KEGG   ORTHOLOGY: K00988
Entry
K00988                      KO                                     

Name
APA1_2
Definition
sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]
Pathway
ko00230  Purine metabolism
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K00988  APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K00988  APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.5  sulfate adenylyltransferase (ADP)
     K00988  APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase
    2.7.7.53  ATP adenylyltransferase
     K00988  APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase
Other DBs
RN: R00126 R00530 R01618
COG: COG4360
GO: 0004780 0003877
Genes
QSU: 112018598
CRE: CHLREDRAFT_177187
VCN: VOLCADRAFT_92922
CSL: COCSUDRAFT_83450
CVR: CHLNCDRAFT_138409
SCE: YCL050C(APA1) YDR530C(APA2)
AGO: AGOS_AFR730W
ERC: Ecym_1023
KLA: KLLA0_C00847g
KMX: KLMA_10035(APA2)
NCS: NCAS_0A00210(NCAS0A00210) NCAS_0B09000(NCAS0B09000)
NDI: NDAI_0A00250(NDAI0A00250) NDAI_0F04610(NDAI0F04610)
TPF: TPHA_0B04890(TPHA0B04890) TPHA_0E03900(TPHA0E03900)
TBL: TBLA_0A05020(TBLA0A05020)
TDL: TDEL_0C06860(TDEL0C06860)
KAF: KAFR_0D00250(KAFR0D00250) KAFR_0H03740(KAFR0H03740)
PIC: PICST_48616(APA2)
CAL: CAALFM_C603410CA(APA2)
SLB: AWJ20_1864(APA1)
NCR: NCU11368
NTE: NEUTE1DRAFT82743(NEUTE1DRAFT_82743)
MAJ: MAA_06104
ANG: ANI_1_1040144(An16g07800)
CNE: CNL04030
CNB: CNBI2740
TASA: A1Q1_08178
ABP: AGABI1DRAFT55635(AGABI1DRAFT_55635)
ABV: AGABI2DRAFT220942(AGABI2DRAFT_220942)
MGL: MGL_2181
MRT: MRET_0327
VTA: B1527
PPR: PBPRA1434(SLL0509)
SHL: Shal_1637
PSEO: OM33_08105
PSPO: PSPO_a1127
HCH: HCH_06654
SVA: SVA_1021
REH: H16_A1656(h16_A1656)
BUB: BW23_5719
BSTG: WT74_17770
BYI: BYI23_B003390(ap4A)
BUE: BRPE67_BCDS05920(ap4A)
BPH: Bphy_6436
BFN: OI25_6142
CABA: SBC2_44610
AFQ: AFA_01870
EBA: ebA5257
AZO: azo1527
AZA: AZKH_2973
AOA: dqs_1650
TCL: Tchl_2289
SYN: sll0509
SYY: SYNGTS_2862(sll0509)
SYT: SYNGTI_2861(sll0509)
SYS: SYNPCCN_2860(sll0509)
SYQ: SYNPCCP_2860(sll0509)
SYC: syc0057_d
SYW: SYNW1233
SYG: sync_1346
SYP: SYNPCC7002_A2555(apa2)
SYNR: KR49_02160
SYND: KR52_09745
LBO: LBWT_6600
PMA: Pro_0961(APA2)
PMM: PMM0874
PMT: PMT_0732
PMB: A9601_09871(apa2)
PMC: P9515_09561(apa2)
PMF: P9303_14851(apa2)
PMG: P9301_09851(apa2)
PMH: P9215_10181(apa2)
PMJ: P9211_08901(apa2)
PME: NATL1_10081(apa2)
PRC: EW14_1018
PRM: EW15_1025
AMR: AM1_3897
CYL: AA637_11335(apa1)
CYT: cce_4376
TER: Tery_0108
ANA: alr4466
NSH: GXM_02581
AVA: Ava_3329
NAZ: Aazo_3644
CTHE: Chro_5370
CEO: ETSB_1145
NJA: NSJP_3293
 » show all
Reference
PMID:2556364
  Authors
Plateau P, Fromant M, Schmitter JM, Buhler JM, Blanquet S
  Title
Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase.
  Journal
J Bacteriol 171:6437-45 (1989)
DOI:10.1128/jb.171.12.6437-6445.1989
  Sequence
[sce:YCL050C]
Reference
PMID:2174863
  Authors
Plateau P, Fromant M, Schmitter JM, Blanquet S
  Title
Catabolism of bis(5'-nucleosidyl) tetraphosphates in Saccharomyces cerevisiae.
  Journal
J Bacteriol 172:6892-9 (1990)
DOI:10.1128/jb.172.12.6892-6899.1990
  Sequence

KEGG   ORTHOLOGY: K22966
Entry
K22966                      KO                                     

Name
HINT4
Definition
sulfate adenylyltransferase (ADP) / adenylylsulfatase [EC:2.7.7.5 3.6.2.1]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K22966  HINT4; sulfate adenylyltransferase (ADP) / adenylylsulfatase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.5  sulfate adenylyltransferase (ADP)
     K22966  HINT4; sulfate adenylyltransferase (ADP) / adenylylsulfatase
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.2  In sulfonyl-containing anhydrides
    3.6.2.1  adenylylsulfatase
     K22966  HINT4; sulfate adenylyltransferase (ADP) / adenylylsulfatase
Other DBs
RN: R00530 R00531
GO: 0004780 0047627
Genes
SRX: 107711620 107721285
SANH: 107659167
CCAR: 109091715
TRU: 101069999 101070225
TNG: GSTEN00030348G001
LCO: 104930551
NCC: 104947347 104965344(hint3)
ONL: 100710593
CVG: 107083367
NFU: 107378793(hint3)
KMR: 108232221(hint3)
AOCE: 111562389(hint3) 111569944
SDU: 111216309
SLAL: 111653045
OTW: 112217689
AEC: 105144064
ACEP: 105625434
PBAR: 105429046
VEM: 105570015
ATH: AT4G16566(HINT4)
CRB: 17879189
BRP: 103869390
BOE: 106326517
RSZ: 108839999
CIT: 102610585
TCC: 18606267
GRA: 105792078
GAB: 108468127
DZI: 111289898
EGR: 104443689
GMX: 100799719
GSJ: 114374327
VRA: 106777109
VAR: 108335357
VUN: 114173180
CAM: 101500605
LJA: Lj2g3v2001930.1(Lj2g3v2001930.1) Lj4g3v1273610.1(Lj4g3v1273610.1)
ADU: 107488224
AIP: 107643042
LANG: 109330604
FVE: 101305557
RCN: 112179630
PPER: 18778076
PMUM: 103337142
PAVI: 110757113
MDM: 103433011
PXB: 103927323
ZJU: 107430292
CSV: 101205151
CMO: 103482613
MCHA: 111021957
CMAX: 111468838
CMOS: 111430257
CPEP: 111809420
RCU: 107262038
JCU: 105632262
HBR: 110668771
MESC: 110609950
POP: 7471623
PEU: 105130865
JRE: 108985353
VVI: 100265964
SLY: 101265563
SPEN: 107027177
SOT: 102601535
CANN: 107851176
NSY: 104225809
NTO: 104117636
NAU: 109232881
INI: 109147075
SIND: 105155842
OEU: 111399180
LSV: 111917633
CCAV: 112527866
DCR: 108197463
BVG: 104907851
SOE: 110788318
OSA: 4336514
DOSA: Os04t0535400-01(Os04g0535400)
OBR: 102702185
BDI: 100844945
ATS: 109752675(LOC109752675)
SBI: 8058342
ZMA: 100284636
SITA: 101769143
PDA: 103705125
EGU: 105043632
MUS: 103985636
DCT: 110110645
PEQ: 110027067
AOF: 109839635
ATR: 18428798
CMT: CCM_00883
CNB: CNBC6530
TASA: A1Q1_02752
ABP: AGABI1DRAFT76327(AGABI1DRAFT_76327)
ABV: AGABI2DRAFT200854(AGABI2DRAFT_200854)
DFA: DFA_00137
 » show all
Reference
  Authors
Guranowski A, Wojdyla AM, Zimny J, Wypijewska A, Kowalska J, Jemielity J, Davis RE, Bieganowski P
  Title
Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases  (forming ADP).
  Journal
FEBS Lett 584:93-8 (2010)
DOI:10.1016/j.febslet.2009.11.003
  Sequence
[ath:AT4G16566]

KEGG   ENZYME: 2.7.7.5
Entry
EC 2.7.7.5                  Enzyme                                 

Name
sulfate adenylyltransferase (ADP);
ADP-sulfurylase;
sulfate (adenosine diphosphate) adenylyltransferase;
adenosine diphosphate sulfurylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
ADP:sulfate adenylyltransferase
Reaction(IUBMB)
ADP + sulfate = phosphate + adenylyl sulfate [RN:R00530]
Reaction(KEGG)
R00530
Substrate
ADP [CPD:C00008];
sulfate [CPD:C00059]
Product
phosphate [CPD:C00009];
adenylyl sulfate [CPD:C00224]
History
EC 2.7.7.5 created 1961
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00988  sulfate adenylyltransferase (ADP) / ATP adenylyltransferase
K22966  sulfate adenylyltransferase (ADP) / adenylylsulfatase
Genes
SRX: 107711620 107721285
SANH: 107659167
CCAR: 109091715
TRU: 101069999 101070225
TNG: GSTEN00030348G001
LCO: 104930551
NCC: 104947347 104965344(hint3)
ONL: 100710593
CVG: 107083367
NFU: 107378793(hint3)
KMR: 108232221(hint3)
AOCE: 111562389(hint3) 111569944
SDU: 111216309
SLAL: 111653045
OTW: 112217689
AEC: 105144064
ACEP: 105625434
PBAR: 105429046
VEM: 105570015
ATH: AT4G16566(HINT4)
CRB: 17879189
BRP: 103869390
BOE: 106326517
RSZ: 108839999
CIT: 102610585
TCC: 18606267
GRA: 105792078
GAB: 108468127
DZI: 111289898
EGR: 104443689
GMX: 100799719
GSJ: 114374327
VRA: 106777109
VAR: 108335357
VUN: 114173180
CAM: 101500605
LJA: Lj2g3v2001930.1(Lj2g3v2001930.1) Lj4g3v1273610.1(Lj4g3v1273610.1)
ADU: 107488224
AIP: 107643042
LANG: 109330604
FVE: 101305557
RCN: 112179630
PPER: 18778076
PMUM: 103337142
PAVI: 110757113
MDM: 103433011
PXB: 103927323
ZJU: 107430292
CSV: 101205151
CMO: 103482613
MCHA: 111021957
CMAX: 111468838
CMOS: 111430257
CPEP: 111809420
RCU: 107262038
JCU: 105632262
HBR: 110668771
MESC: 110609950
POP: 7471623
PEU: 105130865
JRE: 108985353
VVI: 100265964
SLY: 101265563
SPEN: 107027177
SOT: 102601535
CANN: 107851176
NSY: 104225809
NTO: 104117636
NAU: 109232881
INI: 109147075
SIND: 105155842
OEU: 111399180
LSV: 111917633
CCAV: 112527866
DCR: 108197463
BVG: 104907851
SOE: 110788318
OSA: 4336514
DOSA: Os04t0535400-01(Os04g0535400)
OBR: 102702185
BDI: 100844945
ATS: 109752675(LOC109752675)
SBI: 8058342
ZMA: 100284636
SITA: 101769143
PDA: 103705125
EGU: 105043632
MUS: 103985636
DCT: 110110645
PEQ: 110027067
AOF: 109839635
ATR: 18428798
SCE: YCL050C(APA1) YDR530C(APA2)
ERC: Ecym_1023
KMX: KLMA_10035(APA2)
NCS: NCAS_0A00210(NCAS0A00210) NCAS_0B09000(NCAS0B09000)
NDI: NDAI_0A00250(NDAI0A00250) NDAI_0F04610(NDAI0F04610)
TPF: TPHA_0B04890(TPHA0B04890) TPHA_0E03900(TPHA0E03900)
TBL: TBLA_0A05020(TBLA0A05020)
TDL: TDEL_0C06860(TDEL0C06860)
KAF: KAFR_0D00250(KAFR0D00250) KAFR_0H03740(KAFR0H03740)
PIC: PICST_48616(APA2)
CAL: CAALFM_C603410CA(APA2)
SLB: AWJ20_1864(APA1)
NCR: NCU11368
NTE: NEUTE1DRAFT82743(NEUTE1DRAFT_82743)
MAJ: MAA_06104
ANG: ANI_1_1040144(An16g07800)
CNE: CNL04030
ABP: AGABI1DRAFT55635(AGABI1DRAFT_55635) AGABI1DRAFT76327(AGABI1DRAFT_76327)
ABV: AGABI2DRAFT200854(AGABI2DRAFT_200854) AGABI2DRAFT220942(AGABI2DRAFT_220942)
MGL: MGL_2181
MRT: MRET_0327
DFA: DFA_00137
VTA: B1527
PPR: PBPRA1434(SLL0509)
SHL: Shal_1637
PSEO: OM33_08105
PSPO: PSPO_a1127
HCH: HCH_06654
SVA: SVA_1021
REH: H16_A1656(h16_A1656)
BUB: BW23_5719
BSTG: WT74_17770
BYI: BYI23_B003390(ap4A)
BUE: BRPE67_BCDS05920(ap4A)
BPH: Bphy_6436
BFN: OI25_6142
CABA: SBC2_44610
AFQ: AFA_01870
EBA: ebA5257
AZO: azo1527
AZA: AZKH_2973
AOA: dqs_1650
TCL: Tchl_2289
SYN: sll0509
SYY: SYNGTS_2862(sll0509)
SYT: SYNGTI_2861(sll0509)
SYS: SYNPCCN_2860(sll0509)
SYQ: SYNPCCP_2860(sll0509)
SYC: syc0057_d
SYW: SYNW1233
SYG: sync_1346
SYP: SYNPCC7002_A2555(apa2)
SYNR: KR49_02160
SYND: KR52_09745
LBO: LBWT_6600
PMA: Pro_0961(APA2)
PMM: PMM0874
PMT: PMT_0732
PMB: A9601_09871(apa2)
PMC: P9515_09561(apa2)
PMF: P9303_14851(apa2)
PMG: P9301_09851(apa2)
PMH: P9215_10181(apa2)
PMJ: P9211_08901(apa2)
PME: NATL1_10081(apa2)
PRC: EW14_1018
PRM: EW15_1025
AMR: AM1_3897
CYL: AA637_11335(apa1)
CYT: cce_4376
TER: Tery_0108
ANA: alr4466
NSH: GXM_02581
AVA: Ava_3329
NAZ: Aazo_3644
CTHE: Chro_5370
CEO: ETSB_1145
NJA: NSJP_3293
 » show all
Reference
1  [PMID:5964041]
  Authors
Grunberg-Manago M, Del Campillo-Campbell A, Dondon L, Michelson AM.
  Title
[Yeast ADP-sulfurylase catalyzing an exchange between orthophosphate and the terminal phosphate of nucleoside diphosphates]
  Journal
Biochim Biophys Acta 123:1-16 (1966)
DOI:10.1016/0005-2787(66)90153-5
Reference
2  [PMID:13502346]
  Authors
ROBBINS PW, LIPMANN F.
  Title
Isolation and identification of active sulfate.
  Journal
J Biol Chem 229:837-51 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.5
IUBMB Enzyme Nomenclature: 2.7.7.5
ExPASy - ENZYME nomenclature database: 2.7.7.5
BRENDA, the Enzyme Database: 2.7.7.5
CAS: 9027-70-7

KEGG   REACTION: R00530
Entry
R00530                      Reaction                               

Name
ADP:sulfate adenylyltransferase
Definition
ADP + Sulfate <=> Orthophosphate + Adenylyl sulfate
Equation
Reaction class
RC02809  C00059_C00224
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00988  sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]
K22966  sulfate adenylyltransferase (ADP) / adenylylsulfatase [EC:2.7.7.5 3.6.2.1]
Other DBs
RHEA: 16532

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