KEGG   ORTHOLOGY: K00923
Entry
K00923                      KO                                     

Name
PIK3C2
Definition
phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
ko05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.154  phosphatidylinositol-4-phosphate 3-kinase
     K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase
Other DBs
RN: R03362 R05795
GO: 0035005
Genes
HSA: 5286(PIK3C2A) 5287(PIK3C2B) 5288(PIK3C2G)
PTR: 451052(PIK3C2A) 457657(PIK3C2B) 465321(PIK3C2G)
PPS: 100977462(PIK3C2A) 100982135(PIK3C2B) 100986428(PIK3C2G)
GGO: 101127796(PIK3C2A) 101132724(PIK3C2B) 101153676(PIK3C2G)
PON: 100441714(PIK3C2G) 100457125(PIK3C2A) 100461668(PIK3C2B)
NLE: 100579720(PIK3C2G) 100597241(PIK3C2B) 100597578(PIK3C2A)
MCC: 697202(PIK3C2A) 701974(PIK3C2B) 702929(PIK3C2G)
MCF: 102120715(PIK3C2G) 102130782(PIK3C2B)
CSAB: 103218712(PIK3C2G) 103230248(PIK3C2B) 103242212(PIK3C2A)
RRO: 104655305(PIK3C2G) 104662349(PIK3C2A) 104667391(PIK3C2B)
RBB: 108530624(PIK3C2A) 108535188(PIK3C2B) 108539722(PIK3C2G)
CJC: 100399595(PIK3C2A) 100401093(PIK3C2B) 100408183(PIK3C2G)
SBQ: 101034781(PIK3C2B) 101041368(PIK3C2A) 101049696(PIK3C2G)
MMU: 18704(Pik3c2a) 18705(Pik3c2g) 240752(Pik3c2b)
MCAL: 110296060(Pik3c2b) 110296221(Pik3c2g) 110298049(Pik3c2a)
MPAH: 110316706(Pik3c2g) 110322135(Pik3c2b) 110324799(Pik3c2a)
RNO: 116720(Pik3c2g) 289021(Pik3c2b) 361632(Pik3c2a)
MUN: 110548259(Pik3c2b) 110554649(Pik3c2a) 110555432(Pik3c2g) 110555725
CGE: 100754324(Pik3c2g) 100756350(Pik3c2a) 100767102(Pik3c2b)
NGI: 103731878(Pik3c2b) 103733924(Pik3c2g) 103750461(Pik3c2a)
HGL: 101702206(Pik3c2a) 101709126(Pik3c2g) 101721434(Pik3c2b)
CCAN: 109690585 109695658(Pik3c2a) 109701040(Pik3c2g)
OCU: 100337727(PIK3C2G) 100340704(PIK3C2A) 100351938(PIK3C2B)
TUP: 102479782(PIK3C2B) 102482382(PIK3C2G) 102494296(PIK3C2A)
CFA: 477681(PIK3C2G) 478938(PIK3C2B) 485399(PIK3C2A)
VVP: 112914394(PIK3C2B) 112917545(PIK3C2G) 112927036(PIK3C2A)
AML: 100465834(PIK3C2B) 100470614(PIK3C2G) 100481616(PIK3C2A)
UMR: 103671007(PIK3C2B) 103677799(PIK3C2G) 103679391(PIK3C2A)
UAH: 113242503(PIK3C2B) 113246608(PIK3C2A) 113257834(PIK3C2G)
ORO: 101373040(PIK3C2A) 101374529(PIK3C2G) 101381985(PIK3C2B)
FCA: 101082204(PIK3C2B) 101084293(PIK3C2G) 101096512(PIK3C2A)
PTG: 102966367(PIK3C2B) 102967722(PIK3C2G) 102970607(PIK3C2A)
PPAD: 109250467(PIK3C2B) 109268679(PIK3C2G) 109271194(PIK3C2A)
AJU: 106972875(PIK3C2B) 106977170(PIK3C2G) 106977487(PIK3C2A)
BTA: 513301(PIK3C2G) 537396(PIK3C2B) 537790(PIK3C2A)
BOM: 102268893(PIK3C2B) 102274862(PIK3C2A) 102275146(PIK3C2G)
BIU: 109559610(PIK3C2G) 109568816(PIK3C2A) 109570348(PIK3C2B)
BBUB: 102390969(PIK3C2A) 102411841(PIK3C2G) 102415576(PIK3C2B)
CHX: 102172975(PIK3C2G) 102180522(PIK3C2B) 102186784(PIK3C2A)
OAS: 101108766(PIK3C2B) 101114899(PIK3C2A) 101123108(PIK3C2G)
SSC: 100512551(PIK3C2B) 100514626(PIK3C2A) 100523844(PIK3C2G)
CFR: 102505793(PIK3C2B) 102511853(PIK3C2G) 102524329(PIK3C2A)
CDK: 105086672(PIK3C2A) 105096498 105098645(PIK3C2B)
BACU: 103001723(PIK3C2A) 103003092(PIK3C2G) 103013842(PIK3C2B)
LVE: 103070172(PIK3C2B) 103073583(PIK3C2G) 103075790(PIK3C2A)
OOR: 101270509(PIK3C2A) 101270703(PIK3C2G) 101282610(PIK3C2B)
DLE: 111165294(PIK3C2A) 111176819(PIK3C2G) 111184786(PIK3C2B)
PCAD: 102986532(PIK3C2G) 102988401(PIK3C2A) 102996301(PIK3C2B)
ECB: 100054391(PIK3C2B) 100056431(PIK3C2A) 100064130(PIK3C2G)
EAI: 106823801(PIK3C2B) 106823849(PIK3C2G) 106835478(PIK3C2A)
MYB: 102239081(PIK3C2G) 102240421(PIK3C2B) 102241008(PIK3C2A)
MYD: 102753072(PIK3C2G) 102757168(PIK3C2B) 102764227(PIK3C2A)
MNA: 107525348(PIK3C2G) 107539064(PIK3C2B) 107546701(PIK3C2A)
HAI: 109371228(PIK3C2G) 109386461(PIK3C2B) 109388111(PIK3C2A)
DRO: 112303229(PIK3C2A) 112317971(PIK3C2B) 112318462(PIK3C2G)
PALE: 102885293(PIK3C2A) 102886908(PIK3C2G) 102897381(PIK3C2B)
RAY: 107499672(PIK3C2G) 107508035(PIK3C2A) 107508392(PIK3C2B)
MJV: 108384332(PIK3C2G) 108408664(PIK3C2B)
LAV: 100655072(PIK3C2B) 100655519(PIK3C2G) 100660293(PIK3C2A)
MDO: 100017523(PIK3C2B) 100028742(PIK3C2A)
SHR: 100913785(PIK3C2B) 100930379(PIK3C2A)
PCW: 110219604(PIK3C2B) 110220993(PIK3C2A)
OAA: 100075377(PIK3C2B) 100079037(PIK3C2A)
GGA: 418181(PIK3C2G) 419822(PIK3C2B) 423070(PIK3C2A)
CJO: 107314653(PIK3C2A) 107316443(PIK3C2G) 107324700(PIK3C2B)
NMEL: 110388177(PIK3C2B) 110395887(PIK3C2G) 110401611(PIK3C2A)
APLA: 101790027(PIK3C2G) 101797372(PIK3C2B) 101805189(PIK3C2A)
ACYG: 106030889(PIK3C2G) 106033935(PIK3C2A) 106041283(PIK3C2B)
TGU: 100219236(PIK3C2G) 100219982(PIK3C2A) 100228453(PIK3C2B)
LSR: 110468056(PIK3C2A) 110472981(PIK3C2G) 110475005(PIK3C2B)
SCAN: 103820487(PIK3C2G) 103826780(PIK3C2A) 108963600(PIK3C2B)
GFR: 102031753(PIK3C2B) 102034587(PIK3C2A) 102037952(PIK3C2G)
FAB: 101810900(PIK3C2B) 101811315(PIK3C2G) 101813229(PIK3C2A)
PHI: 102100989(PIK3C2B) 102104821(PIK3C2A) 102108230(PIK3C2G)
PMAJ: 107205187(PIK3C2G) 107205946(PIK3C2A) 107214772(PIK3C2B)
CCAE: 111928278(PIK3C2G) 111930817(PIK3C2A) 111939688(PIK3C2B)
CCW: 104684201(PIK3C2A) 104692271(PIK3C2G)
ETL: 114062470(PIK3C2A) 114067902 114069121(PIK3C2B)
FPG: 101914006(PIK3C2A) 101915094(PIK3C2B)
FCH: 102046914(PIK3C2B) 102058269(PIK3C2A) 102059409(PIK3C2G)
CLV: 102093585(PIK3C2B) 102096662(PIK3C2A)
EGZ: 104123200(PIK3C2A) 104125797(PIK3C2B) 104135084(PIK3C2G)
NNI: 104010656(PIK3C2A) 104013205(PIK3C2B) 104017951(PIK3C2G)
ACUN: 113481213(PIK3C2A) 113488343(PIK3C2G) 113488786(PIK3C2B)
PADL: 103919855(PIK3C2B) 103920719(PIK3C2A) 103924344(PIK3C2G)
AAM: 106488942(PIK3C2G) 106497098(PIK3C2A)
ASN: 102380020(PIK3C2B) 102382160(PIK3C2G) 102387688(PIK3C2A)
AMJ: 102564420(PIK3C2B) 102573536(PIK3C2A) 102577227(PIK3C2G)
PSS: 102449395(PIK3C2B) 102453034(PIK3C2A) 102462105
CMY: 102936736(PIK3C2B) 102936873(PIK3C2A) 102941758(PIK3C2G)
CPIC: 101931624(PIK3C2G) 101944776(PIK3C2B) 101951383(PIK3C2A)
ACS: 100557407(pik3c2a) 100567393(pik3c2b)
PVT: 110079700(PIK3C2B) 110083988(PIK3C2A)
PBI: 103049748(PIK3C2A) 103055047(PIK3C2B)
PMUR: 107298464 107302983(PIK3C2B)
TSR: 106552466 106557105(PIK3C2B)
PMUA: 114598648(PIK3C2A) 114599287(PIK3C2B)
GJA: 107119701(PIK3C2B) 107120532(PIK3C2A)
XTR: 100038240(pik3c2a) 100496878(pik3c2g)
NPR: 108791810(PIK3C2G) 108796352(PIK3C2B) 108800795(PIK3C2A)
DRE: 100330514(pik3c2g) 567938(pik3c2b) 571356(pik3c2a)
SANH: 107660757(pik3c2b) 107690350 107690894(pik3c2g) 107691134
IPU: 108254898(pik3c2b) 108264414(pik3c2a) 108264692
PHYP: 113526545(pik3c2a) 113539558(pik3c2b)
AMEX: 103042558(pik3c2a) 103046979(pik3c2b)
EEE: 113576605(pik3c2a) 113576623(pik3c2g) 113589083(pik3c2b)
TRU: 101065977(pik3c2a) 101074574(pik3c2g)
LCO: 104921784(pik3c2a) 104937642(pik3c2b) 104940676(pik3c2g)
NCC: 104942429(pik3c2g)
MZE: 101464810(pik3c2b) 101481785(pik3c2a) 101488075(pik3c2g) 112434824
ONL: 100697097(pik3c2a) 100701633(pik3c2g) 100704299
OLA: 101155105(pik3c2a) 101162831(pik3c2b) 105354205(pik3c2g)
XMA: 102218236(pik3c2b) 102221445(pik3c2g) 102225822(pik3c2a)
XCO: 114135879(pik3c2b) 114157212(pik3c2a) 114159765(pik3c2g)
PRET: 103464245(pik3c2b) 103465708(pik3c2a) 103466393(pik3c2g)
CVG: 107090881(pik3c2a) 107092729(pik3c2g) 107102075(pik3c2b)
NFU: 107384865(pik3c2b) 107388363(pik3c2a) 107388607(pik3c2g)
KMR: 108229826(pik3c2g) 108245738(pik3c2a) 108251758(pik3c2b)
ALIM: 106522805(pik3c2a) 106523395(pik3c2g) 106525737(pik3c2b)
AOCE: 111573650(pik3c2g) 111580508(pik3c2a) 111580517(pik3c2b)
CSEM: 103379820(pik3c2a) 103380432(pik3c2g) 103386838(pik3c2b)
POV: 109623667 109624395(pik3c2a)
SDU: 111219371(pik3c2b) 111229571(pik3c2a) 111229760(pik3c2g)
SLAL: 111650372(pik3c2a) 111656524(pik3c2b) 111661662(pik3c2g)
HCQ: 109507628 109522463(pik3c2b) 109530836(pik3c2a)
BPEC: 110160352(pik3c2a) 110169655 110174613(pik3c2b)
MALB: 109956435(pik3c2a) 109966904(pik3c2b) 109973002(pik3c2g)
ELS: 105016798(pik3c2b) 105018471(pik3c2a) 105028898(pik3c2g)
SFM: 108931427(pik3c2g) 108938229(pik3c2b) 108939855(pik3c2a)
PKI: 111838684(pik3c2b) 111842563(pik3c2a) 111851209
LCM: 102346693(PIK3C2A) 102347853(PIK3C2G) 102365794(PIK3C2B)
CMK: 103174900(pik3c2a) 103182539(pik3c2b)
RTP: 109913339(pik3c2a) 109913828(pik3c2b)
BFO: 118414477
CIN: 100175620
SPU: 586734
APLC: 110975484
SKO: 100371292
DME: Dmel_CG11621(Pi3K68D)
DSE: 6605334
DSI: Dsimw501_GD12776(Dsim_GD12776)
DAN: 6507145
DSR: 110179005
DPE: 6600653
DMN: 108152220
DWI: 6645249
DAZ: 108614224
DNV: 108652118
DHE: 111598385
DVI: 6623593
MDE: 101896512
LCQ: 111684075
AAG: 5576326
AALB: 109407641
AME: 413425
BIM: 100748686
BTER: 100649222
CCAL: 108629757
OBB: 114872695
SOC: 105199002
MPHA: 105829544
AEC: 105147824
ACEP: 105625481
PBAR: 105422981
VEM: 105561766
HST: 105187092
DQU: 106750598
CFO: 105250545
LHU: 105678054
PGC: 109853821
OBO: 105283495
PCF: 106789070
NVI: 100121969
CSOL: 105360131
MDL: 103569923
TCA: 655501
DPA: 109533351
ATD: 109594760
NVL: 108563833
BMOR: 101742216
BMAN: 114241766
PRAP: 110994508
HAW: 110378347
TNL: 113507614
PXY: 105394948
API: 100160780
DNX: 107166792
AGS: 114124237
RMD: 113552736
BTAB: 109042143
CLEC: 106666598
ZNE: 110830244
FCD: 110850824
PVM: 113819838
TUT: 107360527
DPTE: 113793502
CSCU: 111619612
PTEP: 107437171
CEL: CELE_F39B1.1(piki-1)
CBR: CBG07670
BMY: Bm1_05655
PCAN: 112559398
MYI: 110441528
OBI: 106869736
LAK: 106172136
SHX: MS3_04656
EGL: EGR_05933
NVE: 5517990
EPA: 110233446
ADF: 107335827
AMIL: 114955439
PDAM: 113682593
SPIS: 111322228
DGT: 114516438
HMG: 100211167
AQU: 100639364
DDI: DDB_G0291093(pikH)
DFA: DFA_03210(pikH)
 » show all
Reference
PMID:9337861
  Authors
Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD
  Title
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin.
  Journal
Biochem J 326 ( Pt 1):139-47 (1997)
DOI:10.1042/bj3260139
  Sequence
[hsa:5286]

KEGG   ORTHOLOGY: K02649
Entry
K02649                      KO                                     

Name
PIK3R1_2_3
Definition
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04929  GnRH secretion
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko04960  Aldosterone-regulated sodium reabsorption
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05017  Spinocerebellar ataxia
ko05020  Prion disease
ko05100  Bacterial invasion of epithelial cells
ko05131  Shigellosis
ko05135  Yersinia infection
ko05142  Chagas disease
ko05146  Amoebiasis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H01370  SHORT syndrome
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04014 Ras signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04630 JAK-STAT signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04668 TNF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09143 Cell growth and death
   04210 Apoptosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04218 Cellular senescence
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04625 C-type lectin receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocytes
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04929 GnRH secretion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04926 Relaxin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04935 Growth hormone synthesis, secretion and action
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09156 Nervous system
   04725 Cholinergic synapse
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09158 Development and regeneration
   04360 Axon guidance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09149 Aging
   04211 Longevity regulating pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05206 MicroRNAs in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05212 Pancreatic cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05225 Hepatocellular carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05226 Gastric cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05214 Glioma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05218 Melanoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05215 Prostate cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05213 Endometrial cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05224 Breast cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05222 Small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05017 Spinocerebellar ataxia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05020 Prion disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04931 Insulin resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05135 Yersinia infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05100 Bacterial invasion of epithelial cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05170 Human immunodeficiency virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05162 Measles
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05164 Influenza A
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05161 Hepatitis B
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05160 Hepatitis C
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05168 Herpes simplex virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05163 Human cytomegalovirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05142 Chagas disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01524 Platinum drug resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01522 Endocrine resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Other DBs
RN: R03362 R04545 R05795
Genes
HSA: 5295(PIK3R1) 5296(PIK3R2) 8503(PIK3R3)
PTR: 455855(PIK3R2) 456565(PIK3R3) 461836(PIK3R1)
PPS: 100969981(PIK3R2) 100986080(PIK3R3) 100994315(PIK3R1)
GGO: 101129336(PIK3R3) 101130978(PIK3R1) 101135298(PIK3R2)
PON: 100173589(PIK3R1) 100174298(PIK3R3) 100437617(PIK3R2)
NLE: 100591270(PIK3R3) 100599301(PIK3R2) 100605788(PIK3R1)
MCC: 698996(PIK3R1) 707310(PIK3R3) 719367(PIK3R2)
MCF: 101866246(PIK3R1) 102124804(PIK3R2) 102137291(PIK3R3)
CSAB: 103222594(PIK3R1) 103224900(PIK3R3) 103234391(PIK3R2)
RRO: 104662124(PIK3R3) 104675620(PIK3R1) 104680672(PIK3R2)
RBB: 108534276(PIK3R2) 108535636(PIK3R3) 108541175(PIK3R1)
CJC: 100392639(PIK3R1) 100406689(PIK3R2) 100414659(PIK3R3)
SBQ: 101032496(PIK3R1) 101033359(PIK3R2) 101050592(PIK3R3)
MMU: 18708(Pik3r1) 18709(Pik3r2) 18710(Pik3r3)
MCAL: 110292624 110299855(Pik3r2) 110308009(Pik3r1)
MPAH: 110322865(Pik3r3) 110328811(Pik3r1) 110336420(Pik3r2)
RNO: 25513(Pik3r1) 29741(Pik3r2) 60664(Pik3r3)
MUN: 110549145(Pik3r2) 110553683(Pik3r1) 110563512(Pik3r3)
CGE: 100750761(Pik3r1) 100771181(Pik3r2) 100774067
NGI: 103726879(Pik3r2) 103730305(Pik3r3) 103738715(Pik3r1)
HGL: 101703691(Pik3r1) 101717096(Pik3r3) 101718815(Pik3r2)
CCAN: 109682432(Pik3r3) 109682554 109694666(Pik3r1)
OCU: 100345250(PIK3R3) 100357841(PIK3R1)
TUP: 102469401(PIK3R2) 102484444(PIK3R3) 102484500(PIK3R1)
CFA: 100856339(PIK3R3) 487235(PIK3R1) 609956(PIK3R2)
VVP: 112913170(PIK3R2) 112914774 112935820(PIK3R1)
AML: 100467916(PIK3R3) 100475291(PIK3R2) 100483828(PIK3R1)
UMR: 103663617(PIK3R1) 103670766(PIK3R3) 103675162(PIK3R2)
UAH: 113254730(PIK3R3) 113255266(PIK3R1) 113256705(PIK3R2)
ORO: 101370100(PIK3R1) 101371800(PIK3R2) 101374787(PIK3R3)
FCA: 100271864(PIK3R1) 101093286(PIK3R3) 101093586(PIK3R2)
PTG: 102949853(PIK3R3) 102952993(PIK3R1) 102967709(PIK3R2)
PPAD: 109247606(PIK3R2) 109266953(PIK3R3) 109275060(PIK3R1)
AJU: 106969150(PIK3R2) 106973297(PIK3R3) 106976917(PIK3R1)
BTA: 282307(PIK3R1) 282308(PIK3R2) 286865(PIK3R3)
BOM: 102266922(PIK3R1) 102280296(PIK3R3) 102286868(PIK3R2)
BIU: 109556345 109561418(PIK3R2) 109574805(PIK3R1)
BBUB: 102395384 102404517(PIK3R2) 102415109(PIK3R1)
CHX: 102170135(PIK3R2) 102179343(PIK3R3) 102188710(PIK3R1)
OAS: 101111546(PIK3R2) 101121455(PIK3R1) 101123247(PIK3R3)
SSC: 100511937 100623707(PIK3R1) 100739510(PIK3R2)
CFR: 102505690 102513205(PIK3R2) 102520923(PIK3R1)
CDK: 105084758(PIK3R1) 105092913 105101867(PIK3R2)
BACU: 103007464(PIK3R1) 103008077(PIK3R3) 103009307(PIK3R2)
LVE: 103070370(PIK3R1) 103078725(PIK3R3) 103083960(PIK3R2)
OOR: 101277568(PIK3R3) 101281352(PIK3R2) 101285437(PIK3R1)
DLE: 111166652(PIK3R2) 111175760 111185984(PIK3R1)
PCAD: 102975555(PIK3R3) 102991192(PIK3R1) 102991779(PIK3R2)
ECB: 100050227(PIK3R1) 100052122 100146348(PIK3R2)
EPZ: 103548220(PIK3R1) 103551868(PIK3R3) 103561550(PIK3R2)
EAI: 106822593(PIK3R3) 106824993(PIK3R2) 106840141(PIK3R1)
MYB: 102242302(PIK3R1) 102253405(PIK3R2) 102258430(PIK3R3)
MYD: 102753036(PIK3R1) 102760468(PIK3R3) 102763670(PIK3R2)
MNA: 107526728(PIK3R3) 107529317(PIK3R1) 107535325(PIK3R2)
HAI: 109373811(PIK3R3) 109382484(PIK3R2) 109395865(PIK3R1)
DRO: 112305224(PIK3R2) 112314466 112321016(PIK3R1)
PALE: 102879163(PIK3R1) 102879453(PIK3R2) 102891637
RAY: 107498704(PIK3R1) 107517899(PIK3R3) 107521668(PIK3R2)
MJV: 108383561(PIK3R2) 108390475(PIK3R1) 108395975(PIK3R3)
LAV: 100653731(PIK3R1) 100665045(PIK3R2) 100675496(PIK3R3)
MDO: 100019317(PIK3R1) 100032726(PIK3R2) 100616957(PIK3R3)
SHR: 100924976(PIK3R1) 100926892(PIK3R2) 100935230(PIK3R3)
PCW: 110209293(PIK3R3) 110216530(PIK3R1) 110223395(PIK3R2)
OAA: 100080187(PIK3R2) 100082075(PIK3R3) 103167126(PIK3R1)
GGA: 427171(PIK3R1) 429096(PIK3R3) 771142(PIK3R2)
CJO: 107305909(PIK3R1) 107317608 107325533(PIK3R2)
NMEL: 110388756(PIK3R2) 110389564(PIK3R1) 110402756(PIK3R3)
APLA: 101795759 101799717(PIK3R1) 101803461(PIK3R2)
ACYG: 106033049(PIK3R3) 106042106(PIK3R1) 106045000(PIK3R2)
TGU: 100221185 100223949(PIK3R1) 100226234(PIK3R2)
LSR: 110469696 110472594(PIK3R1) 110478008(PIK3R2)
SCAN: 103814989 103821918(PIK3R2) 103823133(PIK3R1) 115483908
GFR: 102032353(PIK3R1) 102035891(PIK3R2) 102039817(PIK3R3)
FAB: 101811808(PIK3R2) 101812251(PIK3R3) 101820843(PIK3R1)
PHI: 102106897(PIK3R2) 102112482(PIK3R3) 102114750(PIK3R1)
PMAJ: 107208273(PIK3R3) 107215603(PIK3R2) 107216262(PIK3R1)
CCAE: 111933104(PIK3R3) 111940405(PIK3R2) 111941370(PIK3R1)
CCW: 104686712(PIK3R1) 104695234(PIK3R3) 104696977(PIK3R2)
FPG: 101913266(PIK3R3) 101915242(PIK3R2) 101924523(PIK3R1)
FCH: 102056135(PIK3R1) 102057083(PIK3R2) 102059517
CLV: 102084272(PIK3R3) 102084904(PIK3R2) 102092838(PIK3R1)
EGZ: 104124880(PIK3R1) 104126253(PIK3R3) 104135641(PIK3R2)
NNI: 104015409(PIK3R3) 104018715(PIK3R2)
ACUN: 113483193 113489298(PIK3R2) 113489600(PIK3R1)
PADL: 103919124(PIK3R3) 103919717(PIK3R1) 103926435(PIK3R2)
AAM: 106485939(PIK3R3) 106495610(PIK3R2) 106499441(PIK3R1)
ASN: 102377899(PIK3R2) 102380057 102382060(PIK3R1)
AMJ: 102567863(PIK3R2) 102570922(PIK3R1) 106737141(PIK3R3)
PSS: 102449585(PIK3R1) 102457516
CMY: 102933845(PIK3R2) 102941819(PIK3R3) 102945631(PIK3R1)
CPIC: 101945673(PIK3R2) 101947423(PIK3R3) 101953817(PIK3R1)
ACS: 100554618(pik3r3) 100555182(pik3r2) 100556883(pik3r1)
PVT: 110072561(PIK3R2) 110073778(PIK3R3) 110073951(PIK3R1)
PBI: 103055280(PIK3R2) 103065132 103065975(PIK3R1)
PMUR: 107282273(PIK3R2) 107283596 107286152(PIK3R1)
TSR: 106538977(PIK3R1) 106543200(PIK3R3) 106552169
PMUA: 114588236(PIK3R2) 114599062 114606162(PIK3R1)
GJA: 107108905(PIK3R1) 107119473(PIK3R3) 107121678(PIK3R2)
XLA: 108706884 108713027 399202(pik3r1.L) 443964(pik3r1.S) 446786(pik3r2) 447594(pik3r3.L)
XTR: 100486835(pik3r1) 100497001(pik3r2) 549983(pik3r3)
NPR: 108789013(PIK3R2) 108797628(PIK3R1) 108802963
DRE: 100000252(pik3r3b) 404211(pik3r2) 557176(pik3r1)
IPU: 108260231(pik3r1) 108272037(pik3r3)
PHYP: 113531632(pik3r1) 113538265
AMEX: 103029972(pik3r3) 103035767 103046618(pik3r1) 111190801
PRET: 103463201(pik3r3) 103463319 103470780 103473324(pik3r1) 103478998 103479173(pik3r2)
MALB: 109957384 109965201(pik3r3) 109966856 109969301(pik3r2) 109969763(pik3r1) 109970672
PKI: 111834821(pik3r3) 111835615(pik3r1) 111847640 111856594 111860386(pik3r2)
LCM: 102348007(PIK3R3) 102353218(PIK3R1)
CMK: 103177781(pik3r1) 103182064(pik3r2) 103182762(pik3r3)
BFO: 118432571
CIN: 100184893
SPU: 588766
APLC: 110977729
SKO: 100372481
DME: Dmel_CG2699(Pi3K21B)
DER: 6543312
DSE: 6621105
DSI: Dsimw501_GD23016(Dsim_GD23016)
DSR: 110187562
DPE: 6593764
DMN: 108163765
DWI: 6651829
DAZ: 108609449
DNV: 108650034
DHE: 111602464
DVI: 6628686
MDE: 101896300
LCQ: 111686430
AAG: 5578257
AALB: 109409609
AME: 408577
BIM: 100743083
BTER: 100643962
CCAL: 108629871
OBB: 114871807
SOC: 105195470
MPHA: 105831984
AEC: 105151922
ACEP: 105620878
PBAR: 105430848
VEM: 105567561
HST: 105192434
DQU: 106748226
CFO: 105255336
LHU: 105667777
PGC: 109854747
OBO: 105284404
PCF: 106792271
NVI: 100122747
CSOL: 105361583
MDL: 103580680
TCA: 100141888
DPA: 109540864
ATD: 109595073
NVL: 108559788
BMOR: 100158253(Pi3k60)
BMAN: 114245941
PMAC: 106714800
PRAP: 110992252
HAW: 110370679
TNL: 113497575
PXY: 105388447
AGS: 114129704
RMD: 113553291
BTAB: 109032766
CLEC: 106664096
FCD: 110845224
PVM: 113810630
DPTE: 113798240
CEL: CELE_Y110A7A.10(aap-1)
CBR: CBG10815(Cbr-aap-1)
BMY: Bm1_37505
TSP: Tsp_02388
CRG: 105321629
OBI: 106879157
SHX: MS3_06277
EGL: EGR_06563
NVE: 5520340
EPA: 110239539
ADF: 107335159
AMIL: 114952874
PDAM: 113679985
SPIS: 111326832
DGT: 114527321
HMG: 100197475
 » show all
Reference
PMID:1849461
  Authors
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J
  Title
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
  Journal
Cell 65:83-90 (1991)
DOI:10.1016/0092-8674(91)90410-Z
  Sequence
[hsa:5295]
Reference
PMID:9582025
  Authors
Janssen JW, Schleithoff L, Bartram CR, Schulz AS
  Title
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.
  Journal
Oncogene 16:1767-72 (1998)
DOI:10.1038/sj.onc.1201695
  Sequence
[hsa:5296]
Reference
PMID:9524259
  Authors
Dey BR, Furlanetto RW, Nissley SP
  Title
Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
  Journal
Gene 209:175-83 (1998)
DOI:10.1016/S0378-1119(98)00045-6
  Sequence
[hsa:8503]

KEGG   ENZYME: 2.7.1.154
Entry
EC 2.7.1.154                Enzyme                                 

Name
phosphatidylinositol-4-phosphate 3-kinase;
type II phosphoinositide 3-kinase;
C2-domain-containing phosphoinositide 3-kinase;
phosphoinositide 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [RN:R05795]
Reaction(KEGG)
R05795;
(other) R03362
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [CPD:C11554]
Comment
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
History
EC 2.7.1.154 created 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00923  phosphatidylinositol-4-phosphate 3-kinase
Genes
HSA: 5286(PIK3C2A) 5287(PIK3C2B) 5288(PIK3C2G)
PTR: 451052(PIK3C2A) 457657(PIK3C2B) 465321(PIK3C2G)
PPS: 100977462(PIK3C2A) 100982135(PIK3C2B) 100986428(PIK3C2G)
GGO: 101127796(PIK3C2A) 101132724(PIK3C2B) 101153676(PIK3C2G)
PON: 100441714(PIK3C2G) 100457125(PIK3C2A) 100461668(PIK3C2B)
NLE: 100579720(PIK3C2G) 100597241(PIK3C2B) 100597578(PIK3C2A)
MCC: 697202(PIK3C2A) 701974(PIK3C2B) 702929(PIK3C2G)
MCF: 102120715(PIK3C2G) 102130782(PIK3C2B)
CSAB: 103218712(PIK3C2G) 103230248(PIK3C2B) 103242212(PIK3C2A)
RRO: 104655305(PIK3C2G) 104662349(PIK3C2A) 104667391(PIK3C2B)
RBB: 108530624(PIK3C2A) 108535188(PIK3C2B) 108539722(PIK3C2G)
CJC: 100399595(PIK3C2A) 100401093(PIK3C2B) 100408183(PIK3C2G)
SBQ: 101034781(PIK3C2B) 101041368(PIK3C2A) 101049696(PIK3C2G)
MMU: 18704(Pik3c2a) 18705(Pik3c2g) 240752(Pik3c2b)
MCAL: 110296060(Pik3c2b) 110296221(Pik3c2g) 110298049(Pik3c2a)
MPAH: 110316706(Pik3c2g) 110322135(Pik3c2b) 110324799(Pik3c2a)
RNO: 116720(Pik3c2g) 289021(Pik3c2b) 361632(Pik3c2a)
MUN: 110548259(Pik3c2b) 110554649(Pik3c2a) 110555432(Pik3c2g) 110555725
CGE: 100754324(Pik3c2g) 100756350(Pik3c2a) 100767102(Pik3c2b)
NGI: 103731878(Pik3c2b) 103733924(Pik3c2g) 103750461(Pik3c2a)
HGL: 101702206(Pik3c2a) 101709126(Pik3c2g) 101721434(Pik3c2b)
CCAN: 109690585 109695658(Pik3c2a) 109701040(Pik3c2g)
OCU: 100337727(PIK3C2G) 100340704(PIK3C2A) 100351938(PIK3C2B)
TUP: 102479782(PIK3C2B) 102482382(PIK3C2G) 102494296(PIK3C2A)
CFA: 477681(PIK3C2G) 478938(PIK3C2B) 485399(PIK3C2A)
VVP: 112914394(PIK3C2B) 112917545(PIK3C2G) 112927036(PIK3C2A)
AML: 100465834(PIK3C2B) 100470614(PIK3C2G) 100481616(PIK3C2A)
UMR: 103671007(PIK3C2B) 103677799(PIK3C2G) 103679391(PIK3C2A)
UAH: 113242503(PIK3C2B) 113246608(PIK3C2A) 113257834(PIK3C2G)
ORO: 101373040(PIK3C2A) 101374529(PIK3C2G) 101381985(PIK3C2B)
FCA: 101082204(PIK3C2B) 101084293(PIK3C2G) 101096512(PIK3C2A)
PTG: 102966367(PIK3C2B) 102967722(PIK3C2G) 102970607(PIK3C2A)
PPAD: 109250467(PIK3C2B) 109268679(PIK3C2G) 109271194(PIK3C2A)
AJU: 106972875(PIK3C2B) 106977170(PIK3C2G) 106977487(PIK3C2A)
BTA: 513301(PIK3C2G) 537396(PIK3C2B) 537790(PIK3C2A)
BOM: 102268893(PIK3C2B) 102274862(PIK3C2A) 102275146(PIK3C2G)
BIU: 109559610(PIK3C2G) 109568816(PIK3C2A) 109570348(PIK3C2B)
BBUB: 102390969(PIK3C2A) 102411841(PIK3C2G) 102415576(PIK3C2B)
CHX: 102172975(PIK3C2G) 102180522(PIK3C2B) 102186784(PIK3C2A)
OAS: 101108766(PIK3C2B) 101114899(PIK3C2A) 101123108(PIK3C2G)
SSC: 100512551(PIK3C2B) 100514626(PIK3C2A) 100523844(PIK3C2G)
CFR: 102505793(PIK3C2B) 102511853(PIK3C2G) 102524329(PIK3C2A)
CDK: 105086672(PIK3C2A) 105096498 105098645(PIK3C2B)
BACU: 103001723(PIK3C2A) 103003092(PIK3C2G) 103013842(PIK3C2B)
LVE: 103070172(PIK3C2B) 103073583(PIK3C2G) 103075790(PIK3C2A)
OOR: 101270509(PIK3C2A) 101270703(PIK3C2G) 101282610(PIK3C2B)
DLE: 111165294(PIK3C2A) 111176819(PIK3C2G) 111184786(PIK3C2B)
PCAD: 102986532(PIK3C2G) 102988401(PIK3C2A) 102996301(PIK3C2B)
ECB: 100054391(PIK3C2B) 100056431(PIK3C2A) 100064130(PIK3C2G)
EAI: 106823801(PIK3C2B) 106823849(PIK3C2G) 106835478(PIK3C2A)
MYB: 102239081(PIK3C2G) 102240421(PIK3C2B) 102241008(PIK3C2A)
MYD: 102753072(PIK3C2G) 102757168(PIK3C2B) 102764227(PIK3C2A)
MNA: 107525348(PIK3C2G) 107539064(PIK3C2B) 107546701(PIK3C2A)
HAI: 109371228(PIK3C2G) 109386461(PIK3C2B) 109388111(PIK3C2A)
DRO: 112303229(PIK3C2A) 112317971(PIK3C2B) 112318462(PIK3C2G)
PALE: 102885293(PIK3C2A) 102886908(PIK3C2G) 102897381(PIK3C2B)
RAY: 107499672(PIK3C2G) 107508035(PIK3C2A) 107508392(PIK3C2B)
MJV: 108384332(PIK3C2G) 108408664(PIK3C2B)
LAV: 100655072(PIK3C2B) 100655519(PIK3C2G) 100660293(PIK3C2A)
MDO: 100017523(PIK3C2B) 100028742(PIK3C2A)
SHR: 100913785(PIK3C2B) 100930379(PIK3C2A)
PCW: 110219604(PIK3C2B) 110220993(PIK3C2A)
OAA: 100075377(PIK3C2B) 100079037(PIK3C2A)
GGA: 418181(PIK3C2G) 419822(PIK3C2B) 423070(PIK3C2A)
CJO: 107314653(PIK3C2A) 107316443(PIK3C2G) 107324700(PIK3C2B)
NMEL: 110388177(PIK3C2B) 110395887(PIK3C2G) 110401611(PIK3C2A)
APLA: 101790027(PIK3C2G) 101797372(PIK3C2B) 101805189(PIK3C2A)
ACYG: 106030889(PIK3C2G) 106033935(PIK3C2A) 106041283(PIK3C2B)
TGU: 100219236(PIK3C2G) 100219982(PIK3C2A) 100228453(PIK3C2B)
LSR: 110468056(PIK3C2A) 110472981(PIK3C2G) 110475005(PIK3C2B)
SCAN: 103820487(PIK3C2G) 103826780(PIK3C2A) 108963600(PIK3C2B)
GFR: 102031753(PIK3C2B) 102034587(PIK3C2A) 102037952(PIK3C2G)
FAB: 101810900(PIK3C2B) 101811315(PIK3C2G) 101813229(PIK3C2A)
PHI: 102100989(PIK3C2B) 102104821(PIK3C2A) 102108230(PIK3C2G)
PMAJ: 107205187(PIK3C2G) 107205946(PIK3C2A) 107214772(PIK3C2B)
CCAE: 111928278(PIK3C2G) 111930817(PIK3C2A) 111939688(PIK3C2B)
CCW: 104684201(PIK3C2A) 104692271(PIK3C2G)
ETL: 114062470(PIK3C2A) 114067902 114069121(PIK3C2B)
FPG: 101914006(PIK3C2A) 101915094(PIK3C2B)
FCH: 102046914(PIK3C2B) 102058269(PIK3C2A) 102059409(PIK3C2G)
CLV: 102093585(PIK3C2B) 102096662(PIK3C2A)
EGZ: 104123200(PIK3C2A) 104125797(PIK3C2B) 104135084(PIK3C2G)
NNI: 104010656(PIK3C2A) 104013205(PIK3C2B) 104017951(PIK3C2G)
ACUN: 113481213(PIK3C2A) 113488343(PIK3C2G) 113488786(PIK3C2B)
PADL: 103919855(PIK3C2B) 103920719(PIK3C2A) 103924344(PIK3C2G)
AAM: 106488942(PIK3C2G) 106497098(PIK3C2A)
ASN: 102380020(PIK3C2B) 102382160(PIK3C2G) 102387688(PIK3C2A)
AMJ: 102564420(PIK3C2B) 102573536(PIK3C2A) 102577227(PIK3C2G)
PSS: 102449395(PIK3C2B) 102453034(PIK3C2A) 102462105
CMY: 102936736(PIK3C2B) 102936873(PIK3C2A) 102941758(PIK3C2G)
CPIC: 101931624(PIK3C2G) 101944776(PIK3C2B) 101951383(PIK3C2A)
ACS: 100557407(pik3c2a) 100567393(pik3c2b)
PVT: 110079700(PIK3C2B) 110083988(PIK3C2A)
PBI: 103049748(PIK3C2A) 103055047(PIK3C2B)
PMUR: 107298464 107302983(PIK3C2B)
TSR: 106552466 106557105(PIK3C2B)
PMUA: 114598648(PIK3C2A) 114599287(PIK3C2B)
GJA: 107119701(PIK3C2B) 107120532(PIK3C2A)
XTR: 100038240(pik3c2a) 100496878(pik3c2g)
NPR: 108791810(PIK3C2G) 108796352(PIK3C2B) 108800795(PIK3C2A)
DRE: 100330514(pik3c2g) 567938(pik3c2b) 571356(pik3c2a)
SANH: 107660757(pik3c2b) 107690350 107690894(pik3c2g) 107691134
IPU: 108254898(pik3c2b) 108264414(pik3c2a) 108264692
PHYP: 113526545(pik3c2a) 113539558(pik3c2b)
AMEX: 103042558(pik3c2a) 103046979(pik3c2b)
EEE: 113576605(pik3c2a) 113576623(pik3c2g) 113589083(pik3c2b)
TRU: 101065977(pik3c2a) 101074574(pik3c2g)
LCO: 104921784(pik3c2a) 104937642(pik3c2b) 104940676(pik3c2g)
NCC: 104942429(pik3c2g)
MZE: 101464810(pik3c2b) 101481785(pik3c2a) 101488075(pik3c2g) 112434824
ONL: 100697097(pik3c2a) 100701633(pik3c2g) 100704299
OLA: 101155105(pik3c2a) 101162831(pik3c2b) 105354205(pik3c2g)
XMA: 102218236(pik3c2b) 102221445(pik3c2g) 102225822(pik3c2a)
XCO: 114135879(pik3c2b) 114157212(pik3c2a) 114159765(pik3c2g)
PRET: 103464245(pik3c2b) 103465708(pik3c2a) 103466393(pik3c2g)
CVG: 107090881(pik3c2a) 107092729(pik3c2g) 107102075(pik3c2b)
NFU: 107384865(pik3c2b) 107388363(pik3c2a) 107388607(pik3c2g)
KMR: 108229826(pik3c2g) 108245738(pik3c2a) 108251758(pik3c2b)
ALIM: 106522805(pik3c2a) 106523395(pik3c2g) 106525737(pik3c2b)
AOCE: 111573650(pik3c2g) 111580508(pik3c2a) 111580517(pik3c2b)
CSEM: 103379820(pik3c2a) 103380432(pik3c2g) 103386838(pik3c2b)
POV: 109623667 109624395(pik3c2a)
SDU: 111219371(pik3c2b) 111229571(pik3c2a) 111229760(pik3c2g)
SLAL: 111650372(pik3c2a) 111656524(pik3c2b) 111661662(pik3c2g)
HCQ: 109507628 109522463(pik3c2b) 109530836(pik3c2a)
BPEC: 110160352(pik3c2a) 110169655 110174613(pik3c2b)
MALB: 109956435(pik3c2a) 109966904(pik3c2b) 109973002(pik3c2g)
ELS: 105016798(pik3c2b) 105018471(pik3c2a) 105028898(pik3c2g)
SFM: 108931427(pik3c2g) 108938229(pik3c2b) 108939855(pik3c2a)
PKI: 111838684(pik3c2b) 111842563(pik3c2a) 111851209
LCM: 102346693(PIK3C2A) 102347853(PIK3C2G) 102365794(PIK3C2B)
CMK: 103174900(pik3c2a) 103182539(pik3c2b)
RTP: 109913339(pik3c2a) 109913828(pik3c2b)
BFO: 118414477
CIN: 100175620
SPU: 586734
APLC: 110975484
SKO: 100371292
DME: Dmel_CG11621(Pi3K68D)
DSE: 6605334
DSI: Dsimw501_GD12776(Dsim_GD12776)
DAN: 6507145
DSR: 110179005
DPE: 6600653
DMN: 108152220
DWI: 6645249
DAZ: 108614224
DNV: 108652118
DHE: 111598385
DVI: 6623593
MDE: 101896512
LCQ: 111684075
AAG: 5576326
AALB: 109407641
AME: 413425
BIM: 100748686
BTER: 100649222
CCAL: 108629757
OBB: 114872695
SOC: 105199002
MPHA: 105829544
AEC: 105147824
ACEP: 105625481
PBAR: 105422981
VEM: 105561766
HST: 105187092
DQU: 106750598
CFO: 105250545
LHU: 105678054
PGC: 109853821
OBO: 105283495
PCF: 106789070
NVI: 100121969
CSOL: 105360131
MDL: 103569923
TCA: 655501
DPA: 109533351
ATD: 109594760
NVL: 108563833
BMOR: 101742216
BMAN: 114241766
PRAP: 110994508
HAW: 110378347
TNL: 113507614
PXY: 105394948
API: 100160780
DNX: 107166792
AGS: 114124237
RMD: 113552736
BTAB: 109042143
CLEC: 106666598
ZNE: 110830244
FCD: 110850824
PVM: 113819838
TUT: 107360527
DPTE: 113793502
CSCU: 111619612
PTEP: 107437171
CEL: CELE_F39B1.1(piki-1)
CBR: CBG07670
BMY: Bm1_05655
PCAN: 112559398
MYI: 110441528
OBI: 106869736
LAK: 106172136
SHX: MS3_04656
EGL: EGR_05933
NVE: 5517990
EPA: 110233446
ADF: 107335827
AMIL: 114955439
PDAM: 113682593
SPIS: 111322228
DGT: 114516438
HMG: 100211167
AQU: 100639364
DDI: DDB_G0291093(pikH)
DFA: DFA_03210(pikH)
 » show all
Reference
1  [PMID:11395417]
  Authors
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD.
  Title
Synthesis and function of 3-phosphorylated inositol lipids.
  Journal
Annu Rev Biochem 70:535-602 (2001)
DOI:10.1146/annurev.biochem.70.1.535
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.154
IUBMB Enzyme Nomenclature: 2.7.1.154
ExPASy - ENZYME nomenclature database: 2.7.1.154
BRENDA, the Enzyme Database: 2.7.1.154
CAS: 141176-94-5

KEGG   REACTION: R03362
Entry
R03362                      Reaction                               

Name
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Definition
ATP + 1-Phosphatidyl-D-myo-inositol <=> ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Equation
Reaction class
RC00002  C00002_C00008
RC00078  C01194_C04549
Enzyme
2.7.1.137       2.7.1.154
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00923  phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Other DBs
RHEA: 12712

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