KEGG ORTHOLOGY: K00888

ORTHOLOGY: K00888

Entry

K00888 KO

Name

PI4KA

Definition

phosphatidylinositol 4-kinase A [EC:2.7.1.67]

Pathway

ko00562

Inositol phosphate metabolism

ko01100

Metabolic pathways

ko04011

MAPK signaling pathway - yeast

ko04070

Phosphatidylinositol signaling system

Module

M00130

Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

Disease

H00271

Polymicrogyria

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00888  PI4KA; phosphatidylinositol 4-kinase A
09130 Environmental Information Processing
  09132 Signal transduction
   04011 MAPK signaling pathway - yeast
    K00888  PI4KA; phosphatidylinositol 4-kinase A
   04070 Phosphatidylinositol signaling system
    K00888  PI4KA; phosphatidylinositol 4-kinase A
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00888  PI4KA; phosphatidylinositol 4-kinase A
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.67  1-phosphatidylinositol 4-kinase
     K00888  PI4KA; phosphatidylinositol 4-kinase A
Membrane trafficking [BR:ko04131]
Endocytosis
  Others
   EFR3-PI4KIII alpha complex and associated proteins
    K00888  PI4KA; phosphatidylinositol 4-kinase A
Endosome - Golgi transport
  Others
   Others
    K00888  PI4KA; phosphatidylinositol 4-kinase A

Other DBs

RN:

R03361

COG:

COG5032

GO:

0004430

Genes

HSA:	5297(PI4KA)

PTR:	458675 470256(PI4KA)

GGO:	101134596 101153974(PI4KA)

PON:	100447096(PI4KA)

NLE:	100596626(PI4KA)

MCC:	698020(PI4KA)

MCF:	102121085(PI4KA)

CSAB:

103222953(PI4KA)

RRO:	104676908(PI4KA)

RBB:	108536081(PI4KA)

CJC:	100390564(PI4KA)

SBQ:	101050412(PI4KA)

MMU:	224020(Pi4ka)

MCAL:

110312019(Pi4ka)

MPAH:

110329476(Pi4ka)

RNO:	64161(Pi4ka)

MUN:	110559214(Pi4ka)

CGE:	100756055(Pi4ka)

NGI:	103741456(Pi4ka)

HGL:	101707981(Pi4ka)

CCAN:

109684374(Pi4ka)

OCU:	100343247(PI4KA)

TUP:	102492744(PI4KA)

CFA:	486443(PI4KA)

VVP:	112907441(PI4KA)

AML:	100467109(PI4KA)

UMR:	103669225(PI4KA)

UAH:	113247022(PI4KA)

ORO:	101369814(PI4KA)

ELK:

111142396

FCA:	101085579(PI4KA)

PTG:	102957817(PI4KA)

PPAD:

109259693(PI4KA)

AJU:	106989989(PI4KA)

BTA:	282309(PI4KA)

BOM:	102277312(PI4KA)

BIU:	109570976(PI4KA)

BBUB:

102391131(PI4KA)

CHX:	102182123(PI4KA)

OAS:	101117020(PI4KA)

SSC:	100157143(PI4KA)

CFR:	102516828(PI4KA)

CDK:	105095293(PI4KA)

BACU:

102997877(PI4KA)

LVE:	103090987(PI4KA)

OOR:	101271039(PI4KA)

DLE:	111162996(PI4KA)

PCAD:

102988352

ECB:	100057017(PI4KA)

EPZ:	103564912(PI4KA)

EAI:	106848276(PI4KA)

MYB:	102248357(PI4KA)

MYD:	102767888(PI4KA)

MNA:	107530543(PI4KA)

HAI:	109394871(PI4KA)

DRO:	112301661(PI4KA)

PALE:

102894886(PI4KA)

RAY:	107497831(PI4KA)

MJV:	108408978(PI4KA)

LAV:	100662889(PI4KA)

TMU:

101356498

MDO:	100027724(PI4KA)

SHR:	100915577(PI4KA)

PCW:	110215149(PI4KA)

OAA:	103167364(PI4KA)

GGA:	416767(PI4KA)

MGP:	100542492(PI4KA)

CJO:	107321047(PI4KA)

NMEL:

110406446(PI4KA)

APLA:

101797721(PI4KA)

ACYG:

106031273(PI4KA)

TGU:	100232416(PI4KA)

LSR:	110481346(PI4KA)

SCAN:

103818272(PI4KA)

GFR:	102044515(PI4KA)

FAB:	101813375(PI4KA)

PHI:	102104215(PI4KA)

PMAJ:

107211581(PI4KA)

CCAE:

111936547(PI4KA)

CCW:	104688603(PI4KA)

ETL:	114061545(PI4KA)

FPG:	101913652(PI4KA)

FCH:	102049439(PI4KA)

CLV:	102083461(PI4KA)

EGZ:	104128945(PI4KA)

NNI:	104009712(PI4KA)

ACUN:

113486159(PI4KA)

PADL:

103922592(PI4KA)

AAM:	106486856(PI4KA)

ASN:	102387430(PI4KA)

AMJ:	102576514(PI4KA)

PSS:	102455675(PI4KA)

CMY:	102941020(PI4KA)

CPIC:

101932464(PI4KA)

ACS:	100554829(pi4ka)

PVT:	110070013(PI4KA)

PBI:	103052390(PI4KA)

PMUR:

107293333(PI4KA) 107300082

TSR:

106539420

PMUA:

114586782(PI4KA)

GJA:	107108780(PI4KA)

XLA:	108716048(pi4ka.L) 446720(pi4ka.S)

XTR:	100127709(pi4ka)

NPR:	108794890(PI4KA)

DRE:	556956(pi4kaa)

SRX:	107706738 107722847 107751806

SANH:

107671001 107698013 107704152

SGH:	107548966(pi4ka) 107559589 107574565 107602220

CCAR:

109110290

IPU:	108277005(pi4ka)

PHYP:

113544787(pi4ka)

AMEX:

103023490 103037259

EEE:	113573309 113584921(pi4ka)

TRU:	101069738 101074153

TNG:	GSTEN00025301G001 GSTEN00028634G001

LCO:	104921671(pi4ka) 104934931

NCC:	104948040 104962151

MZE:	101469810(pi4ka) 101479673

ONL:	100696465(pi4ka) 100710076

OLA:	101154784 101163184

XMA:	102222999 102234647

XCO:	114149407 114154527

PRET:

103470015(pi4ka) 103473227

CVG:	107086063 107089679(pi4ka)

NFU:	107394266 107395697

KMR:	108233728(pi4kab) 108248904(pi4kaa)

ALIM:

106519864(pi4ka)

AOCE:

111577293(pi4ka) 111583378

CSEM:

103389979 103397756(pi4ka)

POV:	109626422 109637086(pi4ka)

LCF:

108897568

SDU:	111217823 111236491

SLAL:

111665970(pi4ka) 111666009

HCQ:	109507158 109526360

BPEC:

110156446(pi4ka) 110172322

MALB:

109952176 109956549(pi4ka)

SASA:

106562720(pi4ka) 106568269 106568281

OTW:	112219586 112237001 112257265

SALP:

111962827 111980689

ELS:	105006710(pi4ka) 105031134

SFM:	108920159(pi4ka) 108934629

PKI:	111842230 111854359(pi4ka)

LCM:	102352737(PI4KA)

CMK:	103184004(pi4ka)

RTP:	109934095(pi4ka)

BFO:

118409646

CIN:

100178675

SPU:	105445366 590935

APLC:

110989424

SKO:

100369572

DME:	Dmel_CG10260(Pi4KIIIalpha)

DER:

6555517

DSE:

6616170

DSI:	Dsimw501_GD16613(Dsim_GD16613)

DYA:	Dyak_GE16267

DAN:

6504900

DSR:

110182586

DPO:	Dpse_GA10199

DPE:

6599997

DMN:

108161252

DWI:

6648993

DGR:	Dgri_GH24853

DMO:	Dmoj_GI14401

DAZ:

108617904

DNV:

108655530

DHE:	111594253 115483038

DVI:

6632208

MDE:

101893906

LCQ:

111682271

AGA:	AgaP_AGAP010801

AAG:

5570029

AALB:

109405134

CQU:	CpipJ_CPIJ000714

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_207018

PMAC:

106714602

PRAP:

110993222

HAW:

110381986

TNL:	113493356 113506898

PXY:	105380525 105389419 105397423

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM607950

ZNE:

110839531

FCD:

110856659

DPX:	DAPPUDRAFT_324239

PVM:

113827251

ISC:	IscW_ISCW015061 IscW_ISCW020487

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_Y75B8A.24(Y75B8A.24)

CBR:

CBG03566

BMY:	Bm1_45855 Bm1_45860

LOA:	LOAG_18436

NAI:	NECAME_14035

TSP:

Tsp_09850

HRO:	HELRODRAFT_117066 HELRODRAFT_194993

LGI:	LOTGIDRAFT_103639

PCAN:

CRG:

MYI:

OBI:

LAK:	106156926 106157120

SMM:	Smp_150660

SHX:

MS3_00289

OVI:	T265_00423

EGL:

EGR_00138

NVE:	5497471 5514424

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_55997

AQU:	100633148 100636334

ATH:	AT1G49340(ATPI4K_ALPHA) AT1G51040

ALY:	9298647 9315361 9327554

CRB:	17898766 17899870

CSAT:

104743982 104744044 104758235 104758398 104779238

EUS:	EUTSA_v10011177mg EUTSA_v10012090mg

BRP:	103868655 103871306 103871413

BNA:	106346077 106346120 106380477 106405786 106419705 106422893 111215628

BOE:	106294640 106300024

RSZ:	108805592 108861992 108862007

THJ:

104804915

CPAP:

110813711

CIT:

102615841

CIC:	CICLE_v10027664mg

TCC:

18608152

GRA:	105779501 105795146

GHI:	107886983 107898766 107940998 107945169

GAB:	108460211 108474856

DZI:	111295616 111309048

EGR:

104452643

GMX:	100777069 100796422

GSJ:	114408477 114414496

PVU:	PHAVU_009G009000g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_3g116250

CAM:

101497866

LJA:	Lj1g3v3404520.1(Lj1g3v3404520.1) Lj1g3v3404520.2(Lj1g3v3404520.2)

ADU:

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:	103423285 103424996

PXB:	103963120 103964599

ZJU:

107404942

CSV:	101214424 101215702

CMO:	103489597 103497500

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:	7464043 7469982

PEU:	105134735 105142712

JRE:

109003302

QSU:	112002745 112009685 112020831

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107774007 107820741

NSY:	104220606 104243045

NTO:	104096321 104099078 104117891

NAU:	109223550 109227085

INI:	109161924 109191348

SIND:

105169619 105172874

OEU:

111394608

HAN:	110872288 110886075

LSV:	111918227 111920216

CCAV:

DCR:

BVG:

SOE:

CQI:	110698493 110705057

NNU:	104596308 104608021

PSOM:

113276378 113343697

OSA:

4333883

DOSA:

Os03t0711200-01(Os03g0711200)

OBR:

102712902

BDI:

100834445

ATS:	109741919(LOC109741919)

SBI:

ZMA:

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_181608 SELMODRAFT_92319

PPP:	112274816 112282552

CRE:	CHLREDRAFT_113185(PIK1)

MNG:	MNEG_13675

CSL:	COCSUDRAFT_19170

CVR:	CHLNCDRAFT_134867

SCE:	YLR305C(STT4)

AGO:	AGOS_ADL033W

ERC:

Ecym_8369

KLA:	KLLA0_C17292g

KMX:	KLMA_30314(STT4)

LTH:	KLTH0D03608g

VPO:	Kpol_414p3

ZRO:	ZYRO0G19888g

CGR:	CAGL0D06446g

NCS:	NCAS_0A05930(NCAS0A05930)

NDI:	NDAI_0D02900(NDAI0D02900)

TPF:	TPHA_0F00400(TPHA0F00400)

TBL:	TBLA_0B09950(TBLA0B09950)

TDL:	TDEL_0E05570(TDEL0E05570)

KAF:	KAFR_0F03050(KAFR0F03050)

ZMK:	HG535_0E05770

PPA:	PAS_chr1-3_0100

DHA:	DEHA2E03982g

PIC:	PICST_79239(STT4)

PGU:	PGUG_03472

SPAA:

SPAPADRAFT_133766

LEL:	LELG_03301

CAL:	CAALFM_CR07090WA(STT4)

CTP:	CTRG_03116

COT:	CORT_0D04400

CDU:	CD36_32670

CTEN:

CANTEDRAFT_105409

YLI:	YALI0E28153g

CLU:	CLUG_01498 CLUG_01499

CLUS:

A9F13_06g03168

CAUR:

CJI97_000474

SLB:	AWJ20_2342(STT4)

PKZ:	C5L36_0D06370

BNN:	FOA43_004017

NCR:	NCU09367(stt4)

NTE:	NEUTE1DRAFT150315(NEUTE1DRAFT_150315)

SMP:	SMAC_04234(putative stt4)

PAN:	PODANSg2129

TTT:	THITE_2113187

MTM:	MYCTH_2296575

CTHR:

CTHT_0010250

MGR:

MGG_13790

TMN:	UCRPA7_7618

SSCK:

SPSK_08270

FGR:	FGSG_01161

FPU:	FPSE_02590

FVR:	FVEG_01286

FOX:	FOXG_00230

NHE:	NECHADRAFT_74607

TRE:	TRIREDRAFT_63347

TRR:	M419DRAFT_81388

MAW:

MAC_04214

MAJ:

MAA_04017

CMT:

CCM_06818

PLJ:	VFPFJ_03475

VAL:	VDBG_05143

VDA:	VDAG_08800

CFJ:	CFIO01_07316

SAPO:

SAPIO_CDS5063

ELA:	UCREL1_5356

PFY:	PFICI_00332

SSL:	SS1G_12900

BFU:	BCIN_01g09500(Bcstt4)

MBE:

MBM_06225

PSCO:

LY89DRAFT_777530

GLZ:	GLAREA_00447

ANI:

AN4278.2

AFM:	AFUA_7G03760

ACT:	ACLA_005440

NFI:	NFIA_024710

AOR:	AO090026000840

ANG:	ANI_1_522114(An13g00110)

AFV:	AFLA_131170

PCS:	Pc20g09090

PDP:	PDIP_01840

TMF:	PMAA_069490

TRG:	TRUGW13939_09661

CIM:	CIMG_07471

CPW:	CPC735_044390

PBL:	PAAG_00825

PBN:	PADG_04005

URE:	UREG_07802

ABE:

ARB_00948

TVE:

TRV_00736

AJE:	HCAG_04050

BGH:	BDBG_01676

PNO:	SNOG_03928

PTE:

PTT_17123

BZE:	COCCADRAFT_5510

BSC:	COCSADRAFT_121880

BOR:	COCMIDRAFT_9675

AALT:

CC77DRAFT_1094373

ZTR:	MYCGRDRAFT_86708(MgStt4)

PFJ:	MYCFIDRAFT_204445

BCOM:

BAUCODRAFT_80102

NPA:	UCRNP2_2120

TML:	GSTUM_00011954001

SPO:	SPBC577.06c(stt4)

CNE:

CNI02140

CNB:

CNBH2020

CGI:	CGB_H3170W

TMS:	TREMEDRAFT_58152

TASA:

A1Q1_03010

TVS:	TRAVEDRAFT_145526

DSQ:	DICSQDRAFT_177519

PCO:	PHACADRAFT_255820

SHS:	STEHIDRAFT_51428

HIR:	HETIRDRAFT_60199

PSQ:	PUNSTDRAFT_71064

ADL:	AURDEDRAFT_97227

FME:	FOMMEDRAFT_134792

GTR:	GLOTRDRAFT_114478

LBC:	LACBIDRAFT_187897

MRR:	Moror_8384

CCI:	CC1G_13883

SCM:	SCHCODRAFT_52048

ABP:	AGABI1DRAFT117967(AGABI1DRAFT_117967)

ABV:	AGABI2DRAFT64231(AGABI2DRAFT_64231)

CPUT:

CONPUDRAFT_117099

SLA:	SERLADRAFT_452259

WSE:	WALSEDRAFT_18505

WIC:	J056_004827

UMA:	UMAG_06103

PFP:	PFL1_02097

MGL:	MGL_2126 MGL_3767

MRT:

MRET_0571

MSYM:

MSY001_1862

PGR:	PGTG_08672

MLR:	MELLADRAFT_42408

ECU:	ECU11_0450

EIN:	Eint_110300

EHE:	EHEL_110310

ERO:	EROM_110300

MBR:	MONBRDRAFT_169

SRE:	PTSG_05114

DDI:	DDB_G0277537

DPP:	DICPUDRAFT_158137

DFA:

DFA_08772

EHI:	EHI_148700(1.t00083)

EDI:	EDI_333940

EIV:	EIN_224370

PYO:	PY17X_0722000

PCB:	PCHAS_073100(PC402561.00.0)

PBE:	PBANKA_0722000

PKN:	PKH_052430

PVX:	PVX_090085

PCY:	PCYB_053420

TAN:

TA08175

TPV:

TP04_0387

TOT:	TOT_040000576

BEQ:	BEWA_005900

BBO:	BBOV_II002790(18.m06228)

BMIC:

BMR1_03g02605

CPV:

cgd6_3390

CHO:	Chro.60392

TET:	TTHERM_00554370

PTM:	GSPATT00029485001

PTI:	PHATRDRAFT_17109 PHATRDRAFT_21501

TPS:	THAPSDRAFT_260874 THAPS_29000

TBR:	Tb927.3.4020

TBG:	TbgDal_III4410

TCR:

510003.30

LMA:	LMJF_29_1450

LIF:	LINJ_29_1550

LDO:	LDBPK_291550

LMI:	LMXM_08_29_1450

LBZ:	LBRM_29_1540

LPAN:

LPMP_291500

NGR:	NAEGRDRAFT_75556

TVA:	TVAG_161620 TVAG_236630

GLA:	GL50803_0016558

» show all

Reference

PMID:25886792

Authors

Bryant KL, Baird B, Holowka D

Title

A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIalpha is important for protein trafficking from the endoplasmic reticulum to the plasma membrane.

Journal

BMC Cell Biol 16:5 (2015)
DOI:10.1186/s12860-015-0049-5

Sequence

[hsa:5297]

Reference

PMID:8288577

Authors

Yoshida S, Ohya Y, Goebl M, Nakano A, Anraku Y

Title

A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae.

Journal

J Biol Chem 269:1166-72 (1994)