KEGG   ORTHOLOGY: K00907
Entry
K00907                      KO                                     

Name
MYLK
Definition
myosin-light-chain kinase [EC:2.7.11.18]
Pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04510  Focal adhesion
ko04611  Platelet activation
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko04971  Gastric acid secretion
Disease
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
   04020 Calcium signaling pathway
    K00907  MYLK; myosin-light-chain kinase
   04022 cGMP-PKG signaling pathway
    K00907  MYLK; myosin-light-chain kinase
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K00907  MYLK; myosin-light-chain kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00907  MYLK; myosin-light-chain kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K00907  MYLK; myosin-light-chain kinase
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K00907  MYLK; myosin-light-chain kinase
  09154 Digestive system
   04971 Gastric acid secretion
    K00907  MYLK; myosin-light-chain kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K00907  MYLK; myosin-light-chain kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     K00907  MYLK; myosin-light-chain kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MLCK family
   K00907  MYLK; myosin-light-chain kinase
Other DBs
GO: 0004687
Genes
HSA: 340156(MYLK4) 4638(MYLK) 85366(MYLK2) 91807(MYLK3)
PTR: 101057233(MYLK) 465143(MYLK3) 471840(MYLK4) 742591(MYLK2)
PPS: 100974667(MYLK3) 100978891(MYLK2) 100979422(MYLK) 100995666(MYLK4)
GGO: 101142619(MYLK3) 101143745(MYLK2) 101151517(MYLK) 101151667(MYLK4)
PON: 100171951(MYLK3) 100444714(MYLK4) 100452913(MYLK) 100453783(MYLK2)
NLE: 100585981(MYLK2) 100591151(MYLK) 100594745(MYLK4) 100604194 115831086(MYLK3)
MCC: 707361(MYLK4) 712830(MYLK2) 715422(MYLK) 716132(MYLK3)
MCF: 102122026(MYLK4) 102130711(MYLK) 102132754(MYLK3) 102145766(MYLK2)
CSAB: 103222295(MYLK4) 103228167(MYLK) 103232215(MYLK3) 103248051(MYLK2)
RRO: 104653717(MYLK2) 104655407(MYLK) 104655430(MYLK3) 104661238(MYLK4)
RBB: 108514260(MYLK4) 108517416(MYLK) 108524142(MYLK2) 108534775(MYLK3)
CJC: 100391801(MYLK2) 100392653(MYLK3) 100392656(MYLK4) 100409440(MYLK)
SBQ: 101029220(MYLK) 101038668(MYLK2) 101049056(MYLK4) 101050910(MYLK3)
MMU: 107589(Mylk) 213435(Mylk3) 228785(Mylk2) 238564(Mylk4)
MCAL: 110290127(Mylk2) 110300419(Mylk3) 110308670(Mylk4) 110311174(Mylk)
MPAH: 110319274(Mylk2) 110329346(Mylk) 110334129(Mylk4) 110337577(Mylk3)
RNO: 100911165(Mylk4) 103689985 117558(Mylk2) 288057(Mylk) 291926(Mylk3)
MUN: 110547228(Mylk) 110550095(Mylk2) 110552995(Mylk3) 110558635(Mylk4)
CGE: 100755963(Mylk2) 100756400(Mylk4) 100758406(Mylk) 100766446(Mylk3)
NGI: 103731078(Mylk2) 103737011(Mylk4) 103741992(Mylk)
HGL: 101701713(Mylk4) 101704236(Mylk) 101712444(Mylk2)
CCAN: 109677703 109691764(Mylk2) 109700226(Mylk4)
OCU: 100009051(MYLK2) 100353972(MYLK4)
TUP: 102476504(MYLK) 102489117(MYLK2) 102498032(MYLK4)
CFA: 475345(MYLK3) 477187(MYLK2) 488012(MYLK) 488190(MYLK4)
VVP: 112907401(MYLK4) 112909931(MYLK2) 112913506(MYLK) 112914947(MYLK3)
AML: 100469244(MYLK2) 100473453(MYLK4) 100474254(MYLK3) 100481263(MYLK)
UMR: 103665161(MYLK4) 103673818(MYLK3) 103674343(MYLK2) 103678824(MYLK)
UAH: 113252202(MYLK3) 113252350(MYLK) 113258196(MYLK2) 113264229(MYLK4)
ORO: 101368074(MYLK4) 101370711(MYLK3) 101378973(MYLK) 101381609(MYLK2)
ELK: 111141709 111154981 111156670 111157401
FCA: 101088408(MYLK4) 101091744(MYLK3) 101095813(MYLK2)
PTG: 102951994(MYLK2) 102962607(MYLK3) 102968305(MYLK4) 102972928(MYLK)
PPAD: 109249481(MYLK4) 109266499(MYLK) 109270987(MYLK3) 109272590(MYLK2)
AJU: 106965987(MYLK3) 106976155(MYLK4) 106984088(MYLK) 106986013(MYLK2)
BTA: 338037(MYLK) 518025(MYLK4) 526379(MYLK3) 533378(MYLK2)
BOM: 102264349(MYLK4) 102269080(MYLK) 102275601(MYLK3) 102276600(MYLK2)
BIU: 109567347(MYLK2) 109572727(MYLK3) 109577322(MYLK4)
BBUB: 102395214(MYLK3) 102402899(MYLK) 102412646(MYLK4) 102415047(MYLK2)
CHX: 102181454(MYLK4) 102181980(MYLK3) 102182147(MYLK2) 102190641(MYLK)
OAS: 101111897(MYLK2) 101113784(MYLK3) 105603910 443334(MYLK)
SSC: 100157526(MYLK4) 100524288(MYLK2) 110260971(MYLK3) 396848(MYLK)
CFR: 102505869(MYLK2) 102511426(MYLK3) 102515628(MYLK4) 102518144(MYLK)
CDK: 105086549(MYLK4) 105090282(MYLK) 105091178(MYLK3) 105100824(MYLK2)
BACU: 103005866(MYLK3) 103008421(MYLK) 103017148(MYLK2) 103020477(MYLK4)
LVE: 103077707(MYLK4) 103079981(MYLK2) 103083551(MYLK3) 103090456(MYLK)
OOR: 101275794(MYLK4) 101282343(MYLK) 101287286(MYLK3) 101289244(MYLK2)
DLE: 111165019(MYLK3) 111171109 111171669(MYLK) 111184432(MYLK2)
PCAD: 102982196(MYLK3) 102982293(MYLK2) 102982405(MYLK) 102984346(MYLK4)
ECB: 100050092(MYLK4) 100053698(MYLK2) 100056559(MYLK3) 100070482(MYLK)
EPZ: 103547465(MYLK) 103548123(MYLK4) 103559162(MYLK2)
EAI: 106823711(MYLK) 106833720(MYLK2) 106842841(MYLK4) 106848229(MYLK3)
MYB: 102259949(MYLK2) 102262704(MYLK4)
MYD: 102755283(MYLK2) 102759237(MYLK) 102765242(MYLK4)
MNA: 107527759(MYLK2) 107542256(MYLK4)
HAI: 109383050(MYLK3) 109384471(MYLK2) 109388085
DRO: 112297606(MYLK4) 112303707(MYLK2) 112320512(MYLK)
PALE: 102890778(MYLK) 102891799(MYLK2) 102894361(MYLK4)
RAY: 107512864(MYLK2) 107516607(MYLK4) 107518034(MYLK)
MJV: 108385316 108393093(MYLK2) 108396719(MYLK) 108402114(MYLK3)
LAV: 100656405(MYLK2) 100665634(MYLK4) 100677183(MYLK)
TMU: 101340959 101345850 101353011
MDO: 100015876(MYLK3) 100019648(MYLK) 100021377(MYLK4)
SHR: 100918090(MYLK4) 100925131(MYLK3)
PCW: 110196726(MYLK4) 110207445(MYLK3) 110208127(MYLK)
OAA: 100079091(MYLK4) 100091283(MYLK) 100092442(MYLK3) 114806177(MYLK2)
GGA: 396356(MYLK2) 396445(MYLK) 415748(MYLK3) 420893(MYLK4) 428278(MYLKSML)
MGP: 100538449 100542497(MYLK2) 100543918(MYLK4) 100547989(MYLK) 100551067(MYLK3) 104914090
CJO: 107309576(MYLK4) 107316813(MYLK) 107319273(MYLK3) 107323244(MYLK2) 107325036
NMEL: 110388525 110393482(MYLK4) 110400604(MYLK) 110404229(MYLK3) 110408280(MYLK2)
APLA: 101793167(MYLK3) 101799935(MYLK4) 101800032 101803931(MYLK2)
ACYG: 106029897(MYLK) 106039596(MYLK3) 106046900 106048980(MYLK4)
TGU: 100218159(MYLK2) 100222880(MYLK4) 100226590(MYLK) 100232455(MYLK3) 115490676
LSR: 110468290(MYLK) 110469015(MYLK2) 110470711(MYLK4) 110475603 110475887(MYLK3)
SCAN: 103814310(MYLK) 103816608(MYLK3) 103818174(MYLK4) 103818839(MYLK2) 103821775
GFR: 102037734(MYLK4) 102037824(MYLK2) 102038683(MYLK3) 102044716(MYLK)
FAB: 101807258(MYLK) 101807804 101809550(MYLK3) 101813259(MYLK2) 101819869(MYLK4)
PHI: 102101059 102104582(MYLK2) 102106790(MYLK) 102111091(MYLK4) 102112254(MYLK3)
PMAJ: 107207555(MYLK) 107209810(MYLK3) 107213081(MYLK2) 107213960(MYLK4) 107215054
CCAE: 111923845(MYLK4) 111932252(MYLK) 111934649(MYLK3) 111938138(MYLK2) 111940063
CCW: 104687441(MYLK3) 104687839(MYLK2) 104694020(MYLK) 104698150(MYLK4) 104698538
ETL: 114058107(MYLK) 114060388(MYLK3) 114063040(MYLK2) 114070606 114071985
FPG: 101910574 101917440(MYLK3) 101922032(MYLK2) 101922066 101922502(MYLK)
FCH: 102050025(MYLK) 102051042(MYLK2) 102051053 102058744(MYLK3)
CLV: 102088141 102093425(MYLK2) 102094050(MYLK4) 102095697(MYLK3)
EGZ: 104122823(MYLK4) 104125557(MYLK3) 104128132(MYLK) 104132337
NNI: 104011279(MYLK3) 104018366(MYLK2) 104018798(MYLK) 104018914 104021845(MYLK4)
ACUN: 113476670(MYLK4) 113482370(MYLK) 113484301(MYLK3) 113489147
PADL: 103913791(MYLK3) 103919008(MYLK4) 103919603(MYLK) 103921929
AAM: 106482002(MYLK4) 106483357(MYLK3) 106495651 106497378(MYLK2) 106499178(MYLK)
ASN: 102369318(MYLK2) 102371849(MYLK3) 102381743(MYLK) 102384108(MYLK4) 102387857
AMJ: 102557905 102561520(MYLK) 102568638(MYLK3) 102574082(MYLK4)
PSS: 102448460(MYLK4) 102458914(MYLK3) 102461616(MYLK)
CMY: 102929389 102929671 102943339(MYLK3) 102943755
CPIC: 101934934(MYLK4) 101935997(MYLK3) 101945225 101950238(MYLK2)
ACS: 100557929(mylk) 100559335(mylk3) 100562117(mylk2) 100567803(mylk4)
PVT: 110076324(MYLK3) 110083010(MYLK) 110086708(MYLK2) 110090626(MYLK4)
PBI: 103059391(MYLK3) 103060340(MYLK) 112540892
PMUR: 107284832(MYLK4) 107290115(MYLK3)
TSR: 106543664(MYLK)
PMUA: 114599828(MYLK2) 114600967(MYLK4) 114602252(MYLK3) 114603926(MYLK)
GJA: 107106205 107108885(MYLK3) 107113908(MYLK)
XLA: 108700969 108701256 108701763 108702240 108714133 108715487 108719107(mylk4.L) 108720081(mylk4.S)
XTR: 100489678(mylkl) 100497991(mylk4) 100498081(xkr7) 100498243(mylk3) 101730432(mylk)
NPR: 108785969 108787381(MYLK4) 108802964(MYLK3)
DRE: 100003770(mylk5) 449707(mylk4b) 492576(mylkb) 558685(mylk2) 561635(mylk3) 566845(mylk4a) 569510(mylka)
SRX: 107708588 107711643 107721383 107721964 107729567 107732064 107734487 107748549 107756349 107757773
SANH: 107658462 107659202 107665331 107671556(mylk4) 107671735 107671840 107674172 107688847 107690728 107701711
SGH: 107549024 107555454 107555775 107562868 107564009 107565501(mylk4) 107572770 107583040 107591027 107598691 107602975
CCAR: 109059236 109060264 109092334(mylk) 109093406 109103271 109111828 109112004
IPU: 108256285 108257896 108259589(mylk3) 108266375 108268043 108273224 108276275(mylk2)
PHYP: 113525255 113528426 113533962 113538345 113540796(mylk3) 113545325(mylk4) 113545533 113547292
AMEX: 103024505(mylk3) 103026233 103031137 103034955 103036671 103040564 103046799
EEE: 113570573 113574000 113580203 113583782 113587239 113588166 113588908(mylk3)
TRU: 101062352(mylk4) 101070888 101072200
TNG: GSTEN00016215G001 GSTEN00022034G001
LCO: 104925897 104931540 104932056 104932396 104939112(mylk)
NCC: 104941115 104943457 104959010
MZE: 101471947 101477846 101479888 101480150
ONL: 100690170 100694458 100698528(mylk4) 100704504 100704574
OLA: 101163967(mylk4) 101167024(mylk) 101171778 101171917
XMA: 102217469 102221101(mylk) 102231025 102231065(mylk4)
XCO: 114146754 114148756(mylk) 114151595(mylk4) 114160258
PRET: 103461832(mylk) 103463388 103469431 103479657 103481492
CVG: 107090039 107091785 107095545 107095655
NFU: 107378449 107383904 107393068 107395143(mylk)
KMR: 108239577 108243578(mylk4) 108243749 108251559(mylk)
ALIM: 106524197 106528162 106530234(mylk) 106533840(mylk4)
AOCE: 111568706 111573396(mylk4) 111576420
CSEM: 103392366(mylk) 103393163 103396270(mylk4)
POV: 109633942 109637330 109639205(mylk4)
LCF: 108879600 108883405 108895282 108901089 108901722
SDU: 111217682 111227561 111230430 111231110
SLAL: 111647650(mylk) 111660594 111661096 111671734
HCQ: 109513812 109517037(mylk) 109521191 109525485
BPEC: 110158772(mylk) 110159535 110167799 110172296(mylk4)
MALB: 109957741 109961257(mylk4) 109964253 109970425(mylk)
SASA: 106566930 106584199 106586160 106587297 106599743 106601032 106607302
OTW: 112222068 112225163 112225996 112226830 112234141 112235615 112246651 112249079 112250079
SALP: 111969255 111971173 111974136 111976280 111979255 111980444 111980481
ELS: 105013359 105013822 105019245 105026354(mylk3) 105026404 109614625(mylk)
SFM: 108926394 108928141 108929005 108937818(mylk3) 108939199(mylk4) 108941557 108942076
PKI: 111839803(mylk2) 111847736(mylk3) 111850056 111854340 111856005 111858342
LCM: 102346967(MYLK3) 102352251
CMK: 103176059(mylk3) 103176418(mylk) 103188646
RTP: 109910570 109928019 109934886(mylk3)
BFO: 118405515 118405516 118405520 118405888 118414661
CIN: 100176083 100177233
SPU: 581963
APLC: 110985015
SKO: 100313660
DME: Dmel_CG42347(sqa)
DPO: Dpse_GA30457
DMN: 108159863 117193338
AGA: AgaP_AGAP006746
AAG: 5566696
AALB: 109425849
CQU: CpipJ_CPIJ005740 CpipJ_CPIJ012235
AME: 413190
BIM: 100741566
BTER: 100649174
NVI: 100118913
TCA: 659444
PRAP: 110996706
TNL: 113500367
API: 100163829
RMD: 113552034
BTAB: 109031131
CLEC: 106664694
PVM: 113830372
ISC: IscW_ISCW020494
TUT: 107363672
DPTE: 113799848
CSCU: 111630964
PTEP: 107439970
CEL: CELE_ZC373.4(mlck-1)
CBR: CBG01967
BMY: Bm1_37415
LOA: LOAG_03589
NAI: NECAME_00034
LGI: LOTGIDRAFT_235177
OBI: 106880214
LAK: 106163548
NVE: 5521343
PFA: PF3D7_1423600
PYO: PY17X_1021700
PCB: PCHAS_102060
PBE: PBANKA_1019800
PKN: PKH_132550
PVX: PVX_085300
 » show all
Reference
PMID:8810874
  Authors
Kohama K, Ye LH, Hayakawa K, Okagaki T
  Title
Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin.
  Journal
Trends Pharmacol Sci 17:284-7 (1996)
DOI:10.1016/0165-6147(96)10033-X
Reference
PMID:8575746
  Authors
Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG
  Title
The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21.
  Journal
Genomics 29:562-70 (1995)
DOI:10.1006/geno.1995.9965
  Sequence
[hsa:4638]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (18)   
   KEGG PATHWAY (18)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5578)   
   KEGG GENES (676)   
   KEGG MGENES (497)   
   RefGene (4384)   
   OC (21)   
Protein sequence (176)   
   UniProt (163)   
   SWISS-PROT (13)   
Literature (2)   
   PubMed (2)   
All databases (5780)   

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