KEGG   ORTHOLOGY: K00718
Entry
K00718                      KO                                     

Name
FUT1_2
Definition
galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]
Pathway
ko00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.69  type 1 galactoside alpha-(1,2)-fucosyltransferase
     K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Glycosyltransferases [BR:ko01003]
 Glycan extension
  ABO blood group
   K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Others
   Fucosyltransferase
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Other DBs
RN: R05968 R06024 R06027 R06031 R06035 R06041 R06085 R06086 R06089 R06090 R06156 R06170
GO: 0008107
CAZy: GT11
Genes
HSA: 2523(FUT1) 2524(FUT2)
PTR: 104001169 468944(FUT2) 468947(FUT1)
PPS: 100990363(FUT1) 100991035(FUT2) 103785330
GGO: 101131113(FUT1) 101146871
PON: 100445051(FUT2)
NLE: 100589182 100589750(FUT2) 100592672(FUT1)
MCC: 718252(FUT1) 718794 722582
MCF: 102121228 102121606(FUT2) 102125198(FUT1)
CSAB: 103234986 103234988 103234996(FUT1)
RRO: 104666550(FUT1) 104666555 104666558
RBB: 108523627 108523645(FUT2) 108523649(FUT1)
CJC: 100389529(FUT1) 100896666(FUT2)
MMU: 14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL: 110298382 110298509(Fut2) 110299147(Fut1)
MPAH: 110334098(Fut1) 110334752(Fut2) 110335813
RNO: 308586(Sec1) 58924(Fut2) 81919(Fut1)
HGL: 101709834(Fut1) 101710190(Fut2)
CCAN: 109682667(Fut2) 109682669(Fut1) 109682676
OCU: 100009290(RFT-II) 100009291(FUT1) 100349124
TUP: 102471780 102474609(FUT1)
CFA: 102151792 484396(FUT1) 484398(FUT2)
VVP: 112931221(FUT1) 112931228(FUT2)
AML: 100472596 100478397(FUT1) 100478902(FUT2)
UAH: 113243333(FUT1) 113243338(FUT2) 113243340
ORO: 101374079(FUT1) 101374953(FUT2) 101375248
FCA: 101080847(FUT1) 101085847
PTG: 102962287(FUT2) 102969895(FUT1)
PPAD: 109253109(FUT1) 109253122(FUT2)
BTA: 281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM: 102282547(FUT1) 102283305(FUT2) 102283588
BIU: 109572956 109573030(FUT2) 109573041(FUT1)
SSC: 100524201(FUT2A) 397138(FUT1) 397139(FUT2)
BACU: 103015344(FUT1)
LVE: 103080875(FUT2) 103081703(FUT1)
OOR: 101289320(FUT1) 101289561(FUT2)
DLE: 111180647(FUT1) 111180654(FUT2) 111180655
PCAD: 102973479(FUT1) 102996473(FUT2) 102996580
EPZ: 103544534 103553324(FUT1) 103553326(FUT2)
MYB: 102257351(FUT1) 102259445(FUT2)
MYD: 102760565(FUT2) 102767518 102768655(FUT1)
MNA: 107531808(FUT2) 107531852(FUT1)
HAI: 109391063(FUT2) 109391098(FUT1)
DRO: 112310077(FUT2) 112310079(FUT1)
PALE: 102885708(FUT1) 102886704(FUT2)
RAY: 107498802(FUT2) 107498851(FUT1)
LAV: 100662459 100674697(FUT1) 100675832(FUT2)
SHR: 100930940 100931578(FUT1)
ACS: 100561462(fut2)
PVT: 110078544(FUT2)
PBI: 103053688(FUT2)
PMUR: 107282448(FUT2)
TSR: 106538382(FUT2)
GJA: 107122202(FUT2)
XLA: 108696739 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
LCM: 102356194 102357968(FUT1)
AAG: 5571570
AALB: 109403576
AME: 726095
BIM: 100743109
BTER: 100642421
CCAL: 108630635
OBB: 114874445
SOC: 105199316
MPHA: 105835366
AEC: 105148166
ACEP: 105624787
PBAR: 105431936
VEM: 105564089
HST: 105188950
DQU: 106741823
CFO: 105255117
LHU: 105672546
PGC: 109852313
OBO: 105284978
PCF: 106790045
NVI: 100116336
MDL: 103570941
TCA: 655912
NVL: 108559505
 » show all
Reference
PMID:2118655
  Authors
Larsen RD, Ernst LK, Nair RP, Lowe JB
  Title
Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.
  Journal
Proc Natl Acad Sci U S A 87:6674-8 (1990)
DOI:10.1073/pnas.87.17.6674
  Sequence
[hsa:2523]
Reference
PMID:7876235
  Authors
Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB
  Title
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.
  Journal
J Biol Chem 270:4640-9 (1995)
DOI:10.1074/jbc.270.9.4640
  Sequence
[hsa:2524]

KEGG   ENZYME: 2.4.1.69
Entry
EC 2.4.1.69                 Enzyme                                 

Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R04081]
Reaction(KEGG)
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G) R06086(G) R06089(G) R06090(G) R06156(G);
(other) R06170(G)
Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:C04656]
Product
GDP [CPD:C00035];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00718  galactoside 2-L-fucosyltransferase 1/2
K12245  bifunctional glycosyltransferase PgtA
Genes
HSA: 2523(FUT1) 2524(FUT2)
PTR: 104001169 468944(FUT2) 468947(FUT1)
PPS: 100990363(FUT1) 100991035(FUT2) 103785330
GGO: 101131113(FUT1) 101146871
PON: 100445051(FUT2)
NLE: 100589182 100589750(FUT2) 100592672(FUT1)
MCC: 718252(FUT1) 718794 722582
MCF: 102121228 102121606(FUT2) 102125198(FUT1)
CSAB: 103234986 103234988 103234996(FUT1)
RRO: 104666550(FUT1) 104666555 104666558
RBB: 108523627 108523645(FUT2) 108523649(FUT1)
CJC: 100389529(FUT1) 100896666(FUT2)
MMU: 14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL: 110298382 110298509(Fut2) 110299147(Fut1)
MPAH: 110334098(Fut1) 110334752(Fut2) 110335813
RNO: 308586(Sec1) 58924(Fut2) 81919(Fut1)
HGL: 101709834(Fut1) 101710190(Fut2)
CCAN: 109682667(Fut2) 109682669(Fut1) 109682676
OCU: 100009290(RFT-II) 100009291(FUT1) 100349124
TUP: 102471780 102474609(FUT1)
CFA: 102151792 484396(FUT1) 484398(FUT2)
VVP: 112931221(FUT1) 112931228(FUT2)
AML: 100472596 100478397(FUT1) 100478902(FUT2)
UAH: 113243333(FUT1) 113243338(FUT2) 113243340
ORO: 101374079(FUT1) 101374953(FUT2) 101375248
FCA: 101080847(FUT1) 101085847
PTG: 102962287(FUT2) 102969895(FUT1)
PPAD: 109253109(FUT1) 109253122(FUT2)
BTA: 281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM: 102282547(FUT1) 102283305(FUT2) 102283588
BIU: 109572956 109573030(FUT2) 109573041(FUT1)
SSC: 100524201(FUT2A) 397138(FUT1) 397139(FUT2)
BACU: 103015344(FUT1)
LVE: 103080875(FUT2) 103081703(FUT1)
OOR: 101289320(FUT1) 101289561(FUT2)
DLE: 111180647(FUT1) 111180654(FUT2) 111180655
PCAD: 102973479(FUT1) 102996473(FUT2) 102996580
EPZ: 103544534 103553324(FUT1) 103553326(FUT2)
MYB: 102257351(FUT1) 102259445(FUT2)
MYD: 102760565(FUT2) 102767518 102768655(FUT1)
MNA: 107531808(FUT2) 107531852(FUT1)
HAI: 109391063(FUT2) 109391098(FUT1)
DRO: 112310077(FUT2) 112310079(FUT1)
PALE: 102885708(FUT1) 102886704(FUT2)
RAY: 107498802(FUT2) 107498851(FUT1)
LAV: 100662459 100674697(FUT1) 100675832(FUT2)
SHR: 100930940 100931578(FUT1)
ACS: 100561462(fut2)
PVT: 110078544(FUT2)
PBI: 103053688(FUT2)
PMUR: 107282448(FUT2)
TSR: 106538382(FUT2)
GJA: 107122202(FUT2)
XLA: 108696739 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
LCM: 102356194 102357968(FUT1)
AAG: 5571570
AALB: 109403576
AME: 726095
BIM: 100743109
BTER: 100642421
CCAL: 108630635
OBB: 114874445
SOC: 105199316
MPHA: 105835366
AEC: 105148166
ACEP: 105624787
PBAR: 105431936
VEM: 105564089
HST: 105188950
DQU: 106741823
CFO: 105255117
LHU: 105672546
PGC: 109852313
OBO: 105284978
PCF: 106790045
NVI: 100116336
MDL: 103570941
TCA: 655912
NVL: 108559505
DDI: DDB_G0283761(pgtA)
DFA: DFA_01805(pgtA)
 » show all
Reference
1  [PMID:7372640]
  Authors
Beyer TA, Hill RL.
  Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 255:5373-9 (1980)
Reference
2  [PMID:6246105]
  Authors
Beyer TA, Sadler JE, Hill RL.
  Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 255:5364-72 (1980)
Reference
3  [PMID:6588382]
  Authors
Kumazaki T, Yoshida A
  Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
  Journal
Proc Natl Acad Sci U S A 81:4193-7 (1984)
DOI:10.1073/pnas.81.13.4193
Reference
4  [PMID:9219535]
  Authors
Koda Y, Soejima M, Wang B, Kimura H
  Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
  Journal
Eur J Biochem 246:750-5 (1997)
DOI:10.1111/j.1432-1033.1997.t01-1-00750.x
Reference
5  [PMID:10589734]
  Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
  Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
  Journal
Microbiology 145 ( Pt 11):3245-53 (1999)
DOI:10.1099/00221287-145-11-3245
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.69
IUBMB Enzyme Nomenclature: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
BRENDA, the Enzyme Database: 2.4.1.69
CAS: 56093-23-3

KEGG   REACTION: R05968
Entry
R05968                      Reaction                               

Definition
GDP-L-fucose + Galactosylgloboside <=> GDP + Globo-H
Equation
Enzyme
Pathway
rn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rn01100  Metabolic pathways
Orthology
K00718  galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]

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