| Entry |
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| Name |
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase;
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase
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| Reaction(IUBMB) |
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN: R02869]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl 3-(methylsulfanyl)propylamine [CPD: C01137];
spermidine [CPD: C00315]
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| Product |
S-methyl-5'-thioadenosine [CPD: C00170];
spermine [CPD: C00750]
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| Comment |
The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
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| History |
EC 2.5.1.22 created 1982, modified 2013
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
| ec00330 | Arginine and proline metabolism |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE. |
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| Title |
Studies of inhibition of rat spermidine synthase and spermine synthase. |
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| Journal |
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| Reference |
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| Authors |
Pajula RL, Raina A, Eloranta T. |
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| Title |
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain. |
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| Journal |
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| Reference |
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| Authors |
Pegg AE, Shuttleworth K, Hibasami H. |
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| Title |
Specificity of mammalian spermidine synthase and spermine synthase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.22 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.22 |
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