KEGG   ORTHOLOGY: K00559
Entry
K00559                      KO                                     
Symbol
SMT1, ERG6
Name
sterol 24-C-methyltransferase [EC:2.1.1.41]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Reaction
R04427  S-adenosyl-L-methionine:zymosterol C-methyltransferase
R07481  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K00559  SMT1, ERG6; sterol 24-C-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.41  sterol 24-C-methyltransferase
     K00559  SMT1, ERG6; sterol 24-C-methyltransferase
Other DBs
COG: COG0500
GO: 0003838
Genes
NAI: NECAME_03546
BMY: BM_BM4647(Bma-strm-1)
AQU: 100639491
ATH: AT5G13710(SMT1)
ALY: 9307650
CRB: 17882375
CSAT: 104705624 104735382 104769590
EUS: EUTSA_v10014014mg
BRP: 103850891 103856028
BNA: 106371823 106431054 106440921
BOE: 106322658 106329263
RSZ: 108839810 108844631
THJ: 104809850 104819084 104819086 104819087
CPAP: 110809321
CIT: 102628258
CIC: CICLE_v10031748mg
PVY: 116132255 116132258
MINC: 123197557 123214703 123216668 123216669 123216670
TCC: 18598956 18614599 18614600
GRA: 105790583
GHI: 107915814 107950679
GAB: 108470188
HSYR: 120129642 120136785 120165276 120188812
DZI: 111305861 111313689
EGR: 104454605 104454641 104454642 104455966
GMX: 100796978 100817534 100818061 548073
GSJ: 114372208 114378245 114379538 114386323
PVU: PHAVU_005G023700g PHAVU_011G011800g PHAVU_011G011900g
VRA: 106760797
VAR: 108332339
VUN: 114165537
VUM: 124835473
CCAJ: 109799147 109806010
APRC: 113854972 113865316
MTR: 11415411
TPRA: 123913735
CAM: 101497864
PSAT: 127085609
VVO: 131636217 131662694
LJA: Lj3g3v0825030.1(Lj3g3v0825030.1) Lj3g3v0825030.2(Lj3g3v0825030.2)
ADU: 107471578 107479358
AIP: 107622756 107630475
AHF: 112716746 112738324 112783834 112790500
LANG: 109333713 109346157
PCIN: 129296047 129315800
QSA: O6P43_006507 O6P43_029576
FVE: 101293342
RCN: 112181939
PPER: 18785581
PMUM: 103330640
PAVI: 110765835
PDUL: 117619806
MDM: 103418631 103438422 114823791
MSYL: 126613669 126628384
ZJU: 107425735
MNT: 112091791 21388176
CSAV: 115709304
CSV: 101217151 101217389
CMO: 103500325 103500326
BHJ: 120089794 120091030
MCHA: 111020326 111020366
CMAX: 111481504 111481505 111493094
CMOS: 111441927 111442447 111452027
CPEP: 111787513 111789805 111789806
RCU: 8259297 8286298
JCU: 105628730
HBR: 110634256 110659984
MESC: 110618568 110620358 110623913
POP: 18095100 18106161 7467341
PEU: 105117376 105126337 105131854 105141731
PALZ: 118027720 118047027 118051651
JRE: 108987693 108988702 109019397
CILL: 122292529 122292668 122293402
CAVE: 132167241 132173586
QSU: 112025906 112027940
QLO: 115953357 115967771 115986962
TWL: 120011980 120014669
VVI: 100252116 100263590
VRI: 117919779 117928779 117928780
SLY: 101252433 101256047
SPEN: 107008176 107032350
SOT: 102581721 102589132
SSTN: 125853521 125866069
SDUL: 129886986
CANN: 107839483 107845155
LBB: 132607399 132644773
NTA: 107772103 107806298 107813194 107813488 107821929 107825894
NSY: 104213731 104221372 104248706
NTO: 104104807 104117345 104120777
NAU: 109216067 109225324 109237978
INI: 109156026 109156027
ITR: 115995625 115997067
SIND: 105169293
OEU: 111410481 111410482
EGT: 105969542
SSPL: 121759270 121791175 121805340 121809614
SMIL: 131022313
SHIS: 125194076 125217903
APAN: 127246285
HAN: 110888576 110918161 110921577
ECAD: 122595873
LSV: 111900335 111912645 111912658
CCAV: 112522572
DCR: 108196395 108226507
CSIN: 114279643 114312087 114318153
RVL: 131326980 131327876 131334351 131334352 131334353
AEW: 130756790 130780608 130782335
BVG: 104907757
SOE: 110778345
CQI: 110702765 110705694
ATRI: 130804259
MOF: 131165006
NNU: 104597375
MING: 122071445 122071905 122091901
TSS: 122642777 122642790 122642791
PSOM: 113313126 113322869 113354420
OSA: 4342690 9269350
DOSA: Os03t0807600-00(Os03g0807600) Os07t0206700-01(Os07g0206700) Os11t0296900-00(Os11g0296900)
OBR: 102713236
OGL: 127755018 127766216 127779788
BDI: 100826864 100834229
ATS: 109734415 109756778
TDC: 119291992 119304087
TAES: 123093722 123105904 543246
TUA: 125529735
LPER: 127292258 127323344
LRD: 124674874 124674972 124697778 124697779
SBI: 8057107 8064726 8078421 8081208
ZMA: 100282501 100286381 541682
SITA: 101753762 101756008 101780888
SVS: 117834191 117845345 117866533
PVIR: 120639714 120644214 120644215 120644245 120645629 120649372 120659670 120665784
PHAI: 112872433 112877095 112883041
PDA: 103696988 103696989 103697536 103717656 103717657 113461272 120104527
EGU: 105035517 105046511 105055167
MUS: 103979889 103980161 103981384 103993068
ZOF: 122020552 122020864 122024007 122024078 122024744 122051188 122055892
DCT: 110109799 110110369 110116065
PEQ: 110018546 110018549
AOF: 109833715
MSIN: 131221626 131222583
NCOL: 116249160
ATR: 18428920 18428921 18428922
SMO: SELMODRAFT_449609(SMT1-2) SELMODRAFT_449613(SMT1-1)
PPP: 112291818
MNG: MNEG_11110
OLU: OSTLU_30710
OTA: OT_ostta03g03830
BPG: Bathy09g04120
MIS: MICPUN_93596(SMT1)
MPP: MICPUCDRAFT_50903(JGI:MicpuC2_50903)
CME: CYME_CMP275C
GSL: Gasu_26310 Gasu_60150
SCE: YML008C(ERG6)
SEUB: DI49_4081
SPAO: SPAR_M01190
AGO: AGOS_ADR196W
ERC: Ecym_4063
KLA: KLLA0_A01738g
KMX: KLMA_30671(ERG6)
LTH: KLTH0G03806g
VPO: Kpol_1004p23
ZRO: ZYRO0D12606g
CGR: CAGL0H04653g
NCS: NCAS_0H02570(NCAS0H02570)
NDI: NDAI_0C01050(NDAI0C01050)
TPF: TPHA_0D02350(TPHA0D02350)
TBL: TBLA_0D01630(TBLA0D01630)
TGB: HG536_0A05480
TDL: TDEL_0A03930(TDEL0A03930)
KAF: KAFR_0C05410(KAFR0C05410)
KNG: KNAG_0B03670(KNAG0B03670)
ZMK: HG535_0D04960
PPA: PAS_chr3_0371
DHA: DEHA2D17622g
PIC: PICST_80971
PGU: PGUG_00661
SPAA: SPAPADRAFT_62031
LEL: PVL30_003580(ERG6)
CAL: CAALFM_C302150CA(ERG6)
CTP: CTRG_02396
COT: CORT_0C04430
CDU: CD36_82130(ERG6)
CTEN: CANTEDRAFT_114072
YLI: YALI0F08701g
CLU: CLUG_02673
CLUS: A9F13_07g01804
CAUR: CJI96_0004127
SLB: AWJ20_2170(ERG6)
PKZ: C5L36_0E02630
BNN: FOA43_002150(ERG6)
BBRX: BRETT_003844(ERG6)
OPA: HPODL_01877
SLUD: SCDLUD_003309
NCR: NCU02502 NCU03006(erg-4)
NTE: NEUTE1DRAFT150553(NEUTE1DRAFT_150553) NEUTE1DRAFT73978(NEUTE1DRAFT_73978)
SMP: SMAC_01214 SMAC_05969
PAN: PODANSg3800 PODANSg4053 PODANSg4704
PBEL: QC761_115810(ERG6_1) QC761_124410(ERG6_2)
PPSD: QC762_115810(ERG6_1) QC762_124410(ERG6_2)
PPSP: QC763_115810(ERG6_1) QC763_124410(ERG6_2)
PPSA: QC764_115810(ERG6_1) QC764_124410(ERG6_2)
TTT: THITE_68084
MTM: MYCTH_110670 MYCTH_42269
CTHR: CTHT_0006340
MGR: MGG_04346 MGG_10568 MGG_10860
PPEI: PpBr36_03960 PpBr36_10036
PGRI: PgNI_03580 PgNI_09085 PgNI_11040
TMN: UCRPA7_4321 UCRPA7_5376 UCRPA7_8731
SSCK: SPSK_06325 SPSK_06557 SPSK_06653
FGR: FGSG_02783 FGSG_05740
FPU: FPSE_05610 FPSE_08317
FPOA: FPOAC1_005133(ERG6_1) FPOAC1_008700(ERG4)
FVN: FVRRES_05661 FVRRES_09296
FVR: FVEG_05904 FVEG_13091
FOX: FOXG_08765 FOXG_15629
NHE: NECHADRAFT_101488 NECHADRAFT_33136 NECHADRAFT_59530
FFC: NCS54_00221300 NCS54_00445000
FKR: NCS57_00216400 NCS57_00451800
FMU: J7337_004853(ERG6_2) J7337_008919(ERG6_3)
TRE: TRIREDRAFT_121166 TRIREDRAFT_56236
TRR: M419DRAFT_108988 M419DRAFT_72858
MAW: MAC_04281 MAC_08238
MAJ: MAA_02798 MAA_10087
PCHM: VFPPC_07182 VFPPC_10999
CMT: CCM_04684 CCM_08656
AMUS: LMH87_001661 LMH87_006959 LMH87_009165
PLJ: VFPFJ_10371 VFPFJ_11119
PTKZ: JDV02_008053(ERG6_1) JDV02_009647(ERG6_2)
VAL: VDBG_01914 VDBG_08910
VDA: VDAG_01643 VDAG_06572
CFJ: CFIO01_00904 CFIO01_00910 CFIO01_12167
CLUP: CLUP02_08421 CLUP02_11674 CLUP02_11681
CHIG: CH63R_07675 CH63R_11163 CH63R_11195
SAPO: SAPIO_CDS4855 SAPIO_CDS6557
ELA: UCREL1_1004 UCREL1_1267 UCREL1_1354
PFY: PFICI_00782 PFICI_01643 PFICI_06847 PFICI_10966
SSL: SS1G_03467 SS1G_03686
BFU: BCIN_04g01200 BCIN_08g01540
MBE: MBM_02476 MBM_07594
PSCO: LY89DRAFT_628125 LY89DRAFT_684462 LY89DRAFT_725473 LY89DRAFT_789176
GLZ: GLAREA_04347 GLAREA_05164
ANI: ANIA_01614 ANIA_07146
AFM: AFUA_4G03630 AFUA_4G09190
ACT: ACLA_048560 ACLA_054780
NFI: NFIA_029790 NFIA_106980
AOR: AO090011000289 AO090012000932 AO090023000624
ANG: An04g04210 An14g01590 An16g00300
AFV: AFLA_002655 AFLA_006968 AFLA_007687
ALUC: AKAW2_40856S(ERG6) AKAW2_51426S
ACHE: ACHE_40345A ACHE_60580A(ERG6)
APUU: APUU_21581S APUU_22198S(ERG6_1) APUU_80754S(ERG6_2)
PCS: N7525_001128 N7525_007611
PDP: PDIP_13570 PDIP_13580 PDIP_57520 PDIP_76970
POU: POX_g09270
TMF: EYB26_009195
TRG: TRUGW13939_07336
CIM: CIMG_06139 CIMG_08444 CIMG_09630
CPW: CPC735_061140
URE: UREG_02519 UREG_04245
PBL: PAAG_01575
PBN: PADG_00204
ABE: ARB_05210 ARB_05997
TVE: TRV_02353 TRV_06345
AJE: HCAG_07564
BGH: BDBG_08700
PNO: SNOG_08443
PTE: PTT_11273
BZE: COCCADRAFT_22623
BSC: COCSADRAFT_39890
BOR: COCMIDRAFT_90360
AALT: CC77DRAFT_1024280 CC77DRAFT_984927
ARAB: EKO05_0005085
ZTR: MYCGRDRAFT_33363 MYCGRDRAFT_70113(ERG6) MYCGRDRAFT_70899 MYCGRDRAFT_98820
PFJ: MYCFIDRAFT_33221 MYCFIDRAFT_64115 MYCFIDRAFT_84237
FFU: CLAFUR5_00943 CLAFUR5_09835
CBET: CB0940_01475 CB0940_06157
BCOM: BAUCODRAFT_129875 BAUCODRAFT_37733 BAUCODRAFT_61348
NPA: UCRNP2_1782 UCRNP2_3336
TML: GSTUM_00004489001
SPO: SPBC16E9.05(erg6)
SOM: SOMG_01545(erg6)
CNE: CNB03100
CNB: CNBB2600
CNG: CNAG_03819
CGI: CGB_A3260C
CDEU: CNBG_1537
TMS: TREMEDRAFT_44172
TASA: A1Q1_06727
CCAC: CcaHIS019_0705320(ERG6)
PPL: POSPLDRAFT_89636
TVS: TRAVEDRAFT_74073
DSQ: DICSQDRAFT_141756
PCO: PHACADRAFT_252042
SHS: STEHIDRAFT_119615
HIR: HETIRDRAFT_388200
PSQ: PUNSTDRAFT_126433
ADL: AURDEDRAFT_110716 AURDEDRAFT_121438 AURDEDRAFT_139717
FME: FOMMEDRAFT_23815
GTR: GLOTRDRAFT_122852
RSX: RhiXN_00557 RhiXN_05850
LBC: LACBIDRAFT_184995(erg6)
CCI: CC1G_05622 CC1G_06149 CC1G_07728
ABP: AGABI1DRAFT115299(AGABI1DRAFT_115299)
ABV: AGABI2DRAFT194260(AGABI2DRAFT_194260)
PCUB: JR316_0008774
MRR: Moror_12565
MORE: E1B28_012717
SCM: SCHCO_02052297(SCHCODRAFT_02052297) SCHCO_02512248(SCHCODRAFT_02512248) SCHCO_02601905(SCHCODRAFT_02601905) SCHCO_02627257(SCHCODRAFT_02627257) SCHCO_02680330(SCHCODRAFT_02680330) SCHCO_02751485(SCHCODRAFT_02751485)
CPUT: CONPUDRAFT_138796
SLA: SERLADRAFT_457598
WSE: WALSEDRAFT_15798
WIC: J056_002357
UMA: UMAG_03182
PFP: PFL1_05601
SGRA: EX895_005848
MGL: MGL_2877
MRT: MRET_3473
MSYM: MSY001_0359
PGR: PGTG_02203 PGTG_17346
PTRC: PtA15_2A427 PtA15_2A801 PtA15_2A804
PSTR: Pst134EA_005187 Pst134EA_005301
MLR: MELLADRAFT_41694 MELLADRAFT_73949
MBR: MONBRDRAFT_33702
DDI: DDB_G0288907(smt1)
DPP: DICPUDRAFT_92595
DFA: DFA_09943(smt1)
ACAN: ACA1_193300 ACA1_237870
SMIN: v1.2.010320.t1(symbB.v1.2.010320.t1) v1.2.040208.t1(symbB.v1.2.040208.t1)
PTI: PHATRDRAFT_10824
TPS: THAPSDRAFT_32029 THAPSDRAFT_36203(SMT1)
AAF: AURANDRAFT_21939 AURANDRAFT_52760 AURANDRAFT_59110
SPAR: SPRG_05001
EHX: EMIHUDRAFT_432780
GTT: GUITHDRAFT_63072
TBR: Tb10.6k15.3820
TBG: TbgDal_X8450
TCR: 504191.10 505683.10 510185.10
LMA: LMJF_36_2380 LMJF_36_2390(LmSMT)
LIF: LINJ_36_2510 LINJ_36_2520
LDO: LDBPK_362510 LDBPK_362520
LMI: LMXM_36_2380 LMXM_36_2390
LBZ: LBRM_35_2600
LPAN: LPMP_352450(LMSMT)
NGR: NAEGRDRAFT_81379 NAEGRDRAFT_83028
TMC: LMI_2904
SALO: EF888_11230
SRK: FGW37_00260
NDK: I601_4050(rebM_4)
AEB: C6I20_03155
FRI: FraEuI1c_2154
ABAI: IMCC26256_112265
SUS: Acid_3267
AEV: EI546_13790
 » show all
Reference
PMID:18563465
  Authors
Jayasimha P, Nes WD
  Title
Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site.
  Journal
Lipids 43:681-93 (2008)
DOI:10.1007/s11745-008-3198-x
  Sequence
[sce:YML008C]
Reference
PMID:20946868
  Authors
Ganapathy K, Kanagasabai R, Nguyen TT, Nes WD
  Title
Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans.
  Journal
Arch Biochem Biophys 505:194-201 (2011)
DOI:10.1016/j.abb.2010.10.008
  Sequence
[cal:CAALFM_C302150CA]
Reference
PMID:10852933
  Authors
Diener AC, Li H, Zhou W, Whoriskey WJ, Nes WD, Fink GR
  Title
Sterol methyltransferase 1 controls the level of cholesterol in plants.
  Journal
Plant Cell 12:853-70 (2000)
DOI:10.1105/tpc.12.6.853
  Sequence
[ath:AT5G13710]

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Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   COG (1)   
Pathway (8)   
   KEGG PATHWAY (6)   
   KEGG MODULE (2)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (7905)   
   KEGG GENES (659)   
   KEGG MGENES (615)   
   RefGene (6619)   
   OC (12)   
Literature (3)   
   PubMed (3)   
All databases (7925)   

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