KEGG   ORTHOLOGY: K00722
Entry
K00722                      KO                                     

Name
GBGT1
Definition
globoside alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.88]
Pathway
ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.88  globoside alpha-N-acetylgalactosaminyltransferase
     K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  FORS blood group (Forssman antigen)
   K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
Other DBs
RN: R05965 R11322
GO: 0047277
CAZy: GT6
Genes
HSA: 26301(GBGT1)
PTR: 464823(GBGT1)
PPS: 100978291(GBGT1)
GGO: 101145846(GBGT1)
PON: 100453106(GBGT1)
NLE: 100590023(GBGT1)
MCC: 106993582(GBGT1)
MCF: 102119767(GBGT1)
CSAB: 103239703(GBGT1)
RRO: 104669732(GBGT1)
RBB: 108513510(GBGT1)
CJC: 103795439(GBGT1)
SBQ: 104652637(GBGT1)
MMU: 227671(Gbgt1)
MCAL: 110290105(Gbgt1)
MPAH: 110319298(Gbgt1)
RNO: 499764
MUN: 110549880(Gbgt1)
CGE: 100771256(Gbgt1)
HGL: 101726516(Gbgt1)
CCAN: 109690998(Gbgt1)
TUP: 102477690(GBGT1)
CFA: 403833(GBGT1)
VVP: 112928011(GBGT1)
AML: 100479644
UMR: 103670247(GBGT1)
UAH: 113266556(GBGT1)
ORO: 101386326(GBGT1)
ELK: 111146249
FCA: 101090810(GBGT1)
PTG: 102954717(GBGT1)
PPAD: 109249974(GBGT1)
AJU: 106985321(GBGT1)
BTA: 618517(GBGT1)
BOM: 102282202(GBGT1)
BIU: 109566575(GBGT1) 109566576
BBUB: 102405974(GBGT1)
CHX: 102180325(GBGT1)
OAS: 101112039(GBGT1)
SSC: 110256486(GBGT1)
CFR: 102511010(GBGT1)
CDK: 105085187(GBGT1)
BACU: 103008412
LVE: 103086807(GBGT1)
OOR: 105747968(GBGT1)
DLE: 111177084(GBGT1)
PCAD: 102993265(GBGT1)
ECB: 100069388(GBGT1)
EPZ: 103553672(GBGT1)
EAI: 106845361(GBGT1)
MYB: 102239613(GBGT1)
MYD: 102767739(GBGT1)
MNA: 107524628(GBGT1)
HAI: 109381005(GBGT1)
DRO: 112306338(GBGT1)
PALE: 102880609(GBGT1)
RAY: 107504585(GBGT1)
MJV: 108388221(GBGT1)
LAV: 100665584(GBGT1)
TMU: 101349194
MDO: 100017839(GBGT1)
SHR: 100918940(GBGT1)
PCW: 110205392(GBGT1)
OAA: 100090987(GBGT1)
GGA: 417163(GBGT1)
MGP: 100540036(CCDC180) 116216187(GBGT1)
CJO: 107321913(GBGT1)
NMEL: 110406850
APLA: 101799653(GBGT1)
ACYG: 106044126(GBGT1)
TGU: 100225394(GBGT1)
LSR: 110477722(GBGT1)
SCAN: 103818975(GBGT1)
GFR: 102040147(GBGT1)
FAB: 101806513(GBGT1)
PHI: 102103511(ABO)
PMAJ: 107212008(GBGT1)
CCAE: 111937029(GBGT1)
CCW: 104688481(GBGT1)
ETL: 114059121
FPG: 101921547(GBGT1)
FCH: 102050463(GBGT1)
CLV: 102095912(GBGT1)
EGZ: 104129328
NNI: 104023282(GBGT1)
ACUN: 113486511(GBGT1)
PADL: 103915270(GBGT1)
AAM: 106483758(GBGT1)
ASN: 102388459(GBGT1)
AMJ: 102565956(GBGT1)
PSS: 102455930(GBGT1)
CMY: 102938627(GBGT1)
CPIC: 101945380(GBGT1)
PVT: 110079644(GBGT1)
PMUA: 114589368(GBGT1)
GJA: 107124818(GBGT1)
DRE: 100005375(si:ch211-135f11.4) 100005565(si:ch211-287c22.1) 100005704(si:dkey-110k5.10) 387303(gbgt1l4) 447881(gbgt1l3) 563897(abo) 566487(gbgt1l2)
AMEX: 103028363
TRU: 101067861
CSEM: 103386423
HCQ: 109522118
CMK: 103178422 103183073(glt6d1)
 » show all
Reference
  Authors
Xu H, Storch T, Yu M, Elliott SP, Haslam DB
  Title
Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions.
  Journal
J Biol Chem 274:29390-8 (1999)
DOI:10.1074/jbc.274.41.29390
  Sequence
[hsa:26301]

KEGG   ENZYME: 2.4.1.88
Entry
EC 2.4.1.88                 Enzyme                                 

Name
globoside alpha-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase;
Forssman synthase;
globoside acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04182 R05965]
Reaction(KEGG)
R04182 R05965(G);
(other) R11322(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.1.88 created 1976
Pathway
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00722  globoside alpha-N-acetylgalactosaminyltransferase
Genes
HSA: 26301(GBGT1)
PTR: 464823(GBGT1)
PPS: 100978291(GBGT1)
GGO: 101145846(GBGT1)
PON: 100453106(GBGT1)
NLE: 100590023(GBGT1)
MCC: 106993582(GBGT1)
MCF: 102119767(GBGT1)
CSAB: 103239703(GBGT1)
RRO: 104669732(GBGT1)
RBB: 108513510(GBGT1)
CJC: 103795439(GBGT1)
SBQ: 104652637(GBGT1)
MMU: 227671(Gbgt1)
MCAL: 110290105(Gbgt1)
MPAH: 110319298(Gbgt1)
RNO: 499764
MUN: 110549880(Gbgt1)
CGE: 100771256(Gbgt1)
HGL: 101726516(Gbgt1)
CCAN: 109690998(Gbgt1)
TUP: 102477690(GBGT1)
CFA: 403833(GBGT1)
VVP: 112928011(GBGT1)
AML: 100479644
UMR: 103670247(GBGT1)
UAH: 113266556(GBGT1)
ORO: 101386326(GBGT1)
ELK: 111146249
FCA: 101090810(GBGT1)
PTG: 102954717(GBGT1)
PPAD: 109249974(GBGT1)
AJU: 106985321(GBGT1)
BTA: 618517(GBGT1)
BOM: 102282202(GBGT1)
BIU: 109566575(GBGT1) 109566576
BBUB: 102405974(GBGT1)
CHX: 102180325(GBGT1)
OAS: 101112039(GBGT1)
SSC: 110256486(GBGT1)
CFR: 102511010(GBGT1)
CDK: 105085187(GBGT1)
BACU: 103008412
LVE: 103086807(GBGT1)
OOR: 105747968(GBGT1)
DLE: 111177084(GBGT1)
PCAD: 102993265(GBGT1)
ECB: 100069388(GBGT1)
EPZ: 103553672(GBGT1)
EAI: 106845361(GBGT1)
MYB: 102239613(GBGT1)
MYD: 102767739(GBGT1)
MNA: 107524628(GBGT1)
HAI: 109381005(GBGT1)
DRO: 112306338(GBGT1)
PALE: 102880609(GBGT1)
RAY: 107504585(GBGT1)
MJV: 108388221(GBGT1)
LAV: 100665584(GBGT1)
TMU: 101349194
MDO: 100017839(GBGT1)
SHR: 100918940(GBGT1)
PCW: 110205392(GBGT1)
OAA: 100090987(GBGT1)
GGA: 417163(GBGT1)
MGP: 100540036(CCDC180) 116216187(GBGT1)
CJO: 107321913(GBGT1)
NMEL: 110406850
APLA: 101799653(GBGT1)
ACYG: 106044126(GBGT1)
TGU: 100225394(GBGT1)
LSR: 110477722(GBGT1)
SCAN: 103818975(GBGT1)
GFR: 102040147(GBGT1)
FAB: 101806513(GBGT1)
PHI: 102103511(ABO)
PMAJ: 107212008(GBGT1)
CCAE: 111937029(GBGT1)
CCW: 104688481(GBGT1)
ETL: 114059121
FPG: 101921547(GBGT1)
FCH: 102050463(GBGT1)
CLV: 102095912(GBGT1)
EGZ: 104129328
NNI: 104023282(GBGT1)
ACUN: 113486511(GBGT1)
PADL: 103915270(GBGT1)
AAM: 106483758(GBGT1)
ASN: 102388459(GBGT1)
AMJ: 102565956(GBGT1)
PSS: 102455930(GBGT1)
CMY: 102938627(GBGT1)
CPIC: 101945380(GBGT1)
PVT: 110079644(GBGT1)
PMUA: 114589368(GBGT1)
GJA: 107124818(GBGT1)
DRE: 100005375(si:ch211-135f11.4) 100005565(si:ch211-287c22.1) 100005704(si:dkey-110k5.10) 387303(gbgt1l4) 447881(gbgt1l3) 563897(abo) 566487(gbgt1l2)
AMEX: 103028363
TRU: 101067861
CSEM: 103386423
HCQ: 109522118
CMK: 103178422 103183073(glt6d1)
 » show all
Reference
1  [PMID:4823436]
  Authors
Kijimoto S, Ishibashi T, Makita A.
  Title
Biosynthesis of Forssman hapten from globoside by alpha-N-acetylgalactosaminyltransferase of guinea pig tissues.
  Journal
Biochem Biophys Res Commun 56:177-84 (1974)
DOI:10.1016/S0006-291X(74)80331-1
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.88
IUBMB Enzyme Nomenclature: 2.4.1.88
ExPASy - ENZYME nomenclature database: 2.4.1.88
BRENDA, the Enzyme Database: 2.4.1.88
CAS: 52037-97-5

KEGG   REACTION: R05965
Entry
R05965                      Reaction                               

Definition
UDP-N-acetyl-D-galactosamine + Globoside <=> UDP + Forssman antigen, IV3GalNAca-Gb4Cer
Equation
Remark
Same as: R04182
Enzyme
Pathway
rn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rn01100  Metabolic pathways
Orthology
K00722  globoside alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.88]

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