KEGG   ORTHOLOGY: K00802
Entry
K00802                      KO                                     

Name
SMS
Definition
spermine synthase [EC:2.5.1.22]
Pathway
ko00270  Cysteine and methionine metabolism
ko00330  Arginine and proline metabolism
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Disease
H00597  Snyder-Robinson syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K00802  SMS; spermine synthase
   00330 Arginine and proline metabolism
    K00802  SMS; spermine synthase
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K00802  SMS; spermine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.22  spermine synthase
     K00802  SMS; spermine synthase
Other DBs
RN: R02869
COG: COG0421
GO: 0016768
Genes
HSA: 6611(SMS)
PTR: 107966193(SMS) 739762
PPS: 100974711 100989256(SMS)
GGO: 101136287(SMS)
PON: 100447565 100455032(SMS)
NLE: 100592294(SMS) 100603217
MCC: 698179(SMS)
MCF: 102139114(SMS)
CSAB: 103231701(SMS)
RRO: 104676688(SMS)
RBB: 108512250
CJC: 100411404(SMS)
SBQ: 101037456(SMS)
MMU: 20603(Sms)
MCAL: 110287180(Sms) 110292244
MPAH: 110313434(Sms) 110326795
RNO: 363469(Sms)
MUN: 110539961(Sms)
NGI: 103730144(Sms)
HGL: 101696715(Sms) 101718865
CCAN: 109685258(Sms) 109685259
OCU: 100340020(SMS)
CFA: 480861(SMS)
VVP: 112916263 112919114(SMS)
AML: 100469558(SMS)
UMR: 103668176(SMS)
UAH: 113242233(SMS)
ORO: 101364730(SMS) 101371201
ELK: 111150447
FCA: 101090842(SMS)
PTG: 102954471(SMS)
PPAD: 109257443(SMS)
AJU: 106968260(SMS)
BTA: 615950(SMS)
BOM: 102270205 102283485(SMS)
BIU: 109554942(SMS) 109559006
BBUB: 102399518(SMS)
CHX: 102190676(SMS)
OAS: 101107419(SMS) 101112287
SSC: 100153052(SMS)
CFR: 102512656(SMS)
CDK: 105105052(SMS)
BACU: 103019290(SMS)
LVE: 103068984
OOR: 101272903(SMS)
DLE: 111167517(SMS)
PCAD: 102987295(SMS)
ECB: 100051857(SMS)
EPZ: 103566846(SMS)
EAI: 106835513(SMS)
MYB: 102251500 102257010(SMS)
MYD: 102760281(SMS)
MNA: 107526796(SMS)
HAI: 109395813(SMS)
DRO: 112313352(SMS)
PALE: 102896435(SMS)
RAY: 107521441(SMS)
MJV: 108396545(SMS)
LAV: 100658418(SMS)
TMU: 101354696
MDO: 100012760(SMS)
SHR: 100928879(SMS)
PCW: 110210823(SMS)
OAA: 100083114(SMS)
GGA: 418602(SMS)
MGP: 100549711(SMS)
CJO: 107324967(SMS)
NMEL: 110404540(SMS)
APLA: 101791698(SMS)
ACYG: 106037821(SMS)
TGU: 100228014(SMS)
LSR: 110483279(SMS)
SCAN: 103815851(SMS)
GFR: 102034236(SMS)
FAB: 101806851(SMS)
PHI: 102114400(SMS)
PMAJ: 107201826(SMS)
CCAE: 111922892(SMS)
CCW: 104686193(SMS)
ETL: 114067188(SMS)
FPG: 101922863(SMS)
FCH: 102049429(SMS)
CLV: 102096362(SMS)
EGZ: 104135174(SMS)
NNI: 104022508(SMS)
ACUN: 113478646
PADL: 103914492(SMS)
AAM: 106492122(SMS)
ASN: 102388291(SMS)
AMJ: 102559699(SMS)
PSS: 102445830(SMS)
CMY: 102933684(SMS)
CPIC: 101931607(SMS)
ACS: 100552713(sms) 100561005
PVT: 110076724(SMS)
PBI: 103049999(SMS)
PMUR: 107286125(SMS)
TSR: 106553354(SMS)
PMUA: 114596224(SMS)
GJA: 107120288(SMS)
XLA: 108708014(sms.L)
XTR: 100497747(sms)
NPR: 108791842(SMS)
DRE: 80872(sms)
IPU: 108279239(sms)
PHYP: 113541383(sms)
AMEX: 103023143(sms)
EEE: 113575324(sms)
TRU: 101072716(sms)
LCO: 104924594(sms)
NCC: 104965977(sms)
MZE: 101475695(sms)
ONL: 100708530(sms)
OLA: 101166897(sms)
XMA: 102233412(sms)
XCO: 114153519(sms)
PRET: 103475438(sms)
CVG: 107086975(sms)
NFU: 107386402(sms)
KMR: 108236978(sms)
ALIM: 106514045(sms)
AOCE: 111567113(sms)
CSEM: 103395717(sms)
POV: 109628585(sms)
LCF: 108893544(sms)
SDU: 111234621(sms)
SLAL: 111666195(sms)
HCQ: 109517965(sms)
BPEC: 110158443(sms)
MALB: 109959604(sms)
SASA: 100195133(spsy) 106603082
ELS: 105010858(sms)
SFM: 108939723(sms)
PKI: 111860978(sms)
LCM: 102363084(SMS)
CMK: 103189993(sms)
RTP: 109931901(sms)
CIN: 100184953
APLC: 110984481
DME: Dmel_CG4300(Sms)
DER: 6545024
DSE: 6605422
DSI: Dsimw501_GD12732(Dsim_GD12732)
DAN: 6507617
DSR: 110179980
DPE: 6596081
DMN: 108152781
DWI: 6645203
DAZ: 108614587
DNV: 108652249
DHE: 111598765
DVI: 6623526
MDE: 101896722
LCQ: 111677486
AAG: 5570348
AME: 410080
BIM: 100742708
BTER: 100647449
CCAL: 108622646
OBB: 114878120
SOC: 105201107
MPHA: 105832350
AEC: 105145851
ACEP: 105618948
PBAR: 105434139
VEM: 105570564
HST: 105184220
DQU: 106740768
CFO: 105258881
LHU: 105667455
PGC: 109857572
OBO: 105283669
PCF: 106790811
NVI: 100116075
CSOL: 105366297
MDL: 103571989
TCA: 656524
DPA: 109542993
ATD: 109600146
NVL: 108563491
BMOR: 101742636
BMAN: 114241374
PMAC: 106710981
PRAP: 110997871
HAW: 110374554
TNL: 113502268
BTAB: 109032705
CLEC: 106662819
ZNE: 110837290
TUT: 107372126
DPTE: 113796146
CSCU: 111623623
PTEP: 107447974
PCAN: 112556767
MYI: 110453256
NVE: 5516689
SCE: YLR146C(SPE4)
KMX: KLMA_50519(SPE4)
NCS: NCAS_0C03110(NCAS0C03110)
NDI: NDAI_0G02420(NDAI0G02420)
TPF: TPHA_0A01420(TPHA0A01420)
TBL: TBLA_0A04140(TBLA0A04140)
TDL: TDEL_0F04780(TDEL0F04780)
KAF: KAFR_0H02120(KAFR0H02120)
CAL: CAALFM_C113330CA(CaO19.4960)
 » show all
Reference
PMID:7546290
  Authors
Korhonen VP, Halmekyto M, Kauppinen L, Myohanen S, Wahlfors J, Keinanen T, Hyvonen T, Alhonen L, Eloranta T, Janne J
  Title
Molecular cloning of a cDNA encoding human spermine synthase.
  Journal
DNA Cell Biol 14:841-7 (1995)
DOI:10.1089/dna.1995.14.841
  Sequence
[hsa:6611]
Reference
PMID:9573363
  Authors
Hamasaki-Katagiri N, Katagiri Y, Tabor CW, Tabor H
  Title
Spermine is not essential for growth of Saccharomyces cerevisiae: identification of the SPE4 gene (spermine synthase) and characterization of a spe4 deletion mutant.
  Journal
Gene 210:195-201 (1998)
DOI:10.1016/s0378-1119(98)00027-4
  Sequence
[sce:YLR146C]
Reference
  Authors
Pegg AE, Michael AJ
  Title
Spermine synthase.
  Journal
Cell Mol Life Sci 67:113-21 (2010)
DOI:10.1007/s00018-009-0165-5

KEGG   ORTHOLOGY: K12259
Entry
K12259                      KO                                     

Name
SMOX, PAO5
Definition
spermine oxidase [EC:1.5.3.16 1.5.3.-]
Pathway
ko00330  Arginine and proline metabolism
ko00410  beta-Alanine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K12259  SMOX, PAO5; spermine oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K12259  SMOX, PAO5; spermine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.16  spermine oxidase
     K12259  SMOX, PAO5; spermine oxidase
    1.5.3.-  
     K12259  SMOX, PAO5; spermine oxidase
Other DBs
RN: R09076
GO: 0046592
Genes
HSA: 54498(SMOX)
PTR: 458074(SMOX)
PPS: 100983105(SMOX)
GGO: 101133425(SMOX)
PON: 100462330(SMOX)
NLE: 100586685(SMOX)
MCC: 718761(SMOX)
MCF: 101867246(SMOX)
RRO: 104674589(SMOX)
RBB: 108533448(SMOX)
CJC: 100397119(SMOX)
SBQ: 101038093(SMOX)
MMU: 228608(Smox)
MCAL: 110311315(Smox)
MPAH: 110317651(Smox)
RNO: 308652(Smox)
MUN: 110556950(Smox)
CGE: 100763379(Smox)
NGI: 103736403(Smox)
HGL: 101707899(Smox)
CCAN: 109701346(Smox)
OCU: 100347645(SMOX)
TUP: 102477539(SMOX)
CFA: 485787(SMOX)
VVP: 112930074(SMOX)
AML: 100480545(SMOX)
UMR: 103674402(SMOX)
UAH: 113258376(SMOX)
ORO: 101369107(SMOX)
ELK: 111141466
FCA: 101084867(SMOX)
PTG: 102953447(SMOX)
PPAD: 109274753(SMOX)
AJU: 106980151(SMOX)
BTA: 527211(SMOX)
BOM: 102278225(SMOX)
BIU: 109567182(SMOX)
BBUB: 102412442(SMOX)
CHX: 102176898(SMOX)
OAS: 101118975(SMOX)
SSC: 100152781(SMOX)
CFR: 102519491(SMOX)
CDK: 105096013(SMOX)
BACU: 103015742(SMOX)
LVE: 103072563(SMOX)
OOR: 101282884(SMOX)
DLE: 111184408(SMOX)
PCAD: 102976849(SMOX)
ECB: 100052311(SMOX)
EPZ: 103541202(SMOX)
EAI: 106847685(SMOX)
MYB: 102248159(SMOX)
MYD: 102768889(SMOX)
MNA: 107536391(SMOX)
HAI: 109383858(SMOX)
DRO: 112303823(SMOX)
PALE: 102891646(SMOX)
RAY: 107505338(SMOX)
MJV: 108399243(SMOX)
LAV: 100671284(SMOX)
TMU: 101347613
MDO: 100030883(SMOX)
SHR: 100917297(SMOX)
PCW: 110218400(SMOX)
OAA: 100085736(SMOX)
GGA: 422934(SMOX)
MGP: 100540689(SMOX)
CJO: 107314119(SMOX)
NMEL: 110397642(SMOX)
APLA: 101789809(SMOX)
ACYG: 106036754(SMOX)
TGU: 100232049(SMOX)
LSR: 110473317(SMOX)
SCAN: 103823102(SMOX)
GFR: 102037069(SMOX)
FAB: 101815717(SMOX)
PHI: 102104257(SMOX)
PMAJ: 107203206(SMOX)
CCAE: 111929109(SMOX)
CCW: 104690827(SMOX)
ETL: 114069487(SMOX)
FPG: 101911959(SMOX)
FCH: 102050731(SMOX)
CLV: 102085808(SMOX)
EGZ: 104124541(SMOX)
NNI: 104018525(SMOX)
ACUN: 113479372(SMOX)
PADL: 103923498(SMOX)
AAM: 106489575(SMOX)
ASN: 102381757(SMOX)
AMJ: 102561876(SMOX)
PSS: 102458431(SMOX)
CMY: 102934652(SMOX)
CPIC: 101941185(SMOX)
ACS: 100556339(smox)
PVT: 110085982(SMOX)
PBI: 103052732(SMOX)
PMUR: 107298236(SMOX)
TSR: 106540406(SMOX)
PMUA: 114604214(SMOX)
GJA: 107110397(SMOX)
XLA: 108697130(smox.L) 108706499
XTR: 733959(smox)
NPR: 108796203(SMOX)
DRE: 387290(smox) 564675(paox1)
PHYP: 113525849 113545780(smox)
TRU: 101071609(smox)
LCO: 104926977(smox)
NCC: 104951180(smox)
MZE: 101476223(smox)
ONL: 100708726(smox)
OLA: 101164210(smox)
XMA: 102226933(smox)
XCO: 114144763(smox)
PRET: 103466331(smox)
CVG: 107091141(smox)
NFU: 107375292(smox)
KMR: 108231759(smox)
ALIM: 106517042(smox)
AOCE: 111582510(smox) 111582579
CSEM: 107988054(smox)
POV: 109637856(smox)
LCF: 108896624(smox)
SDU: 111236651(smox)
SLAL: 111670424(smox)
HCQ: 109511457(smox)
BPEC: 110165329(smox)
MALB: 109961357(smox)
ELS: 105021076(smox)
PKI: 111837406(smox) 111842888
CMK: 103181501(smox)
RTP: 109933762
CIN: 100183817
APLC: 110986019
DER: 26526609
DSI: Dsimw501_GD18558(Dsim_GD18558) Dsimw501_GD27560(Dsim_GD27560)
API: 100165570
RMD: 113548910
TUT: 107359618
PTEP: 107453502
OBI: 106875038
NVE: 5517306
ADF: 107348044
AMIL: 114977429
PDAM: 113668686
SPIS: 111329253
ATH: AT4G29720(PAO5)
ALY: 9303464
CRB: 17880546
CPAP: 110813842
CIT: 102609290
TCC: 18588398
GAB: 108486795
EGR: 104436487
CAM: 101501004
LJA: Lj6g3v1269730.1(Lj6g3v1269730.1) Lj6g3v1269740.1(Lj6g3v1269740.1)
FVE: 101293630
RCN: 112190828
PPER: 18771555
PMUM: 103340722
PAVI: 110751151
ZJU: 107423979
CSV: 101205432
CMO: 103498503
MCHA: 111021855
CMAX: 111493815
CMOS: 111450217
RCU: 8272548
JCU: 105637880
POP: 7484673
QSU: 112025636
VVI: 100243887
BVG: 104884237
SOE: 110798525
OSA: 4327828
DOSA: Os01t0710200-00(Os01g0710200)
OBR: 102707819
BDI: 100823564
ATS: 109740105(LOC109740105)
SBI: 8059172
ZMA: 100383200
SITA: 101782987
PDA: 103699301
EGU: 105032618
ATR: 18448170
APRO: F751_0494
 » show all
Reference
  Authors
Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr
  Title
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.
  Journal
Biochem Biophys Res Commun 304:605-11 (2003)
DOI:10.1016/S0006-291X(03)00636-3
  Sequence
[hsa:54498]

KEGG   ORTHOLOGY: K13366
Entry
K13366                      KO                                     

Name
MPAO, PAO1
Definition
polyamine oxidase [EC:1.5.3.14 1.5.3.16 1.5.3.-]
Pathway
ko00330  Arginine and proline metabolism
ko00410  beta-Alanine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K13366  MPAO, PAO1; polyamine oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K13366  MPAO, PAO1; polyamine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.14  polyamine oxidase (propane-1,3-diamine-forming)
     K13366  MPAO, PAO1; polyamine oxidase
    1.5.3.16  spermine oxidase
     K13366  MPAO, PAO1; polyamine oxidase
    1.5.3.-  
     K13366  MPAO, PAO1; polyamine oxidase
Other DBs
RN: R01914 R09076
GO: 0046592
Genes
BFO: 118415418 118416846 118419065 118423156 118423590
APLC: 110973265 110976671 110981350 110988092 110990939
SKO: 100373364 100378024
NVE: 5507796 5513911 5517304
EPA: 110233784 110238940 110238941 110238942 110238948 110238949 110242583 110250989 110251080
ADF: 107332810 107345156 107345988 107352195
AMIL: 114954540 114954542 114954568 114972653
PDAM: 113672749 113674159 113684841 113686401 113686402 113686403
SPIS: 111320559 111332275 111337183 111339594 111340137 111340138
DGT: 114516813 114521350 114529443 114535219 114536207 114537291 114540637 114541229
ATH: AT5G13700(PAO1)
ALY: 110227624
CRB: 17884351
BRP: 103856027
BOE: 106336146
RSZ: 108847826
CPAP: 110809327
TCC: 18614594
CAM: 101499173
LJA: Lj3g3v0824920.1(Lj3g3v0824920.1)
LANG: 109347912
FVE: 101293925
RCN: 112177639
PPER: 18785878
PAVI: 110744597
MDM: 103412969(PAO) 103438425
CSV: 101209263
CMO: 103499947
MCHA: 111018503
QSU: 112028652
SLY: 101253022
SPEN: 107009669
SOT: 102581392
CANN: 107858653
NTA: 107788770 107832568(pao)
NSY: 104211234
NTO: 104104873
NAU: 109236625
HAN: 110903839
LSV: 111912665
CCAV: 112519613
DCR: 108200790
SOE: 110776356
DOSA: Os09t0368200-00(Os09g0368200) Os09t0368500-01(Os09g0368500)
BDI: 100838312
ATS: 109734081(LOC109734081) 109741342(LOC109741342) 109747506(LOC109747506) 109774256(LOC109774256)
ZMA: 103632539 541983(pao1)
PDA: 103713355
EGU: 105056213
DCT: 110098417
PEQ: 110020682
SSCK: SPSK_01660
MAW: MAC_00210
MAJ: MAA_04956
CMT: CCM_08989
ANI: AN6658.2
ANG: ANI_1_1218084(An09g02560) ANI_1_1716074(An08g01910) ANI_1_1940104(An12g06010) ANI_1_334114(An13g02480)
ABE: ARB_01705
TVE: TRV_03400
PTE: PTT_12979
TASA: A1Q1_01041
 » show all
Reference
PMID:9598979 (1.5.3.14)
  Authors
Tavladoraki P, Schinina ME, Cecconi F, Di Agostino S, Manera F, Rea G, Mariottini P, Federico R, Angelini R
  Title
Maize polyamine oxidase: primary structure from protein and cDNA sequencing.
  Journal
FEBS Lett 426:62-6 (1998)
DOI:10.1016/S0014-5793(98)00311-1
  Sequence
[zma:541983]
Reference
PMID:16778015 (1.5.3.16)
  Authors
Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R
  Title
Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion.
  Journal
Plant Physiol 141:1519-32 (2006)
DOI:10.1104/pp.106.080911
  Sequence
[ath:AT5G13700]

KEGG   ORTHOLOGY: K17839
Entry
K17839                      KO                                     

Name
PAO4, PAO3, PAO2
Definition
polyamine oxidase [EC:1.5.3.17 1.5.3.-]
Pathway
ko00330  Arginine and proline metabolism
ko00410  beta-Alanine metabolism
ko00770  Pantothenate and CoA biosynthesis
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K17839  PAO4, PAO3, PAO2; polyamine oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K17839  PAO4, PAO3, PAO2; polyamine oxidase
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K17839  PAO4, PAO3, PAO2; polyamine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.17  non-specific polyamine oxidase
     K17839  PAO4, PAO3, PAO2; polyamine oxidase
    1.5.3.-  
     K17839  PAO4, PAO3, PAO2; polyamine oxidase
Other DBs
RN: R09076 R09077
Genes
PCAN: 112562815
ATH: AT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
ALY: 9314325 9316084 9323048
CRB: 17887258 17890473 17895855
CSAT: 104699419 104701179 104750367 104781816 104782814 104785057 104787599 104788143 104792182
EUS: EUTSA_v10005954mg EUTSA_v10016573mg EUTSA_v10018447mg
BRP: 103830193 103852299 103858041 103866035 103866687
BNA: 106351646 106351654 106353169 106381329 106385479 106391704 106421166 106428226 106434498 106441217 111211981
BOE: 106296723 106318716 106333466 106336574 106336734
RSZ: 108812262 108820199 108831364 108833605 108845973 108855756
TCC: 18612191
LJA: Lj2g3v3070870.2(Lj2g3v3070870.2) Lj6g3v0366930.1(Lj6g3v0366930.1) Lj6g3v0933770.1(Lj6g3v0933770.1)
ZJU: 107416625
DOSA: Os04t0623300-01(Os04g0623300) Os04t0671200-01(Os04g0671200) Os04t0671300-01(Os04g0671300)
ATS: 109734611(LOC109734611) 109739586(LOC109739586) 109759728(LOC109759728)
ZMA: 100191603(pco077065) 100384522(TIDP3366) 101027113 103631209 103642073
SMIN: v1.2.017081.t1(symbB.v1.2.017081.t1)
PRJ: NCTC6933_02431(puo)
PKC: PKB_2406
CBD: CBUD_1418
CBG: CbuG_0678
MMI: MMAR_1387
MSHG: MSG_01342
 » show all
Reference
PMID:18583528 (PAO3/1.5.3.17)
  Authors
Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA
  Title
Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
  Journal
Plant Physiol 147:1845-57 (2008)
DOI:10.1104/pp.108.123802
  Sequence
[ath:AT3G59050]

KEGG   ORTHOLOGY: K13367
Entry
K13367                      KO                                     

Name
FMS1
Definition
polyamine oxidase [EC:1.5.3.17]
Pathway
ko00330  Arginine and proline metabolism
ko00410  beta-Alanine metabolism
ko00770  Pantothenate and CoA biosynthesis
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K13367  FMS1; polyamine oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K13367  FMS1; polyamine oxidase
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K13367  FMS1; polyamine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.17  non-specific polyamine oxidase
     K13367  FMS1; polyamine oxidase
Other DBs
RN: R03899 R09074 R09076 R09077
GO: 0046592
Genes
SCE: YMR020W(FMS1)
AGO: AGOS_ABR057W
ERC: Ecym_4580
KLA: KLLA0_E07789g
KMX: KLMA_40378(FMS1)
LTH: KLTH0D07942g
ZRO: ZYRO0E06314g
CGR: CAGL0M07612g
NCS: NCAS_0A12730(NCAS0A12730)
NDI: NDAI_0B01530(NDAI0B01530)
TDL: TDEL_0B06550(TDEL0B06550)
KAF: KAFR_0A02140(KAFR0A02140)
CAL: CAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
SLB: AWJ20_1654(FMS1) AWJ20_390(FMS1) AWJ20_4168(FMS1)
MBE: MBM_07212
 » show all
Reference
  Authors
Landry J, Sternglanz R
  Title
Yeast Fms1 is a FAD-utilizing polyamine oxidase.
  Journal
Biochem Biophys Res Commun 303:771-6 (2003)
DOI:10.1016/S0006-291X(03)00416-9
  Sequence
[sce:YMR020W]

KEGG   ENZYME: 1.5.3.16
Entry
EC 1.5.3.16                 Enzyme                                 

Name
spermine oxidase;
PAOh1/SMO;
PAOh1 (ambiguous);
AtPAO1;
AtPAO4;
SMO;
mSMO;
SMO(PAOh1);
SMO/PAOh1;
SMO5;
mSMOmu
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
spermidine:oxygen oxidoreductase (spermidine-forming)
Reaction(IUBMB)
spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076]
Reaction(KEGG)
R09076
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027]
Comment
The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase).
History
EC 1.5.3.16 created 2009
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K12259  spermine oxidase
K13366  polyamine oxidase
Genes
HSA: 54498(SMOX)
PTR: 458074(SMOX)
PPS: 100983105(SMOX)
GGO: 101133425(SMOX)
PON: 100462330(SMOX)
NLE: 100586685(SMOX)
MCC: 718761(SMOX)
MCF: 101867246(SMOX)
RRO: 104674589(SMOX)
RBB: 108533448(SMOX)
CJC: 100397119(SMOX)
SBQ: 101038093(SMOX)
MMU: 228608(Smox)
MCAL: 110311315(Smox)
MPAH: 110317651(Smox)
RNO: 308652(Smox)
MUN: 110556950(Smox)
CGE: 100763379(Smox)
NGI: 103736403(Smox)
HGL: 101707899(Smox)
CCAN: 109701346(Smox)
OCU: 100347645(SMOX)
TUP: 102477539(SMOX)
CFA: 485787(SMOX)
VVP: 112930074(SMOX)
AML: 100480545(SMOX)
UMR: 103674402(SMOX)
UAH: 113258376(SMOX)
ORO: 101369107(SMOX)
ELK: 111141466
FCA: 101084867(SMOX)
PTG: 102953447(SMOX)
PPAD: 109274753(SMOX)
AJU: 106980151(SMOX)
BTA: 527211(SMOX)
BOM: 102278225(SMOX)
BIU: 109567182(SMOX)
BBUB: 102412442(SMOX)
CHX: 102176898(SMOX)
OAS: 101118975(SMOX)
SSC: 100152781(SMOX)
CFR: 102519491(SMOX)
CDK: 105096013(SMOX)
BACU: 103015742(SMOX)
LVE: 103072563(SMOX)
OOR: 101282884(SMOX)
DLE: 111184408(SMOX)
PCAD: 102976849(SMOX)
ECB: 100052311(SMOX)
EPZ: 103541202(SMOX)
EAI: 106847685(SMOX)
MYB: 102248159(SMOX)
MYD: 102768889(SMOX)
MNA: 107536391(SMOX)
HAI: 109383858(SMOX)
DRO: 112303823(SMOX)
PALE: 102891646(SMOX)
RAY: 107505338(SMOX)
MJV: 108399243(SMOX)
LAV: 100671284(SMOX)
TMU: 101347613
MDO: 100030883(SMOX)
SHR: 100917297(SMOX)
PCW: 110218400(SMOX)
OAA: 100085736(SMOX)
GGA: 422934(SMOX)
MGP: 100540689(SMOX)
CJO: 107314119(SMOX)
NMEL: 110397642(SMOX)
APLA: 101789809(SMOX)
ACYG: 106036754(SMOX)
TGU: 100232049(SMOX)
LSR: 110473317(SMOX)
SCAN: 103823102(SMOX)
GFR: 102037069(SMOX)
FAB: 101815717(SMOX)
PHI: 102104257(SMOX)
PMAJ: 107203206(SMOX)
CCAE: 111929109(SMOX)
CCW: 104690827(SMOX)
ETL: 114069487(SMOX)
FPG: 101911959(SMOX)
FCH: 102050731(SMOX)
CLV: 102085808(SMOX)
EGZ: 104124541(SMOX)
NNI: 104018525(SMOX)
ACUN: 113479372(SMOX)
PADL: 103923498(SMOX)
AAM: 106489575(SMOX)
ASN: 102381757(SMOX)
AMJ: 102561876(SMOX)
PSS: 102458431(SMOX)
CMY: 102934652(SMOX)
CPIC: 101941185(SMOX)
ACS: 100556339(smox)
PVT: 110085982(SMOX)
PBI: 103052732(SMOX)
PMUR: 107298236(SMOX)
TSR: 106540406(SMOX)
PMUA: 114604214(SMOX)
GJA: 107110397(SMOX)
XLA: 108697130(smox.L) 108706499
XTR: 733959(smox)
NPR: 108796203(SMOX)
DRE: 387290(smox) 564675(paox1)
PHYP: 113525849 113545780(smox)
TRU: 101071609(smox)
LCO: 104926977(smox)
NCC: 104951180(smox)
MZE: 101476223(smox)
ONL: 100708726(smox)
OLA: 101164210(smox)
XMA: 102226933(smox)
XCO: 114144763(smox)
PRET: 103466331(smox)
CVG: 107091141(smox)
NFU: 107375292(smox)
KMR: 108231759(smox)
ALIM: 106517042(smox)
AOCE: 111582510(smox) 111582579
CSEM: 107988054(smox)
POV: 109637856(smox)
LCF: 108896624(smox)
SDU: 111236651(smox)
SLAL: 111670424(smox)
HCQ: 109511457(smox)
BPEC: 110165329(smox)
MALB: 109961357(smox)
ELS: 105021076(smox)
PKI: 111837406(smox) 111842888
CMK: 103181501(smox)
RTP: 109933762
CIN: 100183817
DER: 26526609
DSI: Dsimw501_GD18558(Dsim_GD18558) Dsimw501_GD27560(Dsim_GD27560)
API: 100165570
RMD: 113548910
TUT: 107359618
PTEP: 107453502
OBI: 106875038
ATH: AT4G29720(PAO5) AT5G13700(PAO1)
LJA: Lj3g3v0824920.1(Lj3g3v0824920.1) Lj6g3v1269730.1(Lj6g3v1269730.1) Lj6g3v1269740.1(Lj6g3v1269740.1)
DOSA: Os01t0710200-00(Os01g0710200) Os09t0368200-00(Os09g0368200) Os09t0368500-01(Os09g0368500)
ATS: 109734081(LOC109734081) 109740105(LOC109740105) 109741342(LOC109741342) 109747506(LOC109747506) 109774256(LOC109774256)
APRO: F751_0494
SSCK: SPSK_01660
MAW: MAC_00210
MAJ: MAA_04956
CMT: CCM_08989
ANI: AN6658.2
ANG: ANI_1_1218084(An09g02560) ANI_1_1716074(An08g01910) ANI_1_1940104(An12g06010) ANI_1_334114(An13g02480)
ABE: ARB_01705
TVE: TRV_03400
PTE: PTT_12979
TASA: A1Q1_01041
 » show all
Reference
1  [PMID:18422650]
  Authors
Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA Jr
  Title
Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.
  Journal
FEBS J 275:2795-806 (2008)
DOI:10.1111/j.1742-4658.2008.06419.x
  Sequence
[hsa:54498]
Reference
2  [PMID:12458219]
  Authors
Cervelli M, Polticelli F, Federico R, Mariottini P
  Title
Heterologous expression and characterization of mouse spermine oxidase.
  Journal
J Biol Chem 278:5271-6 (2003)
DOI:10.1074/jbc.M207888200
Reference
3  [PMID:16778015]
  Authors
Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R
  Title
Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion.
  Journal
Plant Physiol 141:1519-32 (2006)
DOI:10.1104/pp.106.080911
  Sequence
[ath:AT5G13700]
Reference
4  [PMID:12727196]
  Authors
Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr
  Title
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.
  Journal
Biochem Biophys Res Commun 304:605-11 (2003)
DOI:10.1016/S0006-291X(03)00636-3
  Sequence
[hsa:54498]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.16
IUBMB Enzyme Nomenclature: 1.5.3.16
ExPASy - ENZYME nomenclature database: 1.5.3.16
BRENDA, the Enzyme Database: 1.5.3.16

KEGG   ENZYME: 1.5.3.17
Entry
EC 1.5.3.17                 Enzyme                                 

Name
non-specific polyamine oxidase;
polyamine oxidase (ambiguous);
Fms1;
AtPAO3
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming)
Reaction(IUBMB)
(1) spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076];
(2) spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [RN:R09077];
(3) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899];
(4) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074]
Reaction(KEGG)
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001];
spermidine [CPD:C00315];
N1-acetylspermine [CPD:C02567];
N1-acetylspermidine [CPD:C00612]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027];
putrescine [CPD:C00134];
3-acetamidopropanal [CPD:C18170]
Comment
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1].
The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase).
History
EC 1.5.3.17 created 2009
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K13367  polyamine oxidase
K17839  polyamine oxidase
Genes
PCAN: 112562815
ATH: AT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
ALY: 9314325 9316084 9323048
CRB: 17887258 17890473 17895855
CSAT: 104699419 104701179 104750367 104781816 104782814 104785057 104787599 104788143 104792182
EUS: EUTSA_v10005954mg EUTSA_v10016573mg EUTSA_v10018447mg
BRP: 103830193 103852299 103858041 103866035 103866687
BNA: 106351646 106351654 106353169 106381329 106385479 106391704 106421166 106428226 106434498 106441217 111211981
BOE: 106296723 106318716 106333466 106336574 106336734
RSZ: 108812262 108820199 108831364 108833605 108845973 108855756
TCC: 18612191
LJA: Lj2g3v3070870.2(Lj2g3v3070870.2) Lj6g3v0366930.1(Lj6g3v0366930.1) Lj6g3v0933770.1(Lj6g3v0933770.1)
ZJU: 107416625
DOSA: Os04t0623300-01(Os04g0623300) Os04t0671200-01(Os04g0671200) Os04t0671300-01(Os04g0671300)
ATS: 109734611(LOC109734611) 109739586(LOC109739586) 109759728(LOC109759728)
ZMA: 100191603(pco077065) 100384522(TIDP3366) 101027113 103631209 103642073
SCE: YMR020W(FMS1)
ERC: Ecym_4580
KMX: KLMA_40378(FMS1)
NCS: NCAS_0A12730(NCAS0A12730)
NDI: NDAI_0B01530(NDAI0B01530)
TDL: TDEL_0B06550(TDEL0B06550)
KAF: KAFR_0A02140(KAFR0A02140)
CAL: CAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
SLB: AWJ20_1654(FMS1) AWJ20_390(FMS1) AWJ20_4168(FMS1)
MBE: MBM_07212
SMIN: v1.2.017081.t1(symbB.v1.2.017081.t1)
PRJ: NCTC6933_02431(puo)
PKC: PKB_2406
CBD: CBUD_1418
CBG: CbuG_0678
MMI: MMAR_1387
MSHG: MSG_01342
 » show all
Reference
1  [PMID:18583528]
  Authors
Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA
  Title
Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
  Journal
Plant Physiol 147:1845-57 (2008)
DOI:10.1104/pp.108.123802
  Sequence
[ath:AT3G59050]
Reference
2  [PMID:1567380]
  Authors
Muller S, Walter RD
  Title
Purification and characterization of polyamine oxidase from Ascaris suum.
  Journal
Biochem J 283 ( Pt 1):75-80 (1992)
DOI:10.1042/bj2830075
Reference
3  [PMID:12670477]
  Authors
Landry J, Sternglanz R
  Title
Yeast Fms1 is a FAD-utilizing polyamine oxidase.
  Journal
Biochem Biophys Res Commun 303:771-6 (2003)
DOI:10.1016/S0006-291X(03)00416-9
  Sequence
[sce:YMR020W]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.17
IUBMB Enzyme Nomenclature: 1.5.3.17
ExPASy - ENZYME nomenclature database: 1.5.3.17
BRENDA, the Enzyme Database: 1.5.3.17

KEGG   ENZYME: 2.5.1.22
Entry
EC 2.5.1.22                 Enzyme                                 

Name
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase;
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN:R02869]
Reaction(KEGG)
R02869
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
spermidine [CPD:C00315]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment
The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
History
EC 2.5.1.22 created 1982, modified 2013
Pathway
ec00270  Cysteine and methionine metabolism
ec00330  Arginine and proline metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00802  spermine synthase
Genes
HSA: 6611(SMS)
PTR: 107966193(SMS) 739762
PPS: 100974711 100989256(SMS)
GGO: 101136287(SMS)
PON: 100447565 100455032(SMS)
NLE: 100592294(SMS) 100603217
MCC: 698179(SMS)
MCF: 102139114(SMS)
CSAB: 103231701(SMS)
RRO: 104676688(SMS)
RBB: 108512250
CJC: 100411404(SMS)
SBQ: 101037456(SMS)
MMU: 20603(Sms)
MCAL: 110287180(Sms) 110292244
MPAH: 110313434(Sms) 110326795
RNO: 363469(Sms)
MUN: 110539961(Sms)
NGI: 103730144(Sms)
HGL: 101696715(Sms) 101718865
CCAN: 109685258(Sms) 109685259
OCU: 100340020(SMS)
CFA: 480861(SMS)
VVP: 112916263 112919114(SMS)
AML: 100469558(SMS)
UMR: 103668176(SMS)
UAH: 113242233(SMS)
ORO: 101364730(SMS) 101371201
ELK: 111150447
FCA: 101090842(SMS)
PTG: 102954471(SMS)
PPAD: 109257443(SMS)
AJU: 106968260(SMS)
BTA: 615950(SMS)
BOM: 102270205 102283485(SMS)
BIU: 109554942(SMS) 109559006
BBUB: 102399518(SMS)
CHX: 102190676(SMS)
OAS: 101107419(SMS) 101112287
SSC: 100153052(SMS)
CFR: 102512656(SMS)
CDK: 105105052(SMS)
BACU: 103019290(SMS)
LVE: 103068984
OOR: 101272903(SMS)
DLE: 111167517(SMS)
PCAD: 102987295(SMS)
ECB: 100051857(SMS)
EPZ: 103566846(SMS)
EAI: 106835513(SMS)
MYB: 102251500 102257010(SMS)
MYD: 102760281(SMS)
MNA: 107526796(SMS)
HAI: 109395813(SMS)
DRO: 112313352(SMS)
PALE: 102896435(SMS)
RAY: 107521441(SMS)
MJV: 108396545(SMS)
LAV: 100658418(SMS)
TMU: 101354696
MDO: 100012760(SMS)
SHR: 100928879(SMS)
PCW: 110210823(SMS)
OAA: 100083114(SMS)
GGA: 418602(SMS)
MGP: 100549711(SMS)
CJO: 107324967(SMS)
NMEL: 110404540(SMS)
APLA: 101791698(SMS)
ACYG: 106037821(SMS)
TGU: 100228014(SMS)
LSR: 110483279(SMS)
SCAN: 103815851(SMS)
GFR: 102034236(SMS)
FAB: 101806851(SMS)
PHI: 102114400(SMS)
PMAJ: 107201826(SMS)
CCAE: 111922892(SMS)
CCW: 104686193(SMS)
ETL: 114067188(SMS)
FPG: 101922863(SMS)
FCH: 102049429(SMS)
CLV: 102096362(SMS)
EGZ: 104135174(SMS)
NNI: 104022508(SMS)
ACUN: 113478646
PADL: 103914492(SMS)
AAM: 106492122(SMS)
ASN: 102388291(SMS)
AMJ: 102559699(SMS)
PSS: 102445830(SMS)
CMY: 102933684(SMS)
CPIC: 101931607(SMS)
ACS: 100552713(sms) 100561005
PVT: 110076724(SMS)
PBI: 103049999(SMS)
PMUR: 107286125(SMS)
TSR: 106553354(SMS)
PMUA: 114596224(SMS)
GJA: 107120288(SMS)
XLA: 108708014(sms.L)
XTR: 100497747(sms)
NPR: 108791842(SMS)
DRE: 80872(sms)
IPU: 108279239(sms)
PHYP: 113541383(sms)
AMEX: 103023143(sms)
EEE: 113575324(sms)
TRU: 101072716(sms)
LCO: 104924594(sms)
NCC: 104965977(sms)
MZE: 101475695(sms)
ONL: 100708530(sms)
OLA: 101166897(sms)
XMA: 102233412(sms)
XCO: 114153519(sms)
PRET: 103475438(sms)
CVG: 107086975(sms)
NFU: 107386402(sms)
KMR: 108236978(sms)
ALIM: 106514045(sms)
AOCE: 111567113(sms)
CSEM: 103395717(sms)
POV: 109628585(sms)
LCF: 108893544(sms)
SDU: 111234621(sms)
SLAL: 111666195(sms)
HCQ: 109517965(sms)
BPEC: 110158443(sms)
MALB: 109959604(sms)
SASA: 100195133(spsy) 106603082
ELS: 105010858(sms)
SFM: 108939723(sms)
PKI: 111860978(sms)
LCM: 102363084(SMS)
CMK: 103189993(sms)
RTP: 109931901(sms)
CIN: 100184953
APLC: 110984481
DME: Dmel_CG4300(Sms)
DER: 6545024
DSE: 6605422
DSI: Dsimw501_GD12732(Dsim_GD12732)
DAN: 6507617
DSR: 110179980
DPE: 6596081
DMN: 108152781
DWI: 6645203
DAZ: 108614587
DNV: 108652249
DHE: 111598765
DVI: 6623526
MDE: 101896722
LCQ: 111677486
AAG: 5570348
AME: 410080
BIM: 100742708
BTER: 100647449
CCAL: 108622646
OBB: 114878120
SOC: 105201107
MPHA: 105832350
AEC: 105145851
ACEP: 105618948
PBAR: 105434139
VEM: 105570564
HST: 105184220
DQU: 106740768
CFO: 105258881
LHU: 105667455
PGC: 109857572
OBO: 105283669
PCF: 106790811
NVI: 100116075
CSOL: 105366297
MDL: 103571989
TCA: 656524
DPA: 109542993
ATD: 109600146
NVL: 108563491
BMOR: 101742636
BMAN: 114241374
PMAC: 106710981
PRAP: 110997871
HAW: 110374554
TNL: 113502268
BTAB: 109032705
CLEC: 106662819
ZNE: 110837290
TUT: 107372126
DPTE: 113796146
CSCU: 111623623
PTEP: 107447974
PCAN: 112556767
MYI: 110453256
NVE: 5516689
SCE: YLR146C(SPE4)
KMX: KLMA_50519(SPE4)
NCS: NCAS_0C03110(NCAS0C03110)
NDI: NDAI_0G02420(NDAI0G02420)
TPF: TPHA_0A01420(TPHA0A01420)
TBL: TBLA_0A04140(TBLA0A04140)
TDL: TDEL_0F04780(TDEL0F04780)
KAF: KAFR_0H02120(KAFR0H02120)
CAL: CAALFM_C113330CA(CaO19.4960)
 » show all
Reference
1  [PMID:7396856]
  Authors
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
  Title
Studies of inhibition of rat spermidine synthase and spermine synthase.
  Journal
Biochem J 187:419-28 (1980)
DOI:10.1042/bj1870419
Reference
2  [PMID:520313]
  Authors
Pajula RL, Raina A, Eloranta T.
  Title
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
  Journal
Eur J Biochem 101:619-26 (1979)
DOI:10.1111/j.1432-1033.1979.tb19756.x
Reference
3  [PMID:6798961]
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.22
IUBMB Enzyme Nomenclature: 2.5.1.22
ExPASy - ENZYME nomenclature database: 2.5.1.22
BRENDA, the Enzyme Database: 2.5.1.22
CAS: 74812-43-4

KEGG   REACTION: R02869
Entry
R02869                      Reaction                               

Name
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
Definition
S-Adenosylmethioninamine + Spermidine <=> 5'-Methylthioadenosine + Spermine
Equation
Reaction class
RC00021  C00170_C01137
RC00053  C00315_C00750
Enzyme
Pathway
rn00270  Cysteine and methionine metabolism
rn00330  Arginine and proline metabolism
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K00802  spermine synthase [EC:2.5.1.22]
Other DBs
RHEA: 19976

KEGG   REACTION: R09076
Entry
R09076                      Reaction                               

Name
spermidine:oxygen oxidoreductase (spermidine-forming)
Definition
Spermine + Oxygen + H2O <=> Spermidine + 3-Aminopropanal + Hydrogen peroxide
Equation
Reaction class
RC00053  C00315_C00750
RC00225  C00750_C05665
RC02755  C00007_C00027
Enzyme
1.5.3.16        1.5.3.17
Pathway
rn00330  Arginine and proline metabolism
rn00410  beta-Alanine metabolism
rn00770  Pantothenate and CoA biosynthesis
rn01100  Metabolic pathways
Orthology
K12259  spermine oxidase [EC:1.5.3.16 1.5.3.-]
K13366  polyamine oxidase [EC:1.5.3.14 1.5.3.16 1.5.3.-]
K13367  polyamine oxidase [EC:1.5.3.17]
K17839  polyamine oxidase [EC:1.5.3.17 1.5.3.-]
Other DBs
RHEA: 25807

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