KEGG   ORTHOLOGY: K00399
Entry
K00399                      KO                                     

Name
mcrA
Definition
methyl-coenzyme M reductase alpha subunit [EC:2.8.4.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00399  mcrA; methyl-coenzyme M reductase alpha subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.4  Transferring alkylthio groups
    2.8.4.1  coenzyme-B sulfoethylthiotransferase
     K00399  mcrA; methyl-coenzyme M reductase alpha subunit
Other DBs
RN: R04541
GO: 0050524
Genes
MJA: MJ_0083 MJ_0846
MFE: Mefer_0938
MVU: Metvu_0149 Metvu_1194
MFS: MFS40622_0424 MFS40622_1315
MIF: Metin_0281
MJH: JH146_0503 JH146_1056
MIG: Metig_0445 Metig_1237
MMP: MMP1559(mcrA)
MMQ: MmarC5_0017
MMX: MmarC6_1111
MMD: GYY_08645
MMAK: MMKA1_17890(mcrA)
MMAO: MMOS7_16710(mcrA)
MMAD: MMJJ_12770(mcrA)
MAE: Maeo_1268
MVO: Mvol_1128
METF: CFE53_01190(mcrA)
MMG: MTBMA_c15120(mrtA) MTBMA_c15480(mcrA)
MWO: MWSIV6_1521(mrtA) MWSIV6_1556(mcrA)
METK: FVF72_05765(mcrA) FVF72_05940(mcrA)
MTHM: FZP57_07280(mcrA) FZP57_07455(mcrA)
MST: Msp_0321(mrtA)
MRU: mru_1924(mcrA)
MEB: Abm4_1526(mcrA)
MMIL: sm9_1353(mrtA) sm9_2027(mcrA)
MEYE: TL18_09320
METH: MBMB1_1682(mcrA) MBMB1_1825(mrtA)
MFC: BRM9_0935(mcrA) BRM9_2156(mrtA)
MFI: DSM1535_0905(mcrA) DSM1535_1095(mrtA)
MCUB: MCBB_1985(mcrA)
METT: CIT01_01115(mcrA) CIT01_03630(mcrA)
METO: CIT02_08450(mcrA) CIT02_09480(mcrA)
MKA: MK0655(mcrA)
MBAR: MSBR2_2279
MBAK: MSBR3_2340
MAC: MA_4546
MMA: MM_1240
MMAC: MSMAC_0072
METM: MSMTP_0100
MTHR: MSTHT_1644
MTHE: MSTHC_1645
MHOR: MSHOH_0084
MFZ: AOB57_007335(mcrA)
MBU: Mbur_2417(mcrA)
MMET: MCMEM_0559
MMH: Mmah_0612
MPY: Mpsy_0828
MZI: HWN40_04520(mcrA)
MTP: Mthe_0569
MCJ: MCON_0759(mcrA)
MHI: Mhar_0498
MHU: Mhun_2148
MBG: BN140_1521(mcrA1) BN140_1738(mcrA3)
MEMA: MMAB1_1952(mcrA) MMAB1_2235(mcrA)
MBN: Mboo_0582
MPL: Mpal_2309
MPD: MCP_0516(mcrA)
MEZ: Mtc_0908(mcrA)
RCI: RCIX2063(mcrA)
MEAR: Mpt1_c02010(mcrA)
MARC: AR505_1396
BARC: AOA65_0408(mcrA)
BARB: AOA66_1761(mcrA)
 » show all
Reference
PMID:9367957
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457
  Sequence

KEGG   ORTHOLOGY: K00400
Entry
K00400                      KO                                     

Name
K00400
Definition
methyl coenzyme M reductase system, component A2
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00400  K00400; methyl coenzyme M reductase system, component A2
Other DBs
COG: COG1123
Genes
MJA: MJ_1242 MJ_1662
MFE: Mefer_0379 Mefer_0959
MVU: Metvu_1123 Metvu_1469
MFS: MFS40622_0590 MFS40622_0695
MIF: Metin_0537 Metin_0847
MJH: JH146_0483 JH146_1479
MIG: Metig_0484 Metig_0791
MMP: MMP0620(atwA) MMP1630
MMQ: MmarC5_0985 MmarC5_1779
MMX: MmarC6_0271 MmarC6_1040
MMAD: MMJJ_03630(opuCA) MMJJ_12070(artM)
METE: tca_00135(metN) tca_00976(glnQ)
MRU: mru_1262(atwA1) mru_1850(atwA2)
MEB: Abm4_0774 Abm4_1484(atwA)
MMIL: sm9_1384(atwA1) sm9_1934(atwA2)
MFC: BRM9_0862(atwA1) BRM9_1087(atwA2) BRM9_2103(atwA3)
MCJ: MCON_0393(atwA) MCON_2841
MHU: Mhun_2311
MEMA: MMAB1_2079
MPI: Mpet_1904
MBN: Mboo_2434
MPD: MCP_0522(atw-1) MCP_1059(atw-2)
MEZ: Mtc_0912(atw-1) Mtc_1855(atw-2)
MARC: AR505_1392
BARC: AOA65_0403
 » show all
Reference
PMID:9367957
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457

KEGG   ORTHOLOGY: K00401
Entry
K00401                      KO                                     

Name
mcrB
Definition
methyl-coenzyme M reductase beta subunit [EC:2.8.4.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00401  mcrB; methyl-coenzyme M reductase beta subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.4  Transferring alkylthio groups
    2.8.4.1  coenzyme-B sulfoethylthiotransferase
     K00401  mcrB; methyl-coenzyme M reductase beta subunit
Other DBs
RN: R04541
GO: 0050524
Genes
MJA: MJ_0081 MJ_0842
MFE: Mefer_0934
MVU: Metvu_0145 Metvu_1192
MFS: MFS40622_0426 MFS40622_1319
MIF: Metin_0285
MJH: JH146_0505 JH146_1060
MIG: Metig_0442 Metig_1233
MMP: MMP1555(mcrB)
MMQ: MmarC5_0021
MMX: MmarC6_1115
MMD: GYY_08625
MMAK: MMKA1_17850(mcrB)
MMAO: MMOS7_16670(mcrB)
MMAD: MMJJ_12810(mcB)
MAE: Maeo_1264
MVO: Mvol_1124
METF: CFE53_01210(mcrB)
MMG: MTBMA_c15150(mrtB) MTBMA_c15520(mcrB)
MWO: MWSIV6_1524(mrtB) MWSIV6_1560(mcrB)
METK: FVF72_05745(mcrB) FVF72_05925(mcrB)
MTHM: FZP57_07295(mcrB) FZP57_07475(mcrB)
MST: Msp_0318(mrtB)
MRU: mru_1928(mcrB)
MEB: Abm4_1530(mcrB)
MMIL: sm9_1356(mrtB) sm9_2031(mcrB)
MEYE: TL18_09340
METH: MBMB1_1686(mcrB) MBMB1_1822(mrtB)
MFC: BRM9_0939(mcrB) BRM9_2153(mrtB)
MFI: DSM1535_0909(mcrB) DSM1535_1092(mrtB)
MCUB: MCBB_1989(mcrB)
METT: CIT01_01100(mcrB) CIT01_03650(mcrB)
METO: CIT02_08465(mcrB) CIT02_09460(mcrB)
MKA: MK0651(mcrB)
MBAR: MSBR2_2283
MBAK: MSBR3_2344
MAC: MA_4550
MMA: MM_1244
MMAC: MSMAC_0068
METM: MSMTP_0096
MTHR: MSTHT_1640
MTHE: MSTHC_1649
MHOR: MSHOH_0080
MFZ: AOB57_007315(mcrB)
MBU: Mbur_2421(mcrB)
MMET: MCMEM_0563
MMH: Mmah_0616
MPY: Mpsy_0832
MZI: HWN40_04500(mcrB)
MTP: Mthe_0572
MCJ: MCON_0762(mcrB)
MHI: Mhar_0495
MHU: Mhun_2144
MBG: BN140_1524(mcrB1) BN140_1734(mcrB3)
MEMA: MMAB1_1956 MMAB1_2231(mcrB)
MBN: Mboo_0586
MPL: Mpal_2305
MPD: MCP_0512(mcrB)
MEZ: Mtc_0904(mcrB)
RCI: RCIX2059(mcrB)
MEAR: Mpt1_c01980(mcrB)
MARC: AR505_1399
BARC: AOA65_0406(mrtB)
BARB: AOA66_1769(mrtB)
 » show all
Reference
PMID:9367957
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457
  Sequence

KEGG   ORTHOLOGY: K00402
Entry
K00402                      KO                                     

Name
mcrG
Definition
methyl-coenzyme M reductase gamma subunit [EC:2.8.4.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00402  mcrG; methyl-coenzyme M reductase gamma subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.4  Transferring alkylthio groups
    2.8.4.1  coenzyme-B sulfoethylthiotransferase
     K00402  mcrG; methyl-coenzyme M reductase gamma subunit
Other DBs
RN: R04541
GO: 0050524
Genes
MJA: MJ_0082 MJ_0845
MFE: Mefer_0937
MVU: Metvu_0148 Metvu_1193
MFS: MFS40622_0425 MFS40622_1316
MIF: Metin_0282
MJH: JH146_0504 JH146_1057
MIG: Metig_0444 Metig_1236
MMP: MMP1558(mcrG)
MMQ: MmarC5_0018
MMX: MmarC6_1112
MMD: GYY_08640
MMAK: MMKA1_17880(mcrG)
MMAO: MMOS7_16700(mcrG)
MMAD: MMJJ_12780(mcrG)
MAE: Maeo_1267
MVO: Mvol_1127
METF: CFE53_01195(mcrG)
MMG: MTBMA_c15130(mrtG) MTBMA_c15490(mcrG)
MWO: MWSIV6_1522(mrtG) MWSIV6_1557(mcrG)
METK: FVF72_05760(mcrG) FVF72_05935(mcrG)
MTHM: FZP57_07285(mcrG) FZP57_07460(mcrG)
MST: Msp_0320(mrtG)
MRU: mru_1925(mcrG)
MEB: Abm4_1527(mcrG)
MMIL: sm9_1354(mrtG) sm9_2028(mcrG)
MEYE: TL18_09325
METH: MBMB1_1683(mcrG) MBMB1_1824(mrtG)
MFC: BRM9_0936(mcrG) BRM9_2155(mrtG)
MFI: DSM1535_0906(mcrG) DSM1535_1094(mrtG)
MCUB: MCBB_1986(mcrG)
METT: CIT01_01110(mcrG) CIT01_03635(mcrG)
METO: CIT02_08455(mcrG) CIT02_09475(mcrG)
MKA: MK0654(mcrG)
MBAR: MSBR2_2280
MBAK: MSBR3_2341
MAC: MA_4547
MMA: MM_1241
MMAC: MSMAC_0071
METM: MSMTP_0099
MTHR: MSTHT_1643
MTHE: MSTHC_1646
MHOR: MSHOH_0083
MFZ: AOB57_007330(mcrG)
MBU: Mbur_2418(mcrG)
MMET: MCMEM_0560
MMH: Mmah_0613
MPY: Mpsy_0829
MZI: HWN40_04515(mcrG)
MTP: Mthe_0570
MCJ: MCON_0760(mcrG)
MHI: Mhar_0497
MHU: Mhun_2147
MBG: BN140_1522(mcrG1) BN140_1737(mcrG3)
MEMA: MMAB1_1953(mcrG) MMAB1_2234(mcrG)
MBN: Mboo_0583
MPL: Mpal_2308
MPD: MCP_0515(mcrG)
MEZ: Mtc_0907(mcrG)
RCI: RCIX2062(mcrG)
MEAR: Mpt1_c02000(mrtG)
MARC: AR505_1397
BARC: AOA65_0407(mcrG)
BARB: AOA66_1770(mcrG)
 » show all
Reference
PMID:9367957
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457
  Sequence

KEGG   ORTHOLOGY: K03421
Entry
K03421                      KO                                     

Name
mcrC
Definition
methyl-coenzyme M reductase subunit C
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03421  mcrC; methyl-coenzyme M reductase subunit C
Genes
MJA: MJ_0844
MFE: Mefer_0936
MVU: Metvu_0147
MFS: MFS40622_1317
MIF: Metin_0283
MJH: JH146_1058
MIG: Metig_1235
MMP: MMP1557(mcrC)
MMQ: MmarC5_0019
MMX: MmarC6_1113
MMD: GYY_08635
MMAK: MMKA1_17870(mcrC)
MMAO: MMOS7_16690(mcrC)
MMAD: MMJJ_12790(mcrC)
MAE: Maeo_1266
MVO: Mvol_1126
METF: CFE53_01200(mcrC)
MTH: MTH_1166
MMG: MTBMA_c15500(mcrE)
METC: MTCT_1060
MWO: MWSIV6_1558(mcrC)
METE: tca_01123
METK: FVF72_05755(mcrC)
MTHM: FZP57_07465(mcrC)
MST: Msp_0299(mcrC)
MRU: mru_1926(mcrC)
MSI: Msm_1017
MEB: Abm4_1528(mcrC)
MMIL: sm9_2029(mcrC)
MEYE: TL18_09330
MOL: YLM1_1381
METH: MBMB1_1684(mcrC)
MFC: BRM9_0937(mcrC)
MFI: DSM1535_0907(mcrC)
MCUB: MCBB_1987(mcrC)
METT: CIT01_03640(mcrC)
METO: CIT02_09470(mcrC)
MFV: Mfer_0786
MKA: MK0653(mcrC)
MBAR: MSBR2_2281
MBAK: MSBR3_2342
MAC: MA_4548
MMA: MM_1242
MMAC: MSMAC_0070
METM: MSMTP_0098
MTHR: MSTHT_1642
MTHE: MSTHC_1647
MHOR: MSHOH_0082
MFZ: AOB57_007325(mcrC)
MBU: Mbur_2419(mcrC)
MMET: MCMEM_0561
MMH: Mmah_0614
MPY: Mpsy_0830
MZI: HWN40_04510(mcrC)
MTP: Mthe_0546
MCJ: MCON_1450(mcrC)
MHI: Mhar_0529
MHU: Mhun_2146
MLA: Mlab_1563
MBG: BN140_1736(mcrC)
MEMA: MMAB1_2233(mcrC)
MPI: Mpet_2417
MBN: Mboo_0584
MPL: Mpal_2307
MPD: MCP_0514(mcrC)
MEZ: Mtc_0906(mcrC)
RCI: RCIX2061(mcrC)
MEAR: Mpt1_c06080(mcrC)
MARC: AR505_1391
BARB: AOA66_1748(mcrC)
 » show all
Reference
PMID:9367957
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457

KEGG   ORTHOLOGY: K03422
Entry
K03422                      KO                                     

Name
mcrD
Definition
methyl-coenzyme M reductase subunit D
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03422  mcrD; methyl-coenzyme M reductase subunit D
Genes
MJA: MJ_0118 MJ_0843
MFE: Mefer_0817 Mefer_0935
MVU: Metvu_0146 Metvu_1195
MFS: MFS40622_0995 MFS40622_1318
MIF: Metin_0284
MJH: JH146_0749 JH146_1059
MIG: Metig_0443 Metig_1234
MMP: MMP1556(mcrD)
MMQ: MmarC5_0020
MMX: MmarC6_1114
MMD: GYY_08630
MMAK: MMKA1_17860(mcrD)
MMAO: MMOS7_16680(mcrD)
MMAD: MMJJ_12800(mcrD)
MAE: Maeo_1265
MVO: Mvol_1125
METF: CFE53_01205(mcrD)
MMG: MTBMA_c15140(mrtD) MTBMA_c15510(mcrD)
MWO: MWSIV6_1523(mrtD) MWSIV6_1559(mcrD)
METK: FVF72_05750(mcrD) FVF72_05930(mcrD)
MTHM: FZP57_07290(mcrD) FZP57_07470(mcrD)
MST: Msp_0319(mrtD)
MRU: mru_1927(mcrD)
MEB: Abm4_1529(mcrD)
MMIL: sm9_1355(mrtD) sm9_2030(mcrD)
MEYE: TL18_09335
METH: MBMB1_1685(mcrD) MBMB1_1823
MFC: BRM9_0938(mcrD) BRM9_2154(mrtD)
MCUB: MCBB_1988(mcrD)
METT: CIT01_01105(mcrD) CIT01_03645(mcrD)
METO: CIT02_08460(mcrD) CIT02_09465(mcrD)
MKA: MK0652(mcrD)
MBAR: MSBR2_2282
MBAK: MSBR3_2343
MAC: MA_4549
MMA: MM_1243
MMAC: MSMAC_0069
METM: MSMTP_0097
MTHR: MSTHT_1641
MTHE: MSTHC_1648
MHOR: MSHOH_0081
MFZ: AOB57_007320(mcrD)
MBU: Mbur_2420(mcrD)
MMET: MCMEM_0562
MMH: Mmah_0615
MPY: Mpsy_0831
MZI: HWN40_04505(mcrD)
MTP: Mthe_0571
MCJ: MCON_0761(mcrD)
MHI: Mhar_0496
MHU: Mhun_2145
MLA: Mlab_1564
MBG: BN140_1523(mcrD1) BN140_1735(mcrD3)
MEMA: MMAB1_1954 MMAB1_2232(mcrD)
MPI: Mpet_2418
MBN: Mboo_0585
MPL: Mpal_2306
MPD: MCP_0513(mcrD-1) MCP_0559(mcrD-2)
MEZ: Mtc_0905(mcrD)
RCI: RCIX2060(mcrD-1) RCIX962(mcrD-2)
MEAR: Mpt1_c01990(mcrD)
MARC: AR505_1398
BARB: AOA66_1749(mcrD)
 » show all
Reference
PMID:9367957
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457

KEGG   ENZYME: 2.8.4.1
Entry
EC 2.8.4.1                  Enzyme                                 

Name
coenzyme-B sulfoethylthiotransferase;
methyl-CoM reductase;
methyl coenzyme M reductase
Class
Transferases;
Transferring sulfur-containing groups;
Transferring alkylthio groups
Sysname
methyl-CoM:CoB S-(2-sulfoethyl)thiotransferase
Reaction(IUBMB)
methyl-CoM + CoB = CoM-S-S-CoB + methane [RN:R04541]
Reaction(KEGG)
R04541
Substrate
methyl-CoM [CPD:C03920];
CoB [CPD:C04628]
Product
CoM-S-S-CoB [CPD:C04832];
methane [CPD:C01438]
Comment
This enzyme catalyses the final step in methanogenesis, the biological production of methane. This important anaerobic process is carried out only by methanogenic archaea. The enzyme can also function in reverse, for anaerobic oxidation of methane.The enzyme requires the hydroporphinoid nickel complex coenzyme F430. Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. The sulfide sulfur can be replaced by selenium but not by oxygen.
History
EC 2.8.4.1 created 2001, modified 2011
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00399  methyl-coenzyme M reductase alpha subunit
K00401  methyl-coenzyme M reductase beta subunit
K00402  methyl-coenzyme M reductase gamma subunit
Genes
MJA: MJ_0081 MJ_0082 MJ_0083 MJ_0842 MJ_0845 MJ_0846
MFE: Mefer_0934 Mefer_0937 Mefer_0938
MVU: Metvu_0145 Metvu_0148 Metvu_0149 Metvu_1192 Metvu_1193 Metvu_1194
MFS: MFS40622_0424 MFS40622_0425 MFS40622_0426 MFS40622_1315 MFS40622_1316 MFS40622_1319
MIF: Metin_0281 Metin_0282 Metin_0285
MJH: JH146_0503 JH146_0504 JH146_0505 JH146_1056 JH146_1057 JH146_1060
MIG: Metig_0442 Metig_0444 Metig_0445 Metig_1233 Metig_1236 Metig_1237
MMP: MMP1555(mcrB) MMP1558(mcrG) MMP1559(mcrA)
MMQ: MmarC5_0017 MmarC5_0018 MmarC5_0021
MMX: MmarC6_1111 MmarC6_1112 MmarC6_1115
MMAK: MMKA1_17850(mcrB) MMKA1_17880(mcrG) MMKA1_17890(mcrA)
MMAO: MMOS7_16670(mcrB) MMOS7_16700(mcrG) MMOS7_16710(mcrA)
MMAD: MMJJ_12770(mcrA) MMJJ_12780(mcrG) MMJJ_12810(mcB)
METF: CFE53_01190(mcrA) CFE53_01195(mcrG) CFE53_01210(mcrB)
MWO: MWSIV6_1521(mrtA) MWSIV6_1522(mrtG) MWSIV6_1524(mrtB) MWSIV6_1556(mcrA) MWSIV6_1557(mcrG) MWSIV6_1560(mcrB)
METK: FVF72_05745(mcrB) FVF72_05760(mcrG) FVF72_05765(mcrA) FVF72_05925(mcrB) FVF72_05935(mcrG) FVF72_05940(mcrA)
MTHM: FZP57_07280(mcrA) FZP57_07285(mcrG) FZP57_07295(mcrB) FZP57_07455(mcrA) FZP57_07460(mcrG) FZP57_07475(mcrB)
MST: Msp_0318(mrtB) Msp_0320(mrtG) Msp_0321(mrtA)
MRU: mru_1924(mcrA) mru_1925(mcrG) mru_1928(mcrB)
MEB: Abm4_1526(mcrA) Abm4_1527(mcrG) Abm4_1530(mcrB)
MMIL: sm9_1353(mrtA) sm9_1354(mrtG) sm9_1356(mrtB) sm9_2027(mcrA) sm9_2028(mcrG) sm9_2031(mcrB)
METH: MBMB1_1682(mcrA) MBMB1_1683(mcrG) MBMB1_1686(mcrB) MBMB1_1822(mrtB) MBMB1_1824(mrtG) MBMB1_1825(mrtA)
MFC: BRM9_0935(mcrA) BRM9_0936(mcrG) BRM9_0939(mcrB) BRM9_2153(mrtB) BRM9_2155(mrtG) BRM9_2156(mrtA)
MCUB: MCBB_1985(mcrA) MCBB_1986(mcrG) MCBB_1989(mcrB)
METT: CIT01_01100(mcrB) CIT01_01110(mcrG) CIT01_01115(mcrA) CIT01_03630(mcrA) CIT01_03635(mcrG) CIT01_03650(mcrB)
METO: CIT02_08450(mcrA) CIT02_08455(mcrG) CIT02_08465(mcrB) CIT02_09460(mcrB) CIT02_09475(mcrG) CIT02_09480(mcrA)
MKA: MK0651(mcrB) MK0654(mcrG) MK0655(mcrA)
MFZ: AOB57_007315(mcrB) AOB57_007330(mcrG) AOB57_007335(mcrA)
MBU: Mbur_2417(mcrA) Mbur_2418(mcrG) Mbur_2421(mcrB)
MZI: HWN40_04500(mcrB) HWN40_04515(mcrG) HWN40_04520(mcrA)
MCJ: MCON_0759(mcrA) MCON_0760(mcrG) MCON_0762(mcrB)
MBG: BN140_1521(mcrA1) BN140_1522(mcrG1) BN140_1524(mcrB1) BN140_1734(mcrB3) BN140_1737(mcrG3) BN140_1738(mcrA3)
MEMA: MMAB1_1952(mcrA) MMAB1_1953(mcrG) MMAB1_1956 MMAB1_2231(mcrB) MMAB1_2234(mcrG) MMAB1_2235(mcrA)
MPD: MCP_0512(mcrB) MCP_0515(mcrG) MCP_0516(mcrA)
MEZ: Mtc_0904(mcrB) Mtc_0907(mcrG) Mtc_0908(mcrA)
RCI: RCIX2059(mcrB) RCIX2062(mcrG) RCIX2063(mcrA)
MEAR: Mpt1_c01980(mcrB) Mpt1_c02000(mrtG) Mpt1_c02010(mcrA)
BARC: AOA65_0406(mrtB) AOA65_0407(mcrG) AOA65_0408(mcrA)
BARB: AOA66_1761(mcrA) AOA66_1769(mrtB) AOA66_1770(mcrG)
 » show all
Reference
1  [PMID:3122735]
  Authors
Bobik TA, Olson KD, Noll KM, Wolfe RS.
  Title
Evidence that the heterodisulfide of coenzyme M and 7-mercaptoheptanoylthreonine phosphate is a product of the methylreductase reaction in Methanobacterium.
  Journal
Biochem Biophys Res Commun 149:455-60 (1987)
DOI:10.1016/0006-291X(87)90389-5
Reference
2
  Authors
Ellermann, J., Hedderich, R., Boecher, R. and Thauer, R.K.
  Title
The final step in methane formation: investigations with highly purified methyl coenzyme M reductase component C from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 184:63-68 (1988)
Reference
3  [PMID:9367957]
  Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
  Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Journal
Science 278:1457-62 (1997)
DOI:10.1126/science.278.5342.1457
  Sequence
Reference
4  [PMID:11072815]
  Authors
Signor L, Knuppe C, Hug R, Schweizer B, Pfaltz A, Jaun B.
  Title
Methane formation by reaction of a methyl thioether with a photo-excited nickel thiolate--a process mimicking methanogenesis in archaea.
  Journal
Reference
5  [PMID:20520712]
  Authors
Scheller S, Goenrich M, Boecher R, Thauer RK, Jaun B
  Title
The key nickel enzyme of methanogenesis catalyses the anaerobic oxidation of methane.
  Journal
Nature 465:606-8 (2010)
DOI:10.1038/nature09015
Other DBs
ExplorEnz - The Enzyme Database: 2.8.4.1
IUBMB Enzyme Nomenclature: 2.8.4.1
ExPASy - ENZYME nomenclature database: 2.8.4.1
UM-BBD (Biocatalysis/Biodegradation Database): 2.8.4.1
BRENDA, the Enzyme Database: 2.8.4.1

KEGG   REACTION: R04541
Entry
R04541                      Reaction                               

Name
2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase
Definition
Coenzyme B + 2-(Methylthio)ethanesulfonate <=> Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + Methane
Equation
Reaction class
RC00011  C04628_C04832
RC01542  C01438_C03920
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Orthology
K00399  methyl-coenzyme M reductase alpha subunit [EC:2.8.4.1]
K00401  methyl-coenzyme M reductase beta subunit [EC:2.8.4.1]
K00402  methyl-coenzyme M reductase gamma subunit [EC:2.8.4.1]
Other DBs
RHEA: 12535

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