KEGG   ORTHOLOGY: K01110
Entry
K01110                      KO                                     

Name
PTEN
Definition
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04115  p53 signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04212  Longevity regulating pathway - worm
ko04218  Cellular senescence
ko04361  Axon regeneration
ko04510  Focal adhesion
ko04931  Insulin resistance
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05222  Small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05230  Central carbon metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00013  Small cell lung cancer
H00024  Prostate cancer
H00026  Endometrial cancer
H00029  Vulvar cancer
H00031  Breast cancer
H00038  Melanoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H00539  PTEN hamartoma tumor syndrome
H01195  VACTERL/VATER association
H01222  Cowden syndrome
H01463  Mycosis fungoides
H01556  Meningioma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04070 Phosphatidylinositol signaling system
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04071 Sphingolipid signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04151 PI3K-Akt signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04150 mTOR signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09143 Cell growth and death
   04115 p53 signaling pathway
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   04218 Cellular senescence
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09149 Aging
   04212 Longevity regulating pathway - worm
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05206 MicroRNAs in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05230 Central carbon metabolism in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05214 Glioma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05218 Melanoma
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05215 Prostate cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05213 Endometrial cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05224 Breast cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05222 Small cell lung cancer
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
   05165 Human papillomavirus infection
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.48  protein-tyrosine-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Other DBs
RN: R03363 R04513
GO: 0004722 0004725 0008138 0016314 0051800
Genes
HSA: 5728(PTEN)
PTR: 466142(PTEN)
PPS: 100983152(PTEN)
GGO: 101147526(PTEN)
PON: 100171828(PTEN)
NLE: 100605147(PTEN)
MCC: 705121(PTEN)
MCF: 101867036(PTEN)
CSAB: 103216211(PTEN)
RRO: 104675158(PTEN)
RBB: 108527540(PTEN)
CJC: 100393460(PTEN)
SBQ: 101039215(PTEN)
MMU: 19211(Pten)
MCAL: 110285202(Pten)
MPAH: 110312812(Pten)
RNO: 50557(Pten)
MUN: 110561175(Pten)
CGE: 100764294(Pten)
NGI: 103738044(Pten)
HGL: 101714930(Pten)
CCAN: 109689440(Pten) 109689441
OCU: 100358716(PTEN)
TUP: 102489114(PTEN)
CFA: 403832(PTEN)
VVP: 112931976(PTEN)
AML: 100469483(PTEN)
UMR: 103661921(PTEN)
UAH: 113258976(PTEN)
ORO: 101367385(PTEN)
ELK: 111144778
FCA: 101091813(PTEN)
PTG: 102972446(PTEN)
PPAD: 109255395(PTEN)
AJU: 106980972(PTEN)
BTA: 540786(PTEN)
BOM: 102268478(PTEN)
BIU: 109552991(PTEN)
BBUB: 102405361(PTEN)
CHX: 102185891(PTEN)
OAS: 101119351(PTEN)
SSC: 100156264(PTEN)
CFR: 102515104(PTEN)
CDK: 105088956(PTEN)
BACU: 102998704(PTEN)
LVE: 103074298(PTEN)
OOR: 101289838(PTEN)
DLE: 111172530(PTEN)
PCAD: 102984551(PTEN)
ECB: 100062388(PTEN)
EPZ: 103561454(PTEN)
EAI: 106845897(PTEN)
MYB: 102257838(PTEN)
MYD: 102755323(PTEN)
MNA: 107543303(PTEN)
HAI: 109387530(PTEN)
DRO: 112307354(PTEN)
PALE: 102881949(PTEN)
RAY: 107501760(PTEN)
MJV: 108397450(PTEN)
LAV: 100660561(PTEN)
TMU: 101355243
MDO: 100013036(PTEN)
SHR: 100927199(PTEN)
PCW: 110199935(PTEN)
OAA: 100074365(PTEN)
GGA: 423675(PTEN)
MGP: 100541251(PTEN)
CJO: 107315619(PTEN)
NMEL: 110390505(PTEN)
APLA: 101798136(PTEN)
ACYG: 106030781(PTEN)
TGU: 100224148(PTEN)
LSR: 110474026(PTEN)
SCAN: 103814071(PTEN)
GFR: 102039901(PTEN)
FAB: 101815785(PTEN)
PHI: 102106703(PTEN)
PMAJ: 107206954(PTEN)
CCAE: 111931632(PTEN)
CCW: 104695072(PTEN)
ETL: 114069647(PTEN)
FPG: 101912177(PTEN)
FCH: 102050194(PTEN)
CLV: 102094724(PTEN)
EGZ: 104125131(PTEN)
NNI: 104013521(PTEN)
ACUN: 113481870(PTEN)
PADL: 103924277(PTEN)
AAM: 106495308(PTEN)
ASN: 106721809(PTEN)
AMJ: 102558284(PTEN)
PSS: 102443573(PTEN)
CMY: 102941367(PTEN)
CPIC: 101934509(PTEN)
ACS: 100552870(pten)
PVT: 110083120(PTEN)
PBI: 103059990
PMUR: 107285111(PTEN)
TSR: 106555545(PTEN)
PMUA: 114597278(PTEN)
GJA: 107120016(PTEN) 107121111
XLA: 100505440(pten.S) 399142(pten.L)
XTR: 100144716(pten)
NPR: 108788861(PTEN)
DRE: 368415(ptenb) 794088(ptena)
IPU: 108269686 108273661(pten)
PHYP: 113527326(pten) 113547721
AMEX: 103025186(pten) 103046962
EEE: 113579468(pten) 113590406
TRU: 101079654(pten)
LCO: 104929647 104936542(pten)
NCC: 104956663(pten)
OLA: 101171856(pten) 101173689
XMA: 102226067(pten) 102236680
PRET: 103476793 103482129(pten)
CVG: 107094800 107102082(pten)
NFU: 107376033 107387492(pten)
KMR: 108229273 108245338(pten)
ALIM: 106513467 106528198(pten)
CSEM: 103382250(pten) 103387686
POV: 109634811(pten) 109644901
MALB: 109960336(pten) 109969673
ELS: 105006284(pten) 105010650
SFM: 108932873 108939683(pten)
PKI: 111853698(pten) 111858884
LCM: 102348548(PTEN)
CMK: 103180851(pten)
RTP: 109913977(pten)
BFO: 118411114
CIN: 100182434
SKO: 100313711(Pten)
DME: Dmel_CG5671(Pten)
DER: 6541174
DSE: 6611942
DSI: Dsimw501_GD22287(Dsim_GD22287)
DAN: 6496952
DSR: 110183295
DPE: 6589679
DMN: 108161604
DWI: 6642648
DAZ: 108620387
DNV: 115565115
DHE: 111594667
DVI: 6629131
MDE: 101892103
LCQ: 111680908
AAG: 23687644
AME: 411859(Pten)
BIM: 100743534
BTER: 100643227
CCAL: 108628117
OBB: 114877623
SOC: 105195960
MPHA: 105835031
AEC: 105148783
ACEP: 105619919
PBAR: 105426787
VEM: 105558562
HST: 105192370
DQU: 106748504
CFO: 105253074
LHU: 105670175
PGC: 109856638
OBO: 105284147
PCF: 106786252
NVI: 100117148(Pten)
CSOL: 105368591
MDL: 103571159
TCA: 663870
DPA: 109542185
ATD: 109597493
NVL: 108566279
BMOR: 101745952
BMAN: 114242428
PMAC: 106718558
PRAP: 110993954
HAW: 110373249
TNL: 113497664
API: 100163194
DNX: 107172228
AGS: 114128348
RMD: 113555800
BTAB: 109039093
CLEC: 106665060
ZNE: 110831106
FCD: 110842984
PVM: 113829491
TUT: 107359492
DPTE: 113794406
CSCU: 111622749
PTEP: 107437787
CEL: CELE_T07A9.6(daf-18)
CBR: CBG13540(Cbr-daf-18)
BMY: Bm1_36650
TSP: Tsp_07635
PCAN: 112577354
CRG: 105331286
MYI: 110464227
OBI: 106873013
LAK: 106162681
SHX: MS3_07298
EGL: EGR_01192
NVE: 5504087
EPA: 110254143
ADF: 107346271
AMIL: 114954557
PDAM: 113666418
DGT: 114531075
AQU: 100640061
ATH: AT3G19420(PEN2) AT3G50110(PEN3) AT5G39400(PTEN1)
LJA: Lj1g3v2995580.1(Lj1g3v2995580.1) Lj2g3v1904480.1(Lj2g3v1904480.1) Lj5g3v2133750.1(Lj5g3v2133750.1)
OSA: 4352052
DOSA: Os12t0407500-01(Os12g0407500)
OBR: 102704853
BDI: 100846535
ATS: 109747383(LOC109747383)
SBI: 8054522
ZMA: 103648286
SITA: 101758319
CRE: CHLREDRAFT_195975(PTN1)
SCE: YNL128W(TEP1)
ERC: Ecym_8193
KMX: KLMA_60260(TEP1)
NCS: NCAS_0G02390(NCAS0G02390)
NDI: NDAI_0F02880(NDAI0F02880)
TPF: TPHA_0F01890(TPHA0F01890)
TBL: TBLA_0B01210(TBLA0B01210)
TDL: TDEL_0B05030(TDEL0B05030)
KAF: KAFR_0J02170(KAFR0J02170)
PIC: PICST_65227(TEP1)
CAL: CAALFM_C702650WA(TEP1)
SLB: AWJ20_1647(TEP1)
SPO: SPBC609.02(ptn1)
CNE: CNJ02580
CNB: CNBJ0880
ABP: AGABI1DRAFT123067(AGABI1DRAFT_123067)
ABV: AGABI2DRAFT187375(AGABI2DRAFT_187375)
DFA: DFA_00730 DFA_06571(pten)
EHI: EHI_197010(92.t00018)
SMIN: v1.2.038026.t1(symbB.v1.2.038026.t1)
 » show all
Reference
PMID:9072974
  Authors
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R
  Title
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
  Journal
Science 275:1943-7 (1997)
DOI:10.1126/science.275.5308.1943
  Sequence
[hsa:5728]
Reference
PMID:9593664
  Authors
Maehama T, Dixon JE
  Title
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
  Journal
J Biol Chem 273:13375-8 (1998)
DOI:10.1074/jbc.273.22.13375
  Sequence
[hsa:5728]

KEGG   ENZYME: 3.1.3.67
Entry
EC 3.1.3.67                 Enzyme                                 

Name
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase;
PTEN;
MMAC1;
phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate [RN:R04513]
Reaction(KEGG)
R04513;
(other) R03363
Substrate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
phosphate [CPD:C00009]
Comment
Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3
History
EC 3.1.3.67 created 1999, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Genes
HSA: 5728(PTEN)
PTR: 466142(PTEN)
PPS: 100983152(PTEN)
GGO: 101147526(PTEN)
PON: 100171828(PTEN)
NLE: 100605147(PTEN)
MCC: 705121(PTEN)
MCF: 101867036(PTEN)
CSAB: 103216211(PTEN)
RRO: 104675158(PTEN)
RBB: 108527540(PTEN)
CJC: 100393460(PTEN)
SBQ: 101039215(PTEN)
MMU: 19211(Pten)
MCAL: 110285202(Pten)
MPAH: 110312812(Pten)
RNO: 50557(Pten)
MUN: 110561175(Pten)
CGE: 100764294(Pten)
NGI: 103738044(Pten)
HGL: 101714930(Pten)
CCAN: 109689440(Pten) 109689441
OCU: 100358716(PTEN)
TUP: 102489114(PTEN)
CFA: 403832(PTEN)
VVP: 112931976(PTEN)
AML: 100469483(PTEN)
UMR: 103661921(PTEN)
UAH: 113258976(PTEN)
ORO: 101367385(PTEN)
ELK: 111144778
FCA: 101091813(PTEN)
PTG: 102972446(PTEN)
PPAD: 109255395(PTEN)
AJU: 106980972(PTEN)
BTA: 540786(PTEN)
BOM: 102268478(PTEN)
BIU: 109552991(PTEN)
BBUB: 102405361(PTEN)
CHX: 102185891(PTEN)
OAS: 101119351(PTEN)
SSC: 100156264(PTEN)
CFR: 102515104(PTEN)
CDK: 105088956(PTEN)
BACU: 102998704(PTEN)
LVE: 103074298(PTEN)
OOR: 101289838(PTEN)
DLE: 111172530(PTEN)
PCAD: 102984551(PTEN)
ECB: 100062388(PTEN)
EPZ: 103561454(PTEN)
EAI: 106845897(PTEN)
MYB: 102257838(PTEN)
MYD: 102755323(PTEN)
MNA: 107543303(PTEN)
HAI: 109387530(PTEN)
DRO: 112307354(PTEN)
PALE: 102881949(PTEN)
RAY: 107501760(PTEN)
MJV: 108397450(PTEN)
LAV: 100660561(PTEN)
TMU: 101355243
MDO: 100013036(PTEN)
SHR: 100927199(PTEN)
PCW: 110199935(PTEN)
OAA: 100074365(PTEN)
GGA: 423675(PTEN)
MGP: 100541251(PTEN)
CJO: 107315619(PTEN)
NMEL: 110390505(PTEN)
APLA: 101798136(PTEN)
ACYG: 106030781(PTEN)
TGU: 100224148(PTEN)
LSR: 110474026(PTEN)
SCAN: 103814071(PTEN)
GFR: 102039901(PTEN)
FAB: 101815785(PTEN)
PHI: 102106703(PTEN)
PMAJ: 107206954(PTEN)
CCAE: 111931632(PTEN)
CCW: 104695072(PTEN)
ETL: 114069647(PTEN)
FPG: 101912177(PTEN)
FCH: 102050194(PTEN)
CLV: 102094724(PTEN)
EGZ: 104125131(PTEN)
NNI: 104013521(PTEN)
ACUN: 113481870(PTEN)
PADL: 103924277(PTEN)
AAM: 106495308(PTEN)
ASN: 106721809(PTEN)
AMJ: 102558284(PTEN)
PSS: 102443573(PTEN)
CMY: 102941367(PTEN)
CPIC: 101934509(PTEN)
ACS: 100552870(pten)
PVT: 110083120(PTEN)
PBI: 103059990
PMUR: 107285111(PTEN)
TSR: 106555545(PTEN)
PMUA: 114597278(PTEN)
GJA: 107120016(PTEN) 107121111
XLA: 100505440(pten.S) 399142(pten.L)
XTR: 100144716(pten)
NPR: 108788861(PTEN)
DRE: 368415(ptenb) 794088(ptena)
IPU: 108269686 108273661(pten)
PHYP: 113527326(pten) 113547721
AMEX: 103025186(pten) 103046962
EEE: 113579468(pten) 113590406
TRU: 101079654(pten)
LCO: 104929647 104936542(pten)
NCC: 104956663(pten)
OLA: 101171856(pten) 101173689
XMA: 102226067(pten) 102236680
PRET: 103476793 103482129(pten)
CVG: 107094800 107102082(pten)
NFU: 107376033 107387492(pten)
KMR: 108229273 108245338(pten)
ALIM: 106513467 106528198(pten)
CSEM: 103382250(pten) 103387686
POV: 109634811(pten) 109644901
MALB: 109960336(pten) 109969673
ELS: 105006284(pten) 105010650
SFM: 108932873 108939683(pten)
PKI: 111853698(pten) 111858884
LCM: 102348548(PTEN)
CMK: 103180851(pten)
RTP: 109913977(pten)
BFO: 118411114
CIN: 100182434
SKO: 100313711(Pten)
DME: Dmel_CG5671(Pten)
DER: 6541174
DSE: 6611942
DSI: Dsimw501_GD22287(Dsim_GD22287)
DAN: 6496952
DSR: 110183295
DPE: 6589679
DMN: 108161604
DWI: 6642648
DAZ: 108620387
DNV: 115565115
DHE: 111594667
DVI: 6629131
MDE: 101892103
LCQ: 111680908
AAG: 23687644
AME: 411859(Pten)
BIM: 100743534
BTER: 100643227
CCAL: 108628117
OBB: 114877623
SOC: 105195960
MPHA: 105835031
AEC: 105148783
ACEP: 105619919
PBAR: 105426787
VEM: 105558562
HST: 105192370
DQU: 106748504
CFO: 105253074
LHU: 105670175
PGC: 109856638
OBO: 105284147
PCF: 106786252
NVI: 100117148(Pten)
CSOL: 105368591
MDL: 103571159
TCA: 663870
DPA: 109542185
ATD: 109597493
NVL: 108566279
BMOR: 101745952
BMAN: 114242428
PMAC: 106718558
PRAP: 110993954
HAW: 110373249
TNL: 113497664
API: 100163194
DNX: 107172228
AGS: 114128348
RMD: 113555800
BTAB: 109039093
CLEC: 106665060
ZNE: 110831106
FCD: 110842984
PVM: 113829491
TUT: 107359492
DPTE: 113794406
CSCU: 111622749
PTEP: 107437787
CEL: CELE_T07A9.6(daf-18)
CBR: CBG13540(Cbr-daf-18)
BMY: Bm1_36650
TSP: Tsp_07635
PCAN: 112577354
CRG: 105331286
MYI: 110464227
OBI: 106873013
LAK: 106162681
SHX: MS3_07298
EGL: EGR_01192
NVE: 5504087
EPA: 110254143
ADF: 107346271
AMIL: 114954557
PDAM: 113666418
DGT: 114531075
AQU: 100640061
ATH: AT3G19420(PEN2) AT3G50110(PEN3) AT5G39400(PTEN1)
LJA: Lj1g3v2995580.1(Lj1g3v2995580.1) Lj2g3v1904480.1(Lj2g3v1904480.1) Lj5g3v2133750.1(Lj5g3v2133750.1)
OSA: 4352052
DOSA: Os12t0407500-01(Os12g0407500)
OBR: 102704853
BDI: 100846535
ATS: 109747383(LOC109747383)
SBI: 8054522
ZMA: 103648286
SITA: 101758319
CRE: CHLREDRAFT_195975(PTN1)
SCE: YNL128W(TEP1)
ERC: Ecym_8193
KMX: KLMA_60260(TEP1)
NCS: NCAS_0G02390(NCAS0G02390)
NDI: NDAI_0F02880(NDAI0F02880)
TPF: TPHA_0F01890(TPHA0F01890)
TBL: TBLA_0B01210(TBLA0B01210)
TDL: TDEL_0B05030(TDEL0B05030)
KAF: KAFR_0J02170(KAFR0J02170)
PIC: PICST_65227(TEP1)
CAL: CAALFM_C702650WA(TEP1)
SLB: AWJ20_1647(TEP1)
SPO: SPBC609.02(ptn1)
CNE: CNJ02580
CNB: CNBJ0880
ABP: AGABI1DRAFT123067(AGABI1DRAFT_123067)
ABV: AGABI2DRAFT187375(AGABI2DRAFT_187375)
DFA: DFA_00730 DFA_06571(pten)
EHI: EHI_197010(92.t00018)
SMIN: v1.2.038026.t1(symbB.v1.2.038026.t1)
 » show all
Reference
1  [PMID:8681945]
  Authors
Kabuyama Y, Nakatsu N, Homma Y, Fukui Y.
  Title
Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus.
  Journal
Eur J Biochem 238:350-6 (1996)
DOI:10.1111/j.1432-1033.1996.0350z.x
Reference
2  [PMID:9593664]
  Authors
Maehama T, Dixon JE.
  Title
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
  Journal
J Biol Chem 273:13375-8 (1998)
DOI:10.1074/jbc.273.22.13375
  Sequence
[hsa:5728]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.67
IUBMB Enzyme Nomenclature: 3.1.3.67
ExPASy - ENZYME nomenclature database: 3.1.3.67
BRENDA, the Enzyme Database: 3.1.3.67
CAS: 210488-47-4

KEGG   REACTION: R03363
Entry
R03363                      Reaction                               

Name
1-Phosphatidyl-1D-myo-inositol 3-phosphate 3-phosphohydrolase
Definition
1-Phosphatidyl-1D-myo-inositol 3-phosphate + H2O <=> 1-Phosphatidyl-D-myo-inositol + Orthophosphate
Equation
Reaction class
RC00078  C01194_C04549
Enzyme
3.1.3.64        3.1.3.67
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K01108  myotubularin [EC:3.1.3.64 3.1.3.95]
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Other DBs
RHEA: 12319

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