KEGG   ORTHOLOGY: K00501
Entry
K00501                      KO                                     

Name
TH
Definition
tyrosine 3-monooxygenase [EC:1.14.16.2]
Pathway
ko00350  Tyrosine metabolism
ko00790  Folate biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04728  Dopaminergic synapse
ko04917  Prolactin signaling pathway
ko05012  Parkinson disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00501  TH; tyrosine 3-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K00501  TH; tyrosine 3-monooxygenase
  09156 Nervous system
   04728 Dopaminergic synapse
    K00501  TH; tyrosine 3-monooxygenase
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K00501  TH; tyrosine 3-monooxygenase
  09165 Substance dependence
   05030 Cocaine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05031 Amphetamine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05034 Alcoholism
    K00501  TH; tyrosine 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     K00501  TH; tyrosine 3-monooxygenase
Other DBs
RN: R01815 R07212
GO: 0004511
Genes
HSA: 7054(TH)
PTR: 450955(TH)
PPS: 100967895(TH)
GGO: 101135345(TH)
PON: 100454349(TH)
NLE: 100591963(TH)
MCC: 721137(TH)
MCF: 102134074(TH)
CSAB: 103238895(TH)
RRO: 104677105(TH)
RBB: 108539190(TH)
CJC: 100393454(TH)
SBQ: 101037795(TH)
MMU: 21823(Th)
MCAL: 110298803(Th)
MPAH: 110327669(Th)
RNO: 25085(Th)
MUN: 110547270(Th)
NGI: 103738985(Th)
HGL: 101721615(Th)
CCAN: 109689795(Th)
TUP: 102482570(TH)
CFA: 403444(TH)
VVP: 112924141(TH)
AML: 100483681(TH)
UMR: 103671121(TH)
UAH: 113243914(TH)
ORO: 101384343(TH)
ELK: 111149999
FCA: 101090720(TH)
PTG: 102954972(TH)
PPAD: 109259420(TH)
AJU: 106971078(TH)
BTA: 280707(TH)
BOM: 102274970(TH)
BIU: 109554672(TH)
BBUB: 102395073(TH)
CHX: 102179849(TH)
OAS: 101120619(TH)
SSC: 110259705(TH)
CFR: 102508286(TH)
CDK: 105106406(TH)
BACU: 103020745(TH)
LVE: 103086024(TH)
OOR: 101278256(TH)
DLE: 111184074(TH)
PCAD: 102996827(TH)
ECB: 100146648(TH)
EAI: 106824091(TH)
MYD: 102756871(TH)
MNA: 107539915(TH)
HAI: 109395916(TH)
DRO: 112317145(TH)
RAY: 107513264(TH)
MJV: 108402611(TH)
TMU: 101347132
MDO: 100021373
PCW: 110197189(TH) 110205577
OAA: 100075982 103167613(TH)
GGA: 395592(TH) 771761(THL)
MGP: 723977(TH)
CJO: 107314555(TH) 107314887
NMEL: 110398023 110401820(TH)
APLA: 101794316 101794610(TH)
ACYG: 106035805 106042638(TH)
TGU: 100217613 100219119(TH)
LSR: 110468651(TH) 110473828
SCAN: 103819711 103826755(TH)
GFR: 102039412 102044418(TH)
FAB: 101810723 101811971(TH)
PHI: 102108161 102111024(TH)
PMAJ: 107204189 107205413(TH)
CCAE: 111930777(TH) 111931331
CCW: 104687428(TH) 104696496
ETL: 114056146 114059836(TH)
FPG: 101912036 101915572(TH)
FCH: 102049050 102055136(TH)
CLV: 102087146 102092212(TH) 110357291
EGZ: 104124906(TH) 104135597
NNI: 104010421(TH) 104013376
ACUN: 113481167(TH) 113488615
PADL: 103920696(TH) 103924526
AAM: 106488264 106497044(TH)
ASN: 102378400(TH) 102381461
AMJ: 102563069 102565540(TH)
PSS: 102444955(TH) 102446096
CMY: 102935321(TH) 102941678
CPIC: 101937054(TH) 101942670
ACS: 100561541(th) 100562555
PVT: 110076553(TH) 110084772
PBI: 103048677 103061496(TH)
PMUR: 107289468 107294041(TH)
TSR: 106542491 106546997(TH)
PMUA: 114599115(TH) 114605512
GJA: 107108457(TH) 107119992
XLA: 100037248(th.S) 108710245 108713461(th.L)
XTR: 100488900(th) 100495856(th2)
NPR: 108789610 108791996(TH)
DRE: 30384(th) 414844(th2)
SRX: 107707537 107725618(pah) 107740562 107744916
SANH: 107664872 107675254(th) 107688572 107695848
SGH: 107553859(th) 107572878 107587609 107590157
CCAR: 109068217 109068347 109077513
IPU: 108274586 108279869
PHYP: 113529896(th) 113532096
AMEX: 103023599(th) 103026162
EEE: 113584590 113589509(th)
TRU: 101078018(th) 446095
TNG: GSTEN00019792G001 GSTEN00023797G001
LCO: 104920475(th) 104926293
NCC: 104945813 104966229(th)
MZE: 101468237(th) 101477829
ONL: 100702996 100708687(th)
OLA: 101168664(th2) 101171548(th)
XMA: 102222085 102222392(th)
XCO: 114150851(th) 114160620
PRET: 103459397 103466160(th)
CVG: 107085478 107089460(th)
NFU: 107386767 107389022(th)
KMR: 108233218 108237537(th)
ALIM: 106515667(th) 106530261
AOCE: 111582533(th) 111586653
CSEM: 103380366 103382582
POV: 109638922(th) 109640773
LCF: 108875328(th) 108897565
SDU: 111224521 111228409(th)
SLAL: 111661851(th) 111664688
HCQ: 109530099 109530311(th)
BPEC: 110161487 110165894(th)
MALB: 109967816 109967893(th)
SASA: 106560700(th) 106576278 106609447
OTW: 112214922 112218383(th)
SALP: 111961998(th) 111982828
ELS: 105026610(th) 105030168
SFM: 108931392 108942201(th)
PKI: 111846560 111859412(th)
LCM: 102350473 102363425
CMK: 103179919 103186002(th)
RTP: 109914089 109914147
BFO: BRAFLDRAFT_233334
CIN: 493867(th)
SPU: 581094
APLC: 110973102 110983460
SKO: 100329060(TH)
DME: Dmel_CG10118(ple)
DER: 6544948
DSE: 6611046
DSI: Dsimw501_GD13115(Dsim_GD13115)
DYA: Dyak_GE20472
DAN: 6493759
DSR: 110178770
DPO: Dpse_GA10085
DPE: 6601668
DMN: 108153568
DWI: 6645135
DGR: Dgri_GH15635
DMO: Dmoj_GI12682
DAZ: 108614271
DNV: 108652194
DHE: 111600489
DVI: 6623552
MDE: 101896218
LCQ: 111683620
AGA: AgaP_AGAP006023
AAG: 23687518
AALB: 109413955
CQU: CpipJ_CPIJ014156
AME: 408930(TyHyd)
BIM: 100750025
BTER: 100646624
CCAL: 108629537
OBB: 114876902
SOC: 105194448
MPHA: 105838942
AEC: 105145056
ACEP: 105619344
PBAR: 105423652
VEM: 105567121
HST: 105182098
DQU: 106750925
CFO: 105248912
LHU: 105678075
PGC: 109861504
OBO: 105279021
PCF: 106786223
NVI: 100116056
CSOL: 105360534
MDL: 103574339
TCA: 654918(Th)
DPA: 109541904
ATD: 109599398
NVL: 108569991
BMOR: 100270767(Th)
BMAN: 114244521
DPL: KGM_206781
PMAC: 106717258
PRAP: 110997603
HAW: 110377808
TNL: 113493935
PXY: 105380496(Th)
API: 100167369
DNX: 107161975
AGS: 114123079
RMD: 113554456
BTAB: 109044321
CLEC: 106664402
PHU: Phum_PHUM501080
ZNE: 110829545
FCD: 110862051
DPX: DAPPUDRAFT_323742
PVM: 113810884
TUT: 107359687
DPTE: 113794892
CSCU: 111638578
PTEP: 107442680 107453388
CEL: CELE_B0432.5(cat-2)
CBR: CBG07026(Cbr-cat-2)
BMY: Bm1_46865
LOA: LOAG_02149
TSP: Tsp_12013
HRO: HELRODRAFT_66944
LGI: LOTGIDRAFT_106041
PCAN: 112566735
CRG: 105337798
MYI: 110459086
OBI: 106871451
LAK: 106153195 106158393
SMM: Smp_007690
SHX: MS3_00810
OVI: T265_08520
GOG: C1280_12450
GMS: SOIL9_61730
 » show all
Reference
  Authors
Daubner SC, Le T, Wang S
  Title
Tyrosine hydroxylase and regulation of dopamine synthesis.
  Journal
Arch Biochem Biophys 508:1-12 (2011)
DOI:10.1016/j.abb.2010.12.017
Reference
PMID:2887169
  Authors
Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T
  Title
Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.
  Journal
Biochem Biophys Res Commun 146:971-5 (1987)
DOI:10.1016/0006-291x(87)90742-x
  Sequence
[hsa:7054]

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Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (23)   
   KEGG PATHWAY (22)   
   KEGG MODULE (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (4)   
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Gene (1155)   
   KEGG GENES (326)   
   KEGG MGENES (106)   
   RefGene (716)   
   OC (7)   
Protein sequence (110)   
   UniProt (103)   
   SWISS-PROT (7)   
Literature (2)   
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