KEGG   ORTHOLOGY: K00511Help
Entry
K00511                      KO                                     

Name
SQLE, ERG1
Definition
squalene monooxygenase [EC:1.14.14.17]
Pathway
ko00100  Steroid biosynthesis
ko00909  Sesquiterpenoid and triterpenoid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K00511  SQLE, ERG1; squalene monooxygenase
  09109 Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K00511  SQLE, ERG1; squalene monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.17  squalene monooxygenase
     K00511  SQLE, ERG1; squalene monooxygenase
BRITE hierarchy
Other DBs
RN: R02874
GO: 0004506
Genes
HSA: 6713(SQLE)
PTR: 464383(SQLE)
PPS: 100976805(SQLE)
GGO: 101129462(SQLE)
PON: 100453462(SQLE)
NLE: 100585992(SQLE)
MCC: 706764(SQLE)
MCF: 102118907(SQLE)
CSAB: 103237411(SQLE)
RRO: 104662802(SQLE)
RBB: 108538084(SQLE)
CJC: 100410163(SQLE)
SBQ: 101054084(SQLE)
MMU: 20775(Sqle)
MCAL: 110310474(Sqle)
MPAH: 110334642(Sqle)
RNO: 29230(Sqle)
MUN: 110552435(Sqle)
CGE: 100764834
NGI: 103743909(Sqle)
HGL: 101709317(Sqle)
CCAN: 109688126(Sqle)
OCU: 100356021(SQLE)
TUP: 102473783(SQLE)
CFA: 608021(SQLE)
VVP: 112915974(SQLE)
AML: 100465589(SQLE)
UMR: 103661624(SQLE)
UAH: 113252737(SQLE)
ORO: 101386907(SQLE)
ELK: 111146730
FCA: 101086537(SQLE)
PTG: 102948681(SQLE)
PPAD: 109273158(SQLE)
AJU: 106986573(SQLE)
BTA: 526535(SQLE)
BOM: 102264644(SQLE)
BIU: 109568596(SQLE)
BBUB: 102411716(SQLE)
CHX: 102187506(SQLE)
OAS: 100125351(SQLE)
SSC: 100113409(SQLE)
CFR: 102518096(SQLE)
CDK: 105096439(SQLE)
BACU: 103015244(SQLE)
LVE: 103088551(SQLE)
OOR: 101275903(SQLE)
DLE: 111164434(SQLE)
PCAD: 102996556(SQLE)
ECB: 100067615(SQLE)
EPZ: 103555758(SQLE)
EAI: 106839365(SQLE)
MYB: 102239947(SQLE)
MYD: 102766276(SQLE)
MNA: 107539554(SQLE)
HAI: 109383232(SQLE)
DRO: 112315359(SQLE)
PALE: 102894920(SQLE)
RAY: 107521591(SQLE)
MJV: 108400205(SQLE)
LAV: 100664731(SQLE)
TMU: 101359006
MDO: 100032247(SQLE)
SHR: 100918180(SQLE)
PCW: 110193305(SQLE)
OAA: 100076751(SQLE)
GGA: 420335(SQLE)
MGP: 100546703(SQLE)
CJO: 107310534(SQLE)
NMEL: 110394194(SQLE)
APLA: 101802617(SQLE)
ACYG: 106038503(SQLE)
TGU: 100225604(SQLE)
LSR: 110476988(SQLE)
SCAN: 103814522(SQLE)
GFR: 102033103(SQLE)
FAB: 101806873(SQLE)
PHI: 102109574(SQLE)
PMAJ: 107200846(SQLE)
CCAE: 111925120(SQLE)
CCW: 104692651(SQLE)
ETL: 114065244(SQLE)
FPG: 101920264(SQLE)
FCH: 102054050(SQLE)
CLV: 102090054(SQLE)
EGZ: 104134437(SQLE)
NNI: 104017981(SQLE)
ACUN: 113477107(SQLE)
PADL: 103916372(SQLE)
AAM: 106496303(SQLE)
ASN: 102368291(SQLE)
AMJ: 102563308(SQLE)
PSS: 102444614(SQLE)
CMY: 102929627(SQLE)
CPIC: 101943545(SQLE)
ACS: 100557553(sqle)
PVT: 110080534(SQLE)
PMUR: 107295853(SQLE)
PMUA: 114600258(SQLE)
GJA: 107118942(SQLE)
XLA: 108695454(sqle.S) 108719421(sqle.L)
XTR: 100491400(sqle)
NPR: 108789438(SQLE)
DRE: 799528(sqlea)
SRX: 107714342 107719155(sqle)
IPU: 108256332(sqle)
PHYP: 113532934(sqle)
AMEX: 103022030(sqle)
EEE: 113577069(sqle)
TRU: 101073594(sqle)
LCO: 104926267(sqle)
NCC: 104964943(sqle)
MZE: 101469229(sqle)
ONL: 100703372(sqle)
OLA: 101165835(sqle)
XMA: 102218921(sqle)
XCO: 114143874(sqle)
PRET: 103478205(sqle)
CVG: 107090131(sqle)
NFU: 107378852(sqle)
KMR: 108234140(sqle)
ALIM: 106523620(sqle)
AOCE: 111562938(sqle)
CSEM: 103388631(sqle)
POV: 109631985(sqle)
LCF: 108887154(sqle)
SDU: 111227759(sqle)
SLAL: 111658124(sqle)
HCQ: 109507068(sqle)
BPEC: 110171635(sqle)
MALB: 109966629(sqle)
ELS: 105019213(sqle)
SFM: 108940515(sqle)
PKI: 111844075(sqle)
CMK: 103187848(sqle)
RTP: 109919445(sqle)
SPU: 763532
APLC: 110978788
SKO: 100370736
PCAN: 112573399
LAK: 106169642
AQU: 100632870
ATH: AT1G58440(XF1) AT2G22830(SQE2) AT4G37760(SQE3) AT5G24140(SQP2) AT5G24150(SQP1) AT5G24160(SQE6)
LJA: Lj0g3v0267429.1(Lj0g3v0267429.1) Lj0g3v0267429.2(Lj0g3v0267429.2) Lj0g3v0267429.3(Lj0g3v0267429.3) Lj0g3v0267429.4(Lj0g3v0267429.4) Lj0g3v0292939.1(Lj0g3v0292939.1) Lj0g3v0298799.1(Lj0g3v0298799.1) Lj0g3v0298799.2(Lj0g3v0298799.2) Lj1g3v1779010.1(Lj1g3v1779010.1) Lj1g3v1779010.2(Lj1g3v1779010.2) Lj4g3v0412640.1(Lj4g3v0412640.1) Lj4g3v0412640.2(Lj4g3v0412640.2) Lj5g3v0347610.1(Lj5g3v0347610.1) Lj6g3v2171780.1(Lj6g3v2171780.1) Lj6g3v2171780.2(Lj6g3v2171780.2) Lj6g3v2171780.3(Lj6g3v2171780.3)
DOSA: Os03t0231700-01(Os03g0231700) Os03t0231800-02(Os03g0231800)
BDI: 100839945
ATS: 109744486(LOC109744486)
SBI: 8056854
ZMA: 100274333 100285558(pco148653)
SITA: 101777295
ATR: 18446877
PPP: 112296106
MNG: MNEG_6310
APRO: F751_4796
SCE: YGR175C(ERG1)
ERC: Ecym_6016
KMX: KLMA_30204(ERG1)
NCS: NCAS_0A06930(NCAS0A06930)
NDI: NDAI_0D01990(NDAI0D01990)
TPF: TPHA_0E03160(TPHA0E03160)
TBL: TBLA_0C05980(TBLA0C05980) TBLA_0H02130(TBLA0H02130)
TDL: TDEL_0E04440(TDEL0E04440)
KAF: KAFR_0D01720(KAFR0D01720)
PIC: PICST_75910(ERG1)
SPAA: SPAPADRAFT_62808(ERG1)
CAL: CAALFM_C108590CA(ERG1)
SLB: AWJ20_1671(ERG1) AWJ20_1672(ERG1)
NCR: NCU08280
NTE: NEUTE1DRAFT116406(NEUTE1DRAFT_116406)
MGR: MGG_06139
SSCK: SPSK_03260
MAW: MAC_01304
MAJ: MAA_06325
CMT: CCM_07184
BFU: BCIN_01g00360(Bcerg1)
MBE: MBM_00629
ANG: ANI_1_450034(An03g03770)
ABE: ARB_06092
TVE: TRV_00314
PTE: PTT_17609
ZTR: MYCGRDRAFT_108597(ERG1)
SPO: SPBC713.12(erg1)
CNE: CND06110
CNB: CNBD0290
ABP: AGABI1DRAFT69774(AGABI1DRAFT_69774)
ABV: AGABI2DRAFT205454(AGABI2DRAFT_205454)
MGL: MGL_0127
MRT: MRET_1190
DDI: DDB_G0293584(sqle)
DFA: DFA_07098(sqle)
SPAR: SPRG_11641
TCR: 509589.20
MMAI: sS8_2585
CCX: COCOR_01775(ubiF)
MCG: GL4_3111
GES: VT84_21375(ubiF_1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
He F, Zhu Y, He M, Zhang Y
  Title
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.
  Journal
DNA Seq 19:270-3 (2008)
DOI:10.1080/10425170701575026
  Sequence

KEGG   ORTHOLOGY: K23485Help
Entry
K23485                      KO                                     

Name
AltSQE
Definition
alternative squalene epoxidase [EC:1.14.19.-]
Pathway
ko00100  Steroid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K23485  AltSQE; alternative squalene epoxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.-  
     K23485  AltSQE; alternative squalene epoxidase
BRITE hierarchy
Other DBs
RN: R12355
COG: COG3000
Genes
MBR: MONBRDRAFT_33009
SRE: PTSG_10510
SMIN: v1.2.014977.t1(symbB.v1.2.014977.t1)
PTI: PHATRDRAFT_45494
FCY: FRACYDRAFT_234871
TPS: THAPS_10850
AAF: AURANDRAFT_65073
EHX: EMIHUDRAFT_442614
GTT: GUITHDRAFT_66839
TaxonomyKoalaUniProt
Reference
  Authors
Pollier J, Vancaester E, Kuzhiumparambil U, Vickers CE, Vandepoele K, Goossens A, Fabris M
  Title
A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis.
  Journal
Nat Microbiol 4:226-233 (2019)
DOI:10.1038/s41564-018-0305-5
  Sequence

KEGG   ENZYME: 1.14.14.17Help
Entry
EC 1.14.14.17               Enzyme                                 

Name
squalene monooxygenase;
squalene epoxidase;
squalene-2,3-epoxide cyclase;
squalene 2,3-oxidocyclase;
squalene hydroxylase;
squalene oxydocyclase;
squalene-2,3-epoxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
squalene,NADPH---hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
Reaction(IUBMB)
squalene + [reduced NADPH---hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02874]
Reaction(KEGG)
Substrate
squalene [CPD:C00751];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].
History
EC 1.14.14.17 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 1.14.99.7, transferred 2011 to EC 1.14.13.132, transferred 2015 to EC 1.14.14.17
Pathway
ec00100  Steroid biosynthesis
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00511  squalene monooxygenase
Genes
HSA: 6713(SQLE)
PTR: 464383(SQLE)
PPS: 100976805(SQLE)
GGO: 101129462(SQLE)
PON: 100453462(SQLE)
NLE: 100585992(SQLE)
MCC: 706764(SQLE)
MCF: 102118907(SQLE)
CSAB: 103237411(SQLE)
RRO: 104662802(SQLE)
RBB: 108538084(SQLE)
CJC: 100410163(SQLE)
SBQ: 101054084(SQLE)
MMU: 20775(Sqle)
MCAL: 110310474(Sqle)
MPAH: 110334642(Sqle)
RNO: 29230(Sqle)
MUN: 110552435(Sqle)
CGE: 100764834
NGI: 103743909(Sqle)
HGL: 101709317(Sqle)
CCAN: 109688126(Sqle)
OCU: 100356021(SQLE)
TUP: 102473783(SQLE)
CFA: 608021(SQLE)
VVP: 112915974(SQLE)
AML: 100465589(SQLE)
UMR: 103661624(SQLE)
UAH: 113252737(SQLE)
ORO: 101386907(SQLE)
ELK: 111146730
FCA: 101086537(SQLE)
PTG: 102948681(SQLE)
PPAD: 109273158(SQLE)
AJU: 106986573(SQLE)
BTA: 526535(SQLE)
BOM: 102264644(SQLE)
BIU: 109568596(SQLE)
BBUB: 102411716(SQLE)
CHX: 102187506(SQLE)
OAS: 100125351(SQLE)
SSC: 100113409(SQLE)
CFR: 102518096(SQLE)
CDK: 105096439(SQLE)
BACU: 103015244(SQLE)
LVE: 103088551(SQLE)
OOR: 101275903(SQLE)
DLE: 111164434(SQLE)
PCAD: 102996556(SQLE)
ECB: 100067615(SQLE)
EPZ: 103555758(SQLE)
EAI: 106839365(SQLE)
MYB: 102239947(SQLE)
MYD: 102766276(SQLE)
MNA: 107539554(SQLE)
HAI: 109383232(SQLE)
DRO: 112315359(SQLE)
PALE: 102894920(SQLE)
RAY: 107521591(SQLE)
MJV: 108400205(SQLE)
LAV: 100664731(SQLE)
TMU: 101359006
MDO: 100032247(SQLE)
SHR: 100918180(SQLE)
PCW: 110193305(SQLE)
OAA: 100076751(SQLE)
GGA: 420335(SQLE)
MGP: 100546703(SQLE)
CJO: 107310534(SQLE)
NMEL: 110394194(SQLE)
APLA: 101802617(SQLE)
ACYG: 106038503(SQLE)
TGU: 100225604(SQLE)
LSR: 110476988(SQLE)
SCAN: 103814522(SQLE)
GFR: 102033103(SQLE)
FAB: 101806873(SQLE)
PHI: 102109574(SQLE)
PMAJ: 107200846(SQLE)
CCAE: 111925120(SQLE)
CCW: 104692651(SQLE)
ETL: 114065244(SQLE)
FPG: 101920264(SQLE)
FCH: 102054050(SQLE)
CLV: 102090054(SQLE)
EGZ: 104134437(SQLE)
NNI: 104017981(SQLE)
ACUN: 113477107(SQLE)
PADL: 103916372(SQLE)
AAM: 106496303(SQLE)
ASN: 102368291(SQLE)
AMJ: 102563308(SQLE)
PSS: 102444614(SQLE)
CMY: 102929627(SQLE)
CPIC: 101943545(SQLE)
ACS: 100557553(sqle)
PVT: 110080534(SQLE)
PMUR: 107295853(SQLE)
PMUA: 114600258(SQLE)
GJA: 107118942(SQLE)
XLA: 108695454(sqle.S) 108719421(sqle.L)
XTR: 100491400(sqle)
NPR: 108789438(SQLE)
DRE: 799528(sqlea)
SRX: 107714342 107719155(sqle)
IPU: 108256332(sqle)
PHYP: 113532934(sqle)
AMEX: 103022030(sqle)
EEE: 113577069(sqle)
TRU: 101073594(sqle)
LCO: 104926267(sqle)
NCC: 104964943(sqle)
MZE: 101469229(sqle)
ONL: 100703372(sqle)
OLA: 101165835(sqle)
XMA: 102218921(sqle)
XCO: 114143874(sqle)
PRET: 103478205(sqle)
CVG: 107090131(sqle)
NFU: 107378852(sqle)
KMR: 108234140(sqle)
ALIM: 106523620(sqle)
AOCE: 111562938(sqle)
CSEM: 103388631(sqle)
POV: 109631985(sqle)
LCF: 108887154(sqle)
SDU: 111227759(sqle)
SLAL: 111658124(sqle)
HCQ: 109507068(sqle)
BPEC: 110171635(sqle)
MALB: 109966629(sqle)
ELS: 105019213(sqle)
SFM: 108940515(sqle)
PKI: 111844075(sqle)
CMK: 103187848(sqle)
RTP: 109919445(sqle)
SPU: 763532
APLC: 110978788
SKO: 100370736
PCAN: 112573399
LAK: 106169642
AQU: 100632870
ATH: AT1G58440(XF1) AT2G22830(SQE2) AT4G37760(SQE3) AT5G24140(SQP2) AT5G24150(SQP1) AT5G24160(SQE6)
LJA: Lj0g3v0267429.1(Lj0g3v0267429.1) Lj0g3v0267429.2(Lj0g3v0267429.2) Lj0g3v0267429.3(Lj0g3v0267429.3) Lj0g3v0267429.4(Lj0g3v0267429.4) Lj0g3v0292939.1(Lj0g3v0292939.1) Lj0g3v0298799.1(Lj0g3v0298799.1) Lj0g3v0298799.2(Lj0g3v0298799.2) Lj1g3v1779010.1(Lj1g3v1779010.1) Lj1g3v1779010.2(Lj1g3v1779010.2) Lj4g3v0412640.1(Lj4g3v0412640.1) Lj4g3v0412640.2(Lj4g3v0412640.2) Lj5g3v0347610.1(Lj5g3v0347610.1) Lj6g3v2171780.1(Lj6g3v2171780.1) Lj6g3v2171780.2(Lj6g3v2171780.2) Lj6g3v2171780.3(Lj6g3v2171780.3)
DOSA: Os03t0231700-01(Os03g0231700) Os03t0231800-02(Os03g0231800)
BDI: 100839945
ATS: 109744486(LOC109744486)
SBI: 8056854
ZMA: 100274333 100285558(pco148653)
SITA: 101777295
ATR: 18446877
PPP: 112296106
MNG: MNEG_6310
APRO: F751_4796
SCE: YGR175C(ERG1)
ERC: Ecym_6016
KMX: KLMA_30204(ERG1)
NCS: NCAS_0A06930(NCAS0A06930)
NDI: NDAI_0D01990(NDAI0D01990)
TPF: TPHA_0E03160(TPHA0E03160)
TBL: TBLA_0C05980(TBLA0C05980) TBLA_0H02130(TBLA0H02130)
TDL: TDEL_0E04440(TDEL0E04440)
KAF: KAFR_0D01720(KAFR0D01720)
PIC: PICST_75910(ERG1)
SPAA: SPAPADRAFT_62808(ERG1)
CAL: CAALFM_C108590CA(ERG1)
SLB: AWJ20_1671(ERG1) AWJ20_1672(ERG1)
NCR: NCU08280
NTE: NEUTE1DRAFT116406(NEUTE1DRAFT_116406)
MGR: MGG_06139
SSCK: SPSK_03260
MAW: MAC_01304
MAJ: MAA_06325
CMT: CCM_07184
BFU: BCIN_01g00360(Bcerg1)
MBE: MBM_00629
ANG: ANI_1_450034(An03g03770)
ABE: ARB_06092
TVE: TRV_00314
PTE: PTT_17609
ZTR: MYCGRDRAFT_108597(ERG1)
SPO: SPBC713.12(erg1)
CNE: CND06110
CNB: CNBD0290
ABP: AGABI1DRAFT69774(AGABI1DRAFT_69774)
ABV: AGABI2DRAFT205454(AGABI2DRAFT_205454)
MGL: MGL_0127
MRT: MRET_1190
DDI: DDB_G0293584(sqle)
DFA: DFA_07098(sqle)
SPAR: SPRG_11641
TCR: 509589.20
MMAI: sS8_2585
CCX: COCOR_01775(ubiF)
MCG: GL4_3111
GES: VT84_21375(ubiF_1)
 » show all
Taxonomy
Reference
1  [PMID:5918046]
  Authors
Cory EJ, Russey WE, Ortiz de Montellano PR.
  Title
2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene.
  Journal
J Am Chem Soc 88:4750-1 (1966)
Reference
2  [PMID:13438881]
  Authors
TCHEN TT, BLOCH K.
  Title
On the conversion of squalene to lanosterol in vitro.
  Journal
J Biol Chem 226:921-30 (1957)
Reference
3  [PMID:5918048]
  Authors
Van Tamelen EE, Willett JD, Clayton RB, Lord KE.
  Title
Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol.
  Journal
J Am Chem Soc 88:4752-4 (1966)
Reference
4  [PMID:5438357]
  Authors
Yamamoto S, Bloch K.
  Title
Studies on squalene epoxidase of rat liver.
  Journal
J Biol Chem 245:1670-4 (1970)
Reference
5  [PMID:234459]
  Authors
Ono T, Bloch K
  Title
Solubilization and partial characterization of rat liver squalene epoxidase.
  Journal
J Biol Chem 250:1571-9 (1975)
Reference
6  [PMID:8358382]
  Authors
Satoh T, Horie M, Watanabe H, Tsuchiya Y, Kamei T
  Title
Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.
  Journal
Biol Pharm Bull 16:349-52 (1993)
Reference
7  [PMID:12467639]
  Authors
Chugh A, Ray A, Gupta JB
  Title
Squalene epoxidase as hypocholesterolemic drug target revisited.
  Journal
Prog Lipid Res 42:37-50 (2003)
DOI:10.1016/S0163-7827(02)00029-2
Reference
8  [PMID:17852349]
  Authors
He F, Zhu Y, He M, Zhang Y
  Title
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.
  Journal
DNA Seq 19:270-3 (2008)
DOI:10.1080/10425170701575026
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.17
IUBMB Enzyme Nomenclature: 1.14.14.17
ExPASy - ENZYME nomenclature database: 1.14.14.17
BRENDA, the Enzyme Database: 1.14.14.17
CAS: 9029-62-3

KEGG   REACTION: R02874Help
Entry
R02874                      Reaction                               

Name
squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
Definition
Squalene + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> (S)-2,3-Epoxysqualene + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Reaction class
RC00201  C00751_C01054
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Orthology
K00511  squalene monooxygenase [EC:1.14.14.17]
Other DBs
RHEA: 25285

KEGG   REACTION: R12355Help
Entry
R12355                      Reaction                               

Definition
Squalene + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> (S)-2,3-Epoxysqualene + 2 Ferricytochrome b5 + H2O
Equation
Comment
squalene,ferrocytochrome-b5:oxygen oxidoreductase
Reaction class
RC00201  C00751_C01054
Enzyme
1.14.19.-
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Orthology
K23485  alternative squalene epoxidase [EC:1.14.19.-]

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