KEGG   ORTHOLOGY: K00483Help
Entry
K00483                      KO                                     

Name
hpaB
Definition
4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00483  hpaB; 4-hydroxyphenylacetate 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.9  4-hydroxyphenylacetate 3-monooxygenase
     K00483  hpaB; 4-hydroxyphenylacetate 3-monooxygenase
BRITE hierarchy
Other DBs
RN: R02698 R03299
COG: COG2368
GO: 0052881
Genes
EOJ: ECO26_5549(hpaB)
EOI: ECO111_5206(hpaB)
EOH: ECO103_5128(hpaB)
ECOO: ECRM13514_5600
ECOH: ECRM13516_5313
ECX: EcHS_A4576(hpaB)
ECY: ECSE_4621
ECR: ECIAI1_4567(hpaB)
EUM: ECUMN_4966(hpaB)
ECL: EcolC_3710
EBR: ECB_04222(hpaB)
EBD: ECBD_3674
EKF: KO11_23365(hpaB)
ELW: ECW_m4705(hpaB)
ELL: WFL_22920(hpaB)
EBL: ECD_04222(hpaB)
EBE: B21_04188(hpaB)
EFE: EFER_3070(hpaB)
STY: STY1131(hpaB)
STT: t1820(hpaB)
STM: STM1099(hpaB)
SEO: STM14_1247(hpaB)
SEY: SL1344_1038(hpaB)
SEJ: STMUK_1068(hpaB)
SEB: STM474_1091(hpaB)
SEF: UMN798_1140(hpaB)
SENR: STMDT2_10351(hpaB)
SEND: DT104_10811(hpaB)
SENI: CY43_05615
SPT: SPA1751(hpaB)
SEK: SSPA1627
SEI: SPC_2651(hpaB)
SEC: SCH_1049(hpaB)
SEH: SeHA_C1209(hpaB)
SHB: SU5_01730
SEE: SNSL254_A1194(hpaB)
SEW: SeSA_A1163(hpaB)
SEA: SeAg_B1058(hpaB)
SENS: Q786_04910
SED: SeD_A1174(hpaB)
SEG: SG0988(hpaB)
SEL: SPUL_1958(hpaB)
SEGA: SPUCDC_1944(hpaB)
SET: SEN0963(hpaB)
SENA: AU38_04970
SENO: AU37_04960
SENV: AU39_04960
SENQ: AU40_05575
SENL: IY59_05060
SEEP: I137_08900
SENE: IA1_05410
SBG: SBG_0945(hpaB)
SBZ: A464_1038
SALZ: EOS98_14120(hpaB)
SFT: NCTC1_04750(hpaB_1) NCTC1_04751(hpaB_2)
SSN: SSON_4489(hpaB)
SBO: SBO_4404(hpaB)
SBC: SbBS512_E4882(hpaB)
ENC: ECL_00750(hpaB)
ECLO: ENC_44640
ECLX: LI66_03020
ECLY: LI62_03490
ECLZ: LI64_02995
EEC: EcWSU1_00548(hpaB)
ECAN: CWI88_19295(hpaB)
EBG: FAI37_03685(hpaB)
KPN: KPN_04780(hpaB)
KPU: KP1_0734(hpaB)
KPP: A79E_4372
KPT: VK055_2659(hpaB)
KPJ: N559_4516
KPX: PMK1_02239(hpaB)
KPNU: LI86_23210
KPNK: BN49_4414(hpaB)
KVA: Kvar_4472
KOX: KOX_10015
KOE: A225_0705
EAE: EAE_10315
EAR: CCG31932
KQV: B8P98_24240(hpaB)
KLW: DA718_24790(hpaB)
CBRA: A6J81_18505(hpaB)
EBT: EBL_c34040(hpaB)
RAO: DSD31_22280(hpaB)
RTG: NCTC13098_06429(hpaB_1) NCTC13098_06430(hpaB_2)
REE: electrica_04380(hpaB)
KIE: NCTC12125_02693(hpaB_1) NCTC12125_02694(hpaB_2)
LEI: C2U54_07965(hpaB)
LEH: C3F35_08740(hpaB)
LEE: DVA44_20850(hpaB)
LNI: CWR52_09245(hpaB)
BUF: D8682_01795(hpaB)
IZH: FEM41_12670(hpaB)
EBF: D782_3927
EBU: CUC76_12085(hpaB)
YPE: YPO1769(hpaB)
YPK: y2539(hpaB)
YPH: YPC_2512(hpaB)
YPA: YPA_1141
YPN: YPN_2354
YPM: YP_1624(hpaB)
YPG: YpAngola_A1640(hpaB)
YPZ: YPZ3_1949(hpaB)
YPD: YPD4_1567(hpaB)
YPX: YPD8_1987(hpaB)
YPW: CH59_3398(hpaB)
YPJ: CH55_908(hpaB)
YPV: BZ15_1780(hpaB)
YPL: CH46_3354(hpaB)
YPS: YPTB1645(hpaB)
YPO: BZ17_857(hpaB)
YPI: YpsIP31758_2357(hpaB)
YPY: YPK_2453
YPB: YPTS_1769
YPQ: DJ40_578(hpaB)
YPU: BZ21_995(hpaB)
YPR: BZ20_330(hpaB)
YPC: BZ23_1273(hpaB)
YPF: BZ19_1072(hpaB)
SPE: Spro_0634
SRL: SOD_c05020(hpaB)
SPLY: Q5A_002640(hpaB)
SMAF: D781_0578
SMAR: SM39_4967(hpaB)
SMAC: SMDB11_4710(hpaB)
SERF: L085_01150
SERM: CLM71_02800(hpaB)
SQU: E4343_13485(hpaB)
EPE: CI789_23845(hpaB)
PAY: PAU_00189(hpaB) PAU_00478 PAU_00910(hpaB)
XBO: XBJ1_3600
XBV: XBW1_1452(hpaB) XBW1_4467
XDO: XDD1_0415 XDD1_1013(hpaB)
PSI: S70_06520
PSX: DR96_1964(hpaB)
PRG: RB151_008030(hpaB)
PALA: CO695_00795(hpaB)
PHEI: NCTC12003_00816(hpaB)
PRQ: CYG50_11520(hpaB)
PRJ: NCTC6933_00873(hpaB)
HPAR: AL518_09695(hpaB)
PMU: PM1523
PMV: PMCN06_1790(hpaB)
PMP: Pmu_17900(hpaB)
PMUL: DR93_372(hpaB)
PAE: PA4091(hpaA)
PAEV: N297_4221(hpaB)
PAEI: N296_4221(hpaB)
PAU: PA14_11000(hpaA)
PAP: PSPA7_1007(hpaB)
PAG: PLES_08851(hpaA)
PAF: PAM18_0849(hpaA)
PNC: NCGM2_5292(hpaA)
PAEB: NCGM1900_0869(hpaA)
PAEP: PA1S_04375
PAEM: U769_04385
PAEL: T223_04325
PAEU: BN889_04541(hpaB)
PAEG: AI22_29240
PAEC: M802_4219(hpaB)
PAEO: M801_4087(hpaB)
PFL: PFL_3356(hpaB)
PPRC: PFLCHA0_c33860(hpaB)
PPRO: PPC_3380(hpaB)
PSEM: TO66_17310
PSOS: POS17_3333(hpaB)
SWD: Swoo_2019
CPS: CPS_2047
CZA: CYCME_2117(hpaB)
REH: H16_B0496(h16_B0496)
CNC: CNE_2c04450(hpaH) CNE_BB1p03440(tcpA)
BCN: Bcen_4663
BCJ: BCAM0734
BCEN: DM39_4430
BCEO: I35_4633
BCT: GEM_5625
BCED: DM42_4353
BCON: NL30_22200
BLAT: WK25_13940
BSEM: WJ12_23670
BPSL: WS57_10300
BMEC: WJ16_22580
PPNO: DA70_08135
PPNM: LV28_22445
PPUL: RO07_16865
PAPI: SG18_15675
HYF: DTO96_101742(hpaB)
KGY: EHF36_15900(hpaB)
DAC: Daci_3024
MES: Meso_2465
PLA: Plav_1785
RHI: NGR_b20090(hpaB)
SFH: SFHH103_05222(hpaB)
EAD: OV14_a0070(hpaB)
SHZ: shn_16275
VGO: GJW-30_1_02620(hpaB)
AZC: AZC_4189
SNO: Snov_2630
DEQ: XM25_03690(pvcC)
HDI: HDIA_0239(npcA)
PTP: RCA23_c29330(hpaH)
GXL: H845_1141
KEU: S101446_00275(hpaB)
KSC: CD178_01478(hpaH)
ASZ: ASN_1362(hpaB)
BSU: BSU18620(yoaI)
BSR: I33_2090(hpaB)
BSL: A7A1_2448
BSH: BSU6051_18620(yoaI)
BSUT: BSUB_02002(yoaI)
BSUL: BSUA_02002(yoaI)
BSUS: Q433_11010
BSS: BSUW23_09940(yoaI)
BST: GYO_2242(hpaB)
BSQ: B657_18620(yoaI)
BSX: C663_1926
BAY: RBAM_002630(hpaB)
BAQ: BACAU_0205(yoaI)
BYA: BANAU_0209(yoaI)
BAMP: B938_01060
BAML: BAM5036_0217(yoaI)
BAMA: RBAU_0233(yoaI)
BAMN: BASU_0220(yoaI)
BAMB: BAPNAU_0209(yoaI)
BAMT: AJ82_01435
BAMY: V529_02230
BAO: BAMF_0207(yoaI)
BAZ: BAMTA208_01065(yoaI)
BQL: LL3_00211(yoaI)
BQY: MUS_0220(yoaI)
BAMI: KSO_018345
BAMC: U471_02150
BAMF: U722_01355
BHA: BH3836
BCA: BCE_2601
BTHI: BTK_16895
BCL: ABC0890
BMQ: BMQ_2417(hpaB)
BMD: BMD_2382(hpaB)
BMH: BMWSH_2819(pvcC)
BMEG: BG04_4791(hpaB)
BJS: MY9_2034
BACP: SB24_08490
BACB: OY17_04010
BACY: QF06_08435
BACL: BS34A_20630(yoaI)
BALM: BsLM_1985
BGY: BGLY_3123
BACQ: DOE78_09930(hpaB)
OIH: OB2872
OCN: CUC15_07490(hpaB)
GTN: GTNG_2992(hpaB)
GGH: GHH_c22230(yoaI) GHH_c31080(hpaB)
ANM: GFC28_1574(hpaB) GFC28_3725(hpaB)
AAMY: GFC30_1755(hpaB)
ANL: GFC29_1708(hpaB) GFC29_54(hpaB)
LSP: Bsph_3875(pvcC)
LYZ: DCE79_11215(hpaB)
LYG: C1N55_11360(hpaB)
HHD: HBHAL_2383(hpaB) HBHAL_3970(yoaI)
HLI: HLI_17040(hpaB) HLI_19760(hpaB)
VIL: CFK37_10560(hpaB) CFK37_10890(hpaB)
VNE: CFK40_05945(hpaB)
AQT: FN924_04995(hpaB)
PMW: B2K_22570
PLV: ERIC2_c16720(hpaB)
PRI: PRIO_3489
ASOC: CB4_02002(hpaH) CB4_02465
AAC: Aaci_0339
AAD: TC41_0460(hpaB)
SIV: SSIL_0564(yoaI)
SOB: CSE16_08880(hpaB) CSE16_18810(hpaB)
PANC: E2636_09660(hpaB) E2636_17240(hpaB)
LPL: lp_0070
LPJ: JDM1_0079
TMR: Tmar_1818
SAY: TPY_2462(hpaB)
MMC: Mmcs_2617
MKM: Mkms_2661
MJL: Mjls_2646
MVA: Mvan_3156
MVQ: MYVA_2937
CTED: CTEST_09800(nphA1)
NFR: ERS450000_01009(hpaB_1) ERS450000_02023(hpaB_2) ERS450000_05550(hpaB_3)
RER: RER_54270
RHU: A3Q40_03004(nphA1)
RRT: 4535765_04635(hpaB)
GRU: GCWB2_07650(nphA2)
GOM: D7316_01448(nphA1)
SBH: SBI_01405
SVE: SVEN_5100
SALJ: SMD11_6592(hpaB)
ARR: ARUE_c05860(hpaB)
AAU: AAur_0618
BCV: Bcav_0870
PSIM: KR76_24440
AOI: AORI_4289(hpaB)
AJA: AJAP_17445(hpaH)
PSEA: WY02_09470
PSEE: FRP1_25220
PSEH: XF36_28690
PAUT: Pdca_13110
SESP: BN6_55630 BN6_58660(sam5)
ACTI: UA75_20985
ACAD: UA74_20490
FLH: EJ997_06155(hpaB)
RXY: Rxyl_1857
CWO: Cwoe_4365
RCA: Rcas_2414
CAU: Caur_1347
CAG: Cagg_2030
STI: Sthe_2805
KBS: EPA93_17875(hpaB)
DRA: DR_A0223
DGE: Dgeo_2418
DWU: DVJ83_13505(hpaB)
DFC: DFI_17460
TRA: Trad_1888
TTH: TT_C0594
TSC: TSC_c10450(hpaB)
TAQ: TO73_1002
MRB: Mrub_1332
STO: STK_07260(pheA1)
SSO: SSO2053(hpaA)
SAI: Saci_2294(hpaA)
SID: M164_0713
SII: LD85_0739
SIH: SiH_0629
SIR: SiRe_0706
SIC: SiL_0742
POG: Pogu_1357
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Xun L, Sandvik ER
  Title
Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase.
  Journal
Appl Environ Microbiol 66:481-6 (2000)
DOI:10.1128/AEM.66.2.481-486.2000
  Sequence
[elw:ECW_m4705]

KEGG   ORTHOLOGY: K00484Help
Entry
K00484                      KO                                     

Name
hpaC
Definition
flavin reductase (NADH) [EC:1.5.1.36]
Pathway
ko00350  Tyrosine metabolism
ko00740  Riboflavin metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00484  hpaC; flavin reductase (NADH)
  09108 Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K00484  hpaC; flavin reductase (NADH)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.36  flavin reductase (NADH)
     K00484  hpaC; flavin reductase (NADH)
BRITE hierarchy
Other DBs
RN: R02698 R03299 R05705 R09748 R09750
COG: COG1853
GO: 0036382
Genes
EOJ: ECO26_5548(hpaC)
EOI: ECO111_5205(hpaC)
EOH: ECO103_5127(hpaC)
ECOO: ECRM13514_5599
ECOH: ECRM13516_5312
ECX: EcHS_A4575(hpaC)
ECY: ECSE_4620
ECR: ECIAI1_4566(hpaC)
EUM: ECUMN_4965(hpaC)
ECL: EcolC_3711
EBR: ECB_04221(hpaC)
EBD: ECBD_3675
EKF: KO11_23360(hpaC)
ELW: ECW_m4704(hpaC)
ELL: WFL_22915(hpaC)
EBL: ECD_04221(hpaC)
EBE: B21_04187(ybl221)
EFE: EFER_3071(hpaC)
STY: STY1130(hpaC)
STT: t1821(hpaC)
STM: STM1098(hpaC)
SEO: STM14_1246(hpaC)
SEY: SL1344_1037(hpaC)
SEJ: STMUK_1067(hpaC)
SEB: STM474_1090(hpaC)
SEF: UMN798_1139(hpaC)
SETU: STU288_01820(hpaC)
SETC: CFSAN001921_11685(hpaC)
SENR: STMDT2_10341(hpaC)
SEND: DT104_10801(hpaC)
SENI: CY43_05610(hpaC)
SEEN: SE451236_11340(hpaC)
SPT: SPA1752(hpaC)
SEK: SSPA1628
SEI: SPC_2652(hpaC)
SEC: SCH_1048(hpaC)
SEH: SeHA_C1208(hpaC)
SHB: SU5_01729
SENH: CFSAN002069_03530(hpaC)
SEEH: SEEH1578_14715(hpaC)
SEE: SNSL254_A1193(hpaC)
SEW: SeSA_A1162(hpaC)
SEA: SeAg_B1057(hpaC)
SENS: Q786_04905(hpaC)
SED: SeD_A1173(hpaC)
SEG: SG0987(hpaC)
SEL: SPUL_1959(hpaC)
SEGA: SPUCDC_1945(hpaC)
SET: SEN0962(hpaC)
SENA: AU38_04965(hpaC)
SENO: AU37_04955(hpaC)
SENV: AU39_04955(hpaC)
SENQ: AU40_05570(hpaC)
SENL: IY59_05055(hpaC)
SENJ: CFSAN001992_06155(hpaC)
SEEC: CFSAN002050_11885(hpaC)
SEEB: SEEB0189_014080(hpaC)
SEEP: I137_08905(hpaC)
SENB: BN855_10530(hpaC)
SENE: IA1_05405(hpaC)
SENC: SEET0819_12150(hpaC)
SBG: SBG_0944(hpaC)
SBZ: A464_1037
SFL: SF4373(hpaC)
SFX: S4643(hpaC)
SFV: SFV_4374(hpaC)
SFE: SFxv_4767
SFN: SFy_6274
SFS: SFyv_6345
SFT: NCTC1_04749(hpaC)
SSN: SSON_4488(hpaC)
SBO: SBO_4403(hpaC)
SBC: SbBS512_E4881(hpaC)
SHQ: A0259_03500(hpaC)
ENC: ECL_00749(hpaC)
ECLO: ENC_44630
ECLE: ECNIH2_03895(hpaC)
ECLN: ECNIH4_19905(hpaC)
ECLI: ECNIH5_03020(hpaC)
ECLX: LI66_03015(hpaC)
ECLY: LI62_03485(hpaC)
ECLZ: LI64_02990(hpaC)
EHM: AB284_21990(hpaC)
ECLA: ECNIH3_03020(hpaC)
ECLC: ECR091_03000(hpaC)
EAU: DI57_15625(hpaC)
EEC: EcWSU1_00546(hpaC)
ECAN: CWI88_19300(hpaC)
ECLS: LI67_003950(hpaC)
ENX: NI40_002860(hpaC)
KPN: KPN_04779(hpaC)
KPU: KP1_0733(hpaC)
KPP: A79E_4373
KPH: KPNIH24_03220(hpaC)
KPZ: KPNIH27_03095(hpaC)
KPV: KPNIH29_03410(hpaC)
KPW: KPNIH30_03370(hpaC)
KPY: KPNIH31_04695(hpaC)
KPG: KPNIH32_03375(hpaC)
KPC: KPNIH10_03200(hpaC)
KPQ: KPR0928_03210(hpaC)
KPT: VK055_2660(hpaC)
KPE: KPK_4841(hpaC)
KPO: KPN2242_02030(hpaC)
KPR: KPR_0856(hpaC)
KPJ: N559_4517
KPI: D364_24350(hpaC)
KPX: PMK1_02238(hpaC)
KPB: FH42_20415(hpaC)
KPNE: KU54_023375(hpaC)
KPNU: LI86_23215(hpaC)
KPNK: BN49_4415(hpaC)
KVA: Kvar_4473
KPK: A593_13950(hpaC)
KOX: KOX_10010(hpaC)
KOE: A225_0704
KOY: J415_27725(hpaC)
KOM: HR38_08735(hpaC)
KOK: KONIH1_03735(hpaC)
KOC: AB185_32455(hpaC)
EAE: EAE_10310(hpaC)
EAR: CCG31933
KQV: B8P98_24245(hpaC)
CBRA: A6J81_18500(hpaC)
EBT: EBL_c34050(hpaC)
ROR: RORB6_15570(hpaC)
RON: TE10_05450(hpaC)
RTG: NCTC13098_06431(hpaC)
REE: electrica_04381(hpaC)
PGE: LG71_25565(hpaC)
KLE: AO703_02885(hpaC)
KGO: CEW81_19470(hpaC)
KIE: NCTC12125_02692(hpaC)
LAX: APT61_19370(hpaC)
LEI: C2U54_07960(hpaC)
LEH: C3F35_08745(hpaC)
IZH: FEM41_12675(hpaC)
EBF: D782_3928
EBU: CUC76_12090(hpaC)
YPE: YPO1770(hpaC)
YPK: y2538
YPH: YPC_2511(hpaC)
YPA: YPA_1142
YPN: YPN_2353
YPM: YP_1623(hpaC)
YPG: YpAngola_A1639(hpaC)
YPZ: YPZ3_1948(hpaC)
YPD: YPD4_1568(hpaC)
YPX: YPD8_1986(hpaC)
YPW: CH59_3397(hpaC)
YPJ: CH55_907(hpaC)
YPV: BZ15_1779(hpaC)
YPL: CH46_3353(hpaC)
YPS: YPTB1646(hpaC)
YPO: BZ17_856(hpaC)
YPI: YpsIP31758_2356(hpaC)
YPY: YPK_2452
YPB: YPTS_1770
YPQ: DJ40_577(hpaC)
YPU: BZ21_996(hpaC)
YPR: BZ20_329(hpaC)
YPC: BZ23_1274(hpaC)
YPF: BZ19_1073(hpaC)
SPE: Spro_0635
SRL: SOD_c05030(hpaC)
SRY: M621_02655(hpaC)
SPLY: Q5A_002645(hpaC)
SMAF: D781_0579
SMW: SMWW4_v1c05910(rutF)
SMAR: SM39_4968(hpaC)
SMAC: SMDB11_4711(hpaC)
SLQ: M495_02520(hpaC)
SERF: L085_01145
SERM: CLM71_02805(hpaC)
SQU: E4343_13480(hpaC)
SFO: Z042_16845(hpaC)
EPE: CI789_23840(hpaC)
PLU: plu0974(hpaC)
PLUM: A4R40_04865(hpaC)
PAY: PAU_00909(hpaC)
PTT: VY86_13815(hpaC)
PMR: PMI0246(hpaC)
PMIB: BB2000_0397(hpaC)
PVL: AOB99_03995(hpaC)
PVG: CRN77_18180(hpaC)
PHAU: PH4a_11160(hpaC)
XBO: XBJ1_3599(ycdH)
XBV: XBW1_1453(hpaC)
XNE: XNC1_0810(ycdH)
XNM: XNC2_0796(ycdH)
XDO: XDD1_1012(hpaC)
PSI: S70_06525
PSX: DR96_1963(hpaC)
PRG: RB151_008020(hpaC)
PALA: CO695_00800(hpaC)
PHEI: NCTC12003_00815(hpaC)
PRQ: CYG50_11525(hpaC)
PRJ: NCTC6933_00872(hpaC)
MMK: MU9_1190
HAV: AT03_16965(hpaC)
HPAR: AL518_09690(hpaC)
OPO: DSM2777_08260(hpaC)
HDU: HD_0987(hpaC)
GLE: CJD39_07540(hpaC)
PMU: PM1522
PMV: PMCN06_1789(hpaC)
PMP: Pmu_17890(hpaC)
PMUL: DR93_371(hpaC)
PDAG: 4362423_01844(hpaC)
MHT: D648_19650(hpaC)
MHQ: D650_6580(hpaC)
MHAT: B824_19600(hpaC)
MHX: MHH_c28120(hpaC)
MHAE: F382_04765(hpaC)
MHAM: J450_03765(hpaC)
MHAO: J451_05010(hpaC)
MHAL: N220_10895(hpaC)
MHAQ: WC39_03320(hpaC)
MHAY: VK67_03320(hpaC)
MVR: X781_6410
MVE: X875_4960
APL: APL_1349(hpaC)
APJ: APJL_1367(hpaC)
APA: APP7_1401(hpaC)
AEU: ACEE_11280(hpaC)
AIO: EXH44_07625(hpaC)
BTO: WQG_18690
BTRE: F542_3890
BTRH: F543_4540
BTRA: F544_18490
VVY: VV1574
VNI: VIBNI_B1951(hpaC)
VMI: AL543_16395(hpaC)
PAE: PA4092(hpaC)
PAEV: N297_4222(hpaC)
PAEI: N296_4222(hpaC)
PAU: PA14_10990(hpaC)
PAP: PSPA7_1006(hpaC)
PAG: PLES_08841(hpaC)
PAF: PAM18_0848(hpaC)
PNC: NCGM2_5293(hpaC)
PAEB: NCGM1900_0868(hpaC)
PAEP: PA1S_04370
PAEM: U769_04380
PAEL: T223_04320
PAEU: BN889_04542(hpaC)
PAEG: AI22_29245(hpaC)
PAEC: M802_4220(hpaC)
PAEO: M801_4088(hpaC)
PCQ: PcP3B5_30280(hpaC)
PFL: PFL_3357(hpaC)
PPRC: PFLCHA0_c33870(hpaC)
PPRO: PPC_3381(hpaC)
PSEM: TO66_17315
PSOS: POS17_3334(hpaC)
PSIL: PMA3_18105
CJA: CJA_1958
NME: NMB1842
NMP: NMBB_2105
NMH: NMBH4476_1786(hpaC)
NMD: NMBG2136_0375(hpaC)
NMM: NMBM01240149_0343(hpaC)
NMS: NMBM01240355_1776(hpaC)
NMQ: NMBM04240196_1783(hpaC)
NMZ: NMBNZ0533_0480(hpaC)
NMA: NMA0614
NMW: NMAA_0302
NMC: NMC0375
NMN: NMCC_0380
NMT: NMV_2032
NMI: NMO_0320
NGO: NGO0059
NGK: NGK_0083
NLA: NLA_17890
NWE: SAMEA3174300_1574(hpaC)
NSI: A6J88_13285(hpaC)
NMJ: NM96_07675(hpaC)
NEI: BG910_03730(hpaC)
NEK: CGZ77_01410(hpaC)
NFV: FAH67_11135(hpaC)
KKI: KKKWG1_0413(hpaC)
BTE: BTH_II0316(hpaC)
BTQ: BTQ_3610(hpaC)
BTJ: BTJ_4646(hpaC)
BTZ: BTL_5434(hpaC)
BTV: BTHA_4769(hpaC)
BTHE: BTN_5104(hpaC)
BTHM: BTRA_5373(hpaC)
BTHA: DR62_5234
BTHL: BG87_5440(hpaC)
BOK: DM82_6338(hpaC)
BOC: BG90_4336(hpaC)
BCJ: BCAM0638
BCEN: DM39_4519(hpaC) DM39_4923
BCEW: DM40_5612
BCEO: I35_4534 I35_5997(hpaC)
BAM: Bamb_5345
BMK: DM80_4251 DM80_4266(hpaC)
BMUL: NP80_3634(hpaC) NP80_3647
BCED: DM42_4452(hpaC)
BCON: NL30_22660
BLAT: WK25_18270
BSEM: WJ12_23160
BMEC: WJ16_22180
BGU: KS03_3551(hpaC) KS03_4181
BGO: BM43_5956
BGP: BGL_2c23400(hpaC)
BXE: Bxe_B2309
BXB: DR64_4641(hpaC)
BFN: OI25_3713(hpaC)
PARB: CJU94_31905(hpaC)
PHS: C2L64_07300(hpaC) C2L64_36225(hpaC)
PTER: C2L65_07035(hpaC) C2L65_31435(hpaC)
PGP: CUJ91_29455(hpaC)
PSPU: NA29_23280
PLG: NCTC10937_03008(hpaC)
HYF: DTO96_101741(hpaC)
DAR: Daro_0903
AZO: azo1943(hpaC)
MXA: MXAN_4827
CCX: COCOR_03296(ycdH)
BJA: blr7290(hpaC)
RSP: RSP_3957
COQ: D9V35_02155(hpaC)
NFA: NFA_28410
NFR: ERS450000_01248(hpaC)
RHA: RHA1_ro02847(hpaC)
ROP: ROP_25720(hpaC)
SBH: SBI_09695
AOI: AORI_4210(hpaC)
TTH: TT_C0595
TTJ: TTHA0961
TAQ: TO73_1001
MRB: Mrub_1331
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Galan B, Diaz E, Prieto MA, Garcia JL
  Title
Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.
  Journal
J Bacteriol 182:627-36 (2000)
DOI:10.1128/JB.182.3.627-636.2000
  Sequence
[elw:ECW_m4704]

KEGG   ORTHOLOGY: K23492Help
Entry
K23492                      KO                                     

Name
C2-hpah
Definition
4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K23492  C2-hpah; 4-hydroxyphenylacetate 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.9  4-hydroxyphenylacetate 3-monooxygenase
     K23492  C2-hpah; 4-hydroxyphenylacetate 3-monooxygenase
BRITE hierarchy
Other DBs
RN: R02698
COG: COG1960
GO: 0052881
Genes
SFW: WN53_24640
SFG: AV650_20290
SFO: Z042_02305
ETE: ETEE_3249(hsaA)
EDW: QY76_13810
EDL: AAZ33_06645
PFQ: QQ39_14505
VVY: VV1591
VNI: VIBNI_B1950(C2-hpah)
VMI: AL543_16470
PCQ: PcP3B5_43330(C2-hpah)
PPUN: PP4_18910
PFS: PFLU_3290
PFB: VO64_1115
PEN: PSEEN3105(C2-hpah)
PKC: PKB_2463(C2-hpah)
PSES: PSCI_3395
PSEC: CCOS191_2761(C2-hpah)
PANR: A7J50_3697
PSET: THL1_2773
ABAZ: P795_8065
ABAU: IX87_20440
AMAH: DLM_0606
RSP: RSP_3018
RSU: NHU_03033(C2-hpah)
SWI: Swit_1536
SIV: SSIL_0069
MMC: Mmcs_2605
MKM: Mkms_2649
MJL: Mjls_2635
MTHN: 4412656_02473(C2-hpah)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chaiyen P, Suadee C, Wilairat P
  Title
A novel two-protein component flavoprotein hydroxylase.
  Journal
Eur J Biochem 268:5550-61 (2001)
DOI:10.1046/j.1432-1033.2001.02490.x
  Sequence
[abaz:P795_8065]
Reference
  Authors
Thotsaporn K, Sucharitakul J, Wongratana J, Suadee C, Chaiyen P
  Title
Cloning and expression of p-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii: evidence of the divergence of enzymes in the class of two-protein component aromatic hydroxylases.
  Journal
Biochim Biophys Acta 1680:60-6 (2004)
DOI:10.1016/j.bbaexp.2004.08.003
  Sequence
[abaz:P795_8065]

KEGG   ORTHOLOGY: K16901Help
Entry
K16901                      KO                                     

Name
K16901
Definition
anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
Pathway
ko00350  Tyrosine metabolism
ko00380  Tryptophan metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
   00380 Tryptophan metabolism
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.8  anthranilate 3-monooxygenase (FAD)
     K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
    1.14.14.9  4-hydroxyphenylacetate 3-monooxygenase
     K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
BRITE hierarchy
Other DBs
RN: R02698 R03299 R09517
GO: 0052881
Genes
RUE: DT065_13750
BCA: BCE_2148
BCX: BCA_2146
BCF: bcf_10170
BCER: BCK_24265
BCEF: BcrFT9_01682
BTL: BALH_1835
BMYC: DJ92_4629
BMQ: BMQ_3596(hpaB)
BMD: BMD_3581(hpaB)
BMEG: BG04_470
GTN: GTNG_3160
PDX: Psed_0216
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L
  Title
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.
  Journal
Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0
  Sequence
[gtn:GTNG_3160]

KEGG   ORTHOLOGY: K16902Help
Entry
K16902                      KO                                     

Name
E1.5.1.45
Definition
FAD reductase [NAD(P)H] [EC:1.5.1.45]
Pathway
ko00350  Tyrosine metabolism
ko00380  Tryptophan metabolism
ko00740  Riboflavin metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K16902  E1.5.1.45; FAD reductase [NAD(P)H]
   00380 Tryptophan metabolism
    K16902  E1.5.1.45; FAD reductase [NAD(P)H]
  09108 Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K16902  E1.5.1.45; FAD reductase [NAD(P)H]
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.45  FAD reductase [NAD(P)H]
     K16902  E1.5.1.45; FAD reductase [NAD(P)H]
BRITE hierarchy
Other DBs
RN: R02698 R03299 R09517 R09520 R09748
COG: COG0431
Genes
BMQ: BMQ_3594
BMD: BMD_3579
BMEG: BG04_468
GST: HW35_13015
BMUR: ABE28_004135
GTN: GTNG_3158
TaxonomyKoalaUniProt
Reference
  Authors
Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L
  Title
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.
  Journal
Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0
  Sequence
[gtn:GTNG_3158]

KEGG   ENZYME: 1.14.14.9Help
Entry
EC 1.14.14.9                Enzyme                                 

Name
4-hydroxyphenylacetate 3-monooxygenase;
p-hydroxyphenylacetate 3-hydroxylase;
4-hydroxyphenylacetic acid-3-hydroxylase;
p-hydroxyphenylacetate hydroxylase (FAD);
4 HPA 3-hydroxylase;
p-hydroxyphenylacetate 3-hydroxylase (FAD);
HpaB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
4-hydroxyphenylacetate,FADH2:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
Reaction(KEGG)
(other) R02698 R03299
Show
Substrate
4-hydroxyphenylacetate [CPD:C00642];
FADH2 [CPD:C01352];
O2 [CPD:C00007]
Product
3,4-dihydroxyphenylacetate [CPD:C01161];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor [4]. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH) [5,6].
History
EC 1.14.14.9 created 1972 as EC 1.14.13.3, transferred 2011 to EC 1.14.14.9
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00483  4-hydroxyphenylacetate 3-monooxygenase
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
K23492  4-hydroxyphenylacetate 3-monooxygenase
Genes
EOJ: ECO26_5549(hpaB)
EOI: ECO111_5206(hpaB)
EOH: ECO103_5128(hpaB)
ECOO: ECRM13514_5600
ECOH: ECRM13516_5313
ECX: EcHS_A4576(hpaB)
ECY: ECSE_4621
ECR: ECIAI1_4567(hpaB)
EUM: ECUMN_4966(hpaB)
ECL: EcolC_3710
EBR: ECB_04222(hpaB)
EBD: ECBD_3674
EKF: KO11_23365(hpaB)
ELW: ECW_m4705(hpaB)
ELL: WFL_22920(hpaB)
EBL: ECD_04222(hpaB)
EBE: B21_04188(hpaB)
EFE: EFER_3070(hpaB)
STY: STY1131(hpaB)
STT: t1820(hpaB)
STM: STM1099(hpaB)
SEO: STM14_1247(hpaB)
SEY: SL1344_1038(hpaB)
SEJ: STMUK_1068(hpaB)
SEB: STM474_1091(hpaB)
SEF: UMN798_1140(hpaB)
SENR: STMDT2_10351(hpaB)
SEND: DT104_10811(hpaB)
SENI: CY43_05615
SPT: SPA1751(hpaB)
SEK: SSPA1627
SEI: SPC_2651(hpaB)
SEC: SCH_1049(hpaB)
SEH: SeHA_C1209(hpaB)
SHB: SU5_01730
SEE: SNSL254_A1194(hpaB)
SEW: SeSA_A1163(hpaB)
SEA: SeAg_B1058(hpaB)
SENS: Q786_04910
SED: SeD_A1174(hpaB)
SEG: SG0988(hpaB)
SEL: SPUL_1958(hpaB)
SEGA: SPUCDC_1944(hpaB)
SET: SEN0963(hpaB)
SENA: AU38_04970
SENO: AU37_04960
SENV: AU39_04960
SENQ: AU40_05575
SENL: IY59_05060
SEEP: I137_08900
SENE: IA1_05410
SBG: SBG_0945(hpaB)
SBZ: A464_1038
SALZ: EOS98_14120(hpaB)
SFT: NCTC1_04750(hpaB_1) NCTC1_04751(hpaB_2)
SSN: SSON_4489(hpaB)
SBO: SBO_4404(hpaB)
SBC: SbBS512_E4882(hpaB)
ENC: ECL_00750(hpaB)
ECLO: ENC_44640
ECLX: LI66_03020
ECLY: LI62_03490
ECLZ: LI64_02995
EEC: EcWSU1_00548(hpaB)
ECAN: CWI88_19295(hpaB)
EBG: FAI37_03685(hpaB)
KPN: KPN_04780(hpaB)
KPU: KP1_0734(hpaB)
KPP: A79E_4372
KPT: VK055_2659(hpaB)
KPJ: N559_4516
KPX: PMK1_02239(hpaB)
KPNU: LI86_23210
KPNK: BN49_4414(hpaB)
KVA: Kvar_4472
KOX: KOX_10015
KOE: A225_0705
EAE: EAE_10315
EAR: CCG31932
KQV: B8P98_24240(hpaB)
KLW: DA718_24790(hpaB)
CBRA: A6J81_18505(hpaB)
EBT: EBL_c34040(hpaB)
RAO: DSD31_22280(hpaB)
RTG: NCTC13098_06429(hpaB_1) NCTC13098_06430(hpaB_2)
REE: electrica_04380(hpaB)
KIE: NCTC12125_02693(hpaB_1) NCTC12125_02694(hpaB_2)
LEI: C2U54_07965(hpaB)
LEH: C3F35_08740(hpaB)
LEE: DVA44_20850(hpaB)
LNI: CWR52_09245(hpaB)
BUF: D8682_01795(hpaB)
IZH: FEM41_12670(hpaB)
EBF: D782_3927
EBU: CUC76_12085(hpaB)
YPE: YPO1769(hpaB)
YPK: y2539(hpaB)
YPH: YPC_2512(hpaB)
YPA: YPA_1141
YPN: YPN_2354
YPM: YP_1624(hpaB)
YPG: YpAngola_A1640(hpaB)
YPZ: YPZ3_1949(hpaB)
YPD: YPD4_1567(hpaB)
YPX: YPD8_1987(hpaB)
YPW: CH59_3398(hpaB)
YPJ: CH55_908(hpaB)
YPV: BZ15_1780(hpaB)
YPL: CH46_3354(hpaB)
YPS: YPTB1645(hpaB)
YPO: BZ17_857(hpaB)
YPI: YpsIP31758_2357(hpaB)
YPY: YPK_2453
YPB: YPTS_1769
YPQ: DJ40_578(hpaB)
YPU: BZ21_995(hpaB)
YPR: BZ20_330(hpaB)
YPC: BZ23_1273(hpaB)
YPF: BZ19_1072(hpaB)
SPE: Spro_0634
SRL: SOD_c05020(hpaB)
SPLY: Q5A_002640(hpaB)
SMAF: D781_0578
SMAR: SM39_4967(hpaB)
SMAC: SMDB11_4710(hpaB)
SERF: L085_01150
SERM: CLM71_02800(hpaB)
SQU: E4343_13485(hpaB)
EPE: CI789_23845(hpaB)
PAY: PAU_00189(hpaB) PAU_00478 PAU_00910(hpaB)
XBO: XBJ1_3600
XBV: XBW1_1452(hpaB) XBW1_4467
XDO: XDD1_0415 XDD1_1013(hpaB)
PSI: S70_06520
PSX: DR96_1964(hpaB)
PRG: RB151_008030(hpaB)
PALA: CO695_00795(hpaB)
PHEI: NCTC12003_00816(hpaB)
PRQ: CYG50_11520(hpaB)
PRJ: NCTC6933_00873(hpaB)
ETE: ETEE_3249(hsaA)
HPAR: AL518_09695(hpaB)
PMU: PM1523
PMV: PMCN06_1790(hpaB)
PMP: Pmu_17900(hpaB)
PMUL: DR93_372(hpaB)
VVY: VV1591
VNI: VIBNI_B1950(C2-hpah)
PAE: PA4091(hpaA)
PAEV: N297_4221(hpaB)
PAEI: N296_4221(hpaB)
PAU: PA14_11000(hpaA)
PAP: PSPA7_1007(hpaB)
PAG: PLES_08851(hpaA)
PAF: PAM18_0849(hpaA)
PNC: NCGM2_5292(hpaA)
PAEB: NCGM1900_0869(hpaA)
PAEP: PA1S_04375
PAEM: U769_04385
PAEL: T223_04325
PAEU: BN889_04541(hpaB)
PAEG: AI22_29240
PAEC: M802_4219(hpaB)
PAEO: M801_4087(hpaB)
PCQ: PcP3B5_43330(C2-hpah)
PPUN: PP4_18910
PFL: PFL_3356(hpaB)
PPRC: PFLCHA0_c33860(hpaB)
PPRO: PPC_3380(hpaB)
PFS: PFLU_3290
PFB: VO64_1115
PEN: PSEEN3105(C2-hpah)
PKC: PKB_2463(C2-hpah)
PSES: PSCI_3395
PSEM: TO66_17310
PSEC: CCOS191_2761(C2-hpah)
PSOS: POS17_3333(hpaB)
PANR: A7J50_3697
PSET: THL1_2773
ABAZ: P795_8065
ABAU: IX87_20440
SWD: Swoo_2019
CPS: CPS_2047
CZA: CYCME_2117(hpaB)
AMAH: DLM_0606
REH: H16_B0496(h16_B0496)
CNC: CNE_2c04450(hpaH) CNE_BB1p03440(tcpA)
BCN: Bcen_4663
BCJ: BCAM0734
BCEN: DM39_4430
BCEO: I35_4633
BCT: GEM_5625
BCED: DM42_4353
BCON: NL30_22200
BLAT: WK25_13940
BSEM: WJ12_23670
BPSL: WS57_10300
BMEC: WJ16_22580
PPNO: DA70_08135
PPNM: LV28_22445
PPUL: RO07_16865
PAPI: SG18_15675
HYF: DTO96_101742(hpaB)
DAC: Daci_3024
MES: Meso_2465
PLA: Plav_1785
RHI: NGR_b20090(hpaB)
SFH: SFHH103_05222(hpaB)
EAD: OV14_a0070(hpaB)
SHZ: shn_16275
VGO: GJW-30_1_02620(hpaB)
AZC: AZC_4189
SNO: Snov_2630
DEQ: XM25_03690(pvcC)
HDI: HDIA_0239(npcA)
RSP: RSP_3018
PTP: RCA23_c29330(hpaH)
RSU: NHU_03033(C2-hpah)
SWI: Swit_1536
GXL: H845_1141
KEU: S101446_00275(hpaB)
KSC: CD178_01478(hpaH)
ASZ: ASN_1362(hpaB)
BSU: BSU18620(yoaI)
BSR: I33_2090(hpaB)
BSL: A7A1_2448
BSH: BSU6051_18620(yoaI)
BSUT: BSUB_02002(yoaI)
BSUL: BSUA_02002(yoaI)
BSUS: Q433_11010
BSS: BSUW23_09940(yoaI)
BST: GYO_2242(hpaB)
BSQ: B657_18620(yoaI)
BSX: C663_1926
BAY: RBAM_002630(hpaB)
BAQ: BACAU_0205(yoaI)
BYA: BANAU_0209(yoaI)
BAMP: B938_01060
BAML: BAM5036_0217(yoaI)
BAMA: RBAU_0233(yoaI)
BAMN: BASU_0220(yoaI)
BAMB: BAPNAU_0209(yoaI)
BAMT: AJ82_01435
BAMY: V529_02230
BAO: BAMF_0207(yoaI)
BAZ: BAMTA208_01065(yoaI)
BQL: LL3_00211(yoaI)
BQY: MUS_0220(yoaI)
BAMI: KSO_018345
BAMC: U471_02150
BAMF: U722_01355
BHA: BH3836
BCX: BCA_2146
BCF: bcf_10170
BCER: BCK_24265
BTL: BALH_1835
BTHI: BTK_16895
BMYC: DJ92_4629
BCL: ABC0890
BMQ: BMQ_2417(hpaB) BMQ_3596(hpaB)
BMD: BMD_2382(hpaB) BMD_3581(hpaB)
BMH: BMWSH_2819(pvcC)
BMEG: BG04_470 BG04_4791(hpaB)
BJS: MY9_2034
BACP: SB24_08490
BACB: OY17_04010
BACY: QF06_08435
BACL: BS34A_20630(yoaI)
BALM: BsLM_1985
BGY: BGLY_3123
BACQ: DOE78_09930(hpaB)
OIH: OB2872
OCN: CUC15_07490(hpaB)
GTN: GTNG_2992(hpaB) GTNG_3160
GGH: GHH_c22230(yoaI) GHH_c31080(hpaB)
ANM: GFC28_1574(hpaB) GFC28_3725(hpaB)
AAMY: GFC30_1755(hpaB)
ANL: GFC29_1708(hpaB) GFC29_54(hpaB)
LSP: Bsph_3875(pvcC)
LYG: C1N55_11360(hpaB)
HHD: HBHAL_2383(hpaB) HBHAL_3970(yoaI)
HLI: HLI_17040(hpaB) HLI_19760(hpaB)
VIL: CFK37_10560(hpaB) CFK37_10890(hpaB)
VNE: CFK40_05945(hpaB)
AQT: FN924_04995(hpaB)
PMW: B2K_22570
PLV: ERIC2_c16720(hpaB)
PRI: PRIO_3489
ASOC: CB4_02002(hpaH) CB4_02465
AAC: Aaci_0339
AAD: TC41_0460(hpaB)
SIV: SSIL_0069 SSIL_0564(yoaI)
SOB: CSE16_08880(hpaB) CSE16_18810(hpaB)
PANC: E2636_09660(hpaB) E2636_17240(hpaB)
LPL: lp_0070
LPJ: JDM1_0079
TMR: Tmar_1818
SAY: TPY_2462(hpaB)
MVA: Mvan_3156
MVQ: MYVA_2937
MTHN: 4412656_02473(C2-hpah)
CTED: CTEST_09800(nphA1)
NFR: ERS450000_01009(hpaB_1) ERS450000_02023(hpaB_2) ERS450000_05550(hpaB_3)
RER: RER_54270
RHU: A3Q40_03004(nphA1)
RRT: 4535765_04635(hpaB)
GRU: GCWB2_07650(nphA2)
GOM: D7316_01448(nphA1)
SBH: SBI_01405
SVE: SVEN_5100
SALJ: SMD11_6592(hpaB)
ARR: ARUE_c05860(hpaB)
AAU: AAur_0618
BCV: Bcav_0870
PSIM: KR76_24440
AOI: AORI_4289(hpaB)
AJA: AJAP_17445(hpaH)
PSEA: WY02_09470
PSEE: FRP1_25220
PSEH: XF36_28690
PAUT: Pdca_13110
SESP: BN6_55630 BN6_58660(sam5)
ACTI: UA75_20985
ACAD: UA74_20490
FLH: EJ997_06155(hpaB)
RXY: Rxyl_1857
CWO: Cwoe_4365
RCA: Rcas_2414
CAU: Caur_1347
CAG: Cagg_2030
STI: Sthe_2805
KBS: EPA93_17875(hpaB)
DRA: DR_A0223
DGE: Dgeo_2418
DWU: DVJ83_13505(hpaB)
DFC: DFI_17460
TRA: Trad_1888
TTH: TT_C0594
TSC: TSC_c10450(hpaB)
TAQ: TO73_1002
MRB: Mrub_1332
STO: STK_07260(pheA1)
SSO: SSO2053(hpaA)
SAI: Saci_2294(hpaA)
SID: M164_0713
SII: LD85_0739
SIH: SiH_0629
SIR: SiRe_0706
SIC: SiL_0742
POG: Pogu_1357
 » show all
Taxonomy
Reference
1  [PMID:14263147]
  Authors
ADACHI K, TAKEDA Y, SENOH S, KITA H.
  Title
METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS.
  Journal
Biochim Biophys Acta 93:483-93 (1964)
DOI:10.1016/0304-4165(64)90332-0
Reference
2  [PMID:8458860]
  Authors
Prieto MA, Perez-Aranda A, Garcia JL
  Title
Characterization of an Escherichia coli aromatic hydroxylase with a broad substrate range.
  Journal
J Bacteriol 175:2162-7 (1993)
DOI:10.1128/JB.175.7.2162-2167.1993
Reference
3  [PMID:8077235]
  Authors
Prieto MA, Garcia JL
  Title
Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.
  Journal
J Biol Chem 269:22823-9 (1994)
  Sequence
[elw:ECW_m4705]
Reference
4  [PMID:10653707]
  Authors
Xun L, Sandvik ER
  Title
Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase.
  Journal
Appl Environ Microbiol 66:481-6 (2000)
DOI:10.1128/AEM.66.2.481-486.2000
  Sequence
[elw:ECW_m4705]
Reference
5  [PMID:10633095]
  Authors
Galan B, Diaz E, Prieto MA, Garcia JL
  Title
Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.
  Journal
J Bacteriol 182:627-36 (2000)
DOI:10.1128/JB.182.3.627-636.2000
Reference
6  [PMID:12809507]
  Authors
Louie TM, Xie XS, Xun L
  Title
Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase  and 4-hydroxyphenylacetate 3-monooxygenase.
  Journal
Biochemistry 42:7509-17 (2003)
DOI:10.1021/bi034092r
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.9
IUBMB Enzyme Nomenclature: 1.14.14.9
ExPASy - ENZYME nomenclature database: 1.14.14.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.14.9
BRENDA, the Enzyme Database: 1.14.14.9
CAS: 37256-71-6

KEGG   REACTION: R02698Help
Entry
R02698                      Reaction                               

Name
4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)
Definition
4-Hydroxyphenylacetate + Oxygen + NADH + H+ <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O
Equation
Reaction class
RC00001  C00003_C00004
RC00046  C00642_C01161
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K00483  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
K16902  FAD reductase [NAD(P)H] [EC:1.5.1.45]
K23470  4-hydroxyphenylacetate 3-hydroxylase, reductase component [EC:1.5.1.36]
K23492  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
Other DBs
RHEA: 16684

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