| Entry |
|
|---|
| Name |
D-amino-acid transaminase;
D-aspartate transaminase;
D-alanine aminotransferase;
D-aspartic aminotransferase;
D-alanine-D-glutamate transaminase;
D-alanine transaminase;
D-amino acid aminotransferase
|
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
|
|---|
| Sysname |
D-alanine:2-oxoglutarate aminotransferase
|
|---|
| Reaction(IUBMB) |
D-alanine + 2-oxoglutarate = pyruvate + D-glutamate [RN: R01148]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
A pyridoxal-phosphate protein. The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. The enzyme from some other sources has a broader specificity [6].
|
|---|
| History |
EC 2.6.1.21 created 1972 (EC 2.6.1.10 created 1961, incorporated 1972), modified 2005
|
|---|
| Pathway |
| ec00330 | Arginine and proline metabolism |
| ec00472 | D-Arginine and D-ornithine metabolism |
|
|---|
| Orthology |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
THORNE CB, GOMEZ CG, HOUSEWRIGHT RD. |
|---|
| Title |
Transamination of D-amino acids by Bacillus subtilis. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
THORNE CB, MOLNAR DM. |
|---|
| Title |
D-Amino acid transamination in bacillus anthracis. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Martinez-Carrion M, Jenkins WT. |
|---|
| Title |
D-Alanine-D-glutamate transaminase. I. Purification and characterization. |
|---|
| Journal |
J Biol Chem 240:3538-46 (1965) |
|---|
| Reference |
|
|---|
| Authors |
Ogawa T, Fukuda M, Sasaoka K. |
|---|
| Title |
Occurrence of D-amino acid aminotransferase in pea seedlings. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Yonaha K, Misono H, Yamamoto T, Soda K. |
|---|
| Title |
D-amino acid aminotransferase of Bacillus sphaericus. Enzymologic and spectrometric properties. |
|---|
| Journal |
J Biol Chem 250:6983-9 (1975) |
|---|
| Reference |
|
|---|
| Authors |
Tanizawa K, Masu Y, Asano S, Tanaka H, Soda K |
|---|
| Title |
Thermostable D-amino acid aminotransferase from a thermophilic Bacillus species. Purification, characterization, and active site sequence determination. |
|---|
| Journal |
J Biol Chem 264:2445-9 (1989) |
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Fotheringham IG, Bledig SA, Taylor PP |
|---|
| Title |
Characterization of the genes encoding D-amino acid transaminase and glutamate racemase, two D-glutamate biosynthetic enzymes of Bacillus sphaericus ATCC 10208. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
van Ophem PW, Erickson SD, Martinez del Pozo A, Haller I, Chait BT, Yoshimura T, Soda K, Ringe D, Petsko G, Manning JM. |
|---|
| Title |
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Sugio S, Petsko GA, Manning JM, Soda K, Ringe D |
|---|
| Title |
Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.21 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.21 |
|
|---|
