KEGG   ORTHOLOGY: K00913
Entry
K00913                      KO                                     

Name
ITPK1
Definition
inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Module
M00132  Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00913  ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K00913  ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.134  inositol-tetrakisphosphate 1-kinase
     K00913  ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
    2.7.1.159  inositol-1,3,4-trisphosphate 5/6-kinase
     K00913  ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
Other DBs
RN: R03428 R03429 R03479
GO: 0052726 0052725 0047325
Genes
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMU: 217837(Itpk1)
MCAL: 110307175(Itpk1)
MPAH: 110324479(Itpk1)
RNO: 500709(Itpk1)
MUN: 110541472(Itpk1)
CGE: 100768438(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
VVP: 112909607(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
UAH: 113267338(ITPK1)
ORO: 101385854(ITPK1)
ELK: 111148744
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
PPAD: 109274481(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
BBUB: 102415988(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
DLE: 111176142(ITPK1)
PCAD: 102992293(ITPK1)
ECB: 100063828(ITPK1) 111770385
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1)
MNA: 107531577(ITPK1)
HAI: 109376793(ITPK1)
DRO: 112311350(ITPK1)
PALE: 102877958(ITPK1)
RAY: 107511245(ITPK1)
MJV: 108409820(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1)
PCW: 110217744(ITPK1)
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
NMEL: 110402115(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
LSR: 110476414(ITPK1)
SCAN: 103826463(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
ETL: 114060630(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
NNI: 104022228(ITPK1)
ACUN: 113480449(ITPK1)
PADL: 103923943(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1)
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
PMUR: 107295460(ITPK1)
TSR: 106549451(ITPK1)
PMUA: 114590768(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
LCO: 104927221 109142672(itpk1)
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
ONL: 100691819 100698428(itpk1)
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
XCO: 114133945(itpk1)
PRET: 103458928(itpk1)
CVG: 107099127(itpk1)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1)
ALIM: 106521176(itpk1)
AOCE: 111566021 111578952(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
SLAL: 111654242 111659818(itpk1)
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
SFM: 108919611(itpk1)
PKI: 111838846(itpk1) 111854941
LCM: 102351625(ITPK1) 102366649
CMK: 103185398(itpk1)
RTP: 109917182 109929038(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
BIM: 100740014
BTER: 100647743
CCAL: 108625595
OBB: 114880042
SOC: 105195554
MPHA: 105840617
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
VEM: 105569711
HST: 105181094
DQU: 106743443
CFO: 105250081
LHU: 105673912
PGC: 109863770
OBO: 105280103
PCF: 106784291
NVI: 100117094
CSOL: 105361542
MDL: 103578390
TCA: 660348
DPA: 109544935
ATD: 109595277
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
HAW: 110378751
TNL: 113495593
PXY: 105397344
API: 100159102
DNX: 107163234
AGS: 114125796
RMD: 113548798
BTAB: 109030649
CLEC: 106662859
ZNE: 110837839
FCD: 110844108
PVM: 113809605
DPTE: 113793158
CSCU: 111635823
PTEP: 107453142
PCAN: 112570001
CRG: 105337850
MYI: 110440574
OBI: 106874910
SHX: MS3_03232
NVE: 5508018
EPA: 110247170
AMIL: 114966681
PDAM: 113668546
SPIS: 111319149
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ATS: 109732807(LOC109732807) 109748791(LOC109748791) 109751093(LOC109751093) 109759444(LOC109759444) 109773428(LOC109773428)
ZMA: 100194132 100282774 100282992(si618046c10b) 103627151 732818(lpa2)
APRO: F751_4717
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
 » show all
Reference
PMID:8662638
  Authors
Wilson MP, Majerus PW
  Title
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
  Journal
J Biol Chem 271:11904-10 (1996)
DOI:10.1074/jbc.271.20.11904
  Sequence
[hsa:3705]
Reference
PMID:9126335
  Authors
Wilson MP, Majerus PW
  Title
Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase.
  Journal
Biochem Biophys Res Commun 232:678-81 (1997)
DOI:10.1006/bbrc.1997.6355
  Sequence
[ath:AT5G16760]

KEGG   ENZYME: 2.7.1.134
Entry
EC 2.7.1.134                Enzyme                                 

Name
inositol-tetrakisphosphate 1-kinase;
1D-myo-inositol-tetrakisphosphate 1-kinase;
inositol-trisphosphate 6-kinase;
1D-myo-inositol-trisphosphate 6-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase;
inositol-trisphosphate 5-kinase;
1D-myo-inositol-trisphosphate 5-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]
Reaction(KEGG)
R03479
Substrate
ATP [CPD:C00002];
1D-myo-inositol 3,4,5,6-tetrakisphosphate [CPD:C04520]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Comment
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.
History
EC 2.7.1.134 created 1990, (EC 2.7.1.133 created 1989, incorporated 2002; EC 2.7.1.139 created 1992, incorporated 2002), modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
Genes
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMU: 217837(Itpk1)
MCAL: 110307175(Itpk1)
MPAH: 110324479(Itpk1)
RNO: 500709(Itpk1)
MUN: 110541472(Itpk1)
CGE: 100768438(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
VVP: 112909607(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
UAH: 113267338(ITPK1)
ORO: 101385854(ITPK1)
ELK: 111148744
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
PPAD: 109274481(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
BBUB: 102415988(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
DLE: 111176142(ITPK1)
PCAD: 102992293(ITPK1)
ECB: 100063828(ITPK1) 111770385
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1)
MNA: 107531577(ITPK1)
HAI: 109376793(ITPK1)
DRO: 112311350(ITPK1)
PALE: 102877958(ITPK1)
RAY: 107511245(ITPK1)
MJV: 108409820(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1)
PCW: 110217744(ITPK1)
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
NMEL: 110402115(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
LSR: 110476414(ITPK1)
SCAN: 103826463(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
ETL: 114060630(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
NNI: 104022228(ITPK1)
ACUN: 113480449(ITPK1)
PADL: 103923943(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1)
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
PMUR: 107295460(ITPK1)
TSR: 106549451(ITPK1)
PMUA: 114590768(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
LCO: 104927221 109142672(itpk1)
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
ONL: 100691819 100698428(itpk1)
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
XCO: 114133945(itpk1)
PRET: 103458928(itpk1)
CVG: 107099127(itpk1)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1)
ALIM: 106521176(itpk1)
AOCE: 111566021 111578952(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
SLAL: 111654242 111659818(itpk1)
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
SFM: 108919611(itpk1)
PKI: 111838846(itpk1) 111854941
LCM: 102351625(ITPK1) 102366649
CMK: 103185398(itpk1)
RTP: 109917182 109929038(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
BIM: 100740014
BTER: 100647743
CCAL: 108625595
OBB: 114880042
SOC: 105195554
MPHA: 105840617
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
VEM: 105569711
HST: 105181094
DQU: 106743443
CFO: 105250081
LHU: 105673912
PGC: 109863770
OBO: 105280103
PCF: 106784291
NVI: 100117094
CSOL: 105361542
MDL: 103578390
TCA: 660348
DPA: 109544935
ATD: 109595277
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
HAW: 110378751
TNL: 113495593
PXY: 105397344
API: 100159102
DNX: 107163234
AGS: 114125796
RMD: 113548798
BTAB: 109030649
CLEC: 106662859
ZNE: 110837839
FCD: 110844108
PVM: 113809605
DPTE: 113793158
CSCU: 111635823
PTEP: 107453142
PCAN: 112570001
CRG: 105337850
MYI: 110440574
OBI: 106874910
SHX: MS3_03232
NVE: 5508018
EPA: 110247170
AMIL: 114966681
PDAM: 113668546
SPIS: 111319149
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ATS: 109732807(LOC109732807) 109748791(LOC109748791) 109751093(LOC109751093) 109759444(LOC109759444) 109773428(LOC109773428)
ZMA: 100194132 100282774 100282992(si618046c10b) 103627151 732818(lpa2)
APRO: F751_4717
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
 » show all
Reference
1  [PMID:2829850]
  Authors
Stephens LR, Hawkins PT, Morris AJ, Downes PC.
  Title
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
  Journal
Biochem J 249:283-92 (1988)
DOI:10.1042/bj2490283
Reference
2  [PMID:3497156]
  Authors
Balla T, Guillemette G, Baukal AJ, Catt KJ.
  Title
Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells.
  Journal
J Biol Chem 262:9952-5 (1987)
Reference
3  [PMID:2823793]
  Authors
Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ.
  Title
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.
  Journal
Biochem J 246:139-47 (1987)
DOI:10.1042/bj2460139
Reference
4  [PMID:2584198]
  Authors
Shears SB.
  Title
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
  Journal
J Biol Chem 264:19879-86 (1989)
Reference
5  [PMID:11042108]
  Authors
Yang X, Shears SB.
  Title
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
  Journal
Biochem J 351 Pt 3:551-5 (2000)
  Sequence
[hsa:3705]
Reference
6  [PMID:11909533]
  Authors
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB.
  Title
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
  Journal
Curr Biol 12:477-82 (2002)
DOI:10.1016/S0960-9822(02)00713-3
  Sequence
[hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.134
IUBMB Enzyme Nomenclature: 2.7.1.134
ExPASy - ENZYME nomenclature database: 2.7.1.134
BRENDA, the Enzyme Database: 2.7.1.134
CAS: 187175-98-0

KEGG   REACTION: R03479
Entry
R03479                      Reaction                               

Name
ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
Definition
ATP + 1D-myo-Inositol 3,4,5,6-tetrakisphosphate <=> ADP + 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
Equation
Reaction class
RC00002  C00002_C00008
RC00078  C01284_C04520
Enzyme
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134]
Other DBs
RHEA: 12455

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