KEGG   ORTHOLOGY: K00814Help
Entry
K00814                      KO                                     

Name
GPT, ALT
Definition
alanine transaminase [EC:2.6.1.2]
Pathway
ko00220  Arginine biosynthesis
ko00250  Alanine, aspartate and glutamate metabolism
ko00710  Carbon fixation in photosynthetic organisms
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Disease
H00768  Autosomal recessive mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00814  GPT, ALT; alanine transaminase
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K00814  GPT, ALT; alanine transaminase
   00220 Arginine biosynthesis
    K00814  GPT, ALT; alanine transaminase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K00814  GPT, ALT; alanine transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.2  alanine transaminase
     K00814  GPT, ALT; alanine transaminase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class I
   K00814  GPT, ALT; alanine transaminase
BRITE hierarchy
Other DBs
RN: R00258
COG: COG0436
GO: 0004021
Genes
HSA: 2875(GPT) 84706(GPT2)
PTR: 465145(GPT2) 472900(GPT)
PPS: 100975011(GPT2) 100993368(GPT)
GGO: 101142979(GPT2) 101147742(GPT)
PON: 100449644(GPT) 100458005(GPT2)
NLE: 100599113(GPT) 100601247(GPT2)
MCC: 703122(GPT) 716305(GPT2)
MCF: 102129898(GPT) 102134328(GPT2)
CSAB: 103232234(GPT2) 103237635(GPT)
RRO: 104655432(GPT2) 104671661(GPT)
RBB: 108534785(GPT2) 108536616(GPT)
CJC: 100388878(GPT) 100393388(GPT2)
SBQ: 101049559(GPT) 101051222(GPT2)
MMU: 108682(Gpt2) 76282(Gpt)
MCAL: 110299696(Gpt2) 110310118(Gpt)
MPAH: 110334950(Gpt) 110337340(Gpt2)
RNO: 307759(Gpt2) 81670(Gpt)
MUN: 110552985(Gpt2) 110562460(Gpt)
CGE: 100760506(Gpt) 100768176(Gpt2)
NGI: 103731273(Gpt2) 103735239(Gpt)
HGL: 101699130(Gpt2) 101713635(Gpt)
CCAN: 109691162(Gpt) 109696657(Gpt2)
OCU: 100352457(GPT2)
TUP: 102470738(GPT2) 102498588(GPT)
CFA: 609510(GPT2) 609914(GPT)
VVP: 112911118(GPT) 112914705(GPT2)
AML: 100471370(GPT) 100475183(GPT2)
UMR: 103656687(GPT) 103673815(GPT2)
UAH: 113247624(GPT) 113252205(GPT2)
ORO: 101369228(GPT2) 101370510(GPT)
FCA: 101088131(GPT2) 101097207(GPT)
PTG: 102949341(GPT) 102962315(GPT2)
AJU: 106965985(GPT2) 106979145(GPT)
BTA: 539188(GPT) 618400(GPT2)
BOM: 102274288(GPT2) 102277255 102279462(GPT)
BIU: 109568354(GPT) 109572545(GPT2)
BBUB: 102394281(GPT2) 102411530(GPT)
PHD: 102326948(GPT2) 102336532(GPT)
CHX: 102173681(GPT2) 102175221(GPT)
OAS: 101109822(GPT2) 106991334(GPT)
SSC: 100521318(GPT2) 100524618(GPT)
CFR: 102511186(GPT2) 102522153(GPT)
CDK: 105091190(GPT2) 105104985(GPT)
BACU: 103005302(GPT2) 103014779(GPT)
LVE: 103077021(GPT) 103082818(GPT2)
OOR: 101275979(GPT) 101287779(GPT2)
DLE: 111165001(GPT2)
ECB: 100056741(GPT2) 100064717(GPT)
EPZ: 103542725(GPT2) 103554912(GPT)
EAI: 106841923(GPT) 106848237(GPT2)
MYB: 102240718(GPT) 102257468(GPT2)
MYD: 102766483(GPT) 102774968(GPT2)
MNA: 107535854(GPT2) 107539959(GPT)
HAI: 109375063(GPT) 109383061(GPT2)
RSS: 109437734(GPT) 109447455(GPT2)
DRO: 112296777(GPT2) 112315693(GPT)
PALE: 102878972(GPT2) 102892844(GPT)
LAV: 100664054(GPT) 100668654(GPT2)
MDO: 100012906(GPT2) 100019438(GPT)
SHR: 100925652(GPT2) 100926192(GPT)
PCW: 110207447(GPT2) 110214330 110214363(GPT)
OAA: 100089316(GPT) 100681695(GPT2)
GGA: 415746(GPT2)
MGP: 100550762(GPT2)
CJO: 107319277(GPT2)
APLA: 101793959(GPT2) 113841501
ACYG: 106039616(GPT2)
TGU: 100225697(GPT2)
SCAN: 103816611(GPT2) 108964059
GFR: 102038848(GPT2) 102039634
FAB: 101818529(GPT2) 101819797
PMAJ: 107199345 107209732(GPT2)
FPG: 101911152(GPT2) 101921824(GPT)
CLV: 102089178(GPT2) 102090987(GPT)
EGZ: 104125556(GPT2)
NNI: 104011278(GPT2)
ACUN: 113484443(GPT2) 113490615
AAM: 106483215(GPT2) 106490774
ASN: 102371357(GPT) 102372841(GPT2)
AMJ: 102570995 106736972(GPT2)
PSS: 102458275(GPT2)
CMY: 102942679 102943990(GPT2)
CPIC: 101935440(GPT2) 101935632(GPT)
PVT: 110076276(GPT2) 110084837(GPT)
PBI: 103053092(GPT) 103065601(GPT2)
GJA: 107108887(GPT2) 107120811(GPT)
XTR: 100494152(gpt2) 549559(gpt2)
DRE: 100148522(si:ch211-217a12.1) 403086(gpt2l) 799963(gpt2)
CMK: 103176062(gpt2) 103179678(gpt) 103179740
CIN: 100181336
SPU: 580780
APLC: 110981347
SKO: 100374543
DME: Dmel_CG1640(CG1640)
DER: 6550836
DSI: Dsimw501_GD11952(Dsim_GD11952) Dsimw501_GD17120(Dsim_GD17120)
DWI: 6652997
DAZ: 108618211
DNV: 108656383
DHE: 111596884
MDE: 101891106
AAG: 5572547
AME: 409196
BIM: 100743791
BTER: 100648266
MPHA: 105836113
PBAR: 105426447
HST: 105184124
DQU: 106742862
CFO: 105253797
LHU: 105676745
PGC: 109859028
OBO: 105279677
PCF: 106793981
NVI: 100116238
MDL: 103580664
DPA: 109535880
NVL: 108560415
PRAP: 111003492
API: 100164899
DNX: 107166280
AGS: 114122348
CLEC: 106665989
ZNE: 110836059
CEL: CELE_C32F10.8(C32F10.8)
CBR: CBG04059
TSP: Tsp_11214
EGL: EGR_08047
AQU: 100634012
ATH: AT1G17290(AlaAT1) AT1G72330(ALAAT2)
THJ: 104812273
CPAP: 110818370
CIT: 102620489
TCC: 18596312
EGR: 104419532
GMX: 100127413(ALAAT1) 100776235
VRA: 106778197
VAR: 108347646
CCAJ: 109817508
CAM: 101489034
LJA: Lj3g3v2575550.1(Lj3g3v2575550.1) Lj3g3v2575550.2(Lj3g3v2575550.2) Lj3g3v2575550.3(Lj3g3v2575550.3)
ADU: 107473212
AIP: 107624761
FVE: 101294194
PPER: 18781746
PMUM: 103327553
MDM: 103443626
PXB: 103951631
ZJU: 107434241
RCU: 8276551
JCU: 105631325
HBR: 110634614
VVI: 100241156
INI: 109192424
BVG: 104899678
SOE: 110787200
DOSA: Os03t0183600-00(Os03g0183600) Os07t0617800-01(Os07g0617800) Os09t0433900-01(Os09g0433900) Os10t0390500-01(Os10g0390500) Os10t0390600-01(Os10g0390600)
ATS: 109733068(LOC109733068) 109749219(LOC109749219) 109758758(LOC109758758) 109784962(LOC109784962)
ATR: 18423966
CRE: CHLREDRAFT_191703(AAT2)
MNG: MNEG_6213
SCE: YDR111C(ALT2) YLR089C(ALT1)
ERC: Ecym_4307
KMX: KLMA_40139(ALT1)
NCS: NCAS_0B03840(NCAS0B03840) NCAS_0B05020(NCAS0B05020)
NDI: NDAI_0B01990(NDAI0B01990) NDAI_0J01360(NDAI0J01360)
TPF: TPHA_0A01800(TPHA0A01800) TPHA_0J00750(TPHA0J00750)
TBL: TBLA_0E04440(TBLA0E04440) TBLA_0F03060(TBLA0F03060) TBLA_0G01630(TBLA0G01630)
TDL: TDEL_0F03900(TDEL0F03900)
KAF: KAFR_0B02730(KAFR0B02730) KAFR_0B05520(KAFR0B05520) KAFR_0B05530(KAFR0B05530)
PIC: PICST_70108(ALA2)
CAL: CAALFM_C303480CA(ALT1)
SLB: AWJ20_2327(ALT1)
NCR: NCU03973(ala)
NTE: NEUTE1DRAFT132025(NEUTE1DRAFT_132025)
MGR: MGG_06503
SSCK: SPSK_05261
MAW: MAC_03466
MAJ: MAA_02241
CMT: CCM_04522
MBE: MBM_05177
ANI: AN1923.2
ANG: ANI_1_368094(An11g02620)
ABE: ARB_02969
TVE: TRV_03717
PTE: PTT_10298
CNE: CNG01490
CNB: CNBG3290
MRR: Moror_573
ABP: AGABI1DRAFT86113(AGABI1DRAFT_86113)
ABV: AGABI2DRAFT138566(AGABI2DRAFT_138566)
MGL: MGL_3609
DFA: DFA_02711
EHI: EHI_096750(24.t00016) EHI_159710(233.t00009)
SMIN: v1.2.010609.t1(symbB.v1.2.010609.t1) v1.2.011053.t1(symbB.v1.2.011053.t1) v1.2.011053.t2(symbB.v1.2.011053.t2) v1.2.011053.t3(symbB.v1.2.011053.t3) v1.2.014760.t1(symbB.v1.2.014760.t1)
TPS: THAPSDRAFT_412(ALAT_1) THAPS_35402(ALAT_2)
SPAR: SPRG_10592
LMA: LMJF_12_0630(ALAT)
LIF: LINJ.12.0580(ALAT)
LBZ: LBRM_12_0630(ALAT)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang RZ, Blaileanu G, Hansen BC, Shuldiner AR, Gong DW
  Title
cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase.
  Journal
Genomics 79:445-50 (2002)
DOI:10.1006/geno.2002.6722
  Sequence
[hsa:84706]

KEGG   ORTHOLOGY: K14272Help
Entry
K14272                      KO                                     

Name
GGAT
Definition
glutamate--glyoxylate aminotransferase [EC:2.6.1.4 2.6.1.2 2.6.1.44]
Pathway
ko00220  Arginine biosynthesis
ko00250  Alanine, aspartate and glutamate metabolism
ko00260  Glycine, serine and threonine metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko00710  Carbon fixation in photosynthetic organisms
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
M00532  Photorespiration
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K14272  GGAT; glutamate--glyoxylate aminotransferase
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K14272  GGAT; glutamate--glyoxylate aminotransferase
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K14272  GGAT; glutamate--glyoxylate aminotransferase
   00260 Glycine, serine and threonine metabolism
    K14272  GGAT; glutamate--glyoxylate aminotransferase
   00220 Arginine biosynthesis
    K14272  GGAT; glutamate--glyoxylate aminotransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K14272  GGAT; glutamate--glyoxylate aminotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.2  alanine transaminase
     K14272  GGAT; glutamate--glyoxylate aminotransferase
    2.6.1.4  glycine transaminase
     K14272  GGAT; glutamate--glyoxylate aminotransferase
    2.6.1.44  alanine---glyoxylate transaminase
     K14272  GGAT; glutamate--glyoxylate aminotransferase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class I
   K14272  GGAT; glutamate--glyoxylate aminotransferase
BRITE hierarchy
Other DBs
RN: R00258 R00369 R00372
GO: 0047958 0004021 0008453
Genes
ATH: AT1G23310(GGT1) AT1G70580(AOAT2)
ALY: ARALYDRAFT_472589(GGT1) ARALYDRAFT_894873(AOAT2)
CRB: 17895448 17897757
CSAT: 104701699 104712607 104741047 104750897 104756699 104776459
EUS: EUTSA_v10007514mg EUTSA_v10018474mg
BRP: 103829276 103831592 103835672 103840779
BNA: 106356016 106358129 106390498 106406022 106415204 106434229 106440992 111207231
BOE: 106295814 106296220 106312468
THJ: 104822983
CPAP: 110817151
CIT: 102611899
TCC: 18609536
GRA: 105794627
GHI: 107909695
GAB: 108473496
EGR: 104414150
GMX: 100127414(ALAAT2) 100787173
VRA: 106777621
VAR: 108329166
CCAJ: 109800924
CAM: 101508288
LJA: Lj2g3v1415440.1(Lj2g3v1415440.1) Lj2g3v1415440.2(Lj2g3v1415440.2) Lj2g3v1415440.3(Lj2g3v1415440.3)
ADU: 107488817
AIP: 107643316
FVE: 101304831
PPER: 18788891
PMUM: 103321858
PAVI: 110760503
PXB: 103949832
ZJU: 107428611
RCU: 8273496
JCU: 105644652
QSU: 112010088
VVI: 100261274
INI: 109172057
HAN: 110871636
LSV: 111882299
CCAV: 112524428
BVG: 104897276
SOE: 110799230
OSA: 4342210
DOSA: Os07t0108300-01(Os07g0108300)
OBR: 102712276
BDI: 100844005
ATS: 109734653(LOC109734653)
SBI: 110432565
SITA: 101767913
PDA: 103707141
DCT: 110110983
PEQ: 110023535
AOF: 109833434
ATR: 18430615
CRE: CHLREDRAFT_206184(AAT1)
APRO: F751_3918
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3933486
  Authors
Takada Y, Noguchi T
  Title
Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.
  Journal
Biochem J 231:157-63 (1985)
DOI:10.1042/bj2310157
Reference
  Authors
Foyer CH, Bloom AJ, Queval G, Noctor G
  Title
Photorespiratory metabolism: genes, mutants, energetics, and redox signaling.
  Journal
Annu Rev Plant Biol 60:455-84 (2009)
DOI:10.1146/annurev.arplant.043008.091948
Reference
  Authors
Liepman AH, Olsen LJ
  Title
Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis.
  Journal
Plant Physiol 131:215-27 (2003)
DOI:10.1104/pp.011460
  Sequence

KEGG   REACTION: R00258Help
Entry
R00258                      Reaction                               

Name
L-Alanine:2-oxoglutarate aminotransferase
Definition
L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026
RC00008  C00022_C00041
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn00250  Alanine, aspartate and glutamate metabolism
rn00710  Carbon fixation in photosynthetic organisms
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Orthology
K00814  alanine transaminase [EC:2.6.1.2]
K14260  alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
K14272  glutamate--glyoxylate aminotransferase [EC:2.6.1.4 2.6.1.2 2.6.1.44]
Other DBs
RHEA: 19456

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