KEGG   ORTHOLOGY: K00476
Entry
K00476                      KO                                     

Name
ASPH
Definition
aspartate beta-hydroxylase [EC:1.14.11.16]
Pathway
ko04020  Calcium signaling pathway
ko04260  Cardiac muscle contraction
Disease
H02255  FDLAB syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K00476  ASPH; aspartate beta-hydroxylase
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K00476  ASPH; aspartate beta-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.16  peptide-aspartate beta-dioxygenase
     K00476  ASPH; aspartate beta-hydroxylase
Other DBs
GO: 0004597
Genes
HSA: 444(ASPH)
PTR: 464202(ASPH)
PPS: 100977040(ASPH)
GGO: 101139593(ASPH)
PON: 100189667(ASPH)
NLE: 100581524(ASPH)
MCC: 699884(ASPH)
MCF: 101925502(ASPH)
CSAB: 103236861(ASPH)
RRO: 104660101(ASPH)
RBB: 108543145(ASPH)
CJC: 100403503(ASPH)
SBQ: 101045507(ASPH)
MMU: 65973(Asph)
MCAL: 110293480(Asph)
MPAH: 110338639(Asph)
RNO: 312981(Asph)
MUN: 110562911(Asph)
CGE: 100755768(Asph)
NGI: 103737741(Asph)
HGL: 101725986(Asph)
CCAN: 109678257 109697332(Asph)
OCU: 100008743(ASPH) 108176505
TUP: 102478772(ASPH)
CFA: 403846(ASPH)
VVP: 112932148 112932323(ASPH)
AML: 100479314(ASPH)
UMR: 103677467(ASPH)
UAH: 113268067(ASPH)
ORO: 101373057(ASPH)
FCA: 105260207(ASPH)
PTG: 102960536(ASPH)
PPAD: 109250263(ASPH)
AJU: 106973810(ASPH)
BTA: 286771(ASPH)
BOM: 102285100(ASPH)
BIU: 109568307(ASPH)
BBUB: 102396221(ASPH)
CHX: 102189496(ASPH)
OAS: 101118195(ASPH)
SSC: 100526167(ASPH)
CFR: 102505456(ASPH)
CDK: 105093932(ASPH)
BACU: 103017679(ASPH)
LVE: 103068515(ASPH)
OOR: 101274120(ASPH)
DLE: 111185601(ASPH)
PCAD: 102987140(ASPH)
ECB: 100065909(ASPH)
EPZ: 103547567(ASPH)
EAI: 106843667(ASPH)
MYB: 102255804(ASPH)
MYD: 102769038(ASPH)
MNA: 107526441 107526448(ASPH)
HAI: 109377781
DRO: 112315321
PALE: 102885216(ASPH)
RAY: 107519658(ASPH)
MJV: 108395459(ASPH)
LAV: 100670793(ASPH)
TMU: 101360914
MDO: 100029689(ASPH) 103102349
SHR: 100923835
PCW: 110219026(ASPH)
OAA: 100082566(ASPH)
GGA: 421142(ASPH)
MGP: 100540272(ASPH)
CJO: 107310216(ASPH)
NMEL: 110394980(ASPH)
APLA: 101796017(ASPH)
ACYG: 106039040(ASPH)
TGU: 105759899(ASPH)
SCAN: 103812527(ASPH)
GFR: 102038570(ASPH)
FAB: 101809173(ASPH)
PHI: 102100401(ASPH)
PMAJ: 107199898(ASPH)
CCAE: 111924696(ASPH)
CCW: 104690358
ETL: 114062629(ASPH)
FPG: 101911221(ASPH)
FCH: 102046157(ASPH)
CLV: 102097223(ASPH)
EGZ: 104127600(ASPH)
NNI: 104019734(ASPH)
ACUN: 113476412(ASPH)
PADL: 103923683(ASPH)
AAM: 106494372(ASPH)
AMJ: 102572092(ASPH)
PSS: 102460072(ASPH)
CMY: 102937266(ASPH)
CPIC: 101934659(ASPH)
ACS: 100563401(asph)
PVT: 110088966(ASPH)
PBI: 103048046(ASPH)
TSR: 106550102(ASPH) 106556479
GJA: 107114049(ASPH)
XLA: 100137711(asph.L) 108695316
XTR: 548451(asph)
NPR: 108791345(ASPH) 108796606
DRE: 559236(unm_hu7910)
PHYP: 113525363 113540138(asph)
AMEX: 103023508(asph) 103042371
EEE: 113576477 113579299(asph)
LCO: 104932208
NCC: 104957580
PRET: 103456947(asph)
NFU: 107384363 107395322(asph)
KMR: 108250906(asph) 108251691(unm_hu7910)
ALIM: 106527660(asph) 106536003
AOCE: 111569010(asph) 111580824
CSEM: 103377197 103396808(asph)
LCF: 108884981(asph)
SDU: 111233829 111237396(asph)
HCQ: 109515224(asph)
BPEC: 110163976(asph)
ELS: 105030616(asph) 105031615
SFM: 108929627(asph) 108937737
PKI: 111847235(asph)
CMK: 103180766(asph)
RTP: 109932114
BFO: 118405073
CIN: 100185342
SPU: 593797
APLC: 110979582
SKO: 100369952
DME: Dmel_CG8421(Asph)
DER: 6548855
DSI: Dsimw501_GD11159(Dsim_GD11159)
DSR: 110188931
DPE: 6601342
DMN: 108160291
DWI: 6640106
DAZ: 108615400
DNV: 108654292
DHE: 111594021
MDE: 101896755
LCQ: 111683951
AAG: 5566108
AALB: 109409693
CCAL: 108626981
OBB: 114873782
SOC: 105197879
AEC: 105151125
ACEP: 105619868
HST: 105187020
DQU: 106744918
CFO: 105258212
LHU: 105675763
PGC: 109863593
OBO: 105286120
PCF: 106788602
NVI: 100118520
CSOL: 105368488
MDL: 103568298
TCA: 656627
DPA: 109540998
ATD: 109598090
NVL: 108563626
BMOR: 101746449
BMAN: 114246592
PMAC: 106709062
PRAP: 110994810
HAW: 110383774
TNL: 113496816
BTAB: 109041531
CLEC: 106670352
ZNE: 110834569
PVM: 113812951
CSCU: 111635377
PTEP: 107438443
CEL: CELE_K09A9.6(K09A9.6)
CBR: CBG07728
BMY: Bm1_33860
TSP: Tsp_03380
PCAN: 112561951
CRG: 105324538
MYI: 110454515
OBI: 106878285
LAK: 106164016
NVE: 5505006
EPA: 110241474
ADF: 107336775
AMIL: 114961233
PDAM: 113669792
SPIS: 111326569
DGT: 114527612
SMIN: v1.2.008170.t1(symbB.v1.2.008170.t1) v1.2.009162.t1(symbB.v1.2.009162.t1) v1.2.016784.t2(symbB.v1.2.016784.t2) v1.2.017558.t1(symbB.v1.2.017558.t1) v1.2.017824.t1(symbB.v1.2.017824.t1) v1.2.034247.t1(symbB.v1.2.034247.t1) v1.2.039705.t1(symbB.v1.2.039705.t1)
SMAR: SM39_2723
SPE: Spro_3198
SPLY: Q5A_016760
SERF: L085_12380
XPH: XppCFBP6546_04870(XppCFBP6546P_04870)
LEZ: GLE_1103
LEM: LEN_3809
LPN: lpg2463
LPH: LPV_2788
LPO: LPO_2654
LPM: LP6_2493(aspH)
LPF: lpl2383
LPP: lpp2530
LPC: LPC_2013
LPA: lpa_03593
LPE: lp12_2455
BMA: BMAA0571
BMAI: DM57_12665
BMAF: DM51_4292
BMAZ: BM44_4841
BMAB: BM45_4892
BPS: BPSS1421
BPSE: BDL_4728
BPSM: BBQ_4727
BPSU: BBN_4866
BPSD: BBX_3891
BPK: BBK_4030
BPSH: DR55_3854
BPSA: BBU_4617
BPSO: X996_3642
BUT: X994_5697
BTQ: BTQ_4266
BTJ: BTJ_5304
BTZ: BTL_3766
BTD: BTI_3913
BTV: BTHA_4117
BTHE: BTN_3892
BTHM: BTRA_3763
BTHA: DR62_3934
BTHL: BG87_3722
BOK: DM82_5577
BOC: BG90_5033
BVE: AK36_3296
BCN: Bcen_3204
BCJ: BCAM2401
BCEN: DM39_5439
BCEW: DM40_3067
BCEO: I35_6299
BAM: Bamb_4559
BMU: Bmul_3492
BMK: DM80_4883
BMUL: NP80_5043
BCT: GEM_3287
BCED: DM42_5585
BDL: AK34_3415
BCON: NL30_00395
BUB: BW23_3625
BLAT: WK25_27910
BTEI: WS51_08995
BSEM: WJ12_31980
BPSL: WS57_02085
BMEC: WJ16_30505
BGU: KS03_5435
BGO: BM43_4267
BUK: MYA_3088
BUL: BW21_5907
MLO: mll1937
MHUA: MCHK_3497
SPHM: G432_08360
STAX: MC45_05500
SSAN: NX02_26400
SSY: SLG_02380
SYW: SYNW0309
SYNR: KR49_10525
SYND: KR52_00915
 » show all
Reference
  Authors
Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, Neff NT, Link J, Huber RM, Burn TC, Rupar MJ, Cunningham MR, Selling BH, Ma J, Stern AA, Hollis GF, Stein RB, Friedman PA
  Title
Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia.
  Journal
J Biol Chem 277:12970-7 (2002)
DOI:10.1074/jbc.M110389200
  Sequence
[hsa:444] [mmu:65973]

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