KEGG   ORTHOLOGY: K01099
Entry
K01099                      KO                                     

Name
INPP5B_F
Definition
inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Disease
H00692  Lowe syndrome
H00694  Dent disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.36  phosphoinositide 5-phosphatase
     K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
  Rab GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Protein recycling
  Rab GTPases and associated proteins
   Other Rab GTPase associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
 Endosome - Golgi transport
  Rab GTPases and associated proteins
   Rab associated proteins
    K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F
Other DBs
RN: R04404 R09827
GO: 0004439
Genes
HSA: 3633(INPP5B) 4952(OCRL)
PTR: 456767(INPP5B) 465851(OCRL)
PPS: 100972826(INPP5B) 100988033(OCRL)
GGO: 101138003(INPP5B) 101141428(OCRL)
PON: 100172875(OCRL) 100462526(INPP5B)
NLE: 100599622(INPP5B) 100603753(OCRL)
MCC: 702345(OCRL) 716851(INPP5B)
MCF: 101864788 102144048(OCRL)
CSAB: 103225081(INPP5B) 103232534(OCRL)
RRO: 104653630(INPP5B) 104655368(OCRL)
RBB: 108516495(OCRL) 108542199(INPP5B)
CJC: 100393539(INPP5B) 100415106(OCRL)
SBQ: 101036249(INPP5B) 101038137(OCRL)
MMU: 16330(Inpp5b) 320634(Ocrl)
MCAL: 110286794(Ocrl) 110292118(Inpp5b)
MPAH: 110313510(Ocrl) 110322930(Inpp5b)
RNO: 103689941 317576(Ocrl) 362590(Inpp5b)
MUN: 110540123(Inpp5b) 110565395(Ocrl)
CGE: 100751850(Inpp5b) 100774848(Ocrl)
NGI: 103728746(Ocrl) 103747699(Inpp5b)
HGL: 101704216(Inpp5b) 101722262(Ocrl)
CCAN: 109689948 109692797(Inpp5b)
OCU: 100346052(OCRL) 100350043(INPP5B)
TUP: 102476402(INPP5B) 102497673(OCRL)
CFA: 100686373(INPP5B) 492123(OCRL)
VVP: 112914656(INPP5B) 112934629(OCRL)
AML: 100476961(OCRL) 100482018(INPP5B)
UMR: 103666367(INPP5B) 103667611(OCRL)
UAH: 113268264(INPP5B) 113270940(OCRL)
ORO: 101372290(INPP5B) 101379029(OCRL)
FCA: 101092699(INPP5B) 101101038(OCRL)
PTG: 102964378(INPP5B) 102965696(OCRL)
PPAD: 109253769(OCRL) 109255445(INPP5B)
AJU: 106973196(INPP5B) 106981590(OCRL)
BTA: 535844(OCRL) 538291(INPP5B)
BOM: 102274367(INPP5B) 102278951(OCRL)
BIU: 109555222(OCRL) 109556479(INPP5B)
BBUB: 102403119(INPP5B) 102409988(OCRL)
CHX: 102173254(INPP5B) 102173924(OCRL)
OAS: 101119358(INPP5B) 101119794(OCRL)
SSC: 100512110(INPP5B) 100524726(OCRL)
CFR: 102506558(INPP5B) 102521852(OCRL)
CDK: 105086922(INPP5B) 105098825(OCRL)
BACU: 103005365(INPP5B) 103015114(OCRL)
LVE: 103086884(OCRL) 103091471(INPP5B)
OOR: 101270852(INPP5B) 101279498(OCRL) 101284777
DLE: 111168017(OCRL) 111175608(INPP5B)
PCAD: 102986787(INPP5B) 102996158(OCRL)
ECB: 100054559(INPP5B) 100059144(OCRL)
EPZ: 103549507(INPP5B) 103561753(OCRL)
EAI: 106830567(INPP5B) 106847107(OCRL)
MYB: 102242464(OCRL) 102247367(INPP5B)
MYD: 102754754(OCRL) 102759168(INPP5B)
MNA: 107539445(OCRL) 107541563(INPP5B)
HAI: 109388879(OCRL) 109390984(INPP5B)
DRO: 112299369(INPP5B) 112310694(OCRL)
PALE: 102884156(OCRL) 102894285(INPP5B)
RAY: 107514753(OCRL) 107517058(INPP5B)
MJV: 108388426(INPP5B) 108407983(OCRL)
LAV: 100655464(OCRL) 100668271(INPP5B)
MDO: 100021521(OCRL) 100031802(INPP5B)
SHR: 100914199(INPP5B) 100917371(OCRL)
PCW: 110196530(OCRL) 110206332(INPP5B)
OAA: 100081303(INPP5B) 100087165(OCRL)
GGA: 419609(INPP5B) 422136(OCRL)
MGP: 100540459(INPP5B) 100543414(OCRL)
CJO: 107312534(OCRL) 107324005(INPP5B)
NMEL: 110387281(INPP5B) 110403081(OCRL)
APLA: 101802967(INPP5B) 101803505(OCRL)
ACYG: 106037733(OCRL) 106038058(INPP5B)
TGU: 100219842(OCRL) 100220826(INPP5B)
LSR: 110480100(OCRL) 110484229(INPP5B)
SCAN: 103816475(OCRL) 103822631(INPP5B)
GFR: 102033400(OCRL) 102043869(INPP5B)
FAB: 101809360(INPP5B) 101813228(OCRL)
PHI: 102100258(INPP5B) 102104956(OCRL)
PMAJ: 107204051(OCRL) 107214255(INPP5B)
CCAE: 111929316(OCRL) 111942601(INPP5B)
CCW: 104691587(OCRL) 104694716(INPP5B)
ETL: 114058879(INPP5B) 114064640(OCRL)
FPG: 101911635(OCRL) 101917096(INPP5B)
FCH: 102048833(INPP5B) 102051014(OCRL)
CLV: 102088002(OCRL) 102089265(INPP5B)
EGZ: 104121748(OCRL) 104129194(INPP5B)
NNI: 104012637(OCRL) 104017915(INPP5B)
ACUN: 113480012(OCRL) 113488287(INPP5B)
PADL: 103920484(INPP5B) 103923615(OCRL)
AAM: 106484102(OCRL) 106490910(INPP5B)
ASN: 102382497(INPP5B) 102386023(OCRL)
AMJ: 102558549(INPP5B) 102571633(OCRL)
PSS: 102449725(INPP5B) 102460113(OCRL)
CMY: 102936655(INPP5B) 102939662(OCRL)
CPIC: 101936637(INPP5B) 101937608(OCRL)
ACS: 100555494(inpp5b) 100563751(ocrl)
PVT: 110082772(INPP5B) 110084940(OCRL)
PBI: 103056566(INPP5B) 103058036(OCRL)
PMUR: 107291571(OCRL)
TSR: 106550451(OCRL)
PMUA: 114588964(OCRL) 114601753(INPP5B)
GJA: 107106064(OCRL) 107110144(INPP5B)
XLA: 100381066(inpp5b.L) 100873161(ocrl.L) 108700111(ocrl.S)
XTR: 100125214(ocrl) 100497120(inpp5b)
NPR: 108789553(INPP5B) 108793001(OCRL)
DRE: 563543(inpp5b) 777716(ocrl)
CCAR: 109089619 109102283(ocrl) 109105668(inpp5b)
IPU: 108269006(ocrl) 108269428(inpp5b)
PHYP: 113528954(ocrl) 113533888(inpp5b)
AMEX: 103027958(ocrl) 103029810(inpp5b)
EEE: 113578044(inpp5b) 113586134(ocrl)
TRU: 101070368(ocrl) 101074672(inpp5b)
LCO: 104919570(inpp5b) 104919860(ocrl)
NCC: 104941351(ocrl) 104965867(inpp5b)
MZE: 101465648(inpp5b) 101480849(ocrl)
ONL: 100691001(ocrl) 100702112(inpp5b)
OLA: 101162611(ocrl) 101170302(inpp5b)
XMA: 102228425(inpp5b) 102228444(ocrl)
XCO: 114139229(ocrl) 114141914(inpp5b)
PRET: 103471562(ocrl) 103477873(inpp5b)
CVG: 107085195(inpp5b) 107093383(ocrl)
NFU: 107377925(ocrl) 107379367(inpp5b)
KMR: 108231333(ocrl) 108235541(inpp5b)
ALIM: 106514784(ocrl) 106526614(inpp5b)
AOCE: 111572345(inpp5b) 111579767(ocrl)
CSEM: 103387904(inpp5b) 103390532(ocrl)
POV: 109627293(ocrl) 109633526(inpp5b)
LCF: 108895406(ocrl) 108898729(inpp5b)
SDU: 111232467(ocrl) 111235773(inpp5b)
SLAL: 111648202(ocrl) 111651046(inpp5b)
HCQ: 109513101(inpp5b) 109515772(ocrl)
BPEC: 110158945(ocrl) 110174323(inpp5b)
MALB: 109954690(inpp5b) 109955835(ocrl)
ELS: 105006615(ocrl) 105027176(inpp5b)
SFM: 108923154(ocrl) 108927714(inpp5b) 108931048
PKI: 111837993(ocrl) 111848864(inpp5b) 111855471
LCM: 102349621(OCRL) 102364570(INPP5B)
CMK: 103177560(ocrl) 103179631(inpp5b)
RTP: 109913752(inpp5b) 109931919(ocrl)
BFO: 118422800
CIN: 100177344
SPU: 592451
APLC: 110984507
SKO: 100377456
DME: Dmel_CG3573(Ocrl)
DER: 26525993
DSE: 116802338
DSI: Dsimw501_GD27106(Dsim_GD27106)
DSR: 110181538
DPE: 6600688
DMN: 108152499
DWI: 26530142
DAZ: 108618769
DNV: 108656674
DHE: 111605304
DVI: 26531278
MDE: 101897751
LCQ: 111674803
AAG: 5577228
AME: 412731
BIM: 100741804
BTER: 100651293
CCAL: 108629925
SOC: 105195069
MPHA: 105828885
AEC: 105147360
ACEP: 105624817
PBAR: 105424913
VEM: 105567208
HST: 105187545
DQU: 106746699
CFO: 105258604
LHU: 105669453
PGC: 109860124
OBO: 105280493
PCF: 106789367
NVI: 100121409
CSOL: 105367518
MDL: 103576662
TCA: 661520
DPA: 109546616
NVL: 108560079
BMOR: 101735658
BMAN: 114249952
PMAC: 106712764
PRAP: 110991324
HAW: 110381194
TNL: 113501180
PXY: 105381791
API: 100159919
DNX: 107173728
RMD: 113555269
BTAB: 109035116
CLEC: 106674114
ZNE: 110835651
FCD: 110853829
PVM: 113805341
TUT: 107362481
DPTE: 113790206
CSCU: 111628197
PTEP: 107442177
CEL: CELE_C16C2.3(ocrl-1)
CBR: CBG03815(Cbr-ocrl-1)
TSP: Tsp_10203
PCAN: 112566710
CRG: 105319752
MYI: 110452975
OBI: 106875100
EGL: EGR_09836
NVE: 5503077
EPA: 110237303
ADF: 107355825
AMIL: 114968243
PDAM: 113671865
SPIS: 111322633
DGT: 114543218
HMG: 101238065
GMX: 100798039
GSJ: 114418714
VRA: 106756783
VAR: 108345715
VUN: 114181741
CCAJ: 109819201
NTA: 107812880
NSY: 104233283
NCR: NCU01047
NTE: NEUTE1DRAFT120100(NEUTE1DRAFT_120100)
MGR: MGG_16389
SSCK: SPSK_06937
MAW: MAC_05568
MAJ: MAA_10636
CMT: CCM_09079
MBE: MBM_08782
ANI: AN7745.2
ANG: ANI_1_1322034(An03g03860)
ABE: ARB_06083
TVE: TRV_00303
PTE: PTT_13819
CNE: CNK03360
CNB: CNBK0140
TASA: A1Q1_03801
ABP: AGABI1DRAFT101055(AGABI1DRAFT_101055)
ABV: AGABI2DRAFT153211(AGABI2DRAFT_153211)
MGL: MGL_1783
MRT: MRET_2034
DDI: DDB_G0267462(Dd5P4)
DFA: DFA_07655(Dd5P4)
EHI: EHI_153490(13.t00027) EHI_159880(256.t00004)
SMIN: v1.2.000626.t1(symbB.v1.2.000626.t1)
 » show all
Reference
  Authors
Williams C, Choudhury R, McKenzie E, Lowe M
  Title
Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway.
  Journal
J Cell Sci 120:3941-51 (2007)
DOI:10.1242/jcs.014423
  Sequence
[hsa:3633]
Reference
  Authors
van Rahden VA, Brand K, Najm J, Heeren J, Pfeffer SR, Braulke T, Kutsche K
  Title
The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.
  Journal
Hum Mol Genet 21:5019-38 (2012)
DOI:10.1093/hmg/dds343
  Sequence
[hsa:4952]

KEGG   ORTHOLOGY: K20278
Entry
K20278                      KO                                     

Name
INPP5E
Definition
inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Disease
H00530  Joubert syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.36  phosphoinositide 5-phosphatase
     K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E
Other DBs
RN: R04404 R09827
GO: 0004439
Genes
HSA: 56623(INPP5E)
PTR: 748603(INPP5E)
PPS: 100973295(INPP5E)
GGO: 101150746(INPP5E)
PON: 100445730(INPP5E)
NLE: 100601830(INPP5E)
MCC: 710121(INPP5E)
MCF: 102140416(INPP5E)
CSAB: 103239625(INPP5E)
RRO: 104669671(INPP5E)
RBB: 108542841(INPP5E)
CJC: 100399977(INPP5E)
SBQ: 101031749(INPP5E)
MMU: 64436(Inpp5e)
MCAL: 110309573(Inpp5e)
MPAH: 110318558(Inpp5e)
RNO: 114089(Inpp5e)
MUN: 110550858(Inpp5e)
CGE: 100759837(Inpp5e)
NGI: 103741211(Inpp5e)
HGL: 101701719(Inpp5e)
CCAN: 109697436(Inpp5e)
TUP: 102481520(INPP5E)
CFA: 607443(INPP5E)
VVP: 112906951(INPP5E)
AML: 100468432(INPP5E)
UMR: 103675239(INPP5E)
UAH: 113248583 113248636(INPP5E)
ORO: 101386126(INPP5E)
ELK: 111145744
FCA: 101093901(INPP5E)
PTG: 102958429(INPP5E)
PPAD: 109258773(INPP5E)
AJU: 106989561(INPP5E)
BTA: 506349(INPP5E)
BOM: 102275943(INPP5E)
BIU: 109566589(INPP5E)
BBUB: 102414022(INPP5E)
CHX: 102172073(INPP5E)
OAS: 101115530(INPP5E)
SSC: 110258074(INPP5E)
CFR: 102513772(INPP5E)
CDK: 105106024(INPP5E)
BACU: 103017804(INPP5E)
LVE: 103081690(INPP5E)
OOR: 101279115(INPP5E)
DLE: 111177038(INPP5E)
PCAD: 102982683(INPP5E)
ECB: 100068731(INPP5E)
EPZ: 103565349(INPP5E)
EAI: 106845556(INPP5E)
MYB: 102247617(INPP5E)
MYD: 102762883(INPP5E)
MNA: 107535529(INPP5E)
HAI: 109382414(INPP5E)
DRO: 112306323(INPP5E)
PALE: 102886022(INPP5E)
RAY: 107514878(INPP5E)
MJV: 108387655(INPP5E)
LAV: 100670120(INPP5E)
TMU: 101349334
MDO: 100020283(INPP5E)
SHR: 100930476(INPP5E)
PCW: 110205343(INPP5E)
OAA: 100092732(INPP5E)
GGA: 417135(INPP5E)
MGP: 100546617(INPP5E)
CJO: 107321710(INPP5E)
NMEL: 110406835(INPP5E)
APLA: 101805278(INPP5E)
ACYG: 106040740(INPP5E)
TGU: 100218296(INPP5E)
LSR: 110477641(INPP5E)
SCAN: 103818950(INPP5E)
GFR: 102041103(INPP5E)
FAB: 101814688(INPP5E)
PHI: 102113826(INPP5E)
PMAJ: 107212181(INPP5E)
CCAE: 111937067(INPP5E)
CCW: 104688354(INPP5E)
ETL: 114059114(INPP5E)
FPG: 101924984(INPP5E)
FCH: 102047189(INPP5E)
CLV: 102084313(INPP5E)
EGZ: 104129345(INPP5E)
NNI: 104023206(INPP5E)
ACUN: 113486499(INPP5E)
PADL: 103915254(INPP5E)
AAM: 106487004(INPP5E)
ASN: 102380140(INPP5E)
AMJ: 102566738(INPP5E)
PSS: 102446991(INPP5E)
CMY: 102932373(INPP5E)
CPIC: 101940841(INPP5E)
ACS: 100555178(inpp5e)
PVT: 110079694(INPP5E)
PBI: 103053023(INPP5E)
PMUR: 107296233(INPP5E)
TSR: 106539503(INPP5E)
PMUA: 114588931(INPP5E)
GJA: 107112993(INPP5E)
XLA: 108698190
NPR: 108800235(INPP5E)
DRE: 606579(inpp5e)
IPU: 108255662(inpp5e) 108259957
PHYP: 113537180(inpp5e)
AMEX: 103038809(inpp5e)
EEE: 113572910(inpp5e)
TRU: 101070553(inpp5e)
LCO: 104923663(inpp5e)
NCC: 104958594(inpp5e)
MZE: 101474548(inpp5e)
ONL: 100699689(inpp5e)
OLA: 101161245(inpp5e)
XMA: 102222173(inpp5e)
XCO: 114155114(inpp5e)
PRET: 103469902(inpp5e)
CVG: 107098098(inpp5e)
NFU: 107386282(inpp5e)
KMR: 108233566(inpp5e)
ALIM: 106510879 106528771(inpp5e)
AOCE: 111574698(inpp5e)
POV: 109637072(inpp5e)
SDU: 111236487(inpp5e)
HCQ: 109525194(inpp5e)
MALB: 109959114(inpp5e)
ELS: 105014130(inpp5e)
SFM: 108933635(inpp5e)
PKI: 111841813(inpp5e)
LCM: 102357566(INPP5E)
CMK: 103184698(inpp5e)
RTP: 109938974
BFO: 118421660
CIN: 100180050
APLC: 110989031
SKO: 102808256
DME: Dmel_CG10426(INPP5E)
DER: 26526949
DSE: 116801125
DSI: Dsimw501_GD29624(Dsim_GD29624)
DAN: 26514359
DSR: 110179966
DPE: 113565972
DMN: 108153324
DWI: 26529588
DAZ: 108614655
DNV: 108652248
DHE: 111598763
DVI: 26531093
LCQ: 111677545
AAG: 5570350
AME: 409136
BIM: 100741963
BTER: 100651090
CCAL: 108625526
OBB: 114881124
SOC: 105196631
MPHA: 105833739
AEC: 105148446
ACEP: 105627447
PBAR: 105430920
VEM: 105565624
HST: 105188420
DQU: 106748598
CFO: 105258316
LHU: 105671365
PGC: 109853113
OBO: 105279527
PCF: 106793485
NVI: 103316169
CSOL: 105360740
MDL: 103576177
TCA: 658061
DPA: 109536797
NVL: 108556845
BMOR: 101740091
BMAN: 114253343
PMAC: 106717980
HAW: 110375671
TNL: 113491985
API: 100160684
DNX: 107166522
AGS: 114121233
RMD: 113549409
BTAB: 109042302
CLEC: 106669852
ZNE: 110827627
FCD: 110842783
PVM: 113804514
TUT: 107360979
DPTE: 113799757
CSCU: 111612776
PTEP: 107443026
CEL: CELE_T25B9.10(inpp-1)
CBR: CBG17633
BMY: Bm1_40105
TSP: Tsp_01811
PCAN: 112575502
CRG: 105331671
MYI: 110447300
OBI: 106880773
LAK: 106175147
SHX: MS3_06753
NVE: 5515358
AMIL: 114953028
PDAM: 113671666
SPIS: 111343866
DGT: 114533574
HMG: 100208426
AQU: 100637624
SPAR: SPRG_01861
 » show all
Reference
  Authors
Kisseleva MV, Wilson MP, Majerus PW
  Title
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.
  Journal
J Biol Chem 275:20110-6 (2000)
DOI:10.1074/jbc.M910119199
  Sequence
[hsa:56623]

KEGG   ORTHOLOGY: K20279
Entry
K20279                      KO                                     

Name
SYNJ
Definition
synaptojanin [EC:3.1.3.36]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
Disease
H00606  Early infantile epileptic encephalopathy
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K20279  SYNJ; synaptojanin
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K20279  SYNJ; synaptojanin
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K20279  SYNJ; synaptojanin
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.36  phosphoinositide 5-phosphatase
     K20279  SYNJ; synaptojanin
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K20279  SYNJ; synaptojanin
Other DBs
RN: R04404 R09827
GO: 0004439
Genes
HSA: 8867(SYNJ1) 8871(SYNJ2)
PTR: 463094(SYNJ2) 473959(SYNJ1)
PPS: 100969564(SYNJ1) 103786614(SYNJ2)
GGO: 101131117(SYNJ2) 101133552(SYNJ1)
PON: 100437498(SYNJ1) 100454307(SYNJ2)
NLE: 100597231(SYNJ2) 100598449(SYNJ1)
MCC: 705639(SYNJ2) 707829(SYNJ1)
MCF: 101926413(SYNJ2) 102145009(SYNJ1)
CSAB: 103216970(SYNJ1) 103240794(SYNJ2)
RRO: 104658742(SYNJ1) 104676662(SYNJ2)
RBB: 108536847(SYNJ1) 108540517(SYNJ2)
CJC: 100395303(SYNJ1) 100400862(SYNJ2)
SBQ: 101038752(SYNJ1) 101047067(SYNJ2)
MMU: 104015(Synj1) 20975(Synj2)
MCAL: 110311455(Synj1) 110312552(Synj2)
MPAH: 110329565(Synj1) 110338390(Synj2)
RNO: 84018(Synj2) 85238(Synj1)
MUN: 110541789(Synj1) 110547879(Synj2)
CGE: 100757174(Synj1) 100774472(Synj2)
NGI: 103736463(Synj1) 103739168(Synj2)
HGL: 101700219(Synj2) 101718278(Synj1)
CCAN: 109681906(Synj2) 109687710(Synj1)
OCU: 100328807(SYNJ1) 100355301(SYNJ2)
TUP: 102475253(SYNJ1) 102502408(SYNJ2)
CFA: 478403(SYNJ1) 484052(SYNJ2)
VVP: 112909278(SYNJ1) 112935150(SYNJ2)
AML: 100483932(SYNJ1) 100484742(SYNJ2)
UMR: 103660907(SYNJ2) 103673106(SYNJ1)
UAH: 113259600(SYNJ2) 113265426(SYNJ1)
FCA: 101087233(SYNJ2) 101090793(SYNJ1)
PTG: 102953623(SYNJ1) 102958336(SYNJ2)
PPAD: 109245362(SYNJ2) 109249703(SYNJ1)
AJU: 106966463(SYNJ1) 106982681(SYNJ2)
BTA: 282087(SYNJ1) 518435(SYNJ2)
BOM: 102273891(SYNJ1) 102280878(SYNJ2)
BIU: 109563593(SYNJ2) 109576486(SYNJ1)
BBUB: 102394494(SYNJ1) 102396864(SYNJ2)
CHX: 102176266(SYNJ1) 106502498(SYNJ2)
OAS: 101101853(SYNJ1) 101109366(SYNJ2)
SSC: 100516167(SYNJ2) 100525664(SYNJ1)
CFR: 102512179(SYNJ2) 102518942(SYNJ1)
CDK: 105088310(SYNJ2) 105089876(SYNJ1)
BACU: 103005574(SYNJ2) 103018952(SYNJ1)
LVE: 103071058(SYNJ1) 103084395(SYNJ2)
OOR: 101272813(SYNJ2) 101281706(SYNJ1)
DLE: 111163895(SYNJ1) 111167410(SYNJ2)
PCAD: 102975496(SYNJ1) 102983677(SYNJ2)
ECB: 100052605(SYNJ1) 100059716(SYNJ2)
EPZ: 103560448(SYNJ1) 103566834(SYNJ2)
EAI: 106822400(SYNJ1) 106834935(SYNJ2)
MYB: 102239005(SYNJ2) 102244484(SYNJ1)
MYD: 102752783(SYNJ1) 102753741(SYNJ2)
MNA: 107527814(SYNJ2) 107533499(SYNJ1)
HAI: 109383603(SYNJ2) 109393516(SYNJ1)
DRO: 112297287(SYNJ2) 112305515(SYNJ1)
PALE: 102885509(SYNJ2) 102890440(SYNJ1)
RAY: 107519571(SYNJ1) 107519775(SYNJ2)
MJV: 108384746(SYNJ1) 108387578(SYNJ2)
LAV: 100654255(SYNJ2) 100674046(SYNJ1)
MDO: 100016332(SYNJ1) 100032343(SYNJ2)
SHR: 100920906(SYNJ2) 100927587(SYNJ1)
PCW: 110208583(SYNJ2) 110214898(SYNJ1)
OAA: 100074182(SYNJ2) 100083729(SYNJ1)
GGA: 418498(SYNJ1) 421656(SYNJ2)
MGP: 100543286(SYNJ1) 100546337(SYNJ2) 104914270
CJO: 107311628(SYNJ2) 107322859(SYNJ1)
NMEL: 110396172(SYNJ2) 110402357(SYNJ1)
APLA: 101800513(SYNJ2) 101805183(SYNJ1)
ACYG: 106034243(SYNJ2) 106043435(SYNJ1)
TGU: 100227989(SYNJ2) 100228100(SYNJ1)
LSR: 110471439(SYNJ2) 110480543(SYNJ1)
SCAN: 103812415(SYNJ1) 103820593(SYNJ2)
GFR: 102032196(SYNJ1) 102044789(SYNJ2)
FAB: 101806093(SYNJ1) 101807630(SYNJ2) 101807806
PHI: 102108331(SYNJ1) 102112471(SYNJ2)
PMAJ: 107201794(SYNJ2) 107213432(SYNJ1)
CCAE: 111926747(SYNJ2) 111942615(SYNJ1)
CCW: 104684200(SYNJ1) 104689865(SYNJ2)
ETL: 114067495(SYNJ1) 114068579(SYNJ2)
FPG: 101913351(SYNJ2) 101916469(SYNJ1)
FCH: 102048578(SYNJ2) 102055766 102055769(SYNJ1)
CLV: 102097894(SYNJ1) 102098667(SYNJ2)
EGZ: 104128222(SYNJ1) 104131176(SYNJ2)
NNI: 104008794(SYNJ2) 104020117(SYNJ1)
ACUN: 113478293(SYNJ2) 113486212(SYNJ1)
PADL: 103912727(SYNJ2) 103920252(SYNJ1)
AAM: 106494963(SYNJ1) 106498020(SYNJ2)
ASN: 102369635(SYNJ2) 102385377(SYNJ1)
AMJ: 102575458(SYNJ2) 102576848(SYNJ1)
PSS: 102461279(SYNJ2) 102463325(SYNJ1)
CMY: 102938143 102938192(SYNJ2) 102947907(SYNJ1)
CPIC: 101945887(SYNJ1) 101946228(SYNJ2)
ACS: 100562404(synj2) 100567389(synj1)
PVT: 110080388(SYNJ1) 110087755(SYNJ2)
PBI: 103052147(SYNJ2) 103064194(SYNJ1)
PMUR: 107290594(SYNJ1) 107297343(SYNJ2)
PMUA: 114594290(SYNJ2) 114596042(SYNJ1)
GJA: 107106608(SYNJ2) 107114106(SYNJ1)
XLA: 100380968(synj1.S) 108707879(synj1.L) 108716710
XTR: 100216051(synj2) 100487517(synj1)
NPR: 108794041(SYNJ1) 108795871(SYNJ2)
DRE: 337236(synj1)
SRX: 107718780 107720627(synj1)
IPU: 108277096(synj1)
PHYP: 113543430(synj1)
AMEX: 103027086(synj1)
EEE: 113571772(synj1)
TRU: 101077878(synj1)
LCO: 104925188(synj1)
NCC: 104955646(synj1)
MZE: 101485440(synj1)
ONL: 100697157(synj1)
OLA: 101172098(synj1)
XMA: 102229425(synj1)
XCO: 114153029(synj1)
PRET: 103475541(synj1)
CVG: 107087926(synj1)
NFU: 107386947(synj1)
KMR: 108236988(synj1)
ALIM: 106514139(synj1)
AOCE: 111575862(synj1)
CSEM: 103395501(synj1)
POV: 109635830(synj1)
LCF: 108893656(synj1)
SDU: 111217079(synj1)
SLAL: 111652324(synj1)
HCQ: 109516745(synj1)
BPEC: 110158622(synj1)
MALB: 109959213(synj1)
SASA: 106563883 106563886(synj1)
OTW: 112251278
ELS: 105008024(synj1)
SFM: 108936188(synj1)
PKI: 111840437(synj1)
LCM: 102361906(SYNJ2) 102367670(SYNJ1)
CMK: 103181657(synj2) 103187290(synj1)
RTP: 109915938(synj1) 109927188
BFO: 118422328
CIN: 100177642
SPU: 579866
APLC: 110981597
SKO: 102810151
DME: Dmel_CG6562(Synj)
DER: 26526815
DSE: 116800314
DSI: Dsimw501_GD28984(Dsim_GD28984)
DAN: 26514046
DSR: 110177752
DPE: 6593213
DWI: 26530265
DAZ: 108617274
DNV: 108652817
DHE: 111597056
DVI: 26531624
MDE: 101898444
LCQ: 111682521
AAG: 5574778
AME: 411705
BIM: 100748938
BTER: 100649435
CCAL: 108625131
OBB: 114879784
SOC: 105199792
MPHA: 105835932
AEC: 105148006
ACEP: 105623463
PBAR: 105427875
VEM: 105563814
HST: 105190200
DQU: 106747757
CFO: 105250005
LHU: 105676133
PGC: 109852598
OBO: 105280788
PCF: 106785124
NVI: 100123980
CSOL: 105366906
MDL: 103568822
TCA: 659292
DPA: 109532922
BMOR: 101737247
BMAN: 114246073
PMAC: 106714135
PRAP: 110998741
HAW: 110371599
TNL: 113497272
PXY: 105397137
DNX: 107169289
AGS: 114123882
RMD: 113554895
BTAB: 109036368
CLEC: 106668135
ZNE: 110826578
FCD: 110857966
TUT: 107369062
DPTE: 113790082
CSCU: 111641377
PTEP: 107449250
CEL: CELE_JC8.10(unc-26)
CBR: CBG01799(Cbr-unc-26)
BMY: Bm1_02165
PCAN: 112560387
CRG: 105341511
MYI: 110442910
OBI: 106879251
LAK: 106156663
SHX: MS3_03547
EGL: EGR_03116
NVE: 5505223
EPA: 110242821
ADF: 107353636
AMIL: 114960440
PDAM: 113666079
SPIS: 111337087
DGT: 114531045
HMG: 100210418
AQU: 100638418
VRA: 106769857
VUN: 114192016
CCAJ: 109812167
LJA: Lj5g3v1913760.1(Lj5g3v1913760.1) Lj5g3v1913760.2(Lj5g3v1913760.2)
QSU: 112002560
SCE: YIL002C(INP51) YNL106C(INP52) YOR109W(INP53)
KMX: KLMA_50389(INP51) KLMA_60227(INP53)
NCS: NCAS_0A13120(NCAS0A13120) NCAS_0B06910(NCAS0B06910) NCAS_0G02600(NCAS0G02600)
NDI: NDAI_0B01090(NDAI0B01090) NDAI_0B04240(NDAI0B04240) NDAI_0F02700(NDAI0F02700)
TPF: TPHA_0B02960(TPHA0B02960) TPHA_0F01750(TPHA0F01750) TPHA_0L00740(TPHA0L00740)
TBL: TBLA_0B01340(TBLA0B01340) TBLA_0C05610(TBLA0C05610) TBLA_0J01760(TBLA0J01760)
TDL: TDEL_0F01260(TDEL0F01260) TDEL_0H03050(TDEL0H03050)
KAF: KAFR_0B04520(KAFR0B04520) KAFR_0J02020(KAFR0J02020) KAFR_0K01150(KAFR0K01150)
PIC: PICST_58872(INP51) PICST_82710(INP52)
CAL: CAALFM_C209770CA(INP51) CAALFM_C700670CA(CaO19.7052)
SLB: AWJ20_3207(INP53)
NCR: NCU03298
NTE: NEUTE1DRAFT90897(NEUTE1DRAFT_90897)
MGR: MGG_04549
SSCK: SPSK_04824
MAW: MAC_00537
MAJ: MAA_07272
CMT: CCM_06956
MBE: MBM_04833
ANI: AN8288.2
ANG: ANI_1_510114(An13g00020)
ABE: ARB_00953
TVE: TRV_00731
PTE: PTT_18151
SPO: SPBC2G2.02(syj1) SPBC577.13(syj2)
CNE: CNC06500
CNB: CNBC0700
TASA: A1Q1_04449
ABP: AGABI1DRAFT127695(AGABI1DRAFT_127695)
ABV: AGABI2DRAFT150338(AGABI2DRAFT_150338)
MGL: MGL_3338
MRT: MRET_2711
DDI: DDB_G0292392(Dd5P3)
DFA: DFA_03503(Dd5P2) DFA_08200(Dd5P3)
TAN: TA16590
TPV: TP01_1149
BBO: BBOV_IV011560(23.m05797) BBOV_IV011570(23.m05939)
SMIN: v1.2.005687.t2(symbB.v1.2.005687.t2)
 » show all
Reference
PMID:9428629
  Authors
Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P
  Title
Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15.
  Journal
FEBS Lett 419:175-80 (1997)
DOI:10.1016/S0014-5793(97)01451-8
  Sequence
[hsa:8867]
Reference
  Authors
Malecz N, McCabe PC, Spaargaren C, Qiu R, Chuang Y, Symons M
  Title
Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis.
  Journal
Curr Biol 10:1383-6 (2000)
DOI:10.1016/S0960-9822(00)00778-8
  Sequence
[hsa:8871]

KEGG   ENZYME: 3.1.3.36
Entry
EC 3.1.3.36                 Enzyme                                 

Name
phosphoinositide 5-phosphatase;
type II inositol polyphosphate 5-phosphatase;
triphosphoinositide phosphatase;
IP3 phosphatase;
PtdIns(4,5)P2 phosphatase;
triphosphoinositide phosphomonoesterase;
diphosphoinositide phosphatase;
inositol 1,4,5-triphosphate 5-phosphomonoesterase;
inositol triphosphate 5-phosphomonoesterase;
phosphatidylinositol-bisphosphatase;
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase;
phosphatidylinositol 4,5-bisphosphate phosphatase;
polyphosphoinositol lipid 5-phosphatase;
phosphatidyl-inositol-bisphosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Reaction(KEGG)
R04404;
(other) R09827
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277];
phosphate [CPD:C00009]
Comment
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.
History
EC 3.1.3.36 created 1972, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01099  inositol polyphosphate 5-phosphatase INPP5B/F
K20278  inositol polyphosphate 5-phosphatase INPP5E
K20279  synaptojanin
Genes
HSA: 3633(INPP5B) 4952(OCRL) 56623(INPP5E) 8867(SYNJ1) 8871(SYNJ2)
PTR: 456767(INPP5B) 463094(SYNJ2) 465851(OCRL) 473959(SYNJ1) 748603(INPP5E)
PPS: 100969564(SYNJ1) 100972826(INPP5B) 100973295(INPP5E) 100988033(OCRL) 103786614(SYNJ2)
GGO: 101131117(SYNJ2) 101133552(SYNJ1) 101138003(INPP5B) 101141428(OCRL) 101150746(INPP5E)
PON: 100172875(OCRL) 100437498(SYNJ1) 100445730(INPP5E) 100454307(SYNJ2) 100462526(INPP5B)
NLE: 100597231(SYNJ2) 100598449(SYNJ1) 100599622(INPP5B) 100601830(INPP5E) 100603753(OCRL)
MCC: 702345(OCRL) 705639(SYNJ2) 707829(SYNJ1) 710121(INPP5E) 716851(INPP5B)
MCF: 101864788 101926413(SYNJ2) 102140416(INPP5E) 102144048(OCRL) 102145009(SYNJ1)
CSAB: 103216970(SYNJ1) 103225081(INPP5B) 103232534(OCRL) 103239625(INPP5E) 103240794(SYNJ2)
RRO: 104653630(INPP5B) 104655368(OCRL) 104658742(SYNJ1) 104669671(INPP5E) 104676662(SYNJ2)
RBB: 108516495(OCRL) 108536847(SYNJ1) 108540517(SYNJ2) 108542199(INPP5B) 108542841(INPP5E)
CJC: 100393539(INPP5B) 100395303(SYNJ1) 100399977(INPP5E) 100400862(SYNJ2) 100415106(OCRL)
SBQ: 101031749(INPP5E) 101036249(INPP5B) 101038137(OCRL) 101038752(SYNJ1) 101047067(SYNJ2)
MMU: 104015(Synj1) 16330(Inpp5b) 20975(Synj2) 320634(Ocrl) 64436(Inpp5e)
MCAL: 110286794(Ocrl) 110292118(Inpp5b) 110309573(Inpp5e) 110311455(Synj1) 110312552(Synj2)
MPAH: 110313510(Ocrl) 110318558(Inpp5e) 110322930(Inpp5b) 110329565(Synj1) 110338390(Synj2)
RNO: 103689941 114089(Inpp5e) 317576(Ocrl) 362590(Inpp5b) 84018(Synj2) 85238(Synj1)
MUN: 110540123(Inpp5b) 110541789(Synj1) 110547879(Synj2) 110550858(Inpp5e) 110565395(Ocrl)
CGE: 100751850(Inpp5b) 100757174(Synj1) 100759837(Inpp5e) 100774472(Synj2) 100774848(Ocrl)
NGI: 103728746(Ocrl) 103736463(Synj1) 103739168(Synj2) 103741211(Inpp5e) 103747699(Inpp5b)
HGL: 101700219(Synj2) 101701719(Inpp5e) 101704216(Inpp5b) 101718278(Synj1) 101722262(Ocrl)
CCAN: 109681906(Synj2) 109687710(Synj1) 109689948 109692797(Inpp5b) 109697436(Inpp5e)
OCU: 100328807(SYNJ1) 100346052(OCRL) 100350043(INPP5B) 100355301(SYNJ2)
TUP: 102475253(SYNJ1) 102476402(INPP5B) 102481520(INPP5E) 102497673(OCRL) 102502408(SYNJ2)
CFA: 100686373(INPP5B) 478403(SYNJ1) 484052(SYNJ2) 492123(OCRL) 607443(INPP5E)
VVP: 112906951(INPP5E) 112909278(SYNJ1) 112914656(INPP5B) 112934629(OCRL) 112935150(SYNJ2)
AML: 100468432(INPP5E) 100476961(OCRL) 100482018(INPP5B) 100483932(SYNJ1) 100484742(SYNJ2)
UMR: 103660907(SYNJ2) 103666367(INPP5B) 103667611(OCRL) 103673106(SYNJ1) 103675239(INPP5E)
UAH: 113248583 113248636(INPP5E) 113259600(SYNJ2) 113265426(SYNJ1) 113268264(INPP5B) 113270940(OCRL)
ORO: 101362942(SYNJ1) 101371002 101372290(INPP5B) 101379029(OCRL) 101384695 101386126(INPP5E)
FCA: 101087233(SYNJ2) 101090793(SYNJ1) 101092699(INPP5B) 101093901(INPP5E) 101101038(OCRL)
PTG: 102953623(SYNJ1) 102958336(SYNJ2) 102958429(INPP5E) 102964378(INPP5B) 102965696(OCRL)
PPAD: 109245362(SYNJ2) 109249703(SYNJ1) 109253769(OCRL) 109255445(INPP5B) 109258773(INPP5E)
AJU: 106966463(SYNJ1) 106973196(INPP5B) 106981590(OCRL) 106982681(SYNJ2) 106989561(INPP5E)
BTA: 282087(SYNJ1) 506349(INPP5E) 518435(SYNJ2) 535844(OCRL) 538291(INPP5B)
BOM: 102273891(SYNJ1) 102274367(INPP5B) 102275943(INPP5E) 102278951(OCRL) 102280878(SYNJ2)
BIU: 109555222(OCRL) 109556479(INPP5B) 109563593(SYNJ2) 109566589(INPP5E) 109576486(SYNJ1)
BBUB: 102394494(SYNJ1) 102396864(SYNJ2) 102403119(INPP5B) 102409988(OCRL) 102414022(INPP5E)
CHX: 102172073(INPP5E) 102173254(INPP5B) 102173924(OCRL) 102176266(SYNJ1) 106502498(SYNJ2)
OAS: 101101853(SYNJ1) 101109366(SYNJ2) 101115530(INPP5E) 101119358(INPP5B) 101119794(OCRL)
SSC: 100512110(INPP5B) 100516167(SYNJ2) 100524726(OCRL) 100525664(SYNJ1) 110258074(INPP5E)
CFR: 102506558(INPP5B) 102512179(SYNJ2) 102513772(INPP5E) 102518942(SYNJ1) 102521852(OCRL)
CDK: 105086922(INPP5B) 105088310(SYNJ2) 105089876(SYNJ1) 105098825(OCRL) 105106024(INPP5E)
BACU: 103005365(INPP5B) 103005574(SYNJ2) 103015114(OCRL) 103017804(INPP5E) 103018952(SYNJ1)
LVE: 103071058(SYNJ1) 103081690(INPP5E) 103084395(SYNJ2) 103086884(OCRL) 103091471(INPP5B)
OOR: 101270852(INPP5B) 101272813(SYNJ2) 101279115(INPP5E) 101279498(OCRL) 101281706(SYNJ1) 101284777
DLE: 111163895(SYNJ1) 111167410(SYNJ2) 111168017(OCRL) 111175608(INPP5B) 111177038(INPP5E)
PCAD: 102975496(SYNJ1) 102982683(INPP5E) 102983677(SYNJ2) 102986787(INPP5B) 102996158(OCRL)
ECB: 100052605(SYNJ1) 100054559(INPP5B) 100059144(OCRL) 100059716(SYNJ2) 100068731(INPP5E)
EPZ: 103549507(INPP5B) 103560448(SYNJ1) 103561753(OCRL) 103565349(INPP5E) 103566834(SYNJ2)
EAI: 106822400(SYNJ1) 106830567(INPP5B) 106834935(SYNJ2) 106845556(INPP5E) 106847107(OCRL)
MYB: 102239005(SYNJ2) 102242464(OCRL) 102244484(SYNJ1) 102247367(INPP5B) 102247617(INPP5E)
MYD: 102752783(SYNJ1) 102753741(SYNJ2) 102754754(OCRL) 102759168(INPP5B) 102762883(INPP5E)
MNA: 107527814(SYNJ2) 107533499(SYNJ1) 107535529(INPP5E) 107539445(OCRL) 107541563(INPP5B)
HAI: 109382414(INPP5E) 109383603(SYNJ2) 109388879(OCRL) 109390984(INPP5B) 109393516(SYNJ1)
DRO: 112297287(SYNJ2) 112299369(INPP5B) 112305515(SYNJ1) 112306323(INPP5E) 112310694(OCRL)
PALE: 102884156(OCRL) 102885509(SYNJ2) 102886022(INPP5E) 102890440(SYNJ1) 102894285(INPP5B)
RAY: 107514753(OCRL) 107514878(INPP5E) 107517058(INPP5B) 107519571(SYNJ1) 107519775(SYNJ2)
MJV: 108384746(SYNJ1) 108387578(SYNJ2) 108387655(INPP5E) 108388426(INPP5B) 108407983(OCRL)
LAV: 100654255(SYNJ2) 100655464(OCRL) 100668271(INPP5B) 100670120(INPP5E) 100674046(SYNJ1)
MDO: 100016332(SYNJ1) 100020283(INPP5E) 100021521(OCRL) 100031802(INPP5B) 100032343(SYNJ2)
SHR: 100914199(INPP5B) 100917371(OCRL) 100920906(SYNJ2) 100927587(SYNJ1) 100930476(INPP5E)
PCW: 110196530(OCRL) 110205343(INPP5E) 110206332(INPP5B) 110208583(SYNJ2) 110214898(SYNJ1)
OAA: 100074182(SYNJ2) 100081303(INPP5B) 100083729(SYNJ1) 100087165(OCRL) 100092732(INPP5E)
GGA: 417135(INPP5E) 418498(SYNJ1) 419609(INPP5B) 421656(SYNJ2) 422136(OCRL)
MGP: 100540459(INPP5B) 100543286(SYNJ1) 100543414(OCRL) 100546337(SYNJ2) 100546617(INPP5E) 104914270
CJO: 107311628(SYNJ2) 107312534(OCRL) 107321710(INPP5E) 107322859(SYNJ1) 107324005(INPP5B)
NMEL: 110387281(INPP5B) 110396172(SYNJ2) 110402357(SYNJ1) 110403081(OCRL) 110406835(INPP5E)
APLA: 101800513(SYNJ2) 101802967(INPP5B) 101803505(OCRL) 101805183(SYNJ1) 101805278(INPP5E)
ACYG: 106034243(SYNJ2) 106037733(OCRL) 106038058(INPP5B) 106040740(INPP5E) 106043435(SYNJ1)
TGU: 100218296(INPP5E) 100219842(OCRL) 100220826(INPP5B) 100227989(SYNJ2) 100228100(SYNJ1)
LSR: 110471439(SYNJ2) 110477641(INPP5E) 110480100(OCRL) 110480543(SYNJ1) 110484229(INPP5B)
SCAN: 103812415(SYNJ1) 103816475(OCRL) 103818950(INPP5E) 103820593(SYNJ2) 103822631(INPP5B)
GFR: 102032196(SYNJ1) 102033400(OCRL) 102041103(INPP5E) 102043869(INPP5B) 102044789(SYNJ2)
FAB: 101806093(SYNJ1) 101807630(SYNJ2) 101807806 101809360(INPP5B) 101813228(OCRL) 101814688(INPP5E)
PHI: 102100258(INPP5B) 102104956(OCRL) 102108331(SYNJ1) 102112471(SYNJ2) 102113826(INPP5E)
PMAJ: 107201794(SYNJ2) 107204051(OCRL) 107212181(INPP5E) 107213432(SYNJ1) 107214255(INPP5B)
CCAE: 111926747(SYNJ2) 111929316(OCRL) 111937067(INPP5E) 111942601(INPP5B) 111942615(SYNJ1)
CCW: 104684200(SYNJ1) 104688354(INPP5E) 104689865(SYNJ2) 104691587(OCRL) 104694716(INPP5B)
ETL: 114058879(INPP5B) 114059114(INPP5E) 114064640(OCRL) 114067495(SYNJ1) 114068579(SYNJ2)
FPG: 101911635(OCRL) 101913351(SYNJ2) 101916469(SYNJ1) 101917096(INPP5B) 101924984(INPP5E)
FCH: 102047189(INPP5E) 102048578(SYNJ2) 102048833(INPP5B) 102051014(OCRL) 102055766 102055769(SYNJ1)
CLV: 102084313(INPP5E) 102088002(OCRL) 102089265(INPP5B) 102097894(SYNJ1) 102098667(SYNJ2)
EGZ: 104121748(OCRL) 104128222(SYNJ1) 104129194(INPP5B) 104129345(INPP5E) 104131176(SYNJ2)
NNI: 104008794(SYNJ2) 104012637(OCRL) 104017915(INPP5B) 104020117(SYNJ1) 104023206(INPP5E)
ACUN: 113478293(SYNJ2) 113480012(OCRL) 113486212(SYNJ1) 113486499(INPP5E) 113488287(INPP5B)
PADL: 103912727(SYNJ2) 103915254(INPP5E) 103920252(SYNJ1) 103920484(INPP5B) 103923615(OCRL)
AAM: 106484102(OCRL) 106487004(INPP5E) 106490910(INPP5B) 106494963(SYNJ1) 106498020(SYNJ2)
ASN: 102369635(SYNJ2) 102380140(INPP5E) 102382497(INPP5B) 102385377(SYNJ1) 102386023(OCRL)
AMJ: 102558549(INPP5B) 102566738(INPP5E) 102571633(OCRL) 102575458(SYNJ2) 102576848(SYNJ1)
PSS: 102446991(INPP5E) 102449725(INPP5B) 102460113(OCRL) 102461279(SYNJ2) 102463325(SYNJ1)
CMY: 102932373(INPP5E) 102936655(INPP5B) 102938143 102938192(SYNJ2) 102939662(OCRL) 102947907(SYNJ1)
CPIC: 101936637(INPP5B) 101937608(OCRL) 101940841(INPP5E) 101945887(SYNJ1) 101946228(SYNJ2)
ACS: 100555178(inpp5e) 100555494(inpp5b) 100562404(synj2) 100563751(ocrl) 100567389(synj1)
PVT: 110079694(INPP5E) 110080388(SYNJ1) 110082772(INPP5B) 110084940(OCRL) 110087755(SYNJ2)
PBI: 103052147(SYNJ2) 103053023(INPP5E) 103056566(INPP5B) 103058036(OCRL) 103064194(SYNJ1)
PMUR: 107290594(SYNJ1) 107291571(OCRL) 107296233(INPP5E) 107297343(SYNJ2)
TSR: 106539503(INPP5E) 106541959(SYNJ2) 106550433 106550451(OCRL) 106551877
PMUA: 114588931(INPP5E) 114588964(OCRL) 114594290(SYNJ2) 114596042(SYNJ1) 114601753(INPP5B)
GJA: 107106064(OCRL) 107106608(SYNJ2) 107110144(INPP5B) 107112993(INPP5E) 107114106(SYNJ1)
XLA: 100380968(synj1.S) 100381066(inpp5b.L) 100873161(ocrl.L) 108698190 108700111(ocrl.S) 108707879(synj1.L) 108716710
NPR: 108789553(INPP5B) 108793001(OCRL) 108794041(SYNJ1) 108795871(SYNJ2) 108800235(INPP5E)
DRE: 337236(synj1) 563543(inpp5b) 606579(inpp5e) 777716(ocrl)
IPU: 108255662(inpp5e) 108259957 108269006(ocrl) 108269428(inpp5b) 108277096(synj1)
PHYP: 113528954(ocrl) 113533888(inpp5b) 113537180(inpp5e) 113543430(synj1)
AMEX: 103027086(synj1) 103027958(ocrl) 103029810(inpp5b) 103038809(inpp5e)
EEE: 113571772(synj1) 113572910(inpp5e) 113578044(inpp5b) 113586134(ocrl)
TRU: 101070368(ocrl) 101070553(inpp5e) 101074672(inpp5b) 101077878(synj1)
LCO: 104919570(inpp5b) 104919860(ocrl) 104923663(inpp5e) 104925188(synj1)
NCC: 104941351(ocrl) 104955646(synj1) 104958594(inpp5e) 104965867(inpp5b)
MZE: 101465648(inpp5b) 101474548(inpp5e) 101480849(ocrl) 101485440(synj1)
ONL: 100691001(ocrl) 100697157(synj1) 100699689(inpp5e) 100702112(inpp5b)
OLA: 101161245(inpp5e) 101162611(ocrl) 101170302(inpp5b) 101172098(synj1)
XMA: 102222173(inpp5e) 102228425(inpp5b) 102228444(ocrl) 102229425(synj1)
XCO: 114139229(ocrl) 114141914(inpp5b) 114153029(synj1) 114155114(inpp5e)
PRET: 103469902(inpp5e) 103471562(ocrl) 103475541(synj1) 103477873(inpp5b)
CVG: 107085195(inpp5b) 107087926(synj1) 107093383(ocrl) 107098098(inpp5e)
NFU: 107377925(ocrl) 107379367(inpp5b) 107386282(inpp5e) 107386947(synj1)
KMR: 108231333(ocrl) 108233566(inpp5e) 108235541(inpp5b) 108236988(synj1)
ALIM: 106510879 106514139(synj1) 106514784(ocrl) 106526614(inpp5b) 106528771(inpp5e)
AOCE: 111572345(inpp5b) 111574698(inpp5e) 111575862(synj1) 111579767(ocrl)
CSEM: 103387904(inpp5b) 103390532(ocrl) 103395501(synj1) 103396951 103397902
POV: 109627293(ocrl) 109633526(inpp5b) 109635830(synj1) 109637072(inpp5e)
LCF: 108875310 108893042 108893656(synj1) 108895406(ocrl) 108898729(inpp5b)
SDU: 111217079(synj1) 111232467(ocrl) 111235773(inpp5b) 111236487(inpp5e)
SLAL: 111648202(ocrl) 111648733 111651046(inpp5b) 111652324(synj1) 111663074
HCQ: 109513101(inpp5b) 109515772(ocrl) 109516745(synj1) 109525194(inpp5e)
BPEC: 110153533 110155831 110158622(synj1) 110158945(ocrl) 110174323(inpp5b)
MALB: 109954690(inpp5b) 109955835(ocrl) 109959114(inpp5e) 109959213(synj1)
ELS: 105006615(ocrl) 105008024(synj1) 105014130(inpp5e) 105027176(inpp5b)
SFM: 108923154(ocrl) 108927714(inpp5b) 108931048 108933635(inpp5e) 108936188(synj1)
PKI: 111837993(ocrl) 111840437(synj1) 111841813(inpp5e) 111848864(inpp5b) 111855471
LCM: 102349621(OCRL) 102357566(INPP5E) 102361906(SYNJ2) 102364570(INPP5B) 102367670(SYNJ1)
CMK: 103177560(ocrl) 103179631(inpp5b) 103181657(synj2) 103184698(inpp5e) 103187290(synj1)
RTP: 109913752(inpp5b) 109915938(synj1) 109927188 109931919(ocrl) 109938974
DME: Dmel_CG10426(INPP5E) Dmel_CG3573(Ocrl) Dmel_CG6562(Synj)
DSI: Dsimw501_GD27106(Dsim_GD27106) Dsimw501_GD28984(Dsim_GD28984) Dsimw501_GD29624(Dsim_GD29624)
CEL: CELE_C16C2.3(ocrl-1) CELE_JC8.10(unc-26) CELE_T25B9.10(inpp-1)
CBR: CBG01799(Cbr-unc-26) CBG03815(Cbr-ocrl-1) CBG17633
VAR: 108345715
LJA: Lj5g3v1913760.1(Lj5g3v1913760.1) Lj5g3v1913760.2(Lj5g3v1913760.2)
NTA: 107812880
NSY: 104233283
SCE: YIL002C(INP51) YNL106C(INP52) YOR109W(INP53)
KMX: KLMA_50389(INP51) KLMA_60227(INP53)
NCS: NCAS_0A13120(NCAS0A13120) NCAS_0B06910(NCAS0B06910) NCAS_0G02600(NCAS0G02600)
NDI: NDAI_0B01090(NDAI0B01090) NDAI_0B04240(NDAI0B04240) NDAI_0F02700(NDAI0F02700)
TPF: TPHA_0B02960(TPHA0B02960) TPHA_0F01750(TPHA0F01750) TPHA_0L00740(TPHA0L00740)
TBL: TBLA_0B01340(TBLA0B01340) TBLA_0C05610(TBLA0C05610) TBLA_0J01760(TBLA0J01760)
TDL: TDEL_0F01260(TDEL0F01260) TDEL_0H03050(TDEL0H03050)
KAF: KAFR_0B04520(KAFR0B04520) KAFR_0J02020(KAFR0J02020) KAFR_0K01150(KAFR0K01150)
PIC: PICST_58872(INP51) PICST_82710(INP52)
CAL: CAALFM_C209770CA(INP51) CAALFM_C700670CA(CaO19.7052)
SLB: AWJ20_3207(INP53)
NTE: NEUTE1DRAFT120100(NEUTE1DRAFT_120100) NEUTE1DRAFT90897(NEUTE1DRAFT_90897)
ANG: ANI_1_1322034(An03g03860) ANI_1_510114(An13g00020)
SPO: SPBC2G2.02(syj1) SPBC577.13(syj2)
ABP: AGABI1DRAFT101055(AGABI1DRAFT_101055) AGABI1DRAFT127695(AGABI1DRAFT_127695)
ABV: AGABI2DRAFT150338(AGABI2DRAFT_150338) AGABI2DRAFT153211(AGABI2DRAFT_153211)
DDI: DDB_G0267462(Dd5P4) DDB_G0292392(Dd5P3)
DFA: DFA_03503(Dd5P2) DFA_07655(Dd5P4) DFA_08200(Dd5P3)
EHI: EHI_153490(13.t00027) EHI_159880(256.t00004)
TAN: TA16590
TPV: TP01_1149
BBO: BBOV_IV011560(23.m05797) BBOV_IV011570(23.m05939)
SMIN: v1.2.000626.t1(symbB.v1.2.000626.t1) v1.2.005687.t2(symbB.v1.2.005687.t2)
 » show all
Reference
1  [PMID:4284485]
  Authors
Dawson RM, Thompson W.
  Title
The triphosphoinositide phosphomonoesterase of brain tissue.
  Journal
Biochem J 91:244-50 (1964)
DOI:10.1042/bj0910244
Reference
2  [PMID:6271223]
  Authors
Roach PD, Palmer FB.
  Title
Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase.
  Journal
Biochim Biophys Acta 661:323-33 (1981)
DOI:10.1016/0005-2744(81)90021-8
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.36
IUBMB Enzyme Nomenclature: 3.1.3.36
ExPASy - ENZYME nomenclature database: 3.1.3.36
BRENDA, the Enzyme Database: 3.1.3.36
CAS: 9036-01-5

KEGG   REACTION: R09827
Entry
R09827                      Reaction                               

Name
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Definition
Phosphatidylinositol-3,4,5-trisphosphate + H2O <=> 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate + Orthophosphate
Equation
Reaction class
RC00078  C05981_C11554
Enzyme
3.1.3.36        3.1.3.86
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K01099  inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K20278  inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
K20279  synaptojanin [EC:3.1.3.36]
Other DBs
RHEA: 25531

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