Entry |
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Symbol |
purH
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Name |
phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC: 2.1.2.3 3.5.4.10]
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Pathway |
map01110 | Biosynthesis of secondary metabolites |
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Module |
M00048 | De novo purine biosynthesis, PRPP + glutamine => IMP |
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Reaction |
R01127 | IMP 1,2-hydrolase (decyclizing) |
R04560 | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase |
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Disease |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
Enzymes [BR:ko01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.10 IMP cyclohydrolase
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
Exosome [BR:ko04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase
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Other DBs |
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Genes |
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