KEGG ORTHOLOGY: K01044

ORTHOLOGY: K01044

Entry

K01044                      KO

Symbol

CES1

Name

carboxylesterase 1 [EC:3.1.1.1]

Pathway

map00983

Drug metabolism - other enzymes

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K01044  CES1; carboxylesterase 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.1  carboxylesterase
     K01044  CES1; carboxylesterase 1

Other DBs

RN:	R06728 R08220 R08249 R08251 R08255 R08258

GO:

0004091

CAZy:

CE10

Genes

HSA:	1066(CES1)

PTR:	747009 750059

PPS:	100980372 100984384 100990164 100993746

GGO:	101149966 109023710 115931015 115931059

PON:	100174711(CES1) 100450658 100451021

NLE:	100590392(CES1) 100599005

HMH:

116470596

MCC:	699486 707292 707412

MCF:	102127617 102128556

MTHB:

126943833 126943835 126943848

MNI:	105494076 105494077 105494113

CSAB:

103233018(CES1) 103233020 103233528

CATY:

105588496 105588514 105588523

PANU:

101015246(CES1) 101017969

TGE:	112613976 112613977 112614334 112614716

MLEU:

105533465 105533466 105537026 105537501

RRO:	104660506 104665604 104671477

RBB:	108522821 108526381

TFN:	117087802 117088390 117088396 117088598 117088895 117088912

CANG:

105502140

CJC:	100390116 100390472(CES1)

SBQ:

101052402

CIMI:

108298171 108298172

CSYR:

103254554(CES1)

MMUR:

105866535 105866541 105866547 105871709 105875531

LCAT:

123625015 123625043 123625316 123625344

PCOQ:

105808845 105811898 105820846 105825012 105827037

OGA:	100961646 100966144

MMU:	104158(Ces1d) 13884(Ces1c) 13897(Ces1e) 234564(Ces1f)

MCAL:

110299985 110300015 110300388 110300390

MPAH:

110337200 110337337 110337796

RNO:	100125372(Ces1f) 113902(Ces1d) 24346(Ces1c) 291863 29225(Ces1e)

MCOC:

116069875 116069877

ANU:	117722882 117722884 117722885 117722886 117723120 117723470

MUN:	110562839 110562840 110562845

CGE:	100765464 100765753 100766045 100766339 100769145 100769432 100770009

MAUA:

101831681 101831953 101832386 101832654 106021868

PROB:

127227007 127230009 127230010 127230011 127230014

PLEU:

114694523 114694524 114694526 114694527

MORG:

121446904 121446905 121446907 121446973 121447353 121447365

MFOT:

126487805 126487863 126502578 126502579

AAMP:

119801643 119801644 119801645 119802062

NGI:	103731688 103731689 103749862 103750054

HGL:	101724646 101725528

CPOC:

100379237(Ces1d) 100717197 100717473 100721835 100730472

CCAN:

109694656 109694658

DORD:

105994407 105994451

DSP:	122116314 122116316 122116317

PLOP:

125358441 125358442

NCAR:

124966697 124966698 124966858 124966860 124966861

OCU:	100009551 100341773

OPI:	101521389 101524234 101524472

TUP:	102481101(CES1)

CFA:	403643(CES1)

CLUD:

112660181(CES1)

VVP:	112929624(CES1)

VLG:	121497375(CES1)

NPO:	129513690(CES1)

AML:	100465627(CES1)

UMR:	103673786(CES1)

UAH:	113252254(CES1)

UAR:	123798417(CES1)

ELK:

111157342

LLV:

125089304

MPUF:

101676369(CES1)

NVS:	122911439(CES1)

ORO:	101377267(CES1)

EJU:	114204058(CES1)

ZCA:	113935931(CES1)

MLX:	118023774(CES1)

NSU:	110593343(CES1)

LWW:

102729417

FCA:	493774(CES1)

PYU:	121045324(CES1)

PCOO:

112857217(CES1)

PBG:	122494219(CES1)

LRUF:

124511833

PTG:	102957516(CES1)

PPAD:

109270897(CES1)

PUC:

125916116

AJU:

106973293

HHV:	120238338(CES1)

BTA:	508916 512098(CES1)

BOM:

BIU:

BBUB:

BBIS:

CHX:	102188073 102188887

OAS:	101116336 101116756

BTAX:

128063463 128064172

ODA:	120859321 120859322

CCAD:

122420094

SSC:	100736962 397478(CES1)

CFR:	102509275 116665755

CBAI:

105061994(CES1)

CDK:	105096170(CES1) 116147134

VPC:	102545725(CES1)

BACU:

103015234

LVE:	103078800 103080780

OOR:	101276480 101287207

DLE:

111171077

PCAD:

102990478

PSIU:

116744139 116744140

NASI:

112401255(CES1) 112403217

ECB:	100050685 100050764 100050840 100050915 100050992 100051065 106782960

EPZ:	103553186 103553189 103553191 103567206 103567207

EAI:	106822259 106822420 106837701 106837710 123275582 123275586

MYB:	102241821(CES1)

MYD:	102761162 102761447 102763195

MMYO:

118674783(CES1)

MLF:	102417797 102418428

MNA:	107543469(CES1)

PKL:	118720557(CES1)

HAI:	109395626(CES1)

DRO:	112296767(CES1)

AJM:	119046439(CES1)

PDIC:

114488177 114488180

PHAS:

123805750(CES1) 123805751

RFQ:	117035242(CES1)

PALE:

102884390(CES1)

PGIG:

120617293(CES1)

PVP:	105292043(CES1)

RAY:	107499667(CES1)

MJV:	108387933(CES1)

TOD:	119235074 119249232 119250406

SARA:

101540172(CES1)

LAV:	100673502 100673798 100674078 100674358 111752344

TMU:	101340795 101358032

ETF:	101661092(CES1)

DNM:	101443620(CES1)

MDO:	100144615(CES1)

GAS:	123233654 123233656 123233657 123237305 123237306

SHR:

100922782

AFZ:	127546835 127546836 127550724 127550725 127550726

PCW:

110207506

OAA:

100079382

GGA:	415786(CES1L1) 769339(CES1L2) 769704

PCOC:

116244063

MGP:

104912916

CJO:	107307680 107319232 107319292

TPAI:

128082322 128082323 128082324

NMEL:

APLA:

ACYG:

AFUL:

TGU:

SCAN:

PMOA:

OTC:

PRUF:

FAB:

CCAE:

CCW:

CBRC:

ZAB:

ACHL:

103801700(CES1)

SVG:

106863215

FPG:

101920451

FCH:

102058343

CLV:	102095920 106145639

EGZ:

104123642

NNI:

104013262

PLET:

104625924(CES1)

PCRI:

104025490

PCAO:

104040106(CES1)

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

104561232(CES1)

EHS:

104503854

MUI:

104535541

BREG:

104643246

FGA:	104074764(CES1)

GSTE:

LDI:

MNB:

OHA:

NNT:	104407649(CES1)

SHAB:

115619424 115619432

ACAR:

104518924

CPEA:

104396338(CES4A)

AVIT:

CVF:

CUCA:

AAM:

AROW:

NPD:

TGT:

DNE:	112987644 112987670

SCAM:

104143979

ASN:

102383127

AMJ:	102563772(CES1)

CPOO:

GGN:

PSS:

CMY:

TST:

CABI:

MRV:

PVT:

PBI:

PMUR:

CTIG:

TSR:	106547493(CES1)

PGUT:

117670455

PTEX:

113445341

NSS:	113426612(CES1)

PMUA:

114601889

ZVI:	118087254 118093787

HCG:	128326940 128334296 128343661

GJA:	107110324(CES1)

STOW:

BGAR:

SSCV:

CCLU:

PSEX:

CPLA:

BFO:	118404976 118417593 118418077 118418470 118420304 118428824

BBEL:

109473444

SCLV:

120339382 120339584

DME:	Dmel_CG17148(Est-P) Dmel_CG34139(Nlg4) Dmel_CG6917(Est-6)

DER:	6544476 6544591

DSE:	6605412 6605413

DSI:	Dsimw501_GD14366(Dsim_Est-6) Dsimw501_GD14367(Dsim_Est-P)

DYA:	Dyak_GE21892 Dyak_GE21893(Dyak_Est-7)

DAN:	6502816 6507440

DSR:	110186767 110187201

DPO:	4813124 6900444

DPE:	6596069 6596070

DMN:	108151116 117185731

DWI:

6645211

DGR:	6567326 6568036

DMO:	Dmoj_GI22473

DAZ:	108608990 108620982

DNV:

108660307

DHE:	111592380 111604571

DVI:

6632969

CCAT:

101453228(Nlg4) 101462935

BOD:	106616516 106620699

RZE:	108367636 108368274

MDE:

101889364

SCAC:

106089514 106093551 106093552 106093555

LCQ:

111684753

LSQ:	119604965 119610045

HIS:

119660213

AGA:	AgaP_AGAP005372(COEBE3D)

ACOZ:

120953500 120953501 120953502 120953503

AARA:

120895583

AMER:

121587827 121592648 121592649 121592650

ASTE:

118506296 118509411 118509412 118509413 118509414

AALI:

118466761 118468923

CPII:

120415190 120424870

CNS:

116349125

BCOO:

119077853 119079054 119080017

MGEN:

117217990

TPRE:

106648580 111693974

SOY:	115876899 115889079 115890243

CSET:

123308203

AGB:	108904161 108904354 108904482 108904717 108904761 108904864 108907114 108912134 108916575 108917349 108917766 108917805 111691271 111691283 111692105 111692108 111692110 111692359

LDC:

111505753

PPYR:

116167168 116171512 116177945

OTU:	111413494 111414778 111423971

CFEL:

113370735

DCI:

103515895

NLU:	111045596 111052965 111058294

FOC:

TPAL:

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

PPOI:

DSV:

RSAN:

RMP:

DFR:	124494794 124494894 124497207

SDM:

118198124

PMEO:

129588120 129597785 129600350

CEL:	CELE_C52A10.2(cest-35.2) CELE_R12A1.4(ges-1)

CBR:	CBG_06418(Cbr-ges-1)

BGT:

106058060

GAE:

121366612

HRF:

124152895

HRJ:	124273357 124278668

CRG:	105324289 105336052 105336054 105344276 117683537 117683545

PMAX:

117321046 117321047 117333356 117333375 117336910 117336913 117336926

DPOL:

127844542 127859970 127870234 127882442

TRG:	TRUGW13939_06883

» show all

Reference

PMID:15269189

Authors

Furihata T, Hosokawa M, Koyano N, Nakamura T, Satoh T, Chiba K

Title

Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression.

Journal

Drug Metab Dispos 32:1170-7 (2004)
DOI:10.1124/dmd.104.000620

Sequence

[mmu:104158]

Reference

PMID:9169443

Authors

Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF

Title

Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.

Journal

J Biol Chem 272:14769-75 (1997)
DOI:10.1074/jbc.272.23.14769

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   CAZY (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (15)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
   KEGG RCLASS (8)   
Gene (908)   
   KEGG GENES (571)   
   KEGG MGENES (28)   
   RefGene (283)   
   OC (26)   
Literature (2)   
   PubMed (2)   
All databases (931)   

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