KEGG   ORTHOLOGY: K00914
Entry
K00914                      KO                                     

Name
PIK3C3, VPS34
Definition
phosphatidylinositol 3-kinase [EC:2.7.1.137]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04145  Phagosome
ko04371  Apelin signaling pathway
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05131  Shigellosis
ko05132  Salmonella infection
ko05152  Tuberculosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   04070 Phosphatidylinositol signaling system
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   04140 Autophagy - animal
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   04138 Autophagy - yeast
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   04136 Autophagy - other
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   05014 Amyotrophic lateral sclerosis
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   05016 Huntington disease
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   05017 Spinocerebellar ataxia
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   05131 Shigellosis
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
   05152 Tuberculosis
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.137  phosphatidylinositol 3-kinase
     K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
Membrane trafficking [BR:ko04131]
 Endocytosis
  Macropinocytosis
   Kinases
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
  Rab GTPases and associated proteins
   Rab associated proteins
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
 Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab associated proteins
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
 Autophagy
  Autophagosome formation proteins
   PI3K complex
    K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase
Other DBs
RN: R03362
COG: COG5032
GO: 0016303
Genes
HSA: 5289(PIK3C3)
PTR: 455385(PIK3C3)
PPS: 100975178(PIK3C3)
GGO: 101152991(PIK3C3)
PON: 100445919(PIK3C3)
NLE: 100584840(PIK3C3)
MCC: 693918(PIK3C3)
MCF: 102136293(PIK3C3)
CSAB: 103222505(PIK3C3)
RRO: 104658709(PIK3C3)
RBB: 108537659(PIK3C3)
CJC: 100414570(PIK3C3)
SBQ: 101045444(PIK3C3)
MMU: 225326(Pik3c3)
MCAL: 110284734(Pik3c3)
MPAH: 110332837(Pik3c3)
RNO: 65052(Pik3c3)
MUN: 110546919(Pik3c3)
CGE: 100765741(Pik3c3)
NGI: 103733619(Pik3c3)
HGL: 101720820(Pik3c3)
CCAN: 109701401(Pik3c3)
OCU: 100356448(PIK3C3)
TUP: 102473351(PIK3C3)
CFA: 490477(PIK3C3)
VVP: 112918840(PIK3C3)
AML: 100465351(PIK3C3)
UMR: 103663663(PIK3C3)
UAH: 113253361(PIK3C3)
ORO: 101365381(PIK3C3)
ELK: 111142649
FCA: 101099249(PIK3C3)
PTG: 102971493(PIK3C3)
PPAD: 109276389(PIK3C3)
AJU: 106972936(PIK3C3)
BTA: 534815(PIK3C3)
BOM: 102282920(PIK3C3)
BIU: 109577642(PIK3C3)
BBUB: 102404618(PIK3C3)
CHX: 102171561(PIK3C3)
OAS: 101105709(PIK3C3)
SSC: 503700(PIK3C3)
CFR: 102503733(PIK3C3)
CDK: 105085253(PIK3C3)
BACU: 103003736(PIK3C3)
LVE: 103069584(PIK3C3)
OOR: 101273072(PIK3C3)
DLE: 111168878(PIK3C3)
PCAD: 102975170(PIK3C3)
ECB: 100053039(PIK3C3)
EPZ: 103543294
EAI: 106836928(PIK3C3)
MYB: 102257257(PIK3C3)
MYD: 102773363(PIK3C3)
MNA: 107546605(PIK3C3)
HAI: 109380396(PIK3C3)
DRO: 112322978(PIK3C3)
PALE: 102897610(PIK3C3)
RAY: 107500133(PIK3C3)
MJV: 108396919(PIK3C3)
LAV: 100675552(PIK3C3)
TMU: 101345298
MDO: 100011397(PIK3C3)
SHR: 100924620(PIK3C3)
PCW: 110207949(PIK3C3)
OAA: 100076306(PIK3C3)
GGA: 100857877(PIK3C3)
MGP: 100547298(PIK3C3)
CJO: 107305728(PIK3C3)
NMEL: 110389713(PIK3C3)
APLA: 101791899(PIK3C3)
ACYG: 106037333(PIK3C3)
TGU: 100221298(PIK3C3)
LSR: 110475063(PIK3C3)
SCAN: 103820653(PIK3C3)
GFR: 102038172(PIK3C3)
FAB: 101819120(PIK3C3)
PHI: 102104229(PIK3C3)
PMAJ: 107216245(PIK3C3)
CCAE: 111940974(PIK3C3)
CCW: 104694819(PIK3C3)
ETL: 114058250(PIK3C3)
FPG: 101923473(PIK3C3)
FCH: 102050375(PIK3C3)
CLV: 102083533(PIK3C3)
EGZ: 104134209(PIK3C3)
ACUN: 113489677(PIK3C3)
PADL: 103923250(PIK3C3)
AAM: 106489354(PIK3C3)
ASN: 102374393(PIK3C3)
AMJ: 102577320(PIK3C3)
PSS: 102445385(PIK3C3)
CMY: 102940165(PIK3C3)
CPIC: 101944037(PIK3C3)
ACS: 100552043(pik3c3)
PVT: 110091014(PIK3C3)
PBI: 103052307(PIK3C3)
PMUR: 107298510(PIK3C3)
TSR: 106542713(PIK3C3) 106554370
PMUA: 114606411(PIK3C3)
XLA: 108705528(pik3c3.S) 446671(pik3c3.L)
XTR: 100485933(pik3c3)
NPR: 108804436(PIK3C3)
DRE: 548346(pik3c3)
IPU: 108267968(pik3c3)
PHYP: 113540313(pik3c3)
AMEX: 103034827(pik3c3)
EEE: 113578319(pik3c3)
TRU: 101073179(pik3c3)
LCO: 104932921(pik3c3)
NCC: 104958187(pik3c3)
MZE: 101485817(pik3c3)
ONL: 100693616(pik3c3)
OLA: 101175027(pik3c3)
XMA: 102231703(pik3c3)
XCO: 114157271(pik3c3)
PRET: 103475962(pik3c3)
CVG: 107085215(pik3c3)
NFU: 107377258(pik3c3)
KMR: 108245939(pik3c3)
ALIM: 106529974(pik3c3)
AOCE: 111580203(pik3c3)
CSEM: 103388478(pik3c3)
POV: 109634829(pik3c3)
LCF: 108903074(pik3c3)
SDU: 111235652(pik3c3)
SLAL: 111647201(pik3c3)
HCQ: 109508399(pik3c3)
BPEC: 110171971(pik3c3)
MALB: 109971461(pik3c3)
OTW: 112214613
SALP: 111953006(pik3c3) 112073198
ELS: 105020543(pik3c3)
SFM: 108932928(pik3c3)
PKI: 111851000(pik3c3)
LCM: 102353717(PIK3C3)
CMK: 103181014(pik3c3)
BFO: 118409779
CIN: 100182163
SPU: 591736
APLC: 110987621
DME: Dmel_CG5373(Pi3K59F)
DER: 6547886
DSE: 6615739
DSI: Dsimw501_GD11777(Dsim_GD11777)
DAN: 6495908
DSR: 110181124
DPE: 6592426
DMN: 108158712
DWI: 6652137
DAZ: 108617191
DNV: 108654132
DHE: 111603830
DVI: 6626079
MDE: 101893911
LCQ: 111677355
AAG: 23687538
AALB: 109406736
AME: 725770
BIM: 100743734
BTER: 100642247
CCAL: 108632581
SOC: 105207657
MPHA: 105829108
AEC: 105150362
ACEP: 105624623
PBAR: 105432669
VEM: 105562848
HST: 105184260
DQU: 106745184
CFO: 105258094
LHU: 105678308
PGC: 109858806
OBO: 105288170
PCF: 106790430
NVI: 100119508
CSOL: 105366147
MDL: 103579842
TCA: 656409
DPA: 109546210
ATD: 109603468
NVL: 108569716
BMOR: 101743450
PMAC: 106714642
PRAP: 111001008
HAW: 110379084
TNL: 113493781
PXY: 105394691
API: 100166620
DNX: 107168045
AGS: 114123453
RMD: 113551622
BTAB: 109044022
CLEC: 106670969
ZNE: 110837047
FCD: 110849945
PVM: 113808559
TUT: 107364881
DPTE: 113789441
CSCU: 111636620
PTEP: 107450591
CEL: CELE_B0025.1(vps-34)
CBR: CBG22101(Cbr-vps-34)
BMY: Bm1_09860
TSP: Tsp_00889
PCAN: 112553563
CRG: 105334736
MYI: 110455003
OBI: 106868964
LAK: 106169742
SHX: MS3_06240
EGL: EGR_03783
NVE: 5517667
ADF: 107334220
AMIL: 114964824
PDAM: 113683608
SPIS: 111322905
DGT: 114529311
HMG: 100215627
ATH: AT1G60490(VPS34)
ALY: 9322680
CRB: 17894041
BRP: 103838506
BOE: 106319020
CPAP: 110813127
CIT: 102620738
TCC: 18609484
GRA: 105785783
GAB: 108467210
VRA: 106777832
VAR: 108335910
VUN: 114173583
CCAJ: 109798596
CAM: 101495936
LJA: Lj2g3v1414920.1(Lj2g3v1414920.1)
ADU: 107488788
AIP: 107643351
FVE: 101306129
RCN: 112196284
PPER: 18789049
PMUM: 103321780
PAVI: 110753252
ZJU: 107428711
CSV: 101210847
CMO: 103487692
MCHA: 111004800
CMAX: 111491915
CMOS: 111462695
CPEP: 111804694
RCU: 8282588
JCU: 105644608
HBR: 110641632
MESC: 110628260
POP: 7484773
PEU: 105138301
JRE: 108986778
VVI: 100263708
SLY: 101250591
SPEN: 107018245
SOT: 102588478
CANN: 107870091
NTA: 107788462 107795370(PI3K)
NSY: 104247926
NTO: 104099989
NAU: 109211788
INI: 109172080
SIND: 105178723
LSV: 111906428
CCAV: 112527528
DCR: 108223227
BVG: 104897374
SOE: 110782962
NNU: 104606043
OBR: 102711258
ATS: 109774764(LOC109774764)
SBI: 110436820
ZMA: 103653397
SITA: 101768837
MUS: 103991980
DCT: 110096521
PEQ: 110019674
AOF: 109844443
ATR: 18438846
PPP: 112288042
CRE: CHLREDRAFT_196943(VPS34)
APRO: F751_4646
SCE: YLR240W(VPS34)
ERC: Ecym_4166
KMX: KLMA_50575(VPS34)
NCS: NCAS_0C02830(NCAS0C02830)
NDI: NDAI_0G02160(NDAI0G02160)
TPF: TPHA_0C02310(TPHA0C02310)
TBL: TBLA_0H00850(TBLA0H00850)
TDL: TDEL_0F05250(TDEL0F05250)
KAF: KAFR_0H01890(KAFR0H01890)
PIC: PICST_42745(VPS34)
CAL: CAALFM_C106680WA(VPS34)
SLB: AWJ20_4460(VPS34)
NCR: NCU00656
NTE: NEUTE1DRAFT133965(NEUTE1DRAFT_133965)
SMP: SMAC_01337(putative mec1/tel1)
MGR: MGG_03069
SSCK: SPSK_05906
MAW: MAC_00820
MAJ: MAA_07417
CMT: CCM_03362
MBE: MBM_07534
ANI: AN4709.2
ANG: ANI_1_588064(An07g04820)
ABE: ARB_06637
TVE: TRV_02431
PTE: PTT_16627
SPO: SPAC458.05(pik3)
CNE: CNB03120
CNB: CNBB2580
ABP: AGABI1DRAFT75039(AGABI1DRAFT_75039)
ABV: AGABI2DRAFT218336(AGABI2DRAFT_218336)
SLA: SERLADRAFT_369876(Vsp34)
WSE: WALSEDRAFT_56006(Vps34p)
MGL: MGL_1161
MRT: MRET_2991
DDI: DDB_G0289601(pikE)
DFA: DFA_11912(pikE)
EHI: EHI_096560(6.t00051)
PCB: PCHAS_111450(PC400003.00.0)
BBO: BBOV_I002970(19.m02223)
CPV: cgd6_1760
EHX: EMIHUDRAFT_631972(VPS34-2)
 » show all
Reference
PMID:7628435
  Authors
Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD
  Title
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
  Journal
EMBO J 14:3339-48 (1995)
DOI:10.1002/j.1460-2075.1995.tb07340.x
  Sequence
[hsa:5289]

KEGG   ORTHOLOGY: K02649
Entry
K02649                      KO                                     

Name
PIK3R1_2_3
Definition
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04929  GnRH secretion
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko04960  Aldosterone-regulated sodium reabsorption
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05017  Spinocerebellar ataxia
ko05020  Prion disease
ko05100  Bacterial invasion of epithelial cells
ko05131  Shigellosis
ko05135  Yersinia infection
ko05142  Chagas disease
ko05146  Amoebiasis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H01370  SHORT syndrome
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04014 Ras signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04630 JAK-STAT signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04668 TNF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09143 Cell growth and death
   04210 Apoptosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04218 Cellular senescence
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04625 C-type lectin receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocytes
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04929 GnRH secretion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04926 Relaxin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04935 Growth hormone synthesis, secretion and action
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09156 Nervous system
   04725 Cholinergic synapse
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09158 Development and regeneration
   04360 Axon guidance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09149 Aging
   04211 Longevity regulating pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05206 MicroRNAs in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05212 Pancreatic cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05225 Hepatocellular carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05226 Gastric cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05214 Glioma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05218 Melanoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05215 Prostate cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05213 Endometrial cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05224 Breast cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05222 Small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05017 Spinocerebellar ataxia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05020 Prion disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04931 Insulin resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05135 Yersinia infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05100 Bacterial invasion of epithelial cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05170 Human immunodeficiency virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05162 Measles
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05164 Influenza A
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05161 Hepatitis B
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05160 Hepatitis C
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05168 Herpes simplex virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05163 Human cytomegalovirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05142 Chagas disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01524 Platinum drug resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01522 Endocrine resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Other DBs
RN: R03362 R04545 R05795
Genes
HSA: 5295(PIK3R1) 5296(PIK3R2) 8503(PIK3R3)
PTR: 455855(PIK3R2) 456565(PIK3R3) 461836(PIK3R1)
PPS: 100969981(PIK3R2) 100986080(PIK3R3) 100994315(PIK3R1)
GGO: 101129336(PIK3R3) 101130978(PIK3R1) 101135298(PIK3R2)
PON: 100173589(PIK3R1) 100174298(PIK3R3) 100437617(PIK3R2)
NLE: 100591270(PIK3R3) 100599301(PIK3R2) 100605788(PIK3R1)
MCC: 698996(PIK3R1) 707310(PIK3R3) 719367(PIK3R2)
MCF: 101866246(PIK3R1) 102124804(PIK3R2) 102137291(PIK3R3)
CSAB: 103222594(PIK3R1) 103224900(PIK3R3) 103234391(PIK3R2)
RRO: 104662124(PIK3R3) 104675620(PIK3R1) 104680672(PIK3R2)
RBB: 108534276(PIK3R2) 108535636(PIK3R3) 108541175(PIK3R1)
CJC: 100392639(PIK3R1) 100406689(PIK3R2) 100414659(PIK3R3)
SBQ: 101032496(PIK3R1) 101033359(PIK3R2) 101050592(PIK3R3)
MMU: 18708(Pik3r1) 18709(Pik3r2) 18710(Pik3r3)
MCAL: 110292624 110299855(Pik3r2) 110308009(Pik3r1)
MPAH: 110322865(Pik3r3) 110328811(Pik3r1) 110336420(Pik3r2)
RNO: 25513(Pik3r1) 29741(Pik3r2) 60664(Pik3r3)
MUN: 110549145(Pik3r2) 110553683(Pik3r1) 110563512(Pik3r3)
CGE: 100750761(Pik3r1) 100771181(Pik3r2) 100774067
NGI: 103726879(Pik3r2) 103730305(Pik3r3) 103738715(Pik3r1)
HGL: 101703691(Pik3r1) 101717096(Pik3r3) 101718815(Pik3r2)
CCAN: 109682432(Pik3r3) 109682554 109694666(Pik3r1)
OCU: 100345250(PIK3R3) 100357841(PIK3R1)
TUP: 102469401(PIK3R2) 102484444(PIK3R3) 102484500(PIK3R1)
CFA: 100856339(PIK3R3) 487235(PIK3R1) 609956(PIK3R2)
VVP: 112913170(PIK3R2) 112914774 112935820(PIK3R1)
AML: 100467916(PIK3R3) 100475291(PIK3R2) 100483828(PIK3R1)
UMR: 103663617(PIK3R1) 103670766(PIK3R3) 103675162(PIK3R2)
UAH: 113254730(PIK3R3) 113255266(PIK3R1) 113256705(PIK3R2)
ORO: 101370100(PIK3R1) 101371800(PIK3R2) 101374787(PIK3R3)
FCA: 100271864(PIK3R1) 101093286(PIK3R3) 101093586(PIK3R2)
PTG: 102949853(PIK3R3) 102952993(PIK3R1) 102967709(PIK3R2)
PPAD: 109247606(PIK3R2) 109266953(PIK3R3) 109275060(PIK3R1)
AJU: 106969150(PIK3R2) 106973297(PIK3R3) 106976917(PIK3R1)
BTA: 282307(PIK3R1) 282308(PIK3R2) 286865(PIK3R3)
BOM: 102266922(PIK3R1) 102280296(PIK3R3) 102286868(PIK3R2)
BIU: 109556345 109561418(PIK3R2) 109574805(PIK3R1)
BBUB: 102395384 102404517(PIK3R2) 102415109(PIK3R1)
CHX: 102170135(PIK3R2) 102179343(PIK3R3) 102188710(PIK3R1)
OAS: 101111546(PIK3R2) 101121455(PIK3R1) 101123247(PIK3R3)
SSC: 100511937 100623707(PIK3R1) 100739510(PIK3R2)
CFR: 102505690 102513205(PIK3R2) 102520923(PIK3R1)
CDK: 105084758(PIK3R1) 105092913 105101867(PIK3R2)
BACU: 103007464(PIK3R1) 103008077(PIK3R3) 103009307(PIK3R2)
LVE: 103070370(PIK3R1) 103078725(PIK3R3) 103083960(PIK3R2)
OOR: 101277568(PIK3R3) 101281352(PIK3R2) 101285437(PIK3R1)
DLE: 111166652(PIK3R2) 111175760 111185984(PIK3R1)
PCAD: 102975555(PIK3R3) 102991192(PIK3R1) 102991779(PIK3R2)
ECB: 100050227(PIK3R1) 100052122 100146348(PIK3R2)
EPZ: 103548220(PIK3R1) 103551868(PIK3R3) 103561550(PIK3R2)
EAI: 106822593(PIK3R3) 106824993(PIK3R2) 106840141(PIK3R1)
MYB: 102242302(PIK3R1) 102253405(PIK3R2) 102258430(PIK3R3)
MYD: 102753036(PIK3R1) 102760468(PIK3R3) 102763670(PIK3R2)
MNA: 107526728(PIK3R3) 107529317(PIK3R1) 107535325(PIK3R2)
HAI: 109373811(PIK3R3) 109382484(PIK3R2) 109395865(PIK3R1)
DRO: 112305224(PIK3R2) 112314466 112321016(PIK3R1)
PALE: 102879163(PIK3R1) 102879453(PIK3R2) 102891637
RAY: 107498704(PIK3R1) 107517899(PIK3R3) 107521668(PIK3R2)
MJV: 108383561(PIK3R2) 108390475(PIK3R1) 108395975(PIK3R3)
LAV: 100653731(PIK3R1) 100665045(PIK3R2) 100675496(PIK3R3)
MDO: 100019317(PIK3R1) 100032726(PIK3R2) 100616957(PIK3R3)
SHR: 100924976(PIK3R1) 100926892(PIK3R2) 100935230(PIK3R3)
PCW: 110209293(PIK3R3) 110216530(PIK3R1) 110223395(PIK3R2)
OAA: 100080187(PIK3R2) 100082075(PIK3R3) 103167126(PIK3R1)
GGA: 427171(PIK3R1) 429096(PIK3R3) 771142(PIK3R2)
CJO: 107305909(PIK3R1) 107317608 107325533(PIK3R2)
NMEL: 110388756(PIK3R2) 110389564(PIK3R1) 110402756(PIK3R3)
APLA: 101795759 101799717(PIK3R1) 101803461(PIK3R2)
ACYG: 106033049(PIK3R3) 106042106(PIK3R1) 106045000(PIK3R2)
TGU: 100221185 100223949(PIK3R1) 100226234(PIK3R2)
LSR: 110469696 110472594(PIK3R1) 110478008(PIK3R2)
SCAN: 103814989 103821918(PIK3R2) 103823133(PIK3R1) 115483908
GFR: 102032353(PIK3R1) 102035891(PIK3R2) 102039817(PIK3R3)
FAB: 101811808(PIK3R2) 101812251(PIK3R3) 101820843(PIK3R1)
PHI: 102106897(PIK3R2) 102112482(PIK3R3) 102114750(PIK3R1)
PMAJ: 107208273(PIK3R3) 107215603(PIK3R2) 107216262(PIK3R1)
CCAE: 111933104(PIK3R3) 111940405(PIK3R2) 111941370(PIK3R1)
CCW: 104686712(PIK3R1) 104695234(PIK3R3) 104696977(PIK3R2)
FPG: 101913266(PIK3R3) 101915242(PIK3R2) 101924523(PIK3R1)
FCH: 102056135(PIK3R1) 102057083(PIK3R2) 102059517
CLV: 102084272(PIK3R3) 102084904(PIK3R2) 102092838(PIK3R1)
EGZ: 104124880(PIK3R1) 104126253(PIK3R3) 104135641(PIK3R2)
NNI: 104015409(PIK3R3) 104018715(PIK3R2)
ACUN: 113483193 113489298(PIK3R2) 113489600(PIK3R1)
PADL: 103919124(PIK3R3) 103919717(PIK3R1) 103926435(PIK3R2)
AAM: 106485939(PIK3R3) 106495610(PIK3R2) 106499441(PIK3R1)
ASN: 102377899(PIK3R2) 102380057 102382060(PIK3R1)
AMJ: 102567863(PIK3R2) 102570922(PIK3R1) 106737141(PIK3R3)
PSS: 102449585(PIK3R1) 102457516
CMY: 102933845(PIK3R2) 102941819(PIK3R3) 102945631(PIK3R1)
CPIC: 101945673(PIK3R2) 101947423(PIK3R3) 101953817(PIK3R1)
ACS: 100554618(pik3r3) 100555182(pik3r2) 100556883(pik3r1)
PVT: 110072561(PIK3R2) 110073778(PIK3R3) 110073951(PIK3R1)
PBI: 103055280(PIK3R2) 103065132 103065975(PIK3R1)
PMUR: 107282273(PIK3R2) 107283596 107286152(PIK3R1)
TSR: 106538977(PIK3R1) 106543200(PIK3R3) 106552169
PMUA: 114588236(PIK3R2) 114599062 114606162(PIK3R1)
GJA: 107108905(PIK3R1) 107119473(PIK3R3) 107121678(PIK3R2)
XLA: 108706884 108713027 399202(pik3r1.L) 443964(pik3r1.S) 446786(pik3r2) 447594(pik3r3.L)
XTR: 100486835(pik3r1) 100497001(pik3r2) 549983(pik3r3)
NPR: 108789013(PIK3R2) 108797628(PIK3R1) 108802963
DRE: 100000252(pik3r3b) 404211(pik3r2) 557176(pik3r1)
IPU: 108260231(pik3r1) 108272037(pik3r3)
PHYP: 113531632(pik3r1) 113538265
AMEX: 103029972(pik3r3) 103035767 103046618(pik3r1) 111190801
PRET: 103463201(pik3r3) 103463319 103470780 103473324(pik3r1) 103478998 103479173(pik3r2)
MALB: 109957384 109965201(pik3r3) 109966856 109969301(pik3r2) 109969763(pik3r1) 109970672
PKI: 111834821(pik3r3) 111835615(pik3r1) 111847640 111856594 111860386(pik3r2)
LCM: 102348007(PIK3R3) 102353218(PIK3R1)
CMK: 103177781(pik3r1) 103182064(pik3r2) 103182762(pik3r3)
BFO: 118432571
CIN: 100184893
SPU: 588766
APLC: 110977729
SKO: 100372481
DME: Dmel_CG2699(Pi3K21B)
DER: 6543312
DSE: 6621105
DSI: Dsimw501_GD23016(Dsim_GD23016)
DSR: 110187562
DPE: 6593764
DMN: 108163765
DWI: 6651829
DAZ: 108609449
DNV: 108650034
DHE: 111602464
DVI: 6628686
MDE: 101896300
LCQ: 111686430
AAG: 5578257
AALB: 109409609
AME: 408577
BIM: 100743083
BTER: 100643962
CCAL: 108629871
OBB: 114871807
SOC: 105195470
MPHA: 105831984
AEC: 105151922
ACEP: 105620878
PBAR: 105430848
VEM: 105567561
HST: 105192434
DQU: 106748226
CFO: 105255336
LHU: 105667777
PGC: 109854747
OBO: 105284404
PCF: 106792271
NVI: 100122747
CSOL: 105361583
MDL: 103580680
TCA: 100141888
DPA: 109540864
ATD: 109595073
NVL: 108559788
BMOR: 100158253(Pi3k60)
BMAN: 114245941
PMAC: 106714800
PRAP: 110992252
HAW: 110370679
TNL: 113497575
PXY: 105388447
AGS: 114129704
RMD: 113553291
BTAB: 109032766
CLEC: 106664096
FCD: 110845224
PVM: 113810630
DPTE: 113798240
CEL: CELE_Y110A7A.10(aap-1)
CBR: CBG10815(Cbr-aap-1)
BMY: Bm1_37505
TSP: Tsp_02388
CRG: 105321629
OBI: 106879157
SHX: MS3_06277
EGL: EGR_06563
NVE: 5520340
EPA: 110239539
ADF: 107335159
AMIL: 114952874
PDAM: 113679985
SPIS: 111326832
DGT: 114527321
HMG: 100197475
 » show all
Reference
PMID:1849461
  Authors
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J
  Title
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
  Journal
Cell 65:83-90 (1991)
DOI:10.1016/0092-8674(91)90410-Z
  Sequence
[hsa:5295]
Reference
PMID:9582025
  Authors
Janssen JW, Schleithoff L, Bartram CR, Schulz AS
  Title
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.
  Journal
Oncogene 16:1767-72 (1998)
DOI:10.1038/sj.onc.1201695
  Sequence
[hsa:5296]
Reference
PMID:9524259
  Authors
Dey BR, Furlanetto RW, Nissley SP
  Title
Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
  Journal
Gene 209:175-83 (1998)
DOI:10.1016/S0378-1119(98)00045-6
  Sequence
[hsa:8503]

KEGG   ENZYME: 2.7.1.137
Entry
EC 2.7.1.137                Enzyme                                 

Name
phosphatidylinositol 3-kinase;
1-phosphatidylinositol 3-kinase;
type III phosphoinositide 3-kinase;
Vps34p;
type I phosphatidylinositol kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate [RN:R03362]
Reaction(KEGG)
R03362
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol [CPD:C01194]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3-phosphate [CPD:C04549]
Comment
One mammalian isoform is known.
History
EC 2.7.1.137 created 1992, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00914  phosphatidylinositol 3-kinase
Genes
HSA: 5289(PIK3C3)
PTR: 455385(PIK3C3)
PPS: 100975178(PIK3C3)
GGO: 101152991(PIK3C3)
PON: 100445919(PIK3C3)
NLE: 100584840(PIK3C3)
MCC: 693918(PIK3C3)
MCF: 102136293(PIK3C3)
CSAB: 103222505(PIK3C3)
RRO: 104658709(PIK3C3)
RBB: 108537659(PIK3C3)
CJC: 100414570(PIK3C3)
SBQ: 101045444(PIK3C3)
MMU: 225326(Pik3c3)
MCAL: 110284734(Pik3c3)
MPAH: 110332837(Pik3c3)
RNO: 65052(Pik3c3)
MUN: 110546919(Pik3c3)
CGE: 100765741(Pik3c3)
NGI: 103733619(Pik3c3)
HGL: 101720820(Pik3c3)
CCAN: 109701401(Pik3c3)
OCU: 100356448(PIK3C3)
TUP: 102473351(PIK3C3)
CFA: 490477(PIK3C3)
VVP: 112918840(PIK3C3)
AML: 100465351(PIK3C3)
UMR: 103663663(PIK3C3)
UAH: 113253361(PIK3C3)
ORO: 101365381(PIK3C3)
ELK: 111142649
FCA: 101099249(PIK3C3)
PTG: 102971493(PIK3C3)
PPAD: 109276389(PIK3C3)
AJU: 106972936(PIK3C3)
BTA: 534815(PIK3C3)
BOM: 102282920(PIK3C3)
BIU: 109577642(PIK3C3)
BBUB: 102404618(PIK3C3)
CHX: 102171561(PIK3C3)
OAS: 101105709(PIK3C3)
SSC: 503700(PIK3C3)
CFR: 102503733(PIK3C3)
CDK: 105085253(PIK3C3)
BACU: 103003736(PIK3C3)
LVE: 103069584(PIK3C3)
OOR: 101273072(PIK3C3)
DLE: 111168878(PIK3C3)
PCAD: 102975170(PIK3C3)
ECB: 100053039(PIK3C3)
EPZ: 103543294
EAI: 106836928(PIK3C3)
MYB: 102257257(PIK3C3)
MYD: 102773363(PIK3C3)
MNA: 107546605(PIK3C3)
HAI: 109380396(PIK3C3)
DRO: 112322978(PIK3C3)
PALE: 102897610(PIK3C3)
RAY: 107500133(PIK3C3)
MJV: 108396919(PIK3C3)
LAV: 100675552(PIK3C3)
TMU: 101345298
MDO: 100011397(PIK3C3)
SHR: 100924620(PIK3C3)
PCW: 110207949(PIK3C3)
OAA: 100076306(PIK3C3)
GGA: 100857877(PIK3C3)
MGP: 100547298(PIK3C3)
CJO: 107305728(PIK3C3)
NMEL: 110389713(PIK3C3)
APLA: 101791899(PIK3C3)
ACYG: 106037333(PIK3C3)
TGU: 100221298(PIK3C3)
LSR: 110475063(PIK3C3)
SCAN: 103820653(PIK3C3)
GFR: 102038172(PIK3C3)
FAB: 101819120(PIK3C3)
PHI: 102104229(PIK3C3)
PMAJ: 107216245(PIK3C3)
CCAE: 111940974(PIK3C3)
CCW: 104694819(PIK3C3)
ETL: 114058250(PIK3C3)
FPG: 101923473(PIK3C3)
FCH: 102050375(PIK3C3)
CLV: 102083533(PIK3C3)
EGZ: 104134209(PIK3C3)
ACUN: 113489677(PIK3C3)
PADL: 103923250(PIK3C3)
AAM: 106489354(PIK3C3)
ASN: 102374393(PIK3C3)
AMJ: 102577320(PIK3C3)
PSS: 102445385(PIK3C3)
CMY: 102940165(PIK3C3)
CPIC: 101944037(PIK3C3)
ACS: 100552043(pik3c3)
PVT: 110091014(PIK3C3)
PBI: 103052307(PIK3C3)
PMUR: 107298510(PIK3C3)
TSR: 106542713(PIK3C3) 106554370
PMUA: 114606411(PIK3C3)
XLA: 108705528(pik3c3.S) 446671(pik3c3.L)
XTR: 100485933(pik3c3)
NPR: 108804436(PIK3C3)
DRE: 548346(pik3c3)
IPU: 108267968(pik3c3)
PHYP: 113540313(pik3c3)
AMEX: 103034827(pik3c3)
EEE: 113578319(pik3c3)
TRU: 101073179(pik3c3)
LCO: 104932921(pik3c3)
NCC: 104958187(pik3c3)
MZE: 101485817(pik3c3)
ONL: 100693616(pik3c3)
OLA: 101175027(pik3c3)
XMA: 102231703(pik3c3)
XCO: 114157271(pik3c3)
PRET: 103475962(pik3c3)
CVG: 107085215(pik3c3)
NFU: 107377258(pik3c3)
KMR: 108245939(pik3c3)
ALIM: 106529974(pik3c3)
AOCE: 111580203(pik3c3)
CSEM: 103388478(pik3c3)
POV: 109634829(pik3c3)
LCF: 108903074(pik3c3)
SDU: 111235652(pik3c3)
SLAL: 111647201(pik3c3)
HCQ: 109508399(pik3c3)
BPEC: 110171971(pik3c3)
MALB: 109971461(pik3c3)
OTW: 112214613
SALP: 111953006(pik3c3) 112073198
ELS: 105020543(pik3c3)
SFM: 108932928(pik3c3)
PKI: 111851000(pik3c3)
LCM: 102353717(PIK3C3)
CMK: 103181014(pik3c3)
BFO: 118409779
CIN: 100182163
SPU: 591736
APLC: 110987621
DME: Dmel_CG5373(Pi3K59F)
DER: 6547886
DSE: 6615739
DSI: Dsimw501_GD11777(Dsim_GD11777)
DAN: 6495908
DSR: 110181124
DPE: 6592426
DMN: 108158712
DWI: 6652137
DAZ: 108617191
DNV: 108654132
DHE: 111603830
DVI: 6626079
MDE: 101893911
LCQ: 111677355
AAG: 23687538
AALB: 109406736
AME: 725770
BIM: 100743734
BTER: 100642247
CCAL: 108632581
SOC: 105207657
MPHA: 105829108
AEC: 105150362
ACEP: 105624623
PBAR: 105432669
VEM: 105562848
HST: 105184260
DQU: 106745184
CFO: 105258094
LHU: 105678308
PGC: 109858806
OBO: 105288170
PCF: 106790430
NVI: 100119508
CSOL: 105366147
MDL: 103579842
TCA: 656409
DPA: 109546210
ATD: 109603468
NVL: 108569716
BMOR: 101743450
PMAC: 106714642
PRAP: 111001008
HAW: 110379084
TNL: 113493781
PXY: 105394691
API: 100166620
DNX: 107168045
AGS: 114123453
RMD: 113551622
BTAB: 109044022
CLEC: 106670969
ZNE: 110837047
FCD: 110849945
PVM: 113808559
TUT: 107364881
DPTE: 113789441
CSCU: 111636620
PTEP: 107450591
CEL: CELE_B0025.1(vps-34)
CBR: CBG22101(Cbr-vps-34)
BMY: Bm1_09860
TSP: Tsp_00889
PCAN: 112553563
CRG: 105334736
MYI: 110455003
OBI: 106868964
LAK: 106169742
SHX: MS3_06240
EGL: EGR_03783
NVE: 5517667
ADF: 107334220
AMIL: 114964824
PDAM: 113683608
SPIS: 111322905
DGT: 114529311
HMG: 100215627
ATH: AT1G60490(VPS34)
ALY: 9322680
CRB: 17894041
BRP: 103838506
BOE: 106319020
CPAP: 110813127
CIT: 102620738
TCC: 18609484
GRA: 105785783
GAB: 108467210
VRA: 106777832
VAR: 108335910
VUN: 114173583
CCAJ: 109798596
CAM: 101495936
LJA: Lj2g3v1414920.1(Lj2g3v1414920.1)
ADU: 107488788
AIP: 107643351
FVE: 101306129
RCN: 112196284
PPER: 18789049
PMUM: 103321780
PAVI: 110753252
ZJU: 107428711
CSV: 101210847
CMO: 103487692
MCHA: 111004800
CMAX: 111491915
CMOS: 111462695
CPEP: 111804694
RCU: 8282588
JCU: 105644608
HBR: 110641632
MESC: 110628260
POP: 7484773
PEU: 105138301
JRE: 108986778
VVI: 100263708
SLY: 101250591
SPEN: 107018245
SOT: 102588478
CANN: 107870091
NTA: 107788462 107795370(PI3K)
NSY: 104247926
NTO: 104099989
NAU: 109211788
INI: 109172080
SIND: 105178723
LSV: 111906428
CCAV: 112527528
DCR: 108223227
BVG: 104897374
SOE: 110782962
NNU: 104606043
OBR: 102711258
ATS: 109774764(LOC109774764)
SBI: 110436820
ZMA: 103653397
SITA: 101768837
MUS: 103991980
DCT: 110096521
PEQ: 110019674
AOF: 109844443
ATR: 18438846
PPP: 112288042
CRE: CHLREDRAFT_196943(VPS34)
APRO: F751_4646
SCE: YLR240W(VPS34)
ERC: Ecym_4166
KMX: KLMA_50575(VPS34)
NCS: NCAS_0C02830(NCAS0C02830)
NDI: NDAI_0G02160(NDAI0G02160)
TPF: TPHA_0C02310(TPHA0C02310)
TBL: TBLA_0H00850(TBLA0H00850)
TDL: TDEL_0F05250(TDEL0F05250)
KAF: KAFR_0H01890(KAFR0H01890)
PIC: PICST_42745(VPS34)
CAL: CAALFM_C106680WA(VPS34)
SLB: AWJ20_4460(VPS34)
NCR: NCU00656
NTE: NEUTE1DRAFT133965(NEUTE1DRAFT_133965)
SMP: SMAC_01337(putative mec1/tel1)
MGR: MGG_03069
SSCK: SPSK_05906
MAW: MAC_00820
MAJ: MAA_07417
CMT: CCM_03362
MBE: MBM_07534
ANI: AN4709.2
ANG: ANI_1_588064(An07g04820)
ABE: ARB_06637
TVE: TRV_02431
PTE: PTT_16627
SPO: SPAC458.05(pik3)
CNE: CNB03120
CNB: CNBB2580
ABP: AGABI1DRAFT75039(AGABI1DRAFT_75039)
ABV: AGABI2DRAFT218336(AGABI2DRAFT_218336)
SLA: SERLADRAFT_369876(Vsp34)
WSE: WALSEDRAFT_56006(Vps34p)
MGL: MGL_1161
MRT: MRET_2991
DDI: DDB_G0289601(pikE)
DFA: DFA_11912(pikE)
EHI: EHI_096560(6.t00051)
PCB: PCHAS_111450(PC400003.00.0)
BBO: BBOV_I002970(19.m02223)
CPV: cgd6_1760
EHX: EMIHUDRAFT_631972(VPS34-2)
 » show all
Reference
1  [PMID:2833705]
  Authors
Whitman M, Downes CP, Keeler M, Keller T, Cantley L.
  Title
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
  Journal
Nature 332:644-6 (1988)
DOI:10.1038/332644a0
Reference
2  [PMID:11395417]
  Authors
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD.
  Title
Synthesis and function of 3-phosphorylated inositol lipids.
  Journal
Annu Rev Biochem 70:535-602 (2001)
DOI:10.1146/annurev.biochem.70.1.535
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.137
IUBMB Enzyme Nomenclature: 2.7.1.137
ExPASy - ENZYME nomenclature database: 2.7.1.137
BRENDA, the Enzyme Database: 2.7.1.137
CAS: 115926-52-8

KEGG   REACTION: R03362
Entry
R03362                      Reaction                               

Name
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Definition
ATP + 1-Phosphatidyl-D-myo-inositol <=> ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Equation
Reaction class
RC00002  C00002_C00008
RC00078  C01194_C04549
Enzyme
2.7.1.137       2.7.1.154
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00923  phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Other DBs
RHEA: 12712

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