KEGG   ORTHOLOGY: K01099
Entry
K01099                      KO                                     
Symbol
INPP5B_F
Name
inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map04070  Phosphatidylinositol signaling system
Disease
H00692  Lowe syndrome
H00694  Dent disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.36  phosphoinositide 5-phosphatase
     K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
  Rab GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Protein recycling
  Rab GTPases and associated proteins
   Other Rab GTPase associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Endosome - Golgi transport
  Rab GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Other DBs
RN: R04404 R09827
GO: 0004439
Genes
HSA: 3633(INPP5B) 4952(OCRL)
PTR: 456767(INPP5B) 465851(OCRL)
PPS: 100972826(INPP5B) 100988033(OCRL)
GGO: 101138003(INPP5B) 101141428(OCRL)
PON: 100172875(OCRL) 100462526(INPP5B)
NLE: 100599622(INPP5B) 100603753(OCRL)
MCC: 702345(OCRL) 716851(INPP5B)
MCF: 101864788(INPP5B) 102144048(OCRL)
CSAB: 103225081(INPP5B) 103232534(OCRL)
CATY: 105586279(OCRL) 105594735(INPP5B)
PANU: 101001185(OCRL) 101023073(INPP5B)
TGE: 112612768(INPP5B) 112616132(OCRL)
RRO: 104653630(INPP5B) 104655368(OCRL)
RBB: 108516495(OCRL) 108542199(INPP5B)
TFN: 117077455(OCRL) 117092845(INPP5B)
PTEH: 111529592(INPP5B) 111531582(OCRL)
CJC: 100393539(INPP5B) 100415106(OCRL)
SBQ: 101036249(INPP5B) 101038137(OCRL)
CSYR: 103263985(INPP5B) 103272972(OCRL)
MMUR: 105863391(OCRL) 105879562(INPP5B)
LCAT: 123628335(OCRL) 123635735(INPP5B)
OGA: 100943131(INPP5B) 100964391(OCRL)
MMU: 16330(Inpp5b) 320634(Ocrl)
MCAL: 110286794(Ocrl) 110292118(Inpp5b)
MPAH: 110313510(Ocrl) 110322930(Inpp5b)
RNO: 317576(Ocrl) 362590(Inpp5b)
MCOC: 116091389(Ocrl) 116096602(Inpp5b)
MUN: 110540123(Inpp5b) 110565395(Ocrl)
CGE: 100751850(Inpp5b) 100774848(Ocrl)
MAUA: 101829269(Ocrl) 101840967(Inpp5b)
PLEU: 114704300(Inpp5b) 114705463(Ocrl)
AAMP: 119805082(Ocrl) 119816494(Inpp5b)
NGI: 103728746(Ocrl) 103747699(Inpp5b)
HGL: 101704216(Inpp5b) 101722262(Ocrl)
CPOC: 100722491(Inpp5b) 100733180(Ocrl)
CCAN: 109689948 109692797(Inpp5b)
DORD: 105986184(Inpp5b) 105987014(Ocrl)
DSP: 122104182(Inpp5b) 122109957(Ocrl)
OCU: 100346052(OCRL) 100350043(INPP5B)
OPI: 101534385(OCRL) 101536524(INPP5B)
TUP: 102476402(INPP5B) 102497673(OCRL)
CFA: 100686373(INPP5B) 492123(OCRL)
VVP: 112914656(INPP5B) 112934629(OCRL)
VLG: 121481258(INPP5B) 121483108(OCRL)
AML: 100476961(OCRL) 100482018(INPP5B)
UMR: 103666367(INPP5B) 103667611(OCRL)
UAH: 113268264(INPP5B) 113270940(OCRL)
UAR: 123782205(INPP5B) 123789885(OCRL)
MPUF: 101684821(OCRL) 101689454(INPP5B)
ORO: 101372290(INPP5B) 101379029(OCRL)
EJU: 114217015(INPP5B) 114223719(OCRL)
ZCA: 113930758(OCRL) 113937563(INPP5B)
MLX: 118012852(OCRL) 118019661(INPP5B)
FCA: 101092699(INPP5B) 101101038(OCRL)
PYU: 121025582(OCRL) 121026873(INPP5B)
PBG: 122477998(OCRL) 122480302(INPP5B)
PTG: 102964378(INPP5B) 102965696(OCRL)
PPAD: 109253769(OCRL) 109255445(INPP5B)
AJU: 106973196(INPP5B) 106981590(OCRL)
HHV: 120239908(INPP5B) 120244342(OCRL)
BTA: 535844(OCRL) 538291(INPP5B)
BOM: 102274367(INPP5B) 102278951(OCRL)
BIU: 109555222(OCRL) 109556479(INPP5B)
BBUB: 102403119(INPP5B) 102409988(OCRL)
CHX: 102173254(INPP5B) 102173924(OCRL)
OAS: 101119358(INPP5B) 101119794(OCRL)
ODA: 120856377(INPP5B) 120881480(OCRL)
CCAD: 122434872(OCRL) 122437199(INPP5B)
SSC: 100512110(INPP5B) 100524726(OCRL)
CFR: 102506558(INPP5B) 102521852(OCRL)
CBAI: 105072787(INPP5B) 105079683(OCRL)
CDK: 105086922(INPP5B) 105098825(OCRL)
VPC: 102535114(INPP5B) 102543553(OCRL)
BACU: 103005365(INPP5B) 103015114(OCRL)
LVE: 103086884(OCRL) 103091471(INPP5B)
OOR: 101270852(INPP5B) 101279498(OCRL) 101284777
DLE: 111168017(OCRL) 111175608(INPP5B)
PCAD: 102986787(INPP5B) 102996158(OCRL)
PSIU: 116747776(OCRL) 116761310(INPP5B)
ECB: 100054559(INPP5B) 100059144(OCRL)
EPZ: 103549507(INPP5B) 103561753(OCRL)
EAI: 106830567(INPP5B) 106847107(OCRL)
MYB: 102242464(OCRL) 102247367(INPP5B)
MYD: 102754754(OCRL) 102759168(INPP5B)
MMYO: 118654025(OCRL) 118676793(INPP5B)
MLF: 102418071(INPP5B) 102431410(OCRL)
MNA: 107539445(OCRL) 107541563(INPP5B)
PKL: 118722038(OCRL) 118723292(INPP5B)
HAI: 109388879(OCRL) 109390984(INPP5B)
DRO: 112299369(INPP5B) 112310694(OCRL)
SHON: 118977581(INPP5B) 118996077(OCRL)
AJM: 119050682(OCRL) 119052282(INPP5B)
PDIC: 114496638(INPP5B) 114504727(OCRL)
PHAS: 123827781(OCRL) 123832039(INPP5B)
MMF: 118626493(INPP5B) 118635328(OCRL)
RFQ: 117025182(OCRL) 117027172(INPP5B)
PALE: 102884156(OCRL) 102894285(INPP5B)
PGIG: 120593262(INPP5B) 120604302(OCRL)
PVP: 105306390(INPP5B) 105308304(OCRL)
RAY: 107514753(OCRL) 107517058(INPP5B)
MJV: 108388426(INPP5B) 108407983(OCRL)
TOD: 119235142(INPP5B) 119246465(OCRL)
SARA: 101552353(OCRL) 101552919(INPP5B)
LAV: 100655464(OCRL) 100668271(INPP5B)
DNM: 101412799(OCRL) 101419553(INPP5B)
MDO: 100021521(OCRL) 100031802(INPP5B)
GAS: 123234316 123240457(INPP5B) 123253829(OCRL)
SHR: 100914199(INPP5B) 100917371(OCRL)
PCW: 110196530(OCRL) 110206332(INPP5B)
OAA: 100081303(INPP5B) 100087165(OCRL)
GGA: 419609(INPP5B) 422136(OCRL)
PCOC: 116229535(OCRL) 116230033(INPP5B)
MGP: 100540459(INPP5B) 100543414(OCRL)
CJO: 107312534(OCRL) 107324005(INPP5B)
NMEL: 110387281(INPP5B) 110403081(OCRL)
APLA: 101802967(INPP5B) 101803505(OCRL)
ACYG: 106037733(OCRL) 106038058(INPP5B)
AFUL: 116494537(OCRL) 116498155(INPP5B)
TGU: 100219842(OCRL) 100220826(INPP5B)
LSR: 110480100(OCRL) 110484229(INPP5B)
SCAN: 103816475(OCRL) 103822631(INPP5B)
PMOA: 120511740(INPP5B) 120512653(OCRL)
OTC: 121342732(INPP5B) 121346460(OCRL)
PRUF: 121359994(INPP5B) 121362772(OCRL)
GFR: 102033400(OCRL) 102043869(INPP5B)
FAB: 101809360(INPP5B) 101813228(OCRL)
PHI: 102100258(INPP5B) 102104956(OCRL)
PMAJ: 107204051(OCRL) 107214255(INPP5B)
CCAE: 111929316(OCRL) 111942601(INPP5B)
CCW: 104691587(OCRL)
ETL: 114058879(INPP5B) 114064640(OCRL)
ZAB: 102062030(OCRL) 102069370(INPP5B)
FPG: 101911635(OCRL) 101917096(INPP5B)
FCH: 102048833(INPP5B) 102051014(OCRL)
CLV: 102088002(OCRL) 102089265(INPP5B)
EGZ: 104121748(OCRL) 104129194(INPP5B)
NNI: 104012637(OCRL) 104017915(INPP5B)
PLET: 104613615(OCRL) 104625821(INPP5B)
ACUN: 113480012(OCRL) 113488287(INPP5B)
TALA: 104356005(INPP5B) 104366255(OCRL)
PADL: 103920484(INPP5B) 103923615(OCRL)
ACHC: 115333738(OCRL) 115351962(INPP5B)
AAM: 106484102(OCRL) 106490910(INPP5B)
AROW: 112969165(OCRL) 112975649(INPP5B)
NPD: 112947029(OCRL) 112950712(INPP5B)
DNE: 112985222(INPP5B) 112987759(OCRL)
ASN: 102382497(INPP5B) 102386023(OCRL)
AMJ: 102558549(INPP5B) 102571633(OCRL)
CPOO: 109310820(OCRL) 109318585(INPP5B)
GGN: 109294227(INPP5B) 109300503(OCRL)
PSS: 102449725(INPP5B) 102460113(OCRL)
CMY: 102936655(INPP5B) 102939662(OCRL)
CPIC: 101936637(INPP5B) 101937608(OCRL)
TST: 117868193(INPP5B) 117882565(OCRL)
CABI: 116820970(OCRL) 116834282(INPP5B)
MRV: 120371730(OCRL) 120389120(INPP5B)
ACS: 100555494(inpp5b) 100563751(ocrl)
PVT: 110082772(INPP5B) 110084940(OCRL)
SUND: 121916105(INPP5B) 121936340
PBI: 103056566(INPP5B) 103058036(OCRL)
PMUR: 107291571(OCRL)
TSR: 106550451(OCRL)
PGUT: 117663282(INPP5B) 117669542(OCRL)
VKO: 123018888(INPP5B) 123022035(OCRL)
PMUA: 114588964(OCRL) 114601753(INPP5B)
ZVI: 118084052(OCRL) 118087332(INPP5B)
GJA: 107106064(OCRL) 107110144(INPP5B)
STOW: 125435858(INPP5B) 125442571(OCRL)
XLA: 100381066(inpp5b.L) 100873161(ocrl.L) 108700111(ocrl.S)
XTR: 100125214(ocrl) 100497120(inpp5b)
NPR: 108789553(INPP5B) 108793001(OCRL)
RTEM: 120914628(OCRL) 120926907(INPP5B)
BBUF: 120995320(INPP5B) 121009189(OCRL)
BGAR: 122932566(INPP5B) 122946104(OCRL)
DRE: 563543(inpp5b) 777716(ocrl)
CCAR: 109089619 109102283(ocrl) 109105668(inpp5b)
PPRM: 120462650(inpp5b) 120474386(ocrl)
MAMB: 125243087(inpp5b) 125258662(ocrl)
IPU: 108269006(ocrl) 108269428(inpp5b)
PHYP: 113528954(ocrl) 113533888(inpp5b)
SMEO: 124384455(inpp5b) 124385910(ocrl)
TFD: 113635844(ocrl) 113644240(inpp5b)
AMEX: 103027958(ocrl) 103029810(inpp5b)
EEE: 113578044(inpp5b) 113586134(ocrl)
TRU: 101070368(ocrl) 101074672(inpp5b)
LCO: 104919570(inpp5b) 104919860(ocrl)
NCC: 104941351(ocrl) 104965867(inpp5b)
CGOB: 115014744(ocrl) 115021731(inpp5b)
ELY: 117260928(ocrl) 117266446(inpp5b)
PLEP: 121945479(inpp5b) 121947713(ocrl)
SLUC: 116043066(inpp5b) 116052516(ocrl)
ECRA: 117946469(inpp5b) 117951732(ocrl)
PFLV: 114557638(inpp5b) 114562558(ocrl)
GAT: 120810213(inpp5b) 120817350(ocrl)
PPUG: 119197346(inpp5b) 119210409(ocrl)
MSAM: 119888523(ocrl) 119897295(inpp5b) 119897369
CUD: 121514122(inpp5b) 121516216(ocrl)
ALAT: 119005422(inpp5b) 119007253(ocrl)
MZE: 101465648(inpp5b) 101480849(ocrl)
ONL: 100691001(ocrl) 100702112(inpp5b)
OAU: 116317554(ocrl) 116320898(inpp5b)
OLA: 101162611(ocrl) 101170302(inpp5b)
OML: 112143330(inpp5b) 112153433(ocrl)
XMA: 102228425(inpp5b) 102228444(ocrl)
XCO: 114139229(ocrl) 114141914(inpp5b)
XHE: 116714280(ocrl) 116717324(inpp5b)
PRET: 103471562(ocrl) 103477873(inpp5b)
PFOR: 103141582(inpp5b) 103150186(ocrl)
PLAI: 106945455(ocrl) 106948817(inpp5b)
PMEI: 106906613(inpp5b) 106915291(ocrl)
GAF: 122831665(inpp5b) 122837497(ocrl)
CVG: 107085195(inpp5b) 107093383(ocrl)
CTUL: 119786282(ocrl) 119797878(inpp5b)
GMU: 124860281(ocrl) 124865305(inpp5b)
NFU: 107377925(ocrl) 107379367(inpp5b)
KMR: 108231333(ocrl) 108235541(inpp5b)
ALIM: 106514784(ocrl) 106526614(inpp5b)
NWH: 119408871(ocrl) 119409933(inpp5b)
AOCE: 111572345(inpp5b) 111579767(ocrl)
CSEM: 103387904(inpp5b) 103390532(ocrl)
POV: 109627293(ocrl) 109633526(inpp5b)
SSEN: 122774448(inpp5b) 122778243(ocrl)
HHIP: 117769310(ocrl) 117776672(inpp5b)
HSP: 118112513(ocrl) 118113648(inpp5b)
LCF: 108895406(ocrl) 108898729(inpp5b)
SDU: 111232467(ocrl) 111235773(inpp5b)
SLAL: 111648202(ocrl) 111651046(inpp5b)
XGL: 120784153(inpp5b) 120785286(ocrl)
HCQ: 109513101(inpp5b) 109515772(ocrl)
BPEC: 110158945(ocrl) 110174323(inpp5b)
MALB: 109954690(inpp5b) 109955835(ocrl)
BSPL: 114843175(inpp5b) 114863878(ocrl)
OGO: 123997582 124004687(inpp5b) 124010519(ocrl)
ELS: 105006615(ocrl) 105027176(inpp5b)
SFM: 108923154(ocrl) 108927714(inpp5b) 108931048
PKI: 111837993(ocrl) 111848864(inpp5b) 111855471
LOC: 102686271(ocrl) 102694745(inpp5b)
PSPA: 121295833 121303372(inpp5b) 121307607(ocrl)
LCM: 102349621(OCRL) 102364570(INPP5B)
CMK: 103177560(ocrl) 103179631(inpp5b)
RTP: 109913752(inpp5b) 109931919(ocrl)
BFO: 118422800
BBEL: 109481243
CIN: 100177344
SPU: 592451
APLC: 110984507
SKO: 100377456
DME: Dmel_CG3573(Ocrl)
DER: 26525993
DSE: 116802338
DSI: Dsimw501_GD27106(Dsim_GD27106)
DSR: 110181538
DPE: 6600688
DMN: 108152499
DWI: 26530142
DGR: 116805572
DAZ: 108618769
DNV: 108656674
DHE: 111605304
DVI: 26531278
CCAT: 101455114
BOD: 106614422
MDE: 101897751
LCQ: 111674803
LSQ: 119604441
HIS: 119660815
ACOZ: 120956420
AARA: 120902712
AAG: 5577228
CPII: 120428595
CNS: 116352589
AME: 412731
ACER: 107995520
ALAB: 122710613
BIM: 100741804
BBIF: 117211087
BVK: 117232274
BVAN: 117157867
BTER: 100651293
BPYO: 122573479
CCAL: 108629925
MGEN: 117225729
NMEA: 116424340
CGIG: 122395711
SOC: 105195069
MPHA: 105828885
AEC: 105147360
ACEP: 105624817
PBAR: 105424913
VEM: 105567208
HST: 105187545
DQU: 106746699
CFO: 105258604
FEX: 115236333
LHU: 105669453
PGC: 109860124
OBO: 105280493
PCF: 106789367
PFUC: 122513888
VPS: 122631875
NVI: 100121409
CSOL: 105367518
TPRE: 106654934
MDL: 103576662
CGLO: 123274625
FAS: 105266797
DAM: 107046000
AGIF: 122855043
CCIN: 107265391
TCA: 661520
DPA: 109546616
SOY: 115880203
CSET: 123314480
AGB: 108904546
LDC: 111509795
NVL: 108560079
APLN: 108736710
PPYR: 116176647
OTU: 111417904
BMOR: 101735658
BMAN: 114249952
MSEX: 115450620
BANY: 112049327
PMAC: 106712764
PPOT: 106110030
PXU: 106127739
PRAP: 110991324
ZCE: 119829482
HAW: 110381194
TNL: 113501180
SLIU: 111352303
OFU: 114350131
PXY: 105381791
API: 100159919
DNX: 107173728
RMD: 113555269
BTAB: 109035116
CLEC: 106674114
HHAL: 106683721
NLU: 111045780
FOC: 113202291
TPAL: 117644156
ZNE: 110835651
CSEC: 111866438
FCD: 110853829
DMK: 116932803
PVM: 113805341
PJA: 122260508
PCHN: 125034629
HAME: 121857818
PCLA: 123765743
PTRU: 123507583
HAZT: 108677496
EAF: 111699196
LSM: 121119273
PPOI: 119101414
DSV: 119460645
RSAN: 119396913
RMP: 119175001
VDE: 111248392
VJA: 111271426
TUT: 107362481
DPTE: 113790206
DFR: 124498928
CSCU: 111628197
PTEP: 107442177
SDM: 118195980
CEL: CELE_C16C2.3(ocrl-1)
CBR: CBG_03815(Cbr-ocrl-1)
BMY: BM_BM2243(Bma-ocrl-1.1)
TSP: Tsp_10203
PCAN: 112566710
GAE: 121370617
CRG: 105319752
MYI: 110452975
PMAX: 117327728
MMER: 123551873
OBI: 106875100
EGL: EGR_09836
NVE: 5503077
EPA: 110237303
ATEN: 116286962
ADF: 107355825
AMIL: 114968243
PDAM: 113671865
SPIS: 111322633
DGT: 114543218
XEN: 124441693
HMG: 101238065
GMX: 100798039
GSJ: 114418714
VRA: 106756783
VAR: 108345715
VUN: 114181741
CCAJ: 109819201
APRC: 113868098
NTA: 107812880
NSY: 104233283
NCR: NCU01047
NTE: NEUTE1DRAFT120100(NEUTE1DRAFT_120100)
MGR: MGG_16389
SSCK: SPSK_06937
MAW: MAC_05568
MAJ: MAA_10636
CMT: CCM_09079
MBE: MBM_08782
ANI: AN7745.2
ANG: ANI_1_1322034(An03g03860)
ABE: ARB_06083
TVE: TRV_00303
PTE: PTT_13819
CNE: CNK03360
CNB: CNBK0140
TASA: A1Q1_03801
ABP: AGABI1DRAFT101055(AGABI1DRAFT_101055)
ABV: AGABI2DRAFT153211(AGABI2DRAFT_153211)
MGL: MGL_1783
MRT: MRET_2034
DDI: DDB_G0267462(Dd5P4)
DFA: DFA_07655(Dd5P4)
EHI: EHI_153490(13.t00027) EHI_159880(256.t00004)
SMIN: v1.2.000626.t1(symbB.v1.2.000626.t1)
 » show all
Reference
  Authors
Williams C, Choudhury R, McKenzie E, Lowe M
  Title
Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway.
  Journal
J Cell Sci 120:3941-51 (2007)
DOI:10.1242/jcs.014423
  Sequence
[hsa:3633]
Reference
  Authors
van Rahden VA, Brand K, Najm J, Heeren J, Pfeffer SR, Braulke T, Kutsche K
  Title
The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.
  Journal
Hum Mol Genet 21:5019-38 (2012)
DOI:10.1093/hmg/dds343
  Sequence
[hsa:4952]

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