NOCW: ABFU82_00840 ABFU82_15585
NOCL: KM427_07650 KM427_09485 KM427_13535 KM427_19080 KM427_20195 KM427_25045
NOCD: QJ852_01745 QJ852_01820 QJ852_03535 QJ852_06915 QJ852_20170
PSIM: KR76_02295 KR76_07600
AEF: GEV26_09440
KFL: Kfla_5429
KQI: F1D05_08235
TCU: Tcur_0507 Tcur_2584
ACTW: F7P10_01995 F7P10_02275 F7P10_05375 F7P10_37955
AMAZ: LUW76_20480 LUW76_21410 LUW76_45520 LUW76_46175
ACIR: OG979_00835
SPIQ: OHA34_15675
ACTQ: OG417_09765 OG417_33540 OG417_52320
SRO: Sros_4162
NOA: BKM31_20960
NFS: OIE67_14085
FAL: FRAAL3106 FRAAL4875
FRE: Franean1_4778
FRI: FraEuI1c_2529 FraEuI1c_3450 FraEuI1c_3839
NAKA: H7F38_07035 H7F38_07050
MMAR: MODMU_5441
KRA: Krad_3725
AOI: AORI_1327(hmd)
AJA: AJAP_32920(hmd)
AMQ: AMETH_1112(hmd)
AMYC: CU254_15235 CU254_17055
AAB: A4R43_03750 A4R43_05955 A4R43_15265
AMYY: YIM_15240 YIM_19200(fgd7) YIM_38415
AORI: SD37_34555
AACD: LWP59_32320
ARHD: VSH64_05340 VSH64_17390 VSH64_21535
AMOG: QRX60_31140
ACAB: QRX50_23900 QRX50_35680 QRX50_41010
ANW: QP939_46740
AMYD: K1T34_01800 K1T34_35440 K1T34_50760
PDX: Psed_0903 Psed_6467
PSEE: FRP1_24510
PSEH: XF36_06775
PSEQ: AD006_03695
PECQ: AD017_11515
PHH: AFB00_19275
PAUT: Pdca_12860 Pdca_25040 Pdca_29260 Pdca_36040
PBRO: HOP40_21815 HOP40_22515 HOP40_24350 HOP40_29430 HOP40_33255
PPEL: H6H00_24670
PSDS: K1T35_36315 K1T35_44495
APRE: CNX65_14060
AMI: Amir_2778
SESP: BN6_46520
SSYI: EKG83_30205
KUT: JJ691_65440
KBR: Q4V65_11075
AHM: TL08_05110
ACTI: UA75_05060
ACAD: UA74_04945
AHG: AHOG_04820
ACTA: C1701_04395
PMAD: BAY61_05085 BAY61_09825 BAY61_22070 BAY61_24880
ACTY: OG774_02155
MAU: Micau_1979
MIL: ML5_2085
MICB: MicB006_4996
MTUA: CSH63_15015
VMA: VAB18032_19125
MCRA: ID554_06825 ID554_07060 ID554_30065 ID554_30185
VER: HUT12_06135 HUT12_12195 HUT12_14575 HUT12_14800
MCHL: PVK74_00630
MPRN: Q3V37_28925
MICF: QQG74_14965
AFS: AFR_28030
PLAB: C6361_25880
PLAT: C6W10_12970
PFLA: Pflav_022530 Pflav_030270 Pflav_045200
PSUU: Psuf_080170 Psuf_082450 Psuf_093780
ATL: Athai_11400
PRY: Prubr_38560(hmd_1) Prubr_57330 Prubr_59130
DFU: Dfulv_27640 Dfulv_32255
DACT: KZZ52_26755 KZZ52_45065
NHY: JQS43_06565
EKE: EK0264_07735
JCY: M6B22_15170
ABAI: IMCC26256_111288 IMCC26256_111527
RMAR: GBA65_18010
BSOL: FSW04_00070 FSW04_23130
CWO: Cwoe_5617
AYM: YM304_13900
DHI: LH044_19275
ATM: ANT_14450
ABAT: CFX1CAM_1029
PSUB: Pelsub_P1656 Pelsub_P1764
CAP: CLDAP_07980 CLDAP_15430
PBF: CFX0092_A2812
KBB: ccbrp13_67000
THUG: KNN16_08060
PMET: G4Y79_17220 G4Y79_17225
MJA: MJ_1534
MFE: Mefer_1535
MVU: Metvu_0160
MFS: MFS40622_0752
MIF: Metin_0159
MJH: JH146_0139
MESG: MLAUSG7_0920(mer)
MESA: MLASG1_0449(mer)
MIG: Metig_1293
MMP: MMP0058(mer)
MMQ: MmarC5_1619
MMX: MmarC6_0892
MMZ: MmarC7_1055
MMD: GYY_00295
MMAK: MMKA1_00600(mer)
MMAO: MMOS7_00840(mer)
MMAD: MMJJ_10380
MAE: Maeo_0749
MVN: Mevan_1073
MVO: Mvol_1374
MOK: Metok_0200
METF: CFE53_02485(mer)
MTH: MTH_1752
MMG: MTBMA_c03270(mer)
MWO: MWSIV6_0292(mer)
MTEE: MTTB_14460
METC: MTCT_1602
METE: tca_01698
METZ: METMT2_1536
METK: FVF72_02910(mer)
MTHM: FZP57_01345(mer)
METJ: FZP68_06355(mer)
MST: Msp_1128(mer)
METB: AW729_10140
MEIS: PXD04_02020
MRU: mru_0569(mer)
MSI: Msm_0542
MEB: Abm4_1417(mer)
MMIL: sm9_0419(mer)
MEYE: TL18_02180
MOL: YLM1_0233
MARO: MarbSA_08410
METV: K4897_03275(mer)
MEL: Metbo_0510
MEW: MSWAN_1889
METH: MBMB1_1520(mer)
MFC: BRM9_0745(mer)
MFI: DSM1535_0704(mer)
MCUB: MCBB_1769(mer)
MSUB: BK009_06580
METN: BK008_02175
METT: CIT01_07510(mer)
METO: CIT02_10410(mer)
MEME: HYG87_08125(mer)
MFEG: GCM10025860_00380
MEER: NKF70_04385(mer)
MRID: FGU46_07285(mer)
MFV: Mfer_0274
MKA: MK0524(mer)
AFU: AF_1066
AFG: AFULGI_00011650
APO: Arcpr_1585
AVE: Arcve_0808 Arcve_1055
AST: Asulf_00466 Asulf_02156
FPL: Ferp_0743
GAC: GACE_0389
GAH: GAH_01105
MBA: Mbar_A0254
MBY: MSBRM_2698
MBW: MSBRW_0741
MBAR: MSBR2_2654
MBAK: MSBR3_0245 MSBR3_2771
MAC: MA_3733(mer)
MMA: MM_0628
MMJ: MSMAS_0681
MMAC: MSMAC_0682
MVC: MSVAZ_0679
MEK: MSKOL_0657
MLS: MSLAZ_2235
METM: MSMTP_0746
MEF: MSWH1_0878
MEQ: MSWHS_0937
MSJ: MSSAC_3543
MSZ: MSSIH_3084
MSW: MSSIT_3142
MTHR: MSTHT_2388
MTHE: MSTHC_0892
MHOR: MSHOH_0799
MFZ: AOB57_003480(mer)
MHAB: RSJ42_12180(mer)
METW: AAY43_06130
MBU: Mbur_2372(mer)
MMET: MCMEM_0517
MELO: J7W08_00610(mer)
MMH: Mmah_1513
MHAZ: BHR79_06165
MPOT: BKM01_02375
MEV: Metev_2139
MZH: Mzhil_0168
MPY: Mpsy_2035
MZI: HWN40_11975(mer)
MMAV: RE476_11455(mer)
MSEB: RE474_08075(mer)
MHZ: Metho_2247
MEHF: MmiHf6_02030(fgd1)
MEES: MmiEs2_08170(fgd1)
MTP: Mthe_0205
MCJ: MCON_2394(mer)
MHI: Mhar_0856
MHU: Mhun_2257
MRTJ: KHC33_15695
MLA: Mlab_0076
MEM: Memar_0557
MBG: BN140_1674(mer)
MEMA: MMAB1_2155(mer)
MCHK: MchiMG62_06860
MSUM: OH143_09515
MRC: R6Y96_00050
MPI: Mpet_2180
MEND: L6E24_10130
MEFW: F1737_01895
MAQE: RJ40_06375
MFK: E2N92_06510
MOU: OU421_03230
MESB: L1S32_06815
MANQ: L1994_02945
MBN: Mboo_0528
MFO: Metfor_2659
MESK: METHP_00439
MPL: Mpal_0327
MPD: MCP_2681(mer)
MEZ: Mtc_0135(mer)
RCI: RCIX564(mer)
HDL: HALDL1_03000
HHB: Hhub_1106(mer)
HNO: LT974_14745
HLU: LT972_12970
HANX: ABSL23_05355
HSU: HLASF_0416(mer)
HSF: HLASA_0415(mer)
HAHS: HSRCO_0593
SALR: FQU85_03600 FQU85_08510
HALR: EFA46_004740
HJE: HacjB3_04915 HacjB3_13295
HDO: MUK72_11295
HALX: M0R89_08695
HAXZ: M0R88_08905
HAYC: NGM10_10025
HAXY: NGM07_14540
SALI: L593_00135
SAIM: K0C01_04820
HARA: AArcS_2336
HMA: rrnAC2437(mer1)
HSIN: KDQ40_15110
HHI: HAH_2870(mer3)
HHN: HISP_14590
HAB: SG26_06730
HTA: BVU17_13960
HALJ: G9465_05265
NPH: NP_1056A(mer)
NMO: Nmlp_1133(mer)
NHO: HWV23_08180
NSAL: HWV07_10100
HUT: Huta_1395
HTI: HTIA_1288
HALA: Hrd1104_10095
HASV: SVXHr_0236(mer)
HABN: HBNXHr_0227(mer)
HMU: Hmuk_0341
HALZ: E5139_04990
HALL: LC1Hm_2870(mer)
HAZP: GBQ70_04985
HALI: BV210_10785
HSN: DV733_10440
HDS: HSR122_0385
HRR: HZS55_02155
HPEL: HZS54_01595
HLT: I7X12_11140
HARC: HARCEL1_05640
SSAI: N0B31_17585
HAAD: MW046_10005
HWA: HQ_3154A(mer)
HWC: Hqrw_3697(mer)
HVO: HVO_1937(mer)
HALE: G3A49_12675
HLN: SVXHx_2682(mer)
HME: HFX_2030(mer)
HGI: ABY42_09440
HLS: KU306_02840
HBO: Hbor_05330
HAQ: DU484_03660 DU484_04770
HAJ: DU500_04145 DU500_05210
HAER: DU502_01690
HRA: EI982_10810 EI982_11685
HLM: DV707_14720
HALM: FCF25_00710
HLA: Hlac_1680
HALP: DOS48_08290
HALB: EKH57_01810
HEZZ: EO776_10900
HALQ: Hrr1229_013655
HSS: J7656_06825
HSAI: HPS36_12235
HAZZ: KI388_07775
SRUB: C2R22_17165
HAE: halTADL_0321 halTADL_1346
HALN: B4589_005885
HALG: HUG10_11070
HALU: HUG12_00730 HUG12_05610
HMP: K6T50_07940
HRE: K6T36_07775
HRM: K6T25_08045
HACB: Hbl1158_14415
HAH: Halar_1772
HTU: Htur_3573
HSAL: JMJ58_10490
HAKZ: J0X25_05575 J0X25_19080 J0X25_19090
NMG: Nmag_1582(mer)
HXA: Halxa_3407
NAT: NJ7G_2905
NPE: Natpe_0251
NVR: FEJ81_01420
NPL: FGF80_09575
NAY: HYG81_09345
HALY: HYG82_12020
HJT: DVR14_10650
HLO: J0X27_12155
NGE: Natgr_2297
HLC: CHINAEXTREME06980
HRU: Halru_2719
SAWL: NGM29_00760
HALV: NGM15_10290
NOU: Natoc_2482
HLR: HALLA_18435
NAJ: B1756_04330
NAG: AArcMg_0283
NAN: AArc1_0293
NARA: QQ977_13020
NBG: DV706_06150
NAS: GCU68_07730
HDA: BB347_11940
MELU: MTLP_01530
MEAM: MU439_00980
MEAE: QEN48_01625
NIR: NSED_04635
NKR: NKOR_04660
NID: NPIRD3C_1360
NIW: Nisw_00540
NCL: C5F47_04655
NOX: C5F49_04565
NUE: C5F50_06300
NVN: NVIE_004930(mer)
NEV: NTE_01814
NCV: NCAV_1415
CSU: CSUB_C0377 CSUB_C0386 CSUB_C0571 CSUB_C0806 CSUB_C1220 CSUB_C1712
TAH: SU86_001930
CCAI: NAS2_0789
BARC: AOA65_0782(mer_2)
 » show all
Reference
PMID:2298726
  Authors
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
  Journal
J Biol Chem 265:1852-7 (1990)
  Sequence
[mth:MTH_1752]
Reference
PMID:2379499
  Authors
Ma K, Thauer RK
  Title
Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 191:187-93 (1990)
DOI:10.1111/j.1432-1033.1990.tb19109.x
  Sequence
[mmg:MTBMA_c03270]

  All links  
Ontology (2)   
   GO (1)   
   COG (1)   
Gene (2814)   
   MGENES (2385)   
   RefGene (408)   
   OC (21)   
All databases (2816)   

Download RDF
KEGG   ENZYME: 1.5.98.2
Entry
EC 1.5.98.2                 Enzyme                                 
Name
5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
Sysname
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420 [RN:R04464]
Reaction(KEGG)
R04464
Substrate
5-methyltetrahydromethanopterin [CPD:C04488];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methylenetetrahydromethanopterin [CPD:C04377];
reduced coenzyme F420 [CPD:C01080]
Comment
Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.
History
EC 1.5.98.2 created 2000 as EC 1.5.99.11, modified 2004, transferred to EC 1.5.98.2 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00320  5,10-methylenetetrahydromethanopterin reductase
Genes
ZAL: AZF00_03740
HALC: EY643_08545
KIM: G3T16_19900
PSPW: BJG93_33595
DOE: DENOEST_1262
DENI: B9N43_02520
BIC: LMTR13_24555 LMTR13_24680
BRAZ: LRP30_33355 LRP30_33475
RPB: RPB_4412 RPB_4431
NRE: BES08_26800
SWI: Swit_0724
SPHD: HY78_07885 HY78_23075
RDI: CMV14_12235
SPKC: KC8_06245
SBIN: SBA_ch2_0970
SYB: TZ53_18460
SBD: ATN00_17390 ATN00_17485
SPMI: K663_17326 K663_17801
SPHT: K426_23754 K426_23849
SHYD: CJD35_15390 CJD35_15495
SUFL: FIL70_06830 FIL70_06930 FIL70_11560
SPRS: EGM87_05490
CMAN: A9D14_14795
KHA: IFJ82_10875
STI: Sthe_2316 Sthe_2879
MICA: P0L94_12400
ERZ: ER308_02385 ER308_09985 ER308_12970 ER308_13090
MPA: MAP_0675
MAO: MAP4_3189
MAVI: RC58_15805
MAVU: RE97_15835
MAV: MAV_1930 MAV_5061
MIT: OCO_13230 OCO_25030 OCO_39800
MIA: OCU_13700 OCU_24900 OCU_39700
MID: MIP_00259 MIP_03465 MIP_05993
MYO: OEM_23460
MCHI: AN480_12585 AN480_20895
MIR: OCQ_23580 OCQ_28210 OCQ_29400 OCQ_40880
MMAL: CKJ54_11345
MSER: MTY59_40720
MSA: Mycsm_03546 Mycsm_04592 Mycsm_06787 Mycsm_06803
MMC: Mmcs_3824
MKM: Mkms_3898
MJL: Mjls_3810 Mjls_4047
MMM: W7S_08445 W7S_12080 W7S_19830
MYV: G155_01495 G155_03345 G155_28015
MYE: AB431_15950
MDX: BTO20_10285 BTO20_23080 BTO20_34590
MFJ: MFLOJ_08070 MFLOJ_18720 MFLOJ_23560 MFLOJ_42820 MFLOJ_56420
MSTO: MSTO_09290 MSTO_20260 MSTO_27520 MSTO_46930
MSIM: MSIM_14700
MXE: MYXE_08020(hmd)
MPAG: C0J29_20060
MGOR: H0P51_10265
MCOO: MCOO_10090
MSEO: MSEO_32410
MHEK: JMUB5695_00830(fgd)
MBRD: MBRA_11340
MMAM: K3U93_09515
MPAA: MKK62_12720
MWU: PT015_06220
MYW: BVC93_04905 BVC93_07250
MYJ: BCA37_04835
MSM: MSMEG_2103 MSMEG_2456 MSMEG_3445
MSG: MSMEI_2056 MSMEI_2395 MSMEI_3365
MSB: LJ00_10475 LJ00_12225 LJ00_17140
MSN: LI99_10475 LI99_12225 LI99_17145
MSH: LI98_10475 LI98_12230 LI98_17150
MVA: Mvan_0261 Mvan_4259
MGI: Mflv_0410
MSP: Mspyr1_03440
MCB: Mycch_0231
MNE: D174_03035
MYN: MyAD_02965
MFT: XA26_03220 XA26_06010 XA26_56620
MPHL: MPHLCCUG_03824
MVQ: MYVA_0266 MYVA_2357 MYVA_4061
MLL: B1R94_12750 B1R94_16695
MRH: MycrhN_3896
MTHN: 4412656_00262 4412656_03260(fgd1_4)
MHAS: MHAS_00010(fgd1_1)
MDU: MDUV_19340 MDUV_30540 MDUV_40590
MCHT: MCHIJ_11280(hmd_2)
MAUU: NCTC10437_00266 NCTC10437_02307(fgd1_5) NCTC10437_04003 NCTC10437_05699
MMAG: MMAD_05430
MMOR: MMOR_05480 MMOR_22830 MMOR_28450(hmd) MMOR_42210
MAIC: MAIC_27490
MALV: MALV_21310 MALV_28120 MALV_30900 MALV_32630
MTY: MTOK_12730 MTOK_26490 MTOK_30960
MPSC: MPSYJ_06270
MARZ: MARA_16780 MARA_35350 MARA_40190
MGAD: MGAD_45740 MGAD_56050
MHEV: MHEL_32200 MHEL_51230
MANY: MANY_24330(hmd) MANY_41960
MAUB: MAUB_13640 MAUB_36340 MAUB_37910
MPOF: MPOR_08040 MPOR_27800
MPHU: MPHO_32370 MPHO_33950
MMUC: C1S78_001170 C1S78_001810 C1S78_018685
MMAT: MMAGJ_54430
MBOK: MBOE_17960 MBOE_50810
MFG: K6L26_28525
MSEI: MSEDJ_16290
MGO: AFA91_08815 AFA91_27215 AFA91_32745
MSEN: K3U95_03240
MPAE: K0O64_15015
MRF: MJO55_01245
MDF: K0O62_17150
MCRO: MI149_16010
MGRO: FZ046_08030 FZ046_16835
MAUS: JN090_18635
MBUG: MU0053_001369
MYQ: TUM20985_28380 TUM20985_53710
MYH: QU592_03520 QU592_11590
MPAT: MPNTM1_00935
MKR: MKOR_28420
MTER: 4434518_02913 4434518_02982
MMIN: MMIN_35190
MHIB: MHIB_00990(hmd)
MHER: K3U94_10745
MVM: MJO54_10775
MKK: MU0083_002151
NBR: O3I_022250
NNO: NONO_c47850 NONO_c58860
NSL: BOX37_14070
NOZ: DMB37_02885
NWL: NWFMUON74_53980 NWFMUON74_57790
NTC: KHQ06_23305
NYA: LTV02_02545
NYU: D7D52_02180
NVU: V7968_29955
ROA: Pd630_LPD12069
RRT: 4535765_00819
RKO: JWS14_25785 JWS14_43070 JWS14_45920
ROZ: CBI38_22735
RPSK: JWS13_43360
RHJS: OYT95_22340
RHZQ: GO592_11305
GBR: Gbro_3836
GPO: GPOL_c36980
GOR: KTR9_3774
GOQ: ACH46_18365
GTA: BCM27_19765
GOC: CXX93_05420
GRU: GCWB2_11310(fgd4) GCWB2_12090(ssuD) GCWB2_19375
GOM: D7316_01986 D7316_02156(fgd2_4)
GAV: C5O27_08760
GOD: GKZ92_18305 GKZ92_19915
GOS: QAD21_18700
GOJ: GR168_18065
GAM: GII34_07275
GJI: H1R19_18105
GHN: MVF96_18700
GAMI: IHQ52_22285
DIZ: CT688_02325
DPC: A6048_02280
SGB: WQO_00840
SFI: SFUL_290
SCB: SCAB_88981
SSX: SACTE_5139
SVL: Strvi_3235
SRC: M271_09195
SMAL: SMALA_8438
SCW: TU94_30975
SXI: SXIM_17420
STRC: AA958_24575
SPRI: SPRI_3761 SPRI_6783
SLE: sle_06190(sle_06190)
SCLF: BB341_28080
SLS: SLINC_0648
SNR: SNOUR_24160
SALU: DC74_6554
SALL: SAZ_34125
SVU: B1H20_00460
SGE: DWG14_02663(fgd2_1)
SQZ: FQU76_28675
SAST: CD934_00975
SFY: GFH48_04670
SBY: H7H31_03885
STSU: B7R87_28850
SCOE: CP976_04140
SBAT: G4Z16_14350
SHAR: HUT13_11085
SFEU: IM697_21740
SVD: CP969_02205
SCAL: I6J39_00585
SLF: JEQ17_44815
SDEC: L3078_04100
SLON: LGI35_42285
SANT: QR300_07695
SOV: QZH56_33460
SCOA: QU709_44345
STRZ: OYE22_03725
KBU: Q4V64_26565
SARM: DVA86_22795
STRL: HEP84_45755
STSD: HEP87_54900 HEP87_55015 HEP87_62345
STBR: ABDE16_25735
STRI: C7M71_029915
YIA: LO772_01055
MIO: AOA12_21255
MCW: A8L33_00440
MLV: CVS47_00302 CVS47_02477 CVS47_02481
MINV: T9R20_04950
MALP: QSU92_04000 QSU92_04370
RTN: A6122_0692
RRY: C1O28_02305
RIA: C7V51_08830
RFS: C1I64_01265
RTE: GSU10_11605
AGM: DCE93_00245
CART: PA27867_2020
CRY: B7495_09995
MYL: C3E77_14575
SALA: ESZ53_01560
AGG: C1N71_12800
AGX: AGREI_0926
BCV: Bcav_0157 Bcav_1677
BEI: GCM100_01690
IDO: I598_2061(fgd1_2)
CET: B8281_01045 B8281_02715
CCEU: CBR64_09100 CBR64_10955
SKE: Sked_00690
CFL: Cfla_3359
CFI: Celf_0191
CEZ: CBP52_12925
CELZ: E5225_00855 E5225_03090
CEJ: GC089_00780
CELH: GXP71_17345
CIRA: LFM56_01045
CDON: KKR89_14295
OEK: FFI11_002680
PSEI: GCE65_14670
KNO: V6K52_04010
ORZ: FNH13_06330
OFA: NF556_13630
SERW: FY030_06825
HALT: IM660_01200
RHAL: LQF10_01040
RSUA: LQF12_00805
DCP: RN607_11955
MICG: GJV80_12635
NCA: Noca_0856 Noca_1630
NDK: I601_3217
NOY: EXE57_05580
NANO: G5V58_00785 G5V58_03785
NARO: CFH99_04900
NBI: SHK19_16410
NOF: MF408_12615
NOCW: ABFU82_00840 ABFU82_15585
NOCL: KM427_07650 KM427_09485 KM427_13535 KM427_19080 KM427_20195 KM427_25045
NOCD: QJ852_01745 QJ852_01820 QJ852_03535 QJ852_06915 QJ852_20170
PSIM: KR76_02295 KR76_07600
AEF: GEV26_09440
KFL: Kfla_5429
KQI: F1D05_08235
TCU: Tcur_0507 Tcur_2584
ACTW: F7P10_01995 F7P10_02275 F7P10_05375 F7P10_37955
AMAZ: LUW76_20480 LUW76_21410 LUW76_45520 LUW76_46175
ACIR: OG979_00835
SPIQ: OHA34_15675
ACTQ: OG417_09765 OG417_33540 OG417_52320
SRO: Sros_4162
NOA: BKM31_20960
NFS: OIE67_14085
FAL: FRAAL3106 FRAAL4875
FRE: Franean1_4778
FRI: FraEuI1c_2529 FraEuI1c_3450 FraEuI1c_3839
NAKA: H7F38_07035 H7F38_07050
MMAR: MODMU_5441
KRA: Krad_3725
AOI: AORI_1327(hmd)
AJA: AJAP_32920(hmd)
AMQ: AMETH_1112(hmd)
AMYC: CU254_15235 CU254_17055
AAB: A4R43_03750 A4R43_05955 A4R43_15265
AMYY: YIM_15240 YIM_19200(fgd7) YIM_38415
AORI: SD37_34555
AACD: LWP59_32320
ARHD: VSH64_05340 VSH64_17390 VSH64_21535
AMOG: QRX60_31140
ACAB: QRX50_23900 QRX50_35680 QRX50_41010
ANW: QP939_46740
AMYD: K1T34_01800 K1T34_35440 K1T34_50760
PDX: Psed_0903 Psed_6467
PSEE: FRP1_24510
PSEH: XF36_06775
PSEQ: AD006_03695
PECQ: AD017_11515
PHH: AFB00_19275
PAUT: Pdca_12860 Pdca_25040 Pdca_29260 Pdca_36040
PBRO: HOP40_21815 HOP40_22515 HOP40_24350 HOP40_29430 HOP40_33255
PPEL: H6H00_24670
PSDS: K1T35_36315 K1T35_44495
APRE: CNX65_14060
AMI: Amir_2778
SESP: BN6_46520
SSYI: EKG83_30205
KUT: JJ691_65440
KBR: Q4V65_11075
AHM: TL08_05110
ACTI: UA75_05060
ACAD: UA74_04945
AHG: AHOG_04820
ACTA: C1701_04395
PMAD: BAY61_05085 BAY61_09825 BAY61_22070 BAY61_24880
ACTY: OG774_02155
MAU: Micau_1979
MIL: ML5_2085
MICB: MicB006_4996
MTUA: CSH63_15015
VMA: VAB18032_19125
MCRA: ID554_06825 ID554_07060 ID554_30065 ID554_30185
VER: HUT12_06135 HUT12_12195 HUT12_14575 HUT12_14800
MCHL: PVK74_00630
MPRN: Q3V37_28925
MICF: QQG74_14965
AFS: AFR_28030
PLAB: C6361_25880
PLAT: C6W10_12970
PFLA: Pflav_022530 Pflav_030270 Pflav_045200
PSUU: Psuf_080170 Psuf_082450 Psuf_093780
ATL: Athai_11400
PRY: Prubr_38560(hmd_1) Prubr_57330 Prubr_59130
DFU: Dfulv_27640 Dfulv_32255
DACT: KZZ52_26755 KZZ52_45065
NHY: JQS43_06565
EKE: EK0264_07735
JCY: M6B22_15170
ABAI: IMCC26256_111288 IMCC26256_111527
RMAR: GBA65_18010
BSOL: FSW04_00070 FSW04_23130
CWO: Cwoe_5617
AYM: YM304_13900
DHI: LH044_19275
ATM: ANT_14450
ABAT: CFX1CAM_1029
PSUB: Pelsub_P1656 Pelsub_P1764
CAP: CLDAP_07980 CLDAP_15430
PBF: CFX0092_A2812
KBB: ccbrp13_67000
THUG: KNN16_08060
PMET: G4Y79_17220 G4Y79_17225
MJA: MJ_1534
MFE: Mefer_1535
MVU: Metvu_0160
MFS: MFS40622_0752
MIF: Metin_0159
MJH: JH146_0139
MESG: MLAUSG7_0920(mer)
MESA: MLASG1_0449(mer)
MIG: Metig_1293
MMP: MMP0058(mer)
MMQ: MmarC5_1619
MMX: MmarC6_0892
MMZ: MmarC7_1055
MMD: GYY_00295
MMAK: MMKA1_00600(mer)
MMAO: MMOS7_00840(mer)
MMAD: MMJJ_10380
MAE: Maeo_0749
MVN: Mevan_1073
MVO: Mvol_1374
MOK: Metok_0200
METF: CFE53_02485(mer)
MTH: MTH_1752
MMG: MTBMA_c03270(mer)
MWO: MWSIV6_0292(mer)
MTEE: MTTB_14460
METC: MTCT_1602
METE: tca_01698
METZ: METMT2_1536
METK: FVF72_02910(mer)
MTHM: FZP57_01345(mer)
METJ: FZP68_06355(mer)
MST: Msp_1128(mer)
METB: AW729_10140
MEIS: PXD04_02020
MRU: mru_0569(mer)
MSI: Msm_0542
MEB: Abm4_1417(mer)
MMIL: sm9_0419(mer)
MEYE: TL18_02180
MOL: YLM1_0233
MARO: MarbSA_08410
METV: K4897_03275(mer)
MEL: Metbo_0510
MEW: MSWAN_1889
METH: MBMB1_1520(mer)
MFC: BRM9_0745(mer)
MFI: DSM1535_0704(mer)
MCUB: MCBB_1769(mer)
MSUB: BK009_06580
METN: BK008_02175
METT: CIT01_07510(mer)
METO: CIT02_10410(mer)
MEME: HYG87_08125(mer)
MFEG: GCM10025860_00380
MEER: NKF70_04385(mer)
MRID: FGU46_07285(mer)
MFV: Mfer_0274
MKA: MK0524(mer)
AFU: AF_1066
AFG: AFULGI_00011650
APO: Arcpr_1585
AVE: Arcve_0808 Arcve_1055
AST: Asulf_00466 Asulf_02156
FPL: Ferp_0743
GAC: GACE_0389
GAH: GAH_01105
MBA: Mbar_A0254
MBY: MSBRM_2698
MBW: MSBRW_0741
MBAR: MSBR2_2654
MBAK: MSBR3_0245 MSBR3_2771
MAC: MA_3733(mer)
MMA: MM_0628
MMJ: MSMAS_0681
MMAC: MSMAC_0682
MVC: MSVAZ_0679
MEK: MSKOL_0657
MLS: MSLAZ_2235
METM: MSMTP_0746
MEF: MSWH1_0878
MEQ: MSWHS_0937
MSJ: MSSAC_3543
MSZ: MSSIH_3084
MSW: MSSIT_3142
MTHR: MSTHT_2388
MTHE: MSTHC_0892
MHOR: MSHOH_0799
MFZ: AOB57_003480(mer)
MHAB: RSJ42_12180(mer)
METW: AAY43_06130
MBU: Mbur_2372(mer)
MMET: MCMEM_0517
MELO: J7W08_00610(mer)
MMH: Mmah_1513
MHAZ: BHR79_06165
MPOT: BKM01_02375
MEV: Metev_2139
MZH: Mzhil_0168
MPY: Mpsy_2035
MZI: HWN40_11975(mer)
MMAV: RE476_11455(mer)
MSEB: RE474_08075(mer)
MHZ: Metho_2247
MEHF: MmiHf6_02030(fgd1)
MEES: MmiEs2_08170(fgd1)
MTP: Mthe_0205
MCJ: MCON_2394(mer)
MHI: Mhar_0856
MHU: Mhun_2257
MRTJ: KHC33_15695
MLA: Mlab_0076
MEM: Memar_0557
MBG: BN140_1674(mer)
MEMA: MMAB1_2155(mer)
MCHK: MchiMG62_06860
MSUM: OH143_09515
MRC: R6Y96_00050
MPI: Mpet_2180
MEND: L6E24_10130
MEFW: F1737_01895
MAQE: RJ40_06375
MFK: E2N92_06510
MOU: OU421_03230
MESB: L1S32_06815
MANQ: L1994_02945
MBN: Mboo_0528
MFO: Metfor_2659
MESK: METHP_00439
MPL: Mpal_0327
MPD: MCP_2681(mer)
MEZ: Mtc_0135(mer)
RCI: RCIX564(mer)
HDL: HALDL1_03000
HHB: Hhub_1106(mer)
HNO: LT974_14745
HLU: LT972_12970
HANX: ABSL23_05355
HSU: HLASF_0416(mer)
HSF: HLASA_0415(mer)
HAHS: HSRCO_0593
SALR: FQU85_03600 FQU85_08510
HALR: EFA46_004740
HJE: HacjB3_04915 HacjB3_13295
HDO: MUK72_11295
HALX: M0R89_08695
HAXZ: M0R88_08905
HAYC: NGM10_10025
HAXY: NGM07_14540
SALI: L593_00135
SAIM: K0C01_04820
HARA: AArcS_2336
HMA: rrnAC2437(mer1)
HSIN: KDQ40_15110
HHI: HAH_2870(mer3)
HHN: HISP_14590
HAB: SG26_06730
HTA: BVU17_13960
HALJ: G9465_05265
NPH: NP_1056A(mer)
NMO: Nmlp_1133(mer)
NHO: HWV23_08180
NSAL: HWV07_10100
HUT: Huta_1395
HTI: HTIA_1288
HALA: Hrd1104_10095
HASV: SVXHr_0236(mer)
HABN: HBNXHr_0227(mer)
HMU: Hmuk_0341
HALZ: E5139_04990
HALL: LC1Hm_2870(mer)
HAZP: GBQ70_04985
HALI: BV210_10785
HSN: DV733_10440
HDS: HSR122_0385
HRR: HZS55_02155
HPEL: HZS54_01595
HLT: I7X12_11140
HARC: HARCEL1_05640
SSAI: N0B31_17585
HAAD: MW046_10005
HWA: HQ_3154A(mer)
HWC: Hqrw_3697(mer)
HVO: HVO_1937(mer)
HALE: G3A49_12675
HLN: SVXHx_2682(mer)
HME: HFX_2030(mer)
HGI: ABY42_09440
HLS: KU306_02840
HBO: Hbor_05330
HAQ: DU484_03660 DU484_04770
HAJ: DU500_04145 DU500_05210
HAER: DU502_01690
HRA: EI982_10810 EI982_11685
HLM: DV707_14720
HALM: FCF25_00710
HLA: Hlac_1680
HALP: DOS48_08290
HALB: EKH57_01810
HEZZ: EO776_10900
HALQ: Hrr1229_013655
HSS: J7656_06825
HSAI: HPS36_12235
HAZZ: KI388_07775
SRUB: C2R22_17165
HAE: halTADL_0321 halTADL_1346
HALN: B4589_005885
HALG: HUG10_11070
HALU: HUG12_00730 HUG12_05610
HMP: K6T50_07940
HRE: K6T36_07775
HRM: K6T25_08045
HACB: Hbl1158_14415
HAH: Halar_1772
HTU: Htur_3573
HSAL: JMJ58_10490
HAKZ: J0X25_05575 J0X25_19080 J0X25_19090
NMG: Nmag_1582(mer)
HXA: Halxa_3407
NAT: NJ7G_2905
NPE: Natpe_0251
NVR: FEJ81_01420
NPL: FGF80_09575
NAY: HYG81_09345
HALY: HYG82_12020
HJT: DVR14_10650
HLO: J0X27_12155
NGE: Natgr_2297
HLC: CHINAEXTREME06980
HRU: Halru_2719
SAWL: NGM29_00760
HALV: NGM15_10290
NOU: Natoc_2482
HLR: HALLA_18435
NAJ: B1756_04330
NAG: AArcMg_0283
NAN: AArc1_0293
NARA: QQ977_13020
NBG: DV706_06150
NAS: GCU68_07730
HDA: BB347_11940
MELU: MTLP_01530
MEAM: MU439_00980
MEAE: QEN48_01625
NIR: NSED_04635
NKR: NKOR_04660
NID: NPIRD3C_1360
NIW: Nisw_00540
NCL: C5F47_04655
NOX: C5F49_04565
NUE: C5F50_06300
NVN: NVIE_004930(mer)
NEV: NTE_01814
NCV: NCAV_1415
CSU: CSUB_C0377 CSUB_C0386 CSUB_C0571 CSUB_C0806 CSUB_C1220 CSUB_C1712
TAH: SU86_001930
CCAI: NAS2_0789
BARC: AOA65_0782(mer_2)
 » show all
Reference
1  [PMID:2379499]
  Authors
Ma K, Thauer RK
  Title
Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 191:187-93 (1990)
DOI:10.1111/j.1432-1033.1990.tb19109.x
  Sequence
[mmg:MTBMA_c03270]
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim Biophys Acta 1079:293-302 (1991)
DOI:10.1016/0167-4838(91)90072-8
Reference
3  [PMID:1696553]
  Authors
Ma K, Thauer RK.
  Title
Single step purification of methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum by specific binding to blue sepharose CL-6B.
  Journal
FEBS Lett 268:59-62 (1990)
DOI:10.1016/0014-5793(90)80972-L
Reference
4  [PMID:2298726]
  Authors
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
  Journal
J Biol Chem 265:1852-7 (1990)
  Sequence
[mth:MTH_1752]
Reference
5  [PMID:2298699]
  Authors
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri.
  Journal
J Bacteriol 172:564-71 (1990)
DOI:10.1128/JB.172.2.564-571.1990
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.2
IUBMB Enzyme Nomenclature: 1.5.98.2
ExPASy - ENZYME nomenclature database: 1.5.98.2
BRENDA, the Enzyme Database: 1.5.98.2

  All links  
Gene (2793)   
   MGENES (2385)   
   RefGene (408)   
Protein sequence (2490)   
   UniProt (1326)   
   SWISS-PROT (9)   
   RefSeq(pep) (1151)   
   PDBSTR (4)   
DNA sequence (2427)   
   RefSeq(nuc) (1829)   
   GenBank (315)   
   EMBL (283)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   InterPro (4)   
All databases (7715)   

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KEGG   REACTION: R04464
Entry
R04464                      Reaction                               
Name
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Definition
5,10-Methylenetetrahydromethanopterin + Reduced coenzyme F420 <=> 5-Methyl-5,6,7,8-tetrahydromethanopterin + Coenzyme F420
Equation
C04377 + C01080 <=> C04488 + C00876
Reaction class
RC01607  C04377_C04488
RC02628  C00876_C01080
Enzyme
1.5.98.2
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00567  Methanogenesis, CO2 => methane
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.98  With other, known, physiological acceptors
    1.5.98.2
     R04464  5,10-Methylenetetrahydromethanopterin + Reduced coenzyme F420 <=> 5-Methyl-5,6,7,8-tetrahydromethanopterin + Coenzyme F420
Orthology
K00320  5,10-methylenetetrahydromethanopterin reductase [EC:1.5.98.2]
Other DBs
RHEA: 21147

  All links  
Chemical reaction (1)   
   UMBBD-RN (1)   
All databases (1)   

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