KEGG   ORTHOLOGY: K00502
Entry
K00502                      KO                                     

Symbol
TPH1_2
Name
tryptophan 5-monooxygenase [EC:1.14.16.4]
Pathway
map00380  Tryptophan metabolism
map00790  Folate biosynthesis
map01100  Metabolic pathways
map04361  Axon regeneration
map04726  Serotonergic synapse
Module
M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Disease
H01646  Major depressive disorder
H01895  Attention deficit hyperactivity disorder (ADHD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00502  TPH1_2; tryptophan 5-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00502  TPH1_2; tryptophan 5-monooxygenase
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00502  TPH1_2; tryptophan 5-monooxygenase
  09158 Development and regeneration
   04361 Axon regeneration
    K00502  TPH1_2; tryptophan 5-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     K00502  TPH1_2; tryptophan 5-monooxygenase
Other DBs
RN: R01814 R07213
GO: 0004510
Genes
HSA: 121278(TPH2) 7166(TPH1)
PTR: 466453(TPH1) 467070(TPH2)
PPS: 100977344(TPH2) 103782654(TPH1)
GGO: 101132108(TPH1) 101146582(TPH2)
PON: 100459809(TPH2) 103891844(TPH1)
NLE: 100588345(TPH2) 100601780(TPH1)
MCC: 664730(TPH2) 695363(TPH1)
MCF: 102124167(TPH2) 102145077(TPH1)
CSAB: 103238730(TPH2) 103239320(TPH1)
CATY: 105581034(TPH2) 105598886(TPH1)
PANU: 101001223(TPH2) 103875499(TPH1)
RRO: 104667637(TPH1) 104668095(TPH2)
RBB: 108526665(TPH2) 108528377(TPH1)
TFN: 117081781(TPH1) 117089733(TPH2)
PTEH: 111552365(TPH2) 111555044(TPH1)
CJC: 100403096(TPH2) 100415029(TPH1)
SBQ: 101051709(TPH2) 104652952(TPH1)
MMUR: 105856884(TPH2) 105879970(TPH1)
MMU: 216343(Tph2) 21990(Tph1)
MCAL: 110298535(Tph1) 110303601(Tph2)
MPAH: 110326744(Tph2) 110330199(Tph1)
RNO: 24848(Tph1) 317675(Tph2)
MCOC: 116076348(Tph2) 116102248(Tph1)
MUN: 110550489(Tph1) 110555372(Tph2)
CGE: 100763947(Tph2) 100767923(Tph1)
PLEU: 114699018(Tph2) 114700529(Tph1)
NGI: 103734460(Tph1) 103735331(Tph2)
HGL: 101710219(Tph1) 101714361(Tph2)
CPOC: 100718189(Tph1) 100724594(Tph2)
CCAN: 109679995(Tph1)
OCU: 100009100(TPH1) 100101558(TPH1) 100344397(TPH2)
OPI: 101517264(TPH1) 101524788(TPH2)
TUP: 102481223(TPH2) 102487889(TPH1)
CFA: 481165(TPH2) 611956(TPH1)
VVP: 112922180(TPH2) 112927027(TPH1)
VLG: 121476514(TPH1) 121491914(TPH2)
AML: 100467699(TPH1) 100472165(TPH2)
UMR: 103656892(TPH2) 103679407(TPH1)
UAH: 113246602(TPH1) 113256261(TPH2)
ORO: 101364741(TPH1) 101369839(TPH2)
MPUF: 101678853(TPH2) 101685595(TPH1)
MLX: 118004319(TPH1) 118008557(TPH2)
FCA: 101082165(TPH2) 101098575(TPH1)
PYU: 121040737(TPH2) 121043698(TPH1)
PBG: 122474068(TPH2) 122484410(TPH1)
PTG: 102948910(TPH2) 102969936(TPH1)
PPAD: 109270520(TPH2) 109271211(TPH1)
AJU: 106967384(TPH2) 106977480(TPH1)
HHV: 120223353(TPH2) 120234792(TPH1)
BTA: 100336620(TPH2) 781941(TPH1)
BOM: 102269915(TPH1) 102275621(TPH2)
BIU: 109558652(TPH2) 109569943(TPH1)
BBUB: 102396992(TPH2) 102411029(TPH1)
CHX: 102174722(TPH2) 102184739(TPH1)
OAS: 101113620(TPH1) 101120314(TPH2)
ODA: 120857959(TPH2) 120876397(TPH1)
CCAD: 122427666(TPH2) 122450434(TPH1)
SSC: 100511002(TPH1) 100627725(TPH2)
CFR: 102512650(TPH2) 102522464(TPH1)
CBAI: 105072045(TPH2) 105076585(TPH1)
CDK: 105086665(TPH1) 105095994(TPH2)
BACU: 102997866(TPH1) 103006656(TPH2)
LVE: 103083324(TPH1) 103087968(TPH2)
OOR: 101271217(TPH2) 101273510(TPH1)
DLE: 111165253(TPH1) 111173732(TPH2)
PCAD: 102985446(TPH2) 102994832(TPH1)
PSIU: 116758349(TPH1) 116761326(TPH2)
ECB: 100009684(TPH2) 100056614(TPH1)
EPZ: 103559190(TPH1) 103561950(TPH2)
EAI: 106826108(TPH2) 106835485(TPH1)
MYB: 102241626(TPH2) 102244804(TPH1)
MYD: 102753485(TPH2) 102767513(TPH1)
MMYO: 118651936(TPH2) 118663522(TPH1)
MLF: 102418890(TPH1) 102434305(TPH2)
MNA: 107526733(TPH2) 107546725(TPH1)
PKL: 118712480(TPH1) 118730418(TPH2)
HAI: 109387680(TPH2) 109388096(TPH1)
DRO: 112303363(TPH1) 112319064(TPH2)
SHON: 118989337(TPH2) 118989705(TPH1)
AJM: 119053091(TPH1) 119055866
PDIC: 114499999(TPH1) 114513219(TPH2)
MMF: 118624020(TPH2) 118628186(TPH1)
RFQ: 117028733(TPH2) 117030182(TPH1)
PALE: 102882683(TPH1) 102891331(TPH2)
PGIG: 120593610(TPH1) 120605080(TPH2)
RAY: 107508027(TPH1) 107512624(TPH2)
MJV: 108400665(TPH2) 108404860(TPH1)
TOD: 119248285(TPH2) 119254591(TPH1)
LAV: 100658860(TPH1) 100669911(TPH2)
MDO: 100011937(TPH2) 100020009(TPH1)
GAS: 123250170(TPH2) 123251417(TPH1)
SHR: 100915442(TPH1) 100923184(TPH2)
PCW: 110195961(TPH2) 110221097(TPH1)
OAA: 100079349(TPH2) 100090381(TPH1)
GGA: 395799(TPH1) 408026(TPH2)
PCOC: 116226749(TPH2) 116242903(TPH1)
MGP: 100303678(TPH2) 100549515(TPH1)
CJO: 107310284(TPH2) 107314681(TPH1)
NMEL: 110392823(TPH2) 110401279(TPH1)
APLA: 101793780(TPH2) 101797806(TPH1)
ACYG: 106042627 106046728(TPH2)
TGU: 100228542(TPH2) 100229598(TPH1)
LSR: 110468084(TPH1) 110469834(TPH2)
SCAN: 103813668(TPH2) 103826774(TPH1)
PMOA: 120499841(TPH2) 120501148(TPH1)
OTC: 121339484(TPH2) 121341539(TPH1)
PRUF: 121352558(TPH2) 121360970(TPH1)
GFR: 102036017(TPH2) 102041307(TPH1)
FAB: 101817911(TPH2) 101820220(TPH1)
PHI: 102103962(TPH2) 102106431(TPH1)
PMAJ: 107204683(TPH2) 107205260(TPH1)
CCAE: 111930805(TPH1) 111937577(TPH2)
CCW: 104685325(TPH1) 104698473(TPH2)
ETL: 114059440(TPH1) 114059989(TPH2)
FPG: 101914983(TPH1) 101918183(TPH2)
FCH: 102052919(TPH2) 102057315(TPH1)
CLV: 102092014(TPH2) 102095810(TPH1)
EGZ: 104123206(TPH1) 104132957(TPH2)
NNI: 104010591(TPH1) 104011038(TPH2)
ACUN: 113481125(TPH1) 113489370(TPH2)
PADL: 103920030(TPH2) 103920766(TPH1)
AAM: 106488161(TPH2) 106497047(TPH1)
AROW: 112964095(TPH2) 112972385(TPH1)
NPD: 112951457(TPH1) 112958850(TPH2)
DNE: 112978923(TPH1) 112983291(TPH2)
ASN: 102376121(TPH2) 102380987(TPH1)
AMJ: 102560538(TPH1) 102572294(TPH2)
CPOO: 109315970(TPH2) 109321541(TPH1)
GGN: 109297011(TPH2) 109299139(TPH1)
PSS: 102445658(TPH2) 102460535(TPH1)
CMY: 102930035(TPH2) 102934830(TPH1)
CPIC: 101933912(TPH2) 101948172(TPH1)
TST: 117877260(TPH1) 117877915(TPH2)
CABI: 116817165(TPH2) 116838939(TPH1)
MRV: 120383209(TPH2) 120402771(TPH1)
ACS: 100562860(tph1) 100564918(tph2)
PVT: 110084890(TPH2) 110088804(TPH1)
SUND: 121929851(TPH1) 121931396(TPH2)
PBI: 103048564(TPH1) 103062013
PMUR: 107283841(TPH2) 107296796(TPH1)
TSR: 106541682(TPH2) 106552357
PGUT: 117655482(TPH2) 117665266(TPH1)
VKO: 123021233(TPH1) 123033286(TPH2)
PMUA: 114598774(TPH1) 114605959(TPH2)
ZVI: 118089013(TPH1) 118090812(TPH2)
GJA: 107115340(TPH2) 107115550(TPH1)
XLA: 108710258 108713144(tph2.S) 387560(tph1.L)
XTR: 100486097(tph2) 100497239(tph1)
NPR: 108785999(TPH1) 108788312(TPH2)
DRE: 352943(tph1a) 407712(tph2) 415103(tph1b)
IPU: 108259139(tph) 108263971 108274454(tph1)
TRU: 446047(tph1) 446048(tph2)
NCC: 104964502(tph1) 104965427
CGOB: 115004781 115009666(tph1)
ELY: 117257841 117261799(tph1a) 117261880(tph2)
PLEP: 121943098 121950084(tph1a)
SLUC: 116038510(tph1a) 116061876(tph2) 116067391
ECRA: 117947847 117949802(tph1a)
PFLV: 114557592 114559910(tph1) 114560174(tph2)
GAT: 120808697(tph1a) 120809623(tph2) 120833009
PPUG: 119195577(tph2) 119196279(tph1a) 119229676
CUD: 121515571(tph2) 121515765(tph1a)
MZE: 101480764(tph2) 101484460 101486409(tph1)
OAU: 116311354(tph2) 116319109 116326748(tph1a)
OLA: 101166957(tph2) 101170994 101175562(tph1)
XMA: 102216868(tph1) 102234879 102236889(tph2)
XCO: 114142506 114150104(tph2) 114151044(tph1)
XHE: 116710961(tph2) 116718124 116729036(tph1)
PRET: 103462259 103466377(tph2) 103466482(tph1)
GAF: 122835380(tph1a) 122836199(tph2) 122846231
CVG: 107099807(tph2) 107101475 107103791(tph1)
CTUL: 119773716 119781658(tph2) 119787407(tph1a)
NFU: 107381938 107388661(tph1) 107389098(tph2)
KMR: 108229864(tph1a) 108237877 108251439(tph2)
ALIM: 106516735 106521168(tph1) 106531022(tph2)
AOCE: 111578292 111584097(tph1)
CSEM: 103379608(tph2) 103380212(tph1)
POV: 109624178(tph1) 109644721
SSEN: 122775398(tph2) 122776545(tph1a)
HHIP: 117762606(tph1a) 117762648(tph2)
LCF: 108876698(tph1) 108891738(tph2)
SDU: 111229584(tph1) 111233710(tph2)
SLAL: 111648930 111667055(tph1)
XGL: 120793262(tph2) 120793556(tph1a)
HCQ: 109507516(tph1) 109518199(tph2) 109529786
BPEC: 110162577 110168313(tph2) 110169358(tph1)
MALB: 109951036(tph1) 109969076(tph2)
ELS: 105018201(tph1) 105018238(tph2)
LOC: 102682173(tph2) 102697783(tph1)
LCM: 102362567(TPH1) 102363250(TPH2)
BBEL: 109480215
CIN: 100049066
SCLV: 120335756
APLC: 110981081
SKO: 100329006(tph-1)
DME: Dmel_CG9122(Trh)
DER: 6543860
DSE: 6610268
DSI: Dsimw501_GD13494(Dsim_GD13494)
DAN: 6492953
DSR: 110178615
DPE: 6603951
DMN: 108153552
DWI: 6639428
DGR: 6558602
DAZ: 108614428
DNV: 108651306
DHE: 111600458
DVI: 6623307
CCAT: 101460734
BOD: 106622704
MDE: 101893101
SCAC: 106092589
LCQ: 111676820
ACOZ: 120952581
AARA: 120896557
AAG: 23687540
AALB: 109413958
CPII: 120412891
AME: 411200
ACER: 108003440
BIM: 100742465
BBIF: 117204398
BVK: 117233459
BVAN: 117153441
BTER: 100647460
BPYO: 122569193
CCAL: 108624633
OBB: 114876888
MGEN: 117223613
NMEA: 116424137
CGIG: 122395229
SOC: 105194454
MPHA: 105839937
AEC: 105145053
ACEP: 105619346
PBAR: 105430282
VEM: 105567116
HST: 105182103
DQU: 106750935
CFO: 105251016
FEX: 115233862
LHU: 105678051
PGC: 109861523
OBO: 105279028
PCF: 106791737
PFUC: 122524389
VPS: 122634219
NVI: 100123183
CSOL: 105363200
TPRE: 106653657
MDL: 103579283
CGLO: 123267565
FAS: 105264297
DAM: 107046653
AGIF: 122856599
CCIN: 107267966
TCA: 655758
DPA: 109539121
ATD: 109598736
AGB: 108910106
LDC: 111504779
NVL: 108562706
APLN: 108740743
PPYR: 116173900
OTU: 111419229
BMOR: 101740691
BMAN: 114244523
MSEX: 115446095
BANY: 112048662
PMAC: 106717008
PPOT: 106111764
PXU: 106126099
PRAP: 110999042
ZCE: 119835587
HAW: 110378221
TNL: 113499708
PXY: 105389797
API: 100158737
DNX: 107164769
RMD: 113549417
BTAB: 109030678
DCI: 113470334
CLEC: 106661596
HHAL: 106682080
NLU: 111064340
FOC: 113217977
ZNE: 110836317
CSEC: 111875212
FCD: 110856969
DMK: 116922854
PVM: 113812558
PJA: 122249658
HAME: 121870165
HAZT: 108665761
EAF: 111699592
DSV: 119465379
RSAN: 119403156
RMP: 119165283
VDE: 111248677
VJA: 111271616
TUT: 107363777
DPTE: 113789434
PTEP: 107448718
SDM: 118191490
CEL: CELE_ZK1290.2(tph-1)
CBR: CBG_12991(Cbr-tph-1)
PCAN: 112566861
BGT: 106070864
GAE: 121372139
CRG: 105336312
MYI: 110454322
PMAX: 117327242
OBI: 106875341
OSN: 115215674
LAK: 106175748
EGL: EGR_07589
APRO: F751_2362
 » show all
Reference
  Authors
Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M
  Title
Tryptophan hydroxylase as novel target for the treatment of depressive disorders.
  Journal
Pharmacology 85:95-109 (2010)
DOI:10.1159/000279322
Reference
PMID:2377472
  Authors
Boularand S, Darmon MC, Ganem Y, Launay JM, Mallet J
  Title
Complete coding sequence of human tryptophan hydroxylase.
  Journal
Nucleic Acids Res 18:4257 (1990)
DOI:10.1093/nar/18.14.4257
  Sequence
[hsa:7166]

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