KEGG ORTHOLOGY: K00501

ORTHOLOGY: K00501

Entry

K00501 KO

Name

Definition

tyrosine 3-monooxygenase [EC:1.14.16.2]

Pathway

ko00350

Tyrosine metabolism

ko00790

Folate biosynthesis

ko00950

Isoquinoline alkaloid biosynthesis

ko01100

Metabolic pathways

ko01110

Biosynthesis of secondary metabolites

ko04728

Dopaminergic synapse

ko04917

Prolactin signaling pathway

ko05012

Parkinson disease

ko05030

Cocaine addiction

ko05031

Amphetamine addiction

ko05034

Alcoholism

Module

M00042

Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline

Disease

H00831

Primary dystonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00501  TH; tyrosine 3-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K00501  TH; tyrosine 3-monooxygenase
  09156 Nervous system
   04728 Dopaminergic synapse
    K00501  TH; tyrosine 3-monooxygenase
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K00501  TH; tyrosine 3-monooxygenase
  09165 Substance dependence
   05030 Cocaine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05031 Amphetamine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05034 Alcoholism
    K00501  TH; tyrosine 3-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     K00501  TH; tyrosine 3-monooxygenase

Other DBs

RN:	R01815 R07212

GO:

0004511

Genes

HSA:

7054(TH)

PTR:	450955(TH)

PPS:	100967895(TH)

GGO:	101135345(TH)

PON:	100454349(TH)

NLE:	100591963(TH)

MCC:	721137(TH)

MCF:	102134074(TH)

CSAB:

103238895(TH)

RRO:	104677105(TH)

RBB:	108539190(TH)

CJC:	100393454(TH)

SBQ:	101037795(TH)

MMU:

21823(Th)

MCAL:

110298803(Th)

MPAH:

110327669(Th)

RNO:

25085(Th)

MUN:	110547270(Th)

NGI:	103738985(Th)

HGL:	101721615(Th)

CCAN:

109689795(Th)

TUP:	102482570(TH)

CFA:	403444(TH)

VVP:	112924141(TH)

AML:	100483681(TH)

UMR:	103671121(TH)

UAH:	113243914(TH)

ORO:	101384343(TH)

ELK:

111149999

FCA:	101090720(TH)

PTG:	102954972(TH)

PPAD:

109259420(TH)

AJU:	106971078(TH)

BTA:	280707(TH)

BOM:	102274970(TH)

BIU:	109554672(TH)

BBUB:

102395073(TH)

CHX:	102179849(TH)

OAS:	101120619(TH)

SSC:	110259705(TH)

CFR:	102508286(TH)

CDK:	105106406(TH)

BACU:

103020745(TH)

LVE:	103086024(TH)

OOR:	101278256(TH)

DLE:	111184074(TH)

PCAD:

102996827(TH)

ECB:	100146648(TH)

EAI:	106824091(TH)

MYD:	102756871(TH)

MMYO:

118659614(TH)

MNA:	107539915(TH)

HAI:	109395916(TH)

DRO:	112317145(TH)

MMF:	118628135(TH)

RAY:	107513264(TH)

MJV:	108402611(TH)

TMU:

101347132

MDO:

100021373

PCW:	110197189(TH) 110205577

OAA:	100075982 103167613(TH)

GGA:	395592(TH) 771761(THL)

MGP:	723977(TH)

CJO:	107314555(TH) 107314887

NMEL:

110398023 110401820(TH)

APLA:

101794316 101794610(TH)

ACYG:

106035805 106042638(TH)

TGU:	100217613 100219119(TH)

LSR:	110468651(TH) 110473828

SCAN:

103819711 103826755(TH)

GFR:	102039412 102044418(TH)

FAB:	101810723 101811971(TH)

PHI:	102108161 102111024(TH)

PMAJ:

107204189 107205413(TH)

CCAE:

111930777(TH) 111931331

CCW:	104687428(TH) 104696496

ETL:	114056146 114059836(TH)

FPG:	101912036 101915572(TH)

FCH:	102049050 102055136(TH)

CLV:	102087146 102092212(TH) 110357291

EGZ:	104124906(TH) 104135597

NNI:	104010421(TH) 104013376

ACUN:

113481167(TH) 113488615

PADL:

103920696(TH) 103924526

AAM:	106488264 106497044(TH)

ASN:	102378400(TH) 102381461

AMJ:	102563069 102565540(TH)

PSS:	102444955(TH) 102446096

CMY:	102935321(TH) 102941678

CPIC:

101937054(TH) 101942670

ACS:	100561541(th) 100562555

PVT:	110076553(TH) 110084772

PBI:	103048677 103061496(TH)

PMUR:

107289468 107294041(TH)

TSR:	106542491 106546997(TH)

PMUA:

114599115(TH) 114605512

GJA:	107108457(TH) 107119992

XLA:	100037248(th.S) 108710245(th2.L) 108713461(th.L)

XTR:	100488900(th) 100495856(th2)

NPR:	108789610 108791996(TH)

DRE:	30384(th) 414844(th2)

SRX:	107707537 107725618(pah) 107740562 107744916

SANH:

107664872 107675254(th) 107688572 107695848

SGH:	107553859(th) 107572878 107587609 107590157

CCAR:

109068217 109068347 109077513

IPU:	108274586 108279869

PHYP:

113529896(th) 113532096

AMEX:

103023599(th) 103026162

EEE:	113584590 113589509(th)

TRU:	101078018(th) 446095

TNG:	GSTEN00019792G001 GSTEN00023797G001

LCO:	104920475(th) 104926293

NCC:	104945813 104966229(th)

MZE:	101468237(th) 101477829

ONL:	100702996 100708687(th)

OLA:	101168664(th2) 101171548(th)

XMA:	102222085 102222392(th)

XCO:	114150851(th) 114160620

PRET:

103459397 103466160(th)

CVG:	107085478 107089460(th)

NFU:	107386767 107389022(th)

KMR:	108233218(th2) 108237537(th)

ALIM:

106515667(th) 106530261

AOCE:

111582533(th) 111586653

CSEM:

103380366 103382582

POV:	109638922(th) 109640773

LCF:	108875328(th) 108897565

SDU:	111224521 111228409(th)

SLAL:

111661851(th) 111664688

HCQ:	109530099 109530311(th)

BPEC:

110161487 110165894(th)

MALB:

109967816 109967893(th)

SASA:

106560700(th) 106576278 106609447

OTW:	112214922 112218383(th)

SALP:

111961998(th) 111982828

ELS:	105026610(th) 105030168

SFM:	108931392 108942201(th)

PKI:	111846560 111859412(th)

LCM:	102350473 102363425

CMK:	103179919 103186002(th)

RTP:	109914089 109914147

BFO:

118407893

CIN:	493867(th)

SPU:

581094

APLC:

110973102 110983460

SKO:	100329060(TH)

DME:	Dmel_CG10118(ple)

DER:

6544948

DSE:

6611046

DSI:	Dsimw501_GD13115(Dsim_GD13115)

DYA:	Dyak_GE20472

DAN:

6493759

DSR:

110178770

DPO:	Dpse_GA10085

DPE:

6601668

DMN:

108153568

DWI:

6645135

DGR:	Dgri_GH15635

DMO:	Dmoj_GI12682

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP006023

AAG:

23687518

AALB:

109413955

CQU:	CpipJ_CPIJ014156

AME:	408930(TyHyd)

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:	654918(Th)

DPA:

109541904

ATD:

109599398

NVL:

108569991

BMOR:

100270767(Th)

BMAN:

114244521

DPL:	KGM_206781

PMAC:

PRAP:

HAW:

TNL:

PXY:	105380496(Th)

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM501080

ZNE:

110829545

FCD:

110862051

DPX:	DAPPUDRAFT_323742

PVM:

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_B0432.5(cat-2)

CBR:	CBG07026(Cbr-cat-2)

BMY:

Bm1_46865

LOA:	LOAG_02149

TSP:

Tsp_12013

HRO:	HELRODRAFT_66944

LGI:	LOTGIDRAFT_106041

PCAN:

CRG:

MYI:

OBI:

LAK:	106153195 106158393

SMM:	Smp_007690

OVI:	T265_08520

SGM:	GCM10017557_00900(phhA)

MSAG:

GCM10017556_43150

GOG:	C1280_12450

GMS:	SOIL9_61730

FTJ:

FTUN_0679

TSPH:

KIH39_06910

» show all

Reference

PMID:21176768

Authors

Daubner SC, Le T, Wang S

Title

Tyrosine hydroxylase and regulation of dopamine synthesis.

Journal

Arch Biochem Biophys 508:1-12 (2011)
DOI:10.1016/j.abb.2010.12.017

Reference

PMID:2887169

Authors

Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T

Title

Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.

Journal

Biochem Biophys Res Commun 146:971-5 (1987)
DOI:10.1016/0006-291x(87)90742-x

Sequence

[hsa:7054]

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