KEGG   ORTHOLOGY: K00594
Entry
K00594                      KO                                     

Name
xyoA, aldO
Definition
alditol oxidase [EC:1.1.3.41]
Pathway
ko00040  Pentose and glucuronate interconversions
ko00051  Fructose and mannose metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K00594  xyoA, aldO; alditol oxidase
   00051 Fructose and mannose metabolism
    K00594  xyoA, aldO; alditol oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.41  alditol oxidase
     K00594  xyoA, aldO; alditol oxidase
Other DBs
RN: R07152 R11620
COG: COG0277
GO: 0050582
Genes
SUR: STAUR_8333
RHL: LPU83_2792(xyoA)
RGR: FZ934_21205
DEI: C4375_16190
BCIR: C2I06_21335
GRC: GI584_06435
PJD: Pjdr2_3940
GYM: GYMC10_3259
PBV: AR543_14140
PYG: AWM70_16255
SCO: SCO6147(aldo)
SCT: SCAT_p1150(xyoA)
SFA: Sfla_0209
SBH: SBI_09106
SHY: SHJG_7217
SDV: BN159_2173(xyoA)
STRP: F750_6808
SLV: SLIV_07400(xyoA)
SGU: SGLAU_26465(xyoA)
SAMB: SAM23877_5861(xyoA)
SRW: TUE45_06783(xyoA)
SLE: sle_15280(sle_15280)
STRD: NI25_08645
SMAL: SMALA_6973
SGE: DWG14_01922(xyoA)
SRJ: SRO_1690
KSK: KSE_59540
LXL: KDY119_00127(xyoA)
CMI: CMM_2110
CMS: CMS1111(xyoA)
CMC: CMN_02075
MTS: MTES_2201
MOO: BWL13_02828(xyoA)
MLV: CVS47_02873(xyoA)
ART: Arth_4010
ARM: ART_0047
AAU: AAur_0055
ACH: Achl_0055
BCV: Bcav_2879
JDE: Jden_2461
IDO: I598_2577(xyoA)
CFL: Cfla_0930
CFI: Celf_2955
SERJ: SGUI_0471
KFL: Kfla_1819
NDA: Ndas_4763
STRR: EKD16_11800(xyoA)
SRO: Sros_2313
ACE: Acel_0723
GOB: Gobs_2565
BSD: BLASA_2793(xyoA)
MMAR: MODMU_2272
KRA: Krad_3634
AMD: AMED_4426
AMN: RAM_22540
AMM: AMES_4372
AMZ: B737_4372
AOI: AORI_3521
AJA: AJAP_21525(xyoA)
AORI: SD37_18195
AMI: Amir_2301
SESP: BN6_41440
ACTI: UA75_14945
ACAD: UA74_14355
AHG: AHOG_13485(xyoA)
MIL: ML5_3543
ASE: ACPL_1234(xyoA)
ACTN: L083_5339(xyoA)
AFS: AFR_25135
ACTS: ACWT_1115
PFLA: Pflav_087590(xyoA)
PSUU: Psuf_050580(xyoA)
CAI: Caci_1977
ACA: ACP_1928(sox)
ABAS: ACPOL_5628
ABAC: LuPra_00940(xyoA)
MGOT: MgSA37_01412(xyoA)
DFE: Dfer_3313
SLI: Slin_6373
FAE: FAES_2542
PSEZ: HME7025_01300(xyoA)
AG: BAA95146(xyoA)
 » show all
Reference
  Authors
Yamashita M, Omura H, Okamoto E, Furuya Y, Yabuuchi M, Fukahi K, Murooka Y
  Title
Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472.
  Journal
J Biosci Bioeng 89:350-60 (2000)
DOI:10.1016/S1389-1723(00)88958-6
  Sequence

KEGG   ENZYME: 1.1.3.41
Entry
EC 1.1.3.41                 Enzyme                                 

Name
alditol oxidase;
xylitol oxidase;
xylitol:oxygen oxidoreductase;
AldO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
alditol:oxygen oxidoreductase
Reaction(IUBMB)
an alditol + O2 = an aldose + H2O2 [RN:R11618]
Reaction(KEGG)
R11618 > R07152 R11620
Substrate
alditol [CPD:C00717];
O2 [CPD:C00007]
Product
aldose [CPD:C01370];
H2O2 [CPD:C00027]
Comment
The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein [1,2]. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabinitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly [1,2]. Belongs in the vanillyl-alcohol-oxidase family of enzymes [2].
History
EC 1.1.3.41 created 2002, modified 2008
Pathway
ec00040  Pentose and glucuronate interconversions
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K00594  alditol oxidase
Genes
SUR: STAUR_8333
RHL: LPU83_2792(xyoA)
RGR: FZ934_21205
DEI: C4375_16190
BCIR: C2I06_21335
GRC: GI584_06435
PJD: Pjdr2_3940
GYM: GYMC10_3259
PBV: AR543_14140
PYG: AWM70_16255
SCO: SCO6147(aldo)
SCT: SCAT_p1150(xyoA)
SFA: Sfla_0209
SBH: SBI_09106
SHY: SHJG_7217
SDV: BN159_2173(xyoA)
STRP: F750_6808
SLV: SLIV_07400(xyoA)
SGU: SGLAU_26465(xyoA)
SAMB: SAM23877_5861(xyoA)
SRW: TUE45_06783(xyoA)
SLE: sle_15280(sle_15280)
STRD: NI25_08645
SMAL: SMALA_6973
SGE: DWG14_01922(xyoA)
SRJ: SRO_1690
KSK: KSE_59540
LXL: KDY119_00127(xyoA)
CMI: CMM_2110
CMS: CMS1111(xyoA)
CMC: CMN_02075
MTS: MTES_2201
MOO: BWL13_02828(xyoA)
MLV: CVS47_02873(xyoA)
ART: Arth_4010
ARM: ART_0047
AAU: AAur_0055
ACH: Achl_0055
BCV: Bcav_2879
JDE: Jden_2461
IDO: I598_2577(xyoA)
CFL: Cfla_0930
CFI: Celf_2955
SERJ: SGUI_0471
KFL: Kfla_1819
NDA: Ndas_4763
STRR: EKD16_11800(xyoA)
SRO: Sros_2313
ACE: Acel_0723
GOB: Gobs_2565
BSD: BLASA_2793(xyoA)
MMAR: MODMU_2272
KRA: Krad_3634
AMD: AMED_4426
AMN: RAM_22540
AMM: AMES_4372
AMZ: B737_4372
AOI: AORI_3521
AJA: AJAP_21525(xyoA)
AORI: SD37_18195
AMI: Amir_2301
SESP: BN6_41440
ACTI: UA75_14945
ACAD: UA74_14355
AHG: AHOG_13485(xyoA)
MIL: ML5_3543
ASE: ACPL_1234(xyoA)
ACTN: L083_5339(xyoA)
AFS: AFR_25135
ACTS: ACWT_1115
PFLA: Pflav_087590(xyoA)
PSUU: Psuf_050580(xyoA)
CAI: Caci_1977
ACA: ACP_1928(sox)
ABAS: ACPOL_5628
ABAC: LuPra_00940(xyoA)
MGOT: MgSA37_01412(xyoA)
DFE: Dfer_3313
SLI: Slin_6373
FAE: FAES_2542
PSEZ: HME7025_01300(xyoA)
 » show all
Reference
1  [PMID:16232758]
  Authors
Yamashita M, Omura H, Okamoto E, Furuya Y, Yabuuchi M, Fukahi K, Murooka Y.
  Title
Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472.
  Journal
J Biosci Bioeng 89:350-60 (2000)
DOI:10.1016/S1389-1723(00)88958-6
  Sequence
Reference
2  [PMID:17517896]
  Authors
Heuts DP, van Hellemond EW, Janssen DB, Fraaije MW
  Title
Discovery, characterization, and kinetic analysis of an alditol oxidase from Streptomyces coelicolor.
  Journal
J Biol Chem 282:20283-91 (2007)
DOI:10.1074/jbc.M610849200
Reference
3  [PMID:18154360]
  Authors
Forneris F, Heuts DP, Delvecchio M, Rovida S, Fraaije MW, Mattevi A
  Title
Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase.
  Journal
Biochemistry 47:978-85 (2008)
DOI:10.1021/bi701886t
  Sequence
[sco:SCO6147]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.41
IUBMB Enzyme Nomenclature: 1.1.3.41
ExPASy - ENZYME nomenclature database: 1.1.3.41
BRENDA, the Enzyme Database: 1.1.3.41
CAS: 177322-52-0

KEGG   REACTION: R11620
Entry
R11620                      Reaction                               

Name
D-sorbitol:oxygen oxidoreductase
Definition
D-Sorbitol + Oxygen <=> alpha-D-Glucose + Hydrogen peroxide
Equation
Reaction class
RC00108  C00267_C00794
Enzyme
Pathway
rn00051  Fructose and mannose metabolism
Orthology
K00594  alditol oxidase [EC:1.1.3.41]

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