KEGG   ORTHOLOGY: K01135
Entry
K01135                      KO                                     

Name
ARSB
Definition
arylsulfatase B [EC:3.1.6.12]
Pathway
ko00531  Glycosaminoglycan degradation
ko01100  Metabolic pathways
ko04142  Lysosome
Module
M00076  Dermatan sulfate degradation
M00077  Chondroitin sulfate degradation
Disease
H00131  Mucopolysaccharidosis type VI
H00421  Mucopolysaccharidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00531 Glycosaminoglycan degradation
    K01135  ARSB; arylsulfatase B
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01135  ARSB; arylsulfatase B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.6  Sulfuric-ester hydrolases
    3.1.6.12  N-acetylgalactosamine-4-sulfatase
     K01135  ARSB; arylsulfatase B
Other DBs
RN: R07823
GO: 0003943
Genes
HSA: 411(ARSB)
PTR: 737316(ARSB)
PPS: 100987929(ARSB)
GGO: 101138081(ARSB)
PON: 100457196(ARSB)
NLE: 100587589(ARSB)
MCC: 709136(ARSB)
MCF: 102116401(ARSB)
CSAB: 103223561(ARSB)
RRO: 104662974(ARSB)
RBB: 108528898(ARSB)
CJC: 100394090(ARSB)
SBQ: 101045515(ARSB)
MMU: 11881(Arsb)
MCAL: 110308214(Arsb)
MPAH: 110328948(Arsb)
RNO: 25227(Arsb)
MUN: 110558794
CGE: 100759794(Arsb)
NGI: 103750289(Arsb)
HGL: 101719731(Arsb)
CCAN: 109675293(Arsb)
OCU: 103346484(ARSB) 103346606
TUP: 102469500(ARSB)
CFA: 610364(ARSB)
VVP: 112919590(ARSB)
AML: 100467836(ARSB)
UMR: 103681492(ARSB)
UAH: 113255173(ARSB)
ORO: 101374250(ARSB)
ELK: 111148285
FCA: 100216331(ARSB)
PTG: 102963642(ARSB)
PPAD: 109274943
AJU: 106974796(ARSB)
BTA: 538401(ARSB)
BOM: 102279001(ARSB)
BIU: 109564662(ARSB)
BBUB: 102401475(ARSB)
CHX: 102189402(ARSB)
OAS: 101108314(ARSB)
SSC: 102158016(ARSB)
CFR: 102507706(ARSB)
CDK: 105084869(ARSB)
BACU: 103001911(ARSB)
LVE: 103080763(ARSB)
OOR: 101281243(ARSB)
DLE: 111184985(ARSB)
PCAD: 102973706(ARSB)
ECB: 100073268(ARSB)
EPZ: 103548666(ARSB)
EAI: 106841176(ARSB)
MYB: 102252145(ARSB)
MYD: 102758054(ARSB)
HAI: 109381893(ARSB)
DRO: 112307472(ARSB)
PALE: 102887255(ARSB)
RAY: 107497236(ARSB)
MJV: 108398416(ARSB)
LAV: 100665589(ARSB)
TMU: 101359357
MDO: 100032622(ARSB)
SHR: 100931900(ARSB)
PCW: 110216573(ARSB)
OAA: 100088121(ARSB)
GGA: 771459(ARSB)
MGP: 104914958
CJO: 107305934(ARSB)
NMEL: 110389380(ARSB)
APLA: 101802978(ARSB)
ACYG: 106042122(ARSB)
TGU: 100228383(ARSB)
LSR: 110479755(ARSB)
SCAN: 103819543(ARSB)
GFR: 102044758(ARSB)
FAB: 101813661(ARSB)
PHI: 102102961(ARSB)
PMAJ: 107216097(ARSB)
CCAE: 111941403(ARSB)
CCW: 104695689(ARSB)
ETL: 114057492(ARSB)
FPG: 101910790(ARSB)
FCH: 102049359(ARSB)
CLV: 102091560(ARSB)
EGZ: 104124897(ARSB)
NNI: 104017612(ARSB)
ACUN: 113489665(ARSB)
PADL: 103919762(ARSB)
AAM: 106487821
ASN: 102377963(ARSB)
AMJ: 106737251(ARSB)
PSS: 102445150(ARSB)
CMY: 102947173(ARSB)
CPIC: 101938081(ARSB)
ACS: 100564703(arsb)
PVT: 110084605(ARSB)
PBI: 103060554(ARSB)
PMUR: 107287875(ARSB)
TSR: 106544488(ARSB)
PMUA: 114606559(ARSB)
GJA: 107117399(ARSB)
XLA: 108717994(arsb.L)
XTR: 100493013(arsb)
NPR: 108799973(ARSB)
DRE: 100538007(arsb)
SRX: 107724712(arsb)
SANH: 107694537(arsb)
SGH: 107574102(arsb)
CCAR: 109046309
IPU: 108279373(arsb)
PHYP: 113543096(arsb)
AMEX: 103041418(arsb)
EEE: 113590451(arsb)
TRU: 101061832(arsb)
LCO: 104926623(arsb)
NCC: 104966860(arsb)
MZE: 101485324(arsb)
ONL: 100697368(arsb)
OLA: 101169377(arsb)
XMA: 102227522(arsb)
XCO: 114149560(arsb)
PRET: 103473308(arsb)
CVG: 107093772(arsb)
NFU: 107374848(arsb)
KMR: 108251298(arsb)
ALIM: 106515071(arsb)
AOCE: 111570347(arsb)
POV: 109626042(arsb)
LCF: 108895444(arsb)
SDU: 111239020(arsb)
SLAL: 111666800(arsb)
HCQ: 109517689(arsb)
BPEC: 110157319(arsb)
MALB: 109953005(arsb)
SASA: 100380367(arsb)
OTW: 112230814(arsb)
SALP: 111963905(arsb)
ELS: 105015172(arsb)
SFM: 108925070(arsb)
PKI: 111849813(arsb)
LCM: 102353782(ARSB)
CMK: 103177857(arsb)
RTP: 109923016(arsb)
DME: Dmel_CG7402(CG7402) Dmel_CG8646(CG8646)
DER: 6546392
DSE: 6606148
DSI: Dsimw501_GD14734(Dsim_GD14734)
DAN: 6507210
DSR: 110178876
DNV: 108653866
MDE: 101894738
LCQ: 111681211
AALB: 109422334
TCA: 659525 659587(ARSB) 664109
FCD: 110845904
TUT: 107359178
HMG: 100212594
SMIN: v1.2.004770.t3(symbB.v1.2.004770.t3) v1.2.006990.t1(symbB.v1.2.006990.t1) v1.2.006992.t1(symbB.v1.2.006992.t1) v1.2.025906.t1(symbB.v1.2.025906.t1) v1.2.033030.t1(symbB.v1.2.033030.t1) v1.2.034521.t1(symbB.v1.2.034521.t1)
FCY: FRACYDRAFT_182357(ARSB1)
NGD: NGA_0431201(ARSB) NGA_0431202(ARSB)
PAT: Patl_0889
RBS: RHODOSMS8_00747(atsA)
BOS: BSY19_414(arsb)
RBA: RB1475(arsB)
PSL: Psta_1162
PIR: VN12_02835(atsA_6)
FMR: Fuma_03883(atsA_24)
BVO: Pan97_28610(atsA_35)
SACI: Sinac_5718
PBU: L21SP3_02067(atsA_28)
PBP: STSP1_01762(atsA_37)
ASH: AL1_00180
GFL: GRFL_1426
MARF: CJ739_1062
 » show all
Reference
PMID:2303452
  Authors
Peters C, Schmidt B, Rommerskirch W, Rupp K, Zuhlsdorf M, Vingron M, Meyer HE, Pohlmann R, von Figura K
  Title
Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.
  Journal
J Biol Chem 265:3374-81 (1990)
  Sequence
[hsa:411]

KEGG   ENZYME: 3.1.6.12
Entry
EC 3.1.6.12                 Enzyme                                 

Name
N-acetylgalactosamine-4-sulfatase;
chondroitinsulfatase;
chondroitinase;
arylsulfatase B;
acetylgalactosamine 4-sulfatase;
N-acetylgalactosamine 4-sulfate sulfohydrolase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate [RN:R07823]
Reaction(KEGG)
R07823(G)
Comment
Acts also on N-acetylglucosamine 4-sulfate.
History
EC 3.1.6.12 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01135  arylsulfatase B
Genes
HSA: 411(ARSB)
PTR: 737316(ARSB)
PPS: 100987929(ARSB)
GGO: 101138081(ARSB)
PON: 100457196(ARSB)
NLE: 100587589(ARSB)
MCC: 709136(ARSB)
MCF: 102116401(ARSB)
CSAB: 103223561(ARSB)
RRO: 104662974(ARSB)
RBB: 108528898(ARSB)
CJC: 100394090(ARSB)
SBQ: 101045515(ARSB)
MMU: 11881(Arsb)
MCAL: 110308214(Arsb)
MPAH: 110328948(Arsb)
RNO: 25227(Arsb)
MUN: 110558794
CGE: 100759794(Arsb)
NGI: 103750289(Arsb)
HGL: 101719731(Arsb)
CCAN: 109675293(Arsb)
OCU: 103346484(ARSB) 103346606
TUP: 102469500(ARSB)
CFA: 610364(ARSB)
VVP: 112919590(ARSB)
AML: 100467836(ARSB)
UMR: 103681492(ARSB)
UAH: 113255173(ARSB)
ORO: 101374250(ARSB)
ELK: 111148285
FCA: 100216331(ARSB)
PTG: 102963642(ARSB)
PPAD: 109274943
AJU: 106974796(ARSB)
BTA: 538401(ARSB)
BOM: 102279001(ARSB)
BIU: 109564662(ARSB)
BBUB: 102401475(ARSB)
CHX: 102189402(ARSB)
OAS: 101108314(ARSB)
SSC: 102158016(ARSB)
CFR: 102507706(ARSB)
CDK: 105084869(ARSB)
BACU: 103001911(ARSB)
LVE: 103080763(ARSB)
OOR: 101281243(ARSB)
DLE: 111184985(ARSB)
PCAD: 102973706(ARSB)
ECB: 100073268(ARSB)
EPZ: 103548666(ARSB)
EAI: 106841176(ARSB)
MYB: 102252145(ARSB)
MYD: 102758054(ARSB)
HAI: 109381893(ARSB)
DRO: 112307472(ARSB)
PALE: 102887255(ARSB)
RAY: 107497236(ARSB)
MJV: 108398416(ARSB)
LAV: 100665589(ARSB)
TMU: 101359357
MDO: 100032622(ARSB)
SHR: 100931900(ARSB)
PCW: 110216573(ARSB)
OAA: 100088121(ARSB)
GGA: 771459(ARSB)
MGP: 104914958
CJO: 107305934(ARSB)
NMEL: 110389380(ARSB)
APLA: 101802978(ARSB)
ACYG: 106042122(ARSB)
TGU: 100228383(ARSB)
LSR: 110479755(ARSB)
SCAN: 103819543(ARSB)
GFR: 102044758(ARSB)
FAB: 101813661(ARSB)
PHI: 102102961(ARSB)
PMAJ: 107216097(ARSB)
CCAE: 111941403(ARSB)
CCW: 104695689(ARSB)
ETL: 114057492(ARSB)
FPG: 101910790(ARSB)
FCH: 102049359(ARSB)
CLV: 102091560(ARSB)
EGZ: 104124897(ARSB)
NNI: 104017612(ARSB)
ACUN: 113489665(ARSB)
PADL: 103919762(ARSB)
AAM: 106487821
ASN: 102377963(ARSB)
AMJ: 106737251(ARSB)
PSS: 102445150(ARSB)
CMY: 102947173(ARSB)
CPIC: 101938081(ARSB)
ACS: 100564703(arsb)
PVT: 110084605(ARSB)
PBI: 103060554(ARSB)
PMUR: 107287875(ARSB)
TSR: 106544488(ARSB)
PMUA: 114606559(ARSB)
GJA: 107117399(ARSB)
XLA: 108717994(arsb.L)
XTR: 100493013(arsb)
NPR: 108799973(ARSB)
DRE: 100538007(arsb)
SRX: 107724712(arsb)
SANH: 107694537(arsb)
SGH: 107574102(arsb)
CCAR: 109046309
IPU: 108279373(arsb)
PHYP: 113543096(arsb)
AMEX: 103041418(arsb)
EEE: 113590451(arsb)
TRU: 101061832(arsb)
LCO: 104926623(arsb)
NCC: 104966860(arsb)
MZE: 101485324(arsb)
ONL: 100697368(arsb)
OLA: 101169377(arsb)
XMA: 102227522(arsb)
XCO: 114149560(arsb)
PRET: 103473308(arsb)
CVG: 107093772(arsb)
NFU: 107374848(arsb)
KMR: 108251298(arsb)
ALIM: 106515071(arsb)
AOCE: 111570347(arsb)
POV: 109626042(arsb)
LCF: 108895444(arsb)
SDU: 111239020(arsb)
SLAL: 111666800(arsb)
HCQ: 109517689(arsb)
BPEC: 110157319(arsb)
MALB: 109953005(arsb)
SASA: 100380367(arsb)
OTW: 112230814(arsb)
SALP: 111963905(arsb)
ELS: 105015172(arsb)
SFM: 108925070(arsb)
PKI: 111849813(arsb)
LCM: 102353782(ARSB)
CMK: 103177857(arsb)
RTP: 109923016(arsb)
DME: Dmel_CG7402(CG7402) Dmel_CG8646(CG8646)
DER: 6546392
DSE: 6606148
DSI: Dsimw501_GD14734(Dsim_GD14734)
DAN: 6507210
DSR: 110178876
DNV: 108653866
MDE: 101894738
LCQ: 111681211
AALB: 109422334
TCA: 659525 659587(ARSB) 664109
FCD: 110845904
TUT: 107359178
HMG: 100212594
SMIN: v1.2.004770.t3(symbB.v1.2.004770.t3) v1.2.006990.t1(symbB.v1.2.006990.t1) v1.2.006992.t1(symbB.v1.2.006992.t1) v1.2.025906.t1(symbB.v1.2.025906.t1) v1.2.033030.t1(symbB.v1.2.033030.t1) v1.2.034521.t1(symbB.v1.2.034521.t1)
FCY: FRACYDRAFT_182357(ARSB1)
NGD: NGA_0431201(ARSB) NGA_0431202(ARSB)
PAT: Patl_0889
RBS: RHODOSMS8_00747(atsA)
BOS: BSY19_414(arsb)
RBA: RB1475(arsB)
PSL: Psta_1162
PIR: VN12_02835(atsA_6)
FMR: Fuma_03883(atsA_24)
BVO: Pan97_28610(atsA_35)
SACI: Sinac_5718
PBU: L21SP3_02067(atsA_28)
PBP: STSP1_01762(atsA_37)
ASH: AL1_00180
GFL: GRFL_1426
MARF: CJ739_1062
 » show all
Reference
1  [PMID:976430]
  Authors
Farooqui AA.
  Title
The desulphation of hexosamine sulphates by arylsulphatase B.
  Journal
Experientia 32:1242-4 (1976)
DOI:10.1007/BF01953071
Reference
2  [PMID:738706]
  Authors
Gorham SD, Cantz M.
  Title
Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide.
  Journal
Hoppe Seylers Z Physiol Chem 359:1811-4 (1978)
Reference
3  [PMID:7370276]
  Authors
Tsuji M, Nakanishi Y, Habuchi H, Ishihara K, Suzuki S.
  Title
The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase.
  Journal
Biochim Biophys Acta 612:373-83 (1980)
DOI:10.1016/0005-2744(80)90120-5
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.12
IUBMB Enzyme Nomenclature: 3.1.6.12
ExPASy - ENZYME nomenclature database: 3.1.6.12
BRENDA, the Enzyme Database: 3.1.6.12
CAS: 55354-43-3

KEGG   REACTION: R07823
Entry
R07823                      Reaction                               

Name
N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Definition
G12336 + H2O <=> G13043 + Sulfate
Equation
Enzyme
Pathway
rn00531  Glycosaminoglycan degradation
rn01100  Metabolic pathways
Module
M00076  Dermatan sulfate degradation
M00077  Chondroitin sulfate degradation
Orthology
K01135  arylsulfatase B [EC:3.1.6.12]

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