KEGG   ORTHOLOGY: K00778
Entry
K00778                      KO                                     

Name
SIAT1, ST6GAL1
Definition
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]
Pathway
ko00510  N-Glycan biosynthesis
ko00514  Other types of O-glycan biosynthesis
ko01100  Metabolic pathways
Module
M00075  N-glycan biosynthesis, complex type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K00778  SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
   00514 Other types of O-glycan biosynthesis
    K00778  SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00778  SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.99  Transferring other glycosyl groups
    2.4.99.1  beta-galactoside alpha-(2,6)-sialyltransferase
     K00778  SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
Glycosyltransferases [BR:ko01003]
 Terminal extension
  Sialyltransferase
   K00778  SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
Other DBs
RN: R05990 R09298
GO: 0003835
CAZy: GT29
Genes
HSA: 6480(ST6GAL1)
PTR: 460922(ST6GAL1)
PPS: 100969795(ST6GAL1)
GGO: 101142727(ST6GAL1)
PON: 100174088(ST6GAL1)
NLE: 100599869(ST6GAL1)
MCC: 708113(ST6GAL1)
MCF: 102121444(ST6GAL1)
CSAB: 103241877(ST6GAL1)
RRO: 104682948(ST6GAL1)
RBB: 108530462(ST6GAL1)
CJC: 100408699(ST6GAL1)
SBQ: 101032294(ST6GAL1)
MMU: 20440(St6gal1)
MCAL: 110311654(St6gal1)
MPAH: 110329758(St6gal1)
RNO: 25197(St6gal1)
MUN: 110548122(St6gal1)
CGE: 100689389(St6gal1)
NGI: 103750114(St6gal1)
HGL: 101718025(St6gal1)
CCAN: 109691378(St6gal1)
OCU: 100353188(ST6GAL1)
CFA: 478668(ST6GAL1)
VVP: 112926300(ST6GAL1)
AML: 100481066(ST6GAL1)
UMR: 103676045(ST6GAL1)
UAH: 113253796(ST6GAL1)
ORO: 101377549(ST6GAL1)
ELK: 111148556
FCA: 101097832(ST6GAL1)
PTG: 102956769(ST6GAL1)
PPAD: 109275279(ST6GAL1)
AJU: 106968006(ST6GAL1)
BTA: 282073(ST6GAL1)
BOM: 102273022(ST6GAL1)
BIU: 109556984(ST6GAL1)
BBUB: 102400138(ST6GAL1)
CHX: 100861310(ST6GAL1)
OAS: 100913159(ST6GAL1) 114113140
SSC: 100302026(ST6GAL1)
CFR: 102512873(ST6GAL1)
CDK: 105085840(ST6GAL1)
BACU: 103012200(ST6GAL1)
LVE: 103086030(ST6GAL1)
OOR: 101285111(ST6GAL1)
DLE: 111172829(ST6GAL1)
PCAD: 102992136(ST6GAL1)
ECB: 100059539(ST6GAL1)
EPZ: 103567256(ST6GAL1)
EAI: 106832544(ST6GAL1)
MYB: 102244256(ST6GAL1)
MYD: 102753980(ST6GAL1)
MNA: 107527306(ST6GAL1)
HAI: 109396927(ST6GAL1)
DRO: 112308352(ST6GAL1)
PALE: 102886717(ST6GAL1)
RAY: 107505891(ST6GAL1)
MJV: 108401260(ST6GAL1)
LAV: 100664378(ST6GAL1)
TMU: 101351955
MDO: 100617174(ST6GAL1)
SHR: 100922140(ST6GAL1)
PCW: 110221205(ST6GAL1)
OAA: 100093341(ST6GAL1)
GGA: 396169(ST6GAL1)
MGP: 100548556 104909223(ST6GAL1)
CJO: 107317947(ST6GAL1)
NMEL: 110397396(ST6GAL1)
APLA: 101803267(ST6GAL1)
ACYG: 106040277(ST6GAL1)
TGU: 100226346(ST6GAL1)
LSR: 110484834(ST6GAL1)
SCAN: 103815542(ST6GAL1)
GFR: 102042024(ST6GAL1)
FAB: 101820079(ST6GAL1)
PHI: 102107561(ST6GAL1)
PMAJ: 107208898(ST6GAL1)
CCAE: 111933760(ST6GAL1)
CCW: 104693051(ST6GAL1)
ETL: 114057719(ST6GAL1)
FPG: 101924763(ST6GAL1)
FCH: 102058385(ST6GAL1)
CLV: 102097093(ST6GAL1)
EGZ: 104135489(ST6GAL1)
NNI: 104023676(ST6GAL1)
ACUN: 113483390(ST6GAL1)
PADL: 103912776(ST6GAL1)
AAM: 106496189(ST6GAL1)
ASN: 102373489(ST6GAL1)
AMJ: 102575767(ST6GAL1)
PSS: 102446128(ST6GAL1)
CMY: 102941507
CPIC: 101939719 101943605(ST6GAL1)
ACS: 100529109(st6gal1)
PVT: 110088940(ST6GAL1)
PBI: 103061620(ST6GAL1)
PMUR: 107286474
TSR: 106550706(ST6GAL1)
PMUA: 114595050 114597762(ST6GAL1)
GJA: 107110554(ST6GAL1) 107115211
XLA: 108717116(st6gal1.L) 108718183(st6gal1.S)
XTR: 100491268(st6gal1)
NPR: 108785675(ST6GAL1)
DRE: 445376(st6gal1)
SANH: 107667425
CCAR: 109045233
IPU: 108279262
PHYP: 113541806
AMEX: 103030360
EEE: 113576168(st6gal1)
TRU: 445982(st6gal1)
LCO: 104921796
MZE: 101466910
ONL: 100694560
OLA: 100049380(st6gal1)
CVG: 107090303
ALIM: 106514661
BPEC: 110165642
SASA: 106602846
SALP: 111950888
SFM: 108927597
CMK: 103174913(st6gal1)
RTP: 109922745
SKO: 102804577
DME: Dmel_CG4871(SiaT)
DER: 6548509
DSE: 6618867
DSI: Dsimw501_GD24925(Dsim_ST6Gal)
DYA: Dyak_GE11423(Dyak_ST6Gal)
DAN: 6507957
DSR: 110178056
DPO: Dpse_GA18492(Dpse_ST6Gal)
DPE: 6592954
DMN: 108158215
DWI: 6640266
DGR: Dgri_GH21565(Dgri_ST6Gal)
DMO: Dmoj_GI19537(Dmoj_ST6Gal)
DAZ: 108614840
DNV: 108654327
DHE: 111593949
DVI: 6625423
MDE: 101891865
LCQ: 111681785
AAG: 5566828
NVL: 108563142
TUT: 107362587
 » show all
Reference
PMID:2408023
  Authors
Grundmann U, Nerlich C, Rein T, Zettlmeissl G
  Title
Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase.
  Journal
Nucleic Acids Res 18:667 (1990)
DOI:10.1093/nar/18.3.667
  Sequence
[hsa:6480]

KEGG   ORTHOLOGY: K00779
Entry
K00779                      KO                                     

Name
SIAT2, ST6GAL2
Definition
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2) [EC:2.4.99.1]
Pathway
ko00510  N-Glycan biosynthesis
ko00514  Other types of O-glycan biosynthesis
ko01100  Metabolic pathways
Module
M00075  N-glycan biosynthesis, complex type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K00779  SIAT2, ST6GAL2; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
   00514 Other types of O-glycan biosynthesis
    K00779  SIAT2, ST6GAL2; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00779  SIAT2, ST6GAL2; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.99  Transferring other glycosyl groups
    2.4.99.1  beta-galactoside alpha-(2,6)-sialyltransferase
     K00779  SIAT2, ST6GAL2; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
Glycosyltransferases [BR:ko01003]
 Terminal extension
  Sialyltransferase
   K00779  SIAT2, ST6GAL2; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
Other DBs
RN: R06188 R09298
GO: 0003835
CAZy: GT29
Genes
HSA: 84620(ST6GAL2)
PTR: 450198(ST6GAL2)
PPS: 100981465(ST6GAL2)
GGO: 101129847(ST6GAL2)
PON: 100456090(ST6GAL2)
NLE: 100580010(ST6GAL2)
MCC: 713552(ST6GAL2)
MCF: 102142751(ST6GAL2)
CSAB: 103241198(ST6GAL2)
RRO: 104660586(ST6GAL2)
RBB: 108512469(ST6GAL2)
CJC: 100411939(ST6GAL2)
SBQ: 101047107(ST6GAL2)
MMU: 240119(St6gal2)
MCAL: 110284258(St6gal2)
MPAH: 110335627(St6gal2)
RNO: 301155(St6gal2)
MUN: 110560861(St6gal2)
CGE: 100763756(St6gal2)
NGI: 103726632(St6gal2)
HGL: 101722644(St6gal2)
CCAN: 109701499(St6gal2)
OCU: 100358153(ST6GAL2)
TUP: 102500330(ST6GAL2)
CFA: 481315(ST6GAL2)
VVP: 112915370(ST6GAL2)
AML: 100478457(ST6GAL2)
UMR: 103670658(ST6GAL2)
UAH: 113267699(ST6GAL2)
ORO: 101374165(ST6GAL2)
ELK: 111155957
FCA: 101098620(ST6GAL2)
PTG: 102962032(ST6GAL2)
PPAD: 109254527(ST6GAL2)
AJU: 106977960(ST6GAL2)
BTA: 493992(ST6GAL2)
BOM: 102285977(ST6GAL2)
BIU: 109566122(ST6GAL2)
BBUB: 102408407(ST6GAL2)
CHX: 102179776(ST6GAL2)
OAS: 101108300(ST6GAL2)
SSC: 100512775(ST6GAL2)
CFR: 102508797(ST6GAL2)
CDK: 105099139(ST6GAL2)
BACU: 103009068(ST6GAL2)
LVE: 103073782(ST6GAL2)
OOR: 101273721(ST6GAL2)
DLE: 111187445(ST6GAL2)
PCAD: 102984003(ST6GAL2)
ECB: 100062033(ST6GAL2)
EPZ: 103555423(ST6GAL2)
EAI: 106829390(ST6GAL2)
MYB: 102241174(ST6GAL2)
MYD: 102768324(ST6GAL2)
MNA: 107528699(ST6GAL2)
HAI: 109375943(ST6GAL2)
DRO: 112297515(ST6GAL2)
PALE: 102890603(ST6GAL2)
RAY: 107497054(ST6GAL2)
MJV: 108388564
LAV: 100660981(ST6GAL2)
TMU: 101355743
MDO: 100019249(ST6GAL2)
SHR: 100932183(ST6GAL2)
PCW: 110209426(ST6GAL2)
OAA: 100077134(ST6GAL2)
GGA: 403122(ST6GAL2)
MGP: 100545097(ST6GAL2)
CJO: 107306533(ST6GAL2)
NMEL: 110406996(ST6GAL2)
APLA: 101796015(ST6GAL2)
ACYG: 106041658(ST6GAL2)
TGU: 100230425(ST6GAL2)
LSR: 110478726(ST6GAL2)
SCAN: 103812379(ST6GAL2)
GFR: 102038321(ST6GAL2)
FAB: 101810086(ST6GAL2)
PHI: 102109099(ST6GAL2)
PMAJ: 107211419(ST6GAL2)
CCAE: 111922685(ST6GAL2)
CCW: 104686087(ST6GAL2)
ETL: 114066979(ST6GAL2)
FPG: 101914140(ST6GAL2)
FCH: 102056735(ST6GAL2)
CLV: 102087342(ST6GAL2)
EGZ: 104126364(ST6GAL2)
NNI: 104019355(ST6GAL2)
ACUN: 113481283(ST6GAL2)
PADL: 103918841(ST6GAL2)
AAM: 106494052(ST6GAL2)
ASN: 102372316(ST6GAL2)
AMJ: 102569903(ST6GAL2)
PSS: 102453477(ST6GAL2)
CMY: 102943395(ST6GAL2)
CPIC: 101950728(ST6GAL2)
ACS: 100529108(st6gal2)
PVT: 110074124(ST6GAL2)
PBI: 103062404(ST6GAL2)
PMUR: 107288840(ST6GAL2)
TSR: 106540309(ST6GAL2) 106545885
PMUA: 114596422(ST6GAL2)
GJA: 107125130(ST6GAL2)
XLA: 108708393(st6gal2.L) 108709694(st6gal2.S)
XTR: 407846(st6gal2)
NPR: 108785132(ST6GAL2)
DRE: 403116(st6gal2a) 797439(st6gal2b)
IPU: 108266814(st6gal2) 108273345
PHYP: 113525857(st6gal2) 113538434
AMEX: 103024101(st6gal2) 103031874
EEE: 113574044 113584885(st6gal2)
TRU: 777969(st6gal2)
LCO: 104932096(st6gal2) 104934011
NCC: 104957421(st6gal2)
MZE: 101464130(st6gal2)
ONL: 100704184(st6gal2)
OLA: 100049381(st6gal2)
XMA: 102229475(st6gal2) 102231535
XCO: 114148521(st6gal2) 114152599
PRET: 103476390 103480039(st6gal2)
CVG: 107096899(st6gal2)
NFU: 107384328 107389803(st6gal2)
KMR: 108228306 108232466(st6gal2)
ALIM: 106514590 106519824(st6gal2)
AOCE: 111563401(st6gal1) 111570337 111582969(st6gal2)
CSEM: 103391691(st6gal2)
POV: 109631344(st6gal2)
LCF: 108881134 108901078(st6gal2)
SDU: 111218195(st6gal2)
SLAL: 111646873 111662108(st6gal2)
HCQ: 109530661(st6gal2)
BPEC: 110173121(st6gal2)
MALB: 109965389(st6gal2)
SFM: 108920576 108933083(st6gal2)
PKI: 111833845(st6gal2) 111843653
LCM: 102359235(ST6GAL2)
CMK: 103172241(st6gal2)
RTP: 109934254
BMOR: 101744994
PMAC: 106712367
PRAP: 111002097
HAW: 110369814
TNL: 113492654
AGS: 114127655
CLEC: 106664182
ZNE: 110834803
CSCU: 111636481
PTEP: 107450093
 » show all
Reference
  Authors
Takashima S, Tsuji S, Tsujimoto M
  Title
Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures  on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes.
  Journal
J Biol Chem 277:45719-28 (2002)
DOI:10.1074/jbc.M206808200
  Sequence
[hsa:84620]

KEGG   ENZYME: 2.4.99.1
Entry
EC 2.4.99.1                 Enzyme                                 

Name
beta-galactoside alpha-(2,6)-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase;
lactosylceramide alpha-2,6-N-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase;
beta-galactoside alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R [RN:R04532 R06188]
Reaction(KEGG)
R04532 R06188(G);
(other) R03489 R05580 R05905(G) R05906(G) R05990(G) R06121(G) R09298(G)
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-R [CPD:C02900]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
History
EC 2.4.99.1 created 1972, modified 1976, modified 1986, modified 2016 (EC 2.4.99.11 created 1992, incorporated 2016), modified 2017
Pathway
ec00510  N-Glycan biosynthesis
ec00514  Other types of O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00778  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
K12248  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes
HSA: 6480(ST6GAL1) 84620(ST6GAL2)
PTR: 450198(ST6GAL2) 460922(ST6GAL1)
PPS: 100969795(ST6GAL1) 100981465(ST6GAL2)
GGO: 101129847(ST6GAL2) 101142727(ST6GAL1)
PON: 100174088(ST6GAL1) 100456090(ST6GAL2)
NLE: 100580010(ST6GAL2) 100599869(ST6GAL1)
MCC: 708113(ST6GAL1) 713552(ST6GAL2)
MCF: 102121444(ST6GAL1) 102142751(ST6GAL2)
CSAB: 103241198(ST6GAL2) 103241877(ST6GAL1)
RRO: 104660586(ST6GAL2) 104682948(ST6GAL1)
RBB: 108512469(ST6GAL2) 108530462(ST6GAL1)
CJC: 100408699(ST6GAL1) 100411939(ST6GAL2)
SBQ: 101032294(ST6GAL1) 101047107(ST6GAL2)
MMU: 20440(St6gal1) 240119(St6gal2)
MCAL: 110284258(St6gal2) 110311654(St6gal1)
MPAH: 110329758(St6gal1) 110335627(St6gal2)
RNO: 25197(St6gal1) 301155(St6gal2)
MUN: 110548122(St6gal1) 110560861(St6gal2)
CGE: 100689389(St6gal1) 100763756(St6gal2)
NGI: 103726632(St6gal2) 103750114(St6gal1)
HGL: 101718025(St6gal1) 101722644(St6gal2)
CCAN: 109691378(St6gal1) 109701499(St6gal2)
OCU: 100353188(ST6GAL1) 100358153(ST6GAL2)
TUP: 102500330(ST6GAL2)
CFA: 478668(ST6GAL1) 481315(ST6GAL2)
VVP: 112915370(ST6GAL2) 112926300(ST6GAL1)
AML: 100478457(ST6GAL2) 100481066(ST6GAL1)
UMR: 103670658(ST6GAL2) 103676045(ST6GAL1)
UAH: 113253796(ST6GAL1) 113267699(ST6GAL2)
ORO: 101374165(ST6GAL2) 101377549(ST6GAL1)
FCA: 101097832(ST6GAL1) 101098620(ST6GAL2)
PTG: 102956769(ST6GAL1) 102962032(ST6GAL2)
PPAD: 109254527(ST6GAL2) 109275279(ST6GAL1)
AJU: 106968006(ST6GAL1) 106977960(ST6GAL2)
BTA: 282073(ST6GAL1) 493992(ST6GAL2)
BOM: 102273022(ST6GAL1) 102285977(ST6GAL2)
BIU: 109556984(ST6GAL1) 109566122(ST6GAL2)
BBUB: 102400138(ST6GAL1) 102408407(ST6GAL2)
CHX: 100861310(ST6GAL1) 102179776(ST6GAL2)
OAS: 100913159(ST6GAL1) 101108300(ST6GAL2) 114113140
SSC: 100302026(ST6GAL1) 100512775(ST6GAL2)
CFR: 102508797(ST6GAL2) 102512873(ST6GAL1)
CDK: 105085840(ST6GAL1) 105099139(ST6GAL2)
BACU: 103009068(ST6GAL2) 103012200(ST6GAL1)
LVE: 103073782(ST6GAL2) 103086030(ST6GAL1)
OOR: 101273721(ST6GAL2) 101285111(ST6GAL1)
DLE: 111172829(ST6GAL1) 111187445(ST6GAL2)
PCAD: 102984003(ST6GAL2) 102992136(ST6GAL1)
ECB: 100059539(ST6GAL1) 100062033(ST6GAL2)
EPZ: 103555423(ST6GAL2) 103567256(ST6GAL1)
EAI: 106829390(ST6GAL2) 106832544(ST6GAL1)
MYB: 102241174(ST6GAL2) 102244256(ST6GAL1)
MYD: 102753980(ST6GAL1) 102768324(ST6GAL2)
MNA: 107527306(ST6GAL1) 107528699(ST6GAL2)
HAI: 109375943(ST6GAL2) 109396927(ST6GAL1)
DRO: 112297515(ST6GAL2) 112308352(ST6GAL1)
PALE: 102886717(ST6GAL1) 102890603(ST6GAL2)
RAY: 107497054(ST6GAL2) 107505891(ST6GAL1)
MJV: 108388564 108401260(ST6GAL1)
LAV: 100660981(ST6GAL2) 100664378(ST6GAL1)
MDO: 100019249(ST6GAL2) 100617174(ST6GAL1)
SHR: 100922140(ST6GAL1) 100932183(ST6GAL2)
PCW: 110209426(ST6GAL2) 110221205(ST6GAL1)
OAA: 100077134(ST6GAL2) 100093341(ST6GAL1)
GGA: 396169(ST6GAL1) 403122(ST6GAL2)
MGP: 100545097(ST6GAL2) 100548556 104909223(ST6GAL1)
CJO: 107306533(ST6GAL2) 107317947(ST6GAL1)
NMEL: 110397396(ST6GAL1) 110406996(ST6GAL2)
APLA: 101796015(ST6GAL2) 101803267(ST6GAL1)
ACYG: 106040277(ST6GAL1) 106041658(ST6GAL2)
TGU: 100226346(ST6GAL1) 100230425(ST6GAL2)
LSR: 110478726(ST6GAL2) 110484834(ST6GAL1)
SCAN: 103812379(ST6GAL2) 103815542(ST6GAL1)
GFR: 102038321(ST6GAL2) 102042024(ST6GAL1)
FAB: 101810086(ST6GAL2) 101820079(ST6GAL1)
PHI: 102107561(ST6GAL1) 102109099(ST6GAL2)
PMAJ: 107208898(ST6GAL1) 107211419(ST6GAL2)
CCAE: 111922685(ST6GAL2) 111933760(ST6GAL1)
CCW: 104686087(ST6GAL2) 104693051(ST6GAL1)
ETL: 114057719(ST6GAL1) 114066979(ST6GAL2)
FPG: 101914140(ST6GAL2) 101924763(ST6GAL1)
FCH: 102056735(ST6GAL2) 102058385(ST6GAL1)
CLV: 102087342(ST6GAL2) 102097093(ST6GAL1)
EGZ: 104126364(ST6GAL2) 104135489(ST6GAL1)
NNI: 104019355(ST6GAL2) 104023676(ST6GAL1)
ACUN: 113481283(ST6GAL2) 113483390(ST6GAL1)
PADL: 103912776(ST6GAL1) 103918841(ST6GAL2)
AAM: 106494052(ST6GAL2) 106496189(ST6GAL1)
ASN: 102372316(ST6GAL2) 102373489(ST6GAL1)
AMJ: 102569903(ST6GAL2) 102575767(ST6GAL1)
PSS: 102446128(ST6GAL1) 102453477(ST6GAL2)
CMY: 102941507 102943395(ST6GAL2)
CPIC: 101939719 101943605(ST6GAL1) 101950728(ST6GAL2)
ACS: 100529108(st6gal2) 100529109(st6gal1)
PVT: 110074124(ST6GAL2) 110088940(ST6GAL1)
PBI: 103061620(ST6GAL1) 103062404(ST6GAL2)
PMUR: 107286474 107288840(ST6GAL2)
TSR: 106540309(ST6GAL2) 106545885 106550706(ST6GAL1)
PMUA: 114595050 114596422(ST6GAL2) 114597762(ST6GAL1)
GJA: 107110554(ST6GAL1) 107115211 107125130(ST6GAL2)
XLA: 108708393(st6gal2.L) 108709694(st6gal2.S) 108717116(st6gal1.L) 108718183(st6gal1.S)
XTR: 100491268(st6gal1) 407846(st6gal2)
NPR: 108785132(ST6GAL2) 108785675(ST6GAL1)
DRE: 403116(st6gal2a) 445376(st6gal1) 797439(st6gal2b)
PHYP: 113525857(st6gal2) 113538434 113541806
AMEX: 103024101(st6gal2) 103030360 103031874
EEE: 113574044 113576168(st6gal1) 113584885(st6gal2)
TRU: 445982(st6gal1) 777969(st6gal2)
NCC: 104957421(st6gal2)
MZE: 101464130(st6gal2) 101466910
ONL: 100694560 100704184(st6gal2)
OLA: 100049380(st6gal1) 100049381(st6gal2)
XMA: 102229475(st6gal2) 102231535
XCO: 114148521(st6gal2) 114152599
PRET: 103476390 103480039(st6gal2)
CVG: 107090303 107096899(st6gal2)
NFU: 107384328 107389803(st6gal2)
ALIM: 106514590 106514661 106519824(st6gal2)
AOCE: 111563401(st6gal1) 111570337 111582969(st6gal2)
CSEM: 103391691(st6gal2)
POV: 109631344(st6gal2)
LCF: 108881134 108901078(st6gal2)
SDU: 111218195(st6gal2)
SLAL: 111646873 111662108(st6gal2)
HCQ: 109530661(st6gal2)
BPEC: 110165642 110173121(st6gal2)
MALB: 109965389(st6gal2)
CMK: 103172241(st6gal2) 103174913(st6gal1)
DME: Dmel_CG4871(SiaT)
DER: 6548509
DSE: 6618867
DSI: Dsimw501_GD24925(Dsim_ST6Gal)
DYA: Dyak_GE11423(Dyak_ST6Gal)
DAN: 6507957
DSR: 110178056
DPO: Dpse_GA18492(Dpse_ST6Gal)
DPE: 6592954
DMN: 108158215
DWI: 6640266
DGR: Dgri_GH21565(Dgri_ST6Gal)
DMO: Dmoj_GI19537(Dmoj_ST6Gal)
DAZ: 108614840
DNV: 108654327
DHE: 111593949
DVI: 6625423
MDE: 101891865
LCQ: 111681785
AAG: 5566828
NVL: 108563142
BMOR: 101744994
PMAC: 106712367
PRAP: 111002097
HAW: 110369814
TNL: 113492654
AGS: 114127655
CLEC: 106664182
ZNE: 110834803
TUT: 107362587
CSCU: 111636481
PTEP: 107450093
HDU: HD_0053
PMU: PM0188
PMP: Pmu_11250
PMUL: DR93_1878
SWP: swp_5060
 » show all
Reference
1  [PMID:5726897]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.
  Journal
J Biol Chem 243:6520-8 (1968)
Reference
2  [PMID:4313609]
  Authors
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.
  Title
Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.
  Journal
J Biol Chem 245:759-66 (1970)
Reference
3  [PMID:4723915]
  Authors
Bartholomew BA, Jourdian GW, Roseman S.
  Title
The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.
  Journal
J Biol Chem 248:5751-62 (1973)
Reference
4  [PMID:849932]
  Authors
Paulson JC, Beranek WE, Hill RL.
  Title
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.
  Journal
J Biol Chem 252:2356-62 (1977)
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
6  [PMID:2460092]
  Authors
Albarracin I, Lassaga FE, Caputto R.
  Title
Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).
  Journal
Biochem J 254:559-65 (1988)
DOI:10.1042/bj2540559
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.1
IUBMB Enzyme Nomenclature: 2.4.99.1
ExPASy - ENZYME nomenclature database: 2.4.99.1
BRENDA, the Enzyme Database: 2.4.99.1
CAS: 9075-81-4

KEGG   REACTION: R05990
Entry
R05990                      Reaction                               

Name
CMP-N-acetylneuraminate:beta-D-galactosyl 1,4-N-acetyl-beta-D-glucosamine alpha 2,6-N-acetylneuraminyltransferase
Definition
2 CMP-N-acetylneuraminate + G00017 <=> 2 CMP + DS 3
Equation
2 G10616 + G00017 <=> 2 G10621 + G00018
Enzyme
Pathway
rn00510  N-Glycan biosynthesis
rn01100  Metabolic pathways
Module
M00075  N-glycan biosynthesis, complex type
Orthology
K00778  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]

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