KEGG   ORTHOLOGY: K01136
Entry
K01136                      KO                                     

Name
IDS
Definition
iduronate 2-sulfatase [EC:3.1.6.13]
Pathway
map00531  Glycosaminoglycan degradation
map01100  Metabolic pathways
map04142  Lysosome
Module
M00076  Dermatan sulfate degradation
M00078  Heparan sulfate degradation
Disease
H00129  Mucopolysaccharidosis type II
H00421  Mucopolysaccharidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00531 Glycosaminoglycan degradation
    K01136  IDS; iduronate 2-sulfatase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01136  IDS; iduronate 2-sulfatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.6  Sulfuric-ester hydrolases
    3.1.6.13  iduronate-2-sulfatase
     K01136  IDS; iduronate 2-sulfatase
Other DBs
RN: R07812 R07821
GO: 0004423
Genes
HSA: 3423(IDS)
PTR: 465896(IDS)
PPS: 100981796(IDS)
GGO: 101148217(IDS)
PON: 100435640(IDS)
NLE: 100581849(IDS)
MCC: 700892(IDS)
MCF: 102137236(IDS)
CSAB: 103232717(IDS)
CATY: 105595595(IDS)
PANU: 101008279(IDS)
RRO: 104657812(IDS)
RBB: 108539780(IDS)
TFN: 117078229(IDS)
PTEH: 111536373(IDS)
CJC: 100415225(IDS)
SBQ: 101027610(IDS)
MMUR: 105857531(IDS)
MMU: 15931(Ids)
MCAL: 110286776(Ids)
MPAH: 110313631(Ids)
RNO: 363513(Ids)
MCOC: 116085689(Ids)
MUN: 110540175(Ids)
CGE: 100763345(Ids)
PLEU: 114688017(Ids)
NGI: 103737443(Ids)
HGL: 101710577(Ids)
CCAN: 109695031(Ids)
OCU: 100356659(IDS)
TUP: 102483402(IDS)
CFA: 492194(IDS)
VVP: 112927657(IDS)
VLG: 121482887(IDS)
AML: 100469837(IDS)
UMR: 103662556(IDS)
UAH: 113241894(IDS)
ORO: 101382674(IDS)
ELK: 111158976
MPUF: 101690645(IDS)
EJU: 114199013(IDS) 114202770
MLX: 118008400(IDS)
FCA: 101081450(IDS)
PTG: 102968319(IDS)
PPAD: 109258697(IDS)
AJU: 106988547(IDS)
HHV: 120227028(IDS)
BTA: 541272(IDS)
BOM: 102286693(IDS)
BIU: 109554785(IDS)
BBUB: 102410975(IDS)
CHX: 102189563(IDS)
OAS: 101116540(IDS)
ODA: 120881766(IDS)
SSC: 100512880(IDS)
CFR: 102510249(IDS)
CDK: 105104103(IDS)
BACU: 103018480(IDS)
LVE: 103078281(IDS)
OOR: 101289790(IDS)
DLE: 111167853(IDS)
PCAD: 102983735
ECB: 111771607(IDS)
EPZ: 103540044(IDS)
EAI: 106842534(IDS)
MYB: 102251234(IDS)
MYD: 102771465(IDS)
MMYO: 118653914(IDS)
MNA: 107530067(IDS)
HAI: 109388991(IDS)
DRO: 112296325(IDS)
SHON: 118996043(IDS)
AJM: 119051673(IDS)
MMF: 118635949(IDS)
PALE: 102893087(IDS)
RAY: 107502397 107502399(IDS) 107506382 107507519 107507961
MJV: 108405651(IDS)
TOD: 119245842(IDS)
LAV: 100668951(IDS)
TMU: 101348522
MDO: 100025173(IDS)
SHR: 100932918(IDS)
PCW: 110199816(IDS)
OAA: 100081812(IDS)
GGA: 422392(IDS)
PCOC: 116234854(IDS)
MGP: 100548552(IDS)
CJO: 107312964(IDS)
NMEL: 110403286(IDS)
APLA: 101805206(IDS)
ACYG: 106037727(IDS)
TGU: 100231299(IDS)
LSR: 110480065(IDS)
SCAN: 103816359(IDS)
PMOA: 120506191(IDS)
GFR: 102044849(IDS)
FAB: 101817405(IDS)
PHI: 102102287(IDS)
PMAJ: 107204060(IDS)
CCAE: 111928496(IDS)
CCW: 104691675(IDS)
ETL: 114056735(IDS)
FPG: 101917991(IDS)
FCH: 102056477(IDS)
CLV: 102095548(IDS)
EGZ: 104124077(IDS)
NNI: 104019072(IDS)
ACUN: 113480248(IDS)
PADL: 103922912(IDS)
AAM: 106487578(IDS)
ASN: 102375700(IDS)
AMJ: 102571433(IDS)
CPOO: 109313625(IDS)
GGN: 109300820(IDS)
PSS: 102447899(IDS)
CMY: 102931008(IDS)
CPIC: 101944748(IDS)
TST: 117883182(IDS)
CABI: 116824492(IDS)
ACS: 100565846(ids)
PVT: 110082990(IDS)
PBI: 103053966(IDS)
PMUR: 107291666(IDS)
TSR: 106549285(IDS)
PGUT: 117677977(IDS)
PMUA: 114589233(IDS)
ZVI: 118084337(IDS)
GJA: 107107996(IDS)
XLA: 108698425(ids.L)
XTR: 100135738(ids)
NPR: 108783898(IDS)
DRE: 559959(ids)
SRX: 107742636 107754550
SANH: 107703646
SGH: 107588358
CCAR: 109108298(ids)
CAUA: 113113609(ids)
IPU: 108268807(ids)
PHYP: 113542945(ids)
AMEX: 103032782(ids)
EEE: 113572503(ids)
TRU: 101066362 115252486
TNG: GSTEN00010710G001
LCO: 104932265(ids)
NCC: 104948380(ids)
ELY: 117260683(ids)
PLEP: 121947925(ids)
SLUC: 116036600(ids)
ECRA: 117951985(ids)
PFLV: 114562652(ids)
GAT: 120817090(ids)
MSAM: 119888202(ids)
CUD: 121516852(ids)
MZE: 101484170(ids)
ONL: 100701301(ids)
OAU: 116328130(ids)
OLA: 101158287(ids)
OML: 112153796(ids)
XMA: 102223507(ids)
XCO: 114139558(ids)
XHE: 116714780(ids)
PRET: 103471071(ids)
CVG: 107093837(ids)
CTUL: 119797269(ids)
NFU: 107382373(ids)
KMR: 108240015(ids)
ALIM: 106533195(ids)
AOCE: 111582599(ids)
CSEM: 103391272(ids)
POV: 109627356(ids)
LCF: 108878945(ids)
SDU: 111226708(ids)
SLAL: 111646415(ids)
XGL: 120785469(ids)
HCQ: 109524284(ids)
BPEC: 110172172(ids)
MALB: 109957582(ids)
SASA: 106611990(ids)
OTW: 112256025
OMY: 110504761(ids)
SALP: 111965339 112070437(ids)
ELS: 105027395(ids)
SFM: 108922862(ids)
PKI: 111848144(ids)
LOC: 102691141(ids)
PSPA: 121318966(ids)
ARUT: 117412437
LCM: 102348043(IDS)
CMK: 103178266(ids)
RTP: 109937925
BFO: 118419919
CIN: 100185385
SCLV: 120336576
SPU: 100892602 100892667 115918435 115922305 579992 584730 587680 588607 588631
APLC: 110983712 110983804
SKO: 100370796 100374826
DME: Dmel_CG12014(Ids)
DER: 6546473
DSE: 6610634
DSI: Dsimw501_GD13763(Dsim_GD13763)
DYA: Dyak_GE21364
DAN: 6506843
DSR: 110177559
DPO: Dpse_GA11337
DPE: 6601698
DMN: 108152850
DWI: 6645875
DGR: Dgri_GH16111 Dgri_GH23326
DMO: Dmoj_GI12380
DAZ: 108614650
DNV: 108650413
DHE: 111601084
DVI: 6623790
MDE: 101896463
LCQ: 111690708
AGA: AgaP_AGAP005778
ACOZ: 120952744
AARA: 120906700
AAG: 5572289
AALB: 109431614
CQU: CpipJ_CPIJ004938
CPII: 120423600
AME: 724550
ACER: 108003103
BIM: 100747349
BTER: 100647993
CCAL: 108622260
OBB: 114873358 114873437
MGEN: 117226330
NMEA: 116427173
CGIG: 122400255
SOC: 105193763
MPHA: 105837418
AEC: 105147376
ACEP: 105624958
PBAR: 105426620
VEM: 105557423
HST: 105185301
DQU: 106749424
CFO: 105253432
FEX: 115235396
LHU: 105673528
PGC: 109860994
OBO: 105283280
PCF: 106787197
NVI: 100119376
CSOL: 105365576
MDL: 103570322
TCA: 655669
DPA: 109540804
ATD: 109598542
AGB: 108911873
NVL: 108560267
APLN: 108738006
PPYR: 116169867
OTU: 111415433
BMOR: 101744799
BMAN: 114241742
MSEX: 115451146
DPL: KGM_202663
BANY: 112046670
PMAC: 106715653
PPOT: 106105684
PXU: 106113405
PRAP: 111001403
ZCE: 119833535
HAW: 110370991
TNL: 113507089
PXY: 105382488 105389116
BTAB: 109038066
CLEC: 106670417
NLU: 111046525 111061142 120355108 120355801 120356024
PHU: Phum_PHUM557360
ZNE: 110832438
CSEC: 111870513
PVM: 113824470
HAME: 121871886
EAF: 111699044
ISC: IscW_ISCW002030
DSV: 119449692 119449694
RMP: 119169964
CSCU: 111634598
PTEP: 107436780 107441331
SDM: 118181385 118189191
LGI: LOTGIDRAFT_104488 LOTGIDRAFT_123341 LOTGIDRAFT_153520 LOTGIDRAFT_165917 LOTGIDRAFT_182753
PCAN: 112559502 112559503 112559504 112559583 112559713
BGT: 106063888
GAE: 121374686 121377054 121378631 121378632 121378634 121378635
CRG: 105324235 105329839 109620639
MYI: 110456562
OBI: 106871045
LAK: 106169855 106178049
NVE: 5506756
EPA: 110243498
ATEN: 116295503
ADF: 107340223
AMIL: 114970454
PDAM: 113686490 113686493
SPIS: 111326384
AQU: 100632261 100634409 100635941 100636070 100637425 100637941 100638175 100638304 105312205 109584014 109584015 109587233
MBR: MONBRDRAFT_22994 MONBRDRAFT_25248 MONBRDRAFT_27026 MONBRDRAFT_27633 MONBRDRAFT_28811 MONBRDRAFT_30487 MONBRDRAFT_32660
SRE: PTSG_08138 PTSG_08989
NGD: NGA_0701900(IDS)
AAF: AURANDRAFT_24889(ITS3) AURANDRAFT_63017(ITS1) AURANDRAFT_67199(ITS2)
EHX: EMIHUDRAFT_103111 EMIHUDRAFT_103855 EMIHUDRAFT_112105 EMIHUDRAFT_122517 EMIHUDRAFT_194249 EMIHUDRAFT_209682 EMIHUDRAFT_212280 EMIHUDRAFT_217387 EMIHUDRAFT_219397 EMIHUDRAFT_224019 EMIHUDRAFT_226946 EMIHUDRAFT_236119 EMIHUDRAFT_241437 EMIHUDRAFT_250748 EMIHUDRAFT_251085 EMIHUDRAFT_254050 EMIHUDRAFT_449285 EMIHUDRAFT_462481 EMIHUDRAFT_470309 EMIHUDRAFT_98819
VAF: D1115_15455
VAS: GT360_18225
CPS: CPS_2358 CPS_2375 CPS_2381
THT: E2K93_07360
PAT: Patl_0891
CATE: C2869_03515 C2869_06890 C2869_07510 C2869_07615
HALC: EY643_10695
SPHK: SKP52_01945
SPHX: E5675_04665
SPHU: SPPYR_0445
SSAN: NX02_06250
SKR: BRX40_12300
SPLM: BXU08_07020
SHYD: CJD35_08000
ANH: A6F65_00907
ADO: A6F68_00793(betC_2) A6F68_01095(betC_7)
OAC: Oscil6304_3690
VBH: CMV30_08140
ROO: G5S37_04965 G5S37_05100 G5S37_06235 G5S37_09990 G5S37_28180
LUO: HHL09_01145 HHL09_01155 HHL09_08160
VBA: IMCC26134_05065 IMCC26134_14340 IMCC26134_14360
VBS: EGM51_05040 EGM51_06095 EGM51_06440
RBA: RB10612 RB110 RB11127(ids) RB12089 RB2085(betC) RB2254 RB2707 RB5424 RB763
PSL: Psta_0190 Psta_1325 Psta_4390
PIR: VN12_09385 VN12_21255(betC_6) VN12_22170(betC_7)
RUL: UC8_11930 UC8_17290(betC_4) UC8_25850 UC8_36630(betC_8) UC8_53680(betC_12)
MFF: MFFC18_08440(betC_1) MFFC18_24440(betC_5) MFFC18_27880(betC_6) MFFC18_28310 MFFC18_48110
ROL: CA51_00570(betC_1) CA51_05180 CA51_09680 CA51_13020(betC_3) CA51_15580(betC_4) CA51_27610 CA51_27790(betC_7)
AHEL: Q31a_06790(betC_2) Q31a_18220 Q31a_38050 Q31a_39670 Q31a_40250(betC_12) Q31a_49120 Q31a_52450 Q31a_62100(betC_14)
LCRE: Pla8534_31970(betC_9) Pla8534_37420 Pla8534_62290(betC_14)
AAGG: ETAA8_12620 ETAA8_19150(betC_4) ETAA8_29880 ETAA8_34290(betC_7) ETAA8_40770
BVO: Pan97_01350(betC_1) Pan97_04460(betC_3) Pan97_04520 Pan97_05370 Pan97_10250(betC_7) Pan97_11360 Pan97_28910
RLC: K227x_60000(betC_18)
TTF: THTE_1564 THTE_3218 THTE_3574
LPAV: PLANPX_2904
AMUC: Pan181_24280(betC_2) Pan181_35480
PND: Pla175_08790(betC_3) Pla175_16280(betC_7) Pla175_17960 Pla175_22610(betC_9) Pla175_23090 Pla175_29660(betC_16) Pla175_30230(betC_17) Pla175_30620(betC_18) Pla175_34340(betC_19) Pla175_43580(betC_21) Pla175_44060
PLM: Plim_0651 Plim_3206 Plim_3468
PEH: Spb1_00530(betC_1) Spb1_14370(betC_2) Spb1_39310(betC_6)
PBS: Plabr_1704 Plabr_1705 Plabr_2092 Plabr_3173 Plabr_3214 Plabr_3306 Plabr_3888 Plabr_3983
PLS: VT03_16380(betC_4) VT03_26185(betC_5)
FMR: Fuma_00103 Fuma_00319 Fuma_00869(betC_3) Fuma_03662(betC_8) Fuma_05561 Fuma_05572
GMR: GmarT_16040(betC_3) GmarT_33550(betC_6) GmarT_39170(betC_9) GmarT_51320(betC_11) GmarT_52750(betC_12) GmarT_56780(betC_15) GmarT_56970(betC_16)
GIM: F1728_16070 F1728_16135 F1728_17540 F1728_18375 F1728_20155 F1728_26680 F1728_28935 F1728_29645
GPN: Pan110_26060 Pan110_31690(betC_5) Pan110_33350(betC_6) Pan110_37530 Pan110_50420(betC_9) Pan110_52270(betC_11) Pan110_54560(betC_12) Pan110_57880(betC_13) Pan110_58100(betC_14)
MRI: Mal4_02780(betC_2) Mal4_02830 Mal4_11450(betC_3) Mal4_23560 Mal4_25490(betC_10) Mal4_25920 Mal4_38510 Mal4_38980(betC_16) Mal4_43080(betC_18) Mal4_52730
SDYN: Mal52_09100(betC_4) Mal52_09280 Mal52_20470(betC_5) Mal52_23390
PLON: Pla110_26770(betC_3) Pla110_45380(betC_7)
TIM: GMBLW1_10970
LRS: PX52LOC_01054 PX52LOC_03291
FTJ: FTUN_0511
ULI: ETAA1_29150 ETAA1_30410(betC_3) ETAA1_30420 ETAA1_48310(betC_4)
SACI: Sinac_2390 Sinac_5994
PBP: STSP1_02381
PBAS: SMSP2_00670 SMSP2_00786
ALUS: STSP2_00836(betC_2)
HBS: IPV69_00480 IPV69_05370 IPV69_05465 IPV69_06155 IPV69_07740 IPV69_17595
VBL: L21SP4_00397(betC_1) L21SP4_01487 L21SP4_01919(betC_8)
TSA: AciPR4_1572
ABAC: LuPra_00139(betC_1)
BZG: C4H11_09370
BHF: C3V43_10380
BVU: BVU_1771
BDO: EL88_19490
BDH: GV66_08985
PSAC: PSM36_3070
PARY: A4V02_08150
ACOU: A5CBH24_04400
BACC: BRDCF_p1883(betC)
DRC: G0Q07_14495
MCOS: GM418_07545 GM418_10580 GM418_11520 GM418_11530 GM418_15485 GM418_18720 GM418_22600 GM418_24840 GM418_25460
ASX: CDL62_09655
MBAS: ALGA_0045 ALGA_2234
CHIT: FW415_14010 FW415_21965
NIA: A8C56_23685
PGIN: FRZ67_01245 FRZ67_01250
PHE: Phep_2247 Phep_3489
SHG: Sph21_4218 Sph21_5173
SMIZ: 4412673_01943
SPHZ: E3D81_15590
SDJ: NCTC13534_02722(betC_2)
MMAB: HQ865_20705
AGD: FRZ59_08605 FRZ59_09485
OLI: FKG96_18495 FKG96_21210 FKG96_23435
CMR: Cycma_0852 Cycma_3754 Cycma_3797 Cycma_3901
CAMU: CA2015_0736 CA2015_3688 CA2015_3725
EVI: Echvi_0936 Echvi_3776
EST: DN752_02210 DN752_10940 DN752_23000 DN752_23410
ECHI: FKX85_04685 FKX85_17770
ALM: AO498_15650
DFE: Dfer_2051
FIB: A6C57_05995
ALS: DJ013_02320 DJ013_04270 DJ013_06750
FLM: MY04_5044 MY04_5052 MY04_5157 MY04_5164
FLL: EI427_16845 EI427_21685 EI427_21720
FYA: KMW28_27690 KMW28_27725 KMW28_28200
FKA: KM029_23090 KM029_26055
FBT: D770_14535
FFA: FFWV33_10655 FFWV33_14845 FFWV33_15050 FFWV33_17845
FNK: E1750_01020 E1750_01035 E1750_17170 E1750_17200
FBC: FB2170_01941 FB2170_06815
MARM: YQ22_02090
MARE: EJ994_10160 EJ994_10220 EJ994_10435
CAO: Celal_0430 Celal_0431
CLY: Celly_1791 Celly_1796
CLH: IX49_08840 IX49_08865
CBAL: M667_18145 M667_19620
CBAT: M666_18145 M666_19535
ZGA: ZOBELLIA_181(idsA1) ZOBELLIA_2730(idsA2) ZOBELLIA_3146(idsA3) ZOBELLIA_3526(idsA4)
POLA: BXQ17_09695 BXQ17_09710 BXQ17_09750 BXQ17_09845
PHAL: H9I45_05880 H9I45_05905 H9I45_05950 H9I45_05955
WIJ: BWZ20_07955
SZE: AW14_08895 AW14_08920 AW14_08960 AW14_13205 AW14_13220 AW14_13235 AW14_13405 AW14_13435
AHZ: APS56_04555 APS56_05910 APS56_09900
TJE: TJEJU_2924(idsA)
WFU: AXE80_00055 AXE80_06065 AXE80_06125 AXE80_06140 AXE80_07595 AXE80_10200 AXE80_10210 AXE80_10620 AXE80_12690 AXE80_12995
FOH: FORMA_02030 FORMA_02150 FORMA_02410 FORMA_02490 FORMA_02510 FORMA_07140 FORMA_07310
FOP: FNB79_04820 FNB79_14610
SALT: AO058_17590
SEON: BWZ22_10495 BWZ22_10535 BWZ22_10550 BWZ22_11745
AALG: AREALGSMS7_01173 AREALGSMS7_01304
TAJ: C1A40_08420 C1A40_08455 C1A40_13045 C1A40_13085 C1A40_13100
SPON: HME9304_00667
KAN: IMCC3317_46410 IMCC3317_46440
EMAR: D1013_16565
GAA: HX109_03365 HX109_13995
FBU: UJ101_00816 UJ101_00822(GNS)
FBE: FF125_02310 FF125_03865 FF125_12590 FF125_15540
ORH: Ornrh_1056
ORI: Q785_05885
 » show all
Reference
  Authors
Coronado-Pons I, Novials A, Casas S, Clark A, Gomis R
  Title
Identification of iduronate-2-sulfatase in mouse pancreatic islets.
  Journal
Am J Physiol Endocrinol Metab 287:E983-90 (2004)
DOI:10.1152/ajpendo.00528.2003
  Sequence
[mmu:15931]

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KEGG   ENZYME: 3.1.6.13
Entry
EC 3.1.6.13                 Enzyme                                 

Name
iduronate-2-sulfatase;
chondroitinsulfatase;
idurono-2-sulfatase;
iduronide-2-sulfate sulfatase;
L-iduronosulfatase;
L-idurono sulfate sulfatase;
iduronate sulfatase;
sulfo-L-iduronate sulfatase;
L-iduronate 2-sulfate sulfatase;
sulfoiduronate sulfohydrolase;
2-sulfo-L-iduronate 2-sulfatase;
iduronate-2-sulfate sulfatase;
iduronate sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
L-iduronate-2-sulfate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821]
Reaction(KEGG)
R07812(G) R07821(G)
History
EC 3.1.6.13 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01136  iduronate 2-sulfatase
Genes
HSA: 3423(IDS)
PTR: 465896(IDS)
PPS: 100981796(IDS)
GGO: 101148217(IDS)
PON: 100435640(IDS)
NLE: 100581849(IDS)
MCC: 700892(IDS)
MCF: 102137236(IDS)
CSAB: 103232717(IDS)
CATY: 105595595(IDS)
PANU: 101008279(IDS)
RRO: 104657812(IDS)
RBB: 108539780(IDS)
TFN: 117078229(IDS)
PTEH: 111536373(IDS)
CJC: 100415225(IDS)
SBQ: 101027610(IDS)
MMUR: 105857531(IDS)
MMU: 15931(Ids)
MCAL: 110286776(Ids)
MPAH: 110313631(Ids)
RNO: 363513(Ids)
MCOC: 116085689(Ids)
MUN: 110540175(Ids)
CGE: 100763345(Ids)
PLEU: 114688017(Ids)
NGI: 103737443(Ids)
HGL: 101710577(Ids)
CCAN: 109695031(Ids)
OCU: 100356659(IDS)
TUP: 102483402(IDS)
CFA: 492194(IDS)
VVP: 112927657(IDS)
VLG: 121482887(IDS)
AML: 100469837(IDS)
UMR: 103662556(IDS)
UAH: 113241894(IDS)
ORO: 101382674(IDS)
ELK: 111158976
MPUF: 101690645(IDS)
EJU: 114199013(IDS) 114202770
MLX: 118008400(IDS)
FCA: 101081450(IDS)
PTG: 102968319(IDS)
PPAD: 109258697(IDS)
AJU: 106988547(IDS)
HHV: 120227028(IDS)
BTA: 541272(IDS)
BOM: 102286693(IDS)
BIU: 109554785(IDS)
BBUB: 102410975(IDS)
CHX: 102189563(IDS)
OAS: 101116540(IDS)
ODA: 120881766(IDS)
SSC: 100512880(IDS)
CFR: 102510249(IDS)
CDK: 105104103(IDS)
BACU: 103018480(IDS)
LVE: 103078281(IDS)
OOR: 101289790(IDS)
DLE: 111167853(IDS)
PCAD: 102983735
ECB: 111771607(IDS)
EPZ: 103540044(IDS)
EAI: 106842534(IDS)
MYB: 102251234(IDS)
MYD: 102771465(IDS)
MMYO: 118653914(IDS)
MNA: 107530067(IDS)
HAI: 109388991(IDS)
DRO: 112296325(IDS)
SHON: 118996043(IDS)
AJM: 119051673(IDS)
MMF: 118635949(IDS)
PALE: 102893087(IDS)
RAY: 107502397 107502399(IDS) 107506382 107507519 107507961
MJV: 108405651(IDS)
TOD: 119245842(IDS)
LAV: 100668951(IDS)
TMU: 101348522
MDO: 100025173(IDS)
SHR: 100932918(IDS)
PCW: 110199816(IDS)
OAA: 100081812(IDS)
GGA: 422392(IDS)
PCOC: 116234854(IDS)
MGP: 100548552(IDS)
CJO: 107312964(IDS)
NMEL: 110403286(IDS)
APLA: 101805206(IDS)
ACYG: 106037727(IDS)
TGU: 100231299(IDS)
LSR: 110480065(IDS)
SCAN: 103816359(IDS)
PMOA: 120506191(IDS)
GFR: 102044849(IDS)
FAB: 101817405(IDS)
PHI: 102102287(IDS)
PMAJ: 107204060(IDS)
CCAE: 111928496(IDS)
CCW: 104691675(IDS)
ETL: 114056735(IDS)
FPG: 101917991(IDS)
FCH: 102056477(IDS)
CLV: 102095548(IDS)
EGZ: 104124077(IDS)
NNI: 104019072(IDS)
ACUN: 113480248(IDS)
PADL: 103922912(IDS)
AAM: 106487578(IDS)
ASN: 102375700(IDS)
AMJ: 102571433(IDS)
CPOO: 109313625(IDS)
GGN: 109300820(IDS)
PSS: 102447899(IDS)
CMY: 102931008(IDS)
CPIC: 101944748(IDS)
TST: 117883182(IDS)
CABI: 116824492(IDS)
ACS: 100565846(ids)
PVT: 110082990(IDS)
PBI: 103053966(IDS)
PMUR: 107291666(IDS)
TSR: 106549285(IDS)
PGUT: 117677977(IDS)
PMUA: 114589233(IDS)
ZVI: 118084337(IDS)
GJA: 107107996(IDS)
XLA: 108698425(ids.L)
XTR: 100135738(ids)
NPR: 108783898(IDS)
DRE: 559959(ids)
SRX: 107742636 107754550
SANH: 107703646
SGH: 107588358
CCAR: 109108298(ids)
CAUA: 113113609(ids)
IPU: 108268807(ids)
PHYP: 113542945(ids)
AMEX: 103032782(ids)
EEE: 113572503(ids)
TRU: 101066362 115252486
TNG: GSTEN00010710G001
LCO: 104932265(ids)
NCC: 104948380(ids)
ELY: 117260683(ids)
PLEP: 121947925(ids)
SLUC: 116036600(ids)
ECRA: 117951985(ids)
PFLV: 114562652(ids)
GAT: 120817090(ids)
MSAM: 119888202(ids)
CUD: 121516852(ids)
MZE: 101484170(ids)
ONL: 100701301(ids)
OAU: 116328130(ids)
OLA: 101158287(ids)
OML: 112153796(ids)
XMA: 102223507(ids)
XCO: 114139558(ids)
XHE: 116714780(ids)
PRET: 103471071(ids)
CVG: 107093837(ids)
CTUL: 119797269(ids)
NFU: 107382373(ids)
KMR: 108240015(ids)
ALIM: 106533195(ids)
AOCE: 111582599(ids)
CSEM: 103391272(ids)
POV: 109627356(ids)
LCF: 108878945(ids)
SDU: 111226708(ids)
SLAL: 111646415(ids)
XGL: 120785469(ids)
HCQ: 109524284(ids)
BPEC: 110172172(ids)
MALB: 109957582(ids)
SASA: 106611990(ids)
OTW: 112256025
OMY: 110504761(ids)
SALP: 111965339 112070437(ids)
ELS: 105027395(ids)
SFM: 108922862(ids)
PKI: 111848144(ids)
LOC: 102691141(ids)
PSPA: 121318966(ids)
ARUT: 117412437
LCM: 102348043(IDS)
CMK: 103178266(ids)
RTP: 109937925
BFO: 118419919
CIN: 100185385
SCLV: 120336576
SPU: 100892602 100892667 115918435 115922305 579992 584730 587680 588607 588631
APLC: 110983712 110983804
SKO: 100370796 100374826
DME: Dmel_CG12014(Ids)
DER: 6546473
DSE: 6610634
DSI: Dsimw501_GD13763(Dsim_GD13763)
DYA: Dyak_GE21364
DAN: 6506843
DSR: 110177559
DPO: Dpse_GA11337
DPE: 6601698
DMN: 108152850
DWI: 6645875
DGR: Dgri_GH16111 Dgri_GH23326
DMO: Dmoj_GI12380
DAZ: 108614650
DNV: 108650413
DHE: 111601084
DVI: 6623790
MDE: 101896463
LCQ: 111690708
AGA: AgaP_AGAP005778
ACOZ: 120952744
AARA: 120906700
AAG: 5572289
AALB: 109431614
CQU: CpipJ_CPIJ004938
CPII: 120423600
AME: 724550
ACER: 108003103
BIM: 100747349
BTER: 100647993
CCAL: 108622260
OBB: 114873358 114873437
MGEN: 117226330
NMEA: 116427173
CGIG: 122400255
SOC: 105193763
MPHA: 105837418
AEC: 105147376
ACEP: 105624958
PBAR: 105426620
VEM: 105557423
HST: 105185301
DQU: 106749424
CFO: 105253432
FEX: 115235396
LHU: 105673528
PGC: 109860994
OBO: 105283280
PCF: 106787197
NVI: 100119376
CSOL: 105365576
MDL: 103570322
TCA: 655669
DPA: 109540804
ATD: 109598542
AGB: 108911873
NVL: 108560267
APLN: 108738006
PPYR: 116169867
OTU: 111415433
BMOR: 101744799
BMAN: 114241742
MSEX: 115451146
DPL: KGM_202663
BANY: 112046670
PMAC: 106715653
PPOT: 106105684
PXU: 106113405
PRAP: 111001403
ZCE: 119833535
HAW: 110370991
TNL: 113507089
PXY: 105382488 105389116
BTAB: 109038066
CLEC: 106670417
NLU: 111046525 111061142 120355108 120355801 120356024
PHU: Phum_PHUM557360
ZNE: 110832438
CSEC: 111870513
PVM: 113824470
HAME: 121871886
EAF: 111699044
ISC: IscW_ISCW002030
DSV: 119449692 119449694
RMP: 119169964
CSCU: 111634598
PTEP: 107436780 107441331
SDM: 118181385 118189191
LGI: LOTGIDRAFT_104488 LOTGIDRAFT_123341 LOTGIDRAFT_153520 LOTGIDRAFT_165917 LOTGIDRAFT_182753
PCAN: 112559502 112559503 112559504 112559583 112559713
BGT: 106063888
GAE: 121374686 121377054 121378631 121378632 121378634 121378635
CRG: 105324235 105329839 109620639
MYI: 110456562
OBI: 106871045
LAK: 106169855 106178049
NVE: 5506756
EPA: 110243498
ATEN: 116295503
ADF: 107340223
AMIL: 114970454
PDAM: 113686490 113686493
SPIS: 111326384
AQU: 100632261 100634409 100635941 100636070 100637425 100637941 100638175 100638304 105312205 109584014 109584015 109587233
MBR: MONBRDRAFT_22994 MONBRDRAFT_25248 MONBRDRAFT_27026 MONBRDRAFT_27633 MONBRDRAFT_28811 MONBRDRAFT_30487 MONBRDRAFT_32660
SRE: PTSG_08138 PTSG_08989
NGD: NGA_0701900(IDS)
AAF: AURANDRAFT_24889(ITS3) AURANDRAFT_63017(ITS1) AURANDRAFT_67199(ITS2)
EHX: EMIHUDRAFT_103111 EMIHUDRAFT_103855 EMIHUDRAFT_112105 EMIHUDRAFT_122517 EMIHUDRAFT_194249 EMIHUDRAFT_209682 EMIHUDRAFT_212280 EMIHUDRAFT_217387 EMIHUDRAFT_219397 EMIHUDRAFT_224019 EMIHUDRAFT_226946 EMIHUDRAFT_236119 EMIHUDRAFT_241437 EMIHUDRAFT_250748 EMIHUDRAFT_251085 EMIHUDRAFT_254050 EMIHUDRAFT_449285 EMIHUDRAFT_462481 EMIHUDRAFT_470309 EMIHUDRAFT_98819
VAF: D1115_15455
VAS: GT360_18225
CPS: CPS_2358 CPS_2375 CPS_2381
THT: E2K93_07360
PAT: Patl_0891
CATE: C2869_03515 C2869_06890 C2869_07510 C2869_07615
HALC: EY643_10695
SPHK: SKP52_01945
SPHX: E5675_04665
SPHU: SPPYR_0445
SSAN: NX02_06250
SKR: BRX40_12300
SPLM: BXU08_07020
SHYD: CJD35_08000
ANH: A6F65_00907
ADO: A6F68_00793(betC_2) A6F68_01095(betC_7)
OAC: Oscil6304_3690
VBH: CMV30_08140
ROO: G5S37_04965 G5S37_05100 G5S37_06235 G5S37_09990 G5S37_28180
LUO: HHL09_01145 HHL09_01155 HHL09_08160
VBA: IMCC26134_05065 IMCC26134_14340 IMCC26134_14360
VBS: EGM51_05040 EGM51_06095 EGM51_06440
RBA: RB10612 RB110 RB11127(ids) RB12089 RB2085(betC) RB2254 RB2707 RB5424 RB763
PSL: Psta_0190 Psta_1325 Psta_4390
PIR: VN12_09385 VN12_21255(betC_6) VN12_22170(betC_7)
RUL: UC8_11930 UC8_17290(betC_4) UC8_25850 UC8_36630(betC_8) UC8_53680(betC_12)
MFF: MFFC18_08440(betC_1) MFFC18_24440(betC_5) MFFC18_27880(betC_6) MFFC18_28310 MFFC18_48110
ROL: CA51_00570(betC_1) CA51_05180 CA51_09680 CA51_13020(betC_3) CA51_15580(betC_4) CA51_27610 CA51_27790(betC_7)
AHEL: Q31a_06790(betC_2) Q31a_18220 Q31a_38050 Q31a_39670 Q31a_40250(betC_12) Q31a_49120 Q31a_52450 Q31a_62100(betC_14)
LCRE: Pla8534_31970(betC_9) Pla8534_37420 Pla8534_62290(betC_14)
AAGG: ETAA8_12620 ETAA8_19150(betC_4) ETAA8_29880 ETAA8_34290(betC_7) ETAA8_40770
BVO: Pan97_01350(betC_1) Pan97_04460(betC_3) Pan97_04520 Pan97_05370 Pan97_10250(betC_7) Pan97_11360 Pan97_28910
RLC: K227x_60000(betC_18)
TTF: THTE_1564 THTE_3218 THTE_3574
LPAV: PLANPX_2904
AMUC: Pan181_24280(betC_2) Pan181_35480
PND: Pla175_08790(betC_3) Pla175_16280(betC_7) Pla175_17960 Pla175_22610(betC_9) Pla175_23090 Pla175_29660(betC_16) Pla175_30230(betC_17) Pla175_30620(betC_18) Pla175_34340(betC_19) Pla175_43580(betC_21) Pla175_44060
PLM: Plim_0651 Plim_3206 Plim_3468
PEH: Spb1_00530(betC_1) Spb1_14370(betC_2) Spb1_39310(betC_6)
PBS: Plabr_1704 Plabr_1705 Plabr_2092 Plabr_3173 Plabr_3214 Plabr_3306 Plabr_3888 Plabr_3983
PLS: VT03_16380(betC_4) VT03_26185(betC_5)
FMR: Fuma_00103 Fuma_00319 Fuma_00869(betC_3) Fuma_03662(betC_8) Fuma_05561 Fuma_05572
GMR: GmarT_16040(betC_3) GmarT_33550(betC_6) GmarT_39170(betC_9) GmarT_51320(betC_11) GmarT_52750(betC_12) GmarT_56780(betC_15) GmarT_56970(betC_16)
GIM: F1728_16070 F1728_16135 F1728_17540 F1728_18375 F1728_20155 F1728_26680 F1728_28935 F1728_29645
GPN: Pan110_26060 Pan110_31690(betC_5) Pan110_33350(betC_6) Pan110_37530 Pan110_50420(betC_9) Pan110_52270(betC_11) Pan110_54560(betC_12) Pan110_57880(betC_13) Pan110_58100(betC_14)
MRI: Mal4_02780(betC_2) Mal4_02830 Mal4_11450(betC_3) Mal4_23560 Mal4_25490(betC_10) Mal4_25920 Mal4_38510 Mal4_38980(betC_16) Mal4_43080(betC_18) Mal4_52730
SDYN: Mal52_09100(betC_4) Mal52_09280 Mal52_20470(betC_5) Mal52_23390
PLON: Pla110_26770(betC_3) Pla110_45380(betC_7)
TIM: GMBLW1_10970
LRS: PX52LOC_01054 PX52LOC_03291
FTJ: FTUN_0511
ULI: ETAA1_29150 ETAA1_30410(betC_3) ETAA1_30420 ETAA1_48310(betC_4)
SACI: Sinac_2390 Sinac_5994
PBP: STSP1_02381
PBAS: SMSP2_00670 SMSP2_00786
ALUS: STSP2_00836(betC_2)
HBS: IPV69_00480 IPV69_05370 IPV69_05465 IPV69_06155 IPV69_07740 IPV69_17595
VBL: L21SP4_00397(betC_1) L21SP4_01487 L21SP4_01919(betC_8)
TSA: AciPR4_1572
ABAC: LuPra_00139(betC_1)
BZG: C4H11_09370
BHF: C3V43_10380
BVU: BVU_1771
BDO: EL88_19490
BDH: GV66_08985
PSAC: PSM36_3070
PARY: A4V02_08150
ACOU: A5CBH24_04400
BACC: BRDCF_p1883(betC)
DRC: G0Q07_14495
MCOS: GM418_07545 GM418_10580 GM418_11520 GM418_11530 GM418_15485 GM418_18720 GM418_22600 GM418_24840 GM418_25460
ASX: CDL62_09655
MBAS: ALGA_0045 ALGA_2234
CHIT: FW415_14010 FW415_21965
NIA: A8C56_23685
PGIN: FRZ67_01245 FRZ67_01250
PHE: Phep_2247 Phep_3489
SHG: Sph21_4218 Sph21_5173
SMIZ: 4412673_01943
SPHZ: E3D81_15590
SDJ: NCTC13534_02722(betC_2)
MMAB: HQ865_20705
AGD: FRZ59_08605 FRZ59_09485
OLI: FKG96_18495 FKG96_21210 FKG96_23435
CMR: Cycma_0852 Cycma_3754 Cycma_3797 Cycma_3901
CAMU: CA2015_0736 CA2015_3688 CA2015_3725
EVI: Echvi_0936 Echvi_3776
EST: DN752_02210 DN752_10940 DN752_23000 DN752_23410
ECHI: FKX85_04685 FKX85_17770
ALM: AO498_15650
DFE: Dfer_2051
FIB: A6C57_05995
ALS: DJ013_02320 DJ013_04270 DJ013_06750
FLM: MY04_5044 MY04_5052 MY04_5157 MY04_5164
FLL: EI427_16845 EI427_21685 EI427_21720
FYA: KMW28_27690 KMW28_27725 KMW28_28200
FKA: KM029_23090 KM029_26055
FBT: D770_14535
FFA: FFWV33_10655 FFWV33_14845 FFWV33_15050 FFWV33_17845
FNK: E1750_01020 E1750_01035 E1750_17170 E1750_17200
FBC: FB2170_01941 FB2170_06815
MARM: YQ22_02090
MARE: EJ994_10160 EJ994_10220 EJ994_10435
CAO: Celal_0430 Celal_0431
CLY: Celly_1791 Celly_1796
CLH: IX49_08840 IX49_08865
CBAL: M667_18145 M667_19620
CBAT: M666_18145 M666_19535
ZGA: ZOBELLIA_181(idsA1) ZOBELLIA_2730(idsA2) ZOBELLIA_3146(idsA3) ZOBELLIA_3526(idsA4)
POLA: BXQ17_09695 BXQ17_09710 BXQ17_09750 BXQ17_09845
PHAL: H9I45_05880 H9I45_05905 H9I45_05950 H9I45_05955
WIJ: BWZ20_07955
SZE: AW14_08895 AW14_08920 AW14_08960 AW14_13205 AW14_13220 AW14_13235 AW14_13405 AW14_13435
AHZ: APS56_04555 APS56_05910 APS56_09900
TJE: TJEJU_2924(idsA)
WFU: AXE80_00055 AXE80_06065 AXE80_06125 AXE80_06140 AXE80_07595 AXE80_10200 AXE80_10210 AXE80_10620 AXE80_12690 AXE80_12995
FOH: FORMA_02030 FORMA_02150 FORMA_02410 FORMA_02490 FORMA_02510 FORMA_07140 FORMA_07310
FOP: FNB79_04820 FNB79_14610
SALT: AO058_17590
SEON: BWZ22_10495 BWZ22_10535 BWZ22_10550 BWZ22_11745
AALG: AREALGSMS7_01173 AREALGSMS7_01304
TAJ: C1A40_08420 C1A40_08455 C1A40_13045 C1A40_13085 C1A40_13100
SPON: HME9304_00667
KAN: IMCC3317_46410 IMCC3317_46440
EMAR: D1013_16565
GAA: HX109_03365 HX109_13995
FBU: UJ101_00816 UJ101_00822(GNS)
FBE: FF125_02310 FF125_03865 FF125_12590 FF125_15540
ORH: Ornrh_1056
ORI: Q785_05885
 » show all
Reference
1  [PMID:6816283]
  Authors
Archer IM, Harper PS, Wusteman FS.
  Title
Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids.
  Journal
Biochim Biophys Acta 708:134-40 (1982)
DOI:10.1016/0167-4838(82)90213-8
Reference
2  [PMID:4269173]
  Authors
Bach G, Eisenberg F Jr, Cantz M, Neufeld EF.
  Title
The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase.
  Journal
Proc Natl Acad Sci U S A 70:2134-8 (1973)
DOI:10.1073/pnas.70.7.2134
Reference
3  [PMID:6945876]
  Authors
Di Natale P, Ronsisvalle L.
  Title
Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta.
  Journal
Biochim Biophys Acta 661:106-11 (1981)
DOI:10.1016/0005-2744(81)90088-7
Reference
4  [PMID:6950934]
  Authors
Yutaka T, Fluharty AL, Stevens RL, Kihara H.
  Title
Purification and some properties of human liver iduronate sulfatase.
  Journal
J Biochem (Tokyo) 91:433-41 (1982)
DOI:10.1093/oxfordjournals.jbchem.a133715
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.13
IUBMB Enzyme Nomenclature: 3.1.6.13
ExPASy - ENZYME nomenclature database: 3.1.6.13
BRENDA, the Enzyme Database: 3.1.6.13
CAS: 50936-59-9

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Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (2)   
   KEGG GLYCAN (4)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (26790)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (749)   
   KEGG MGENES (22001)   
   RefGene (4039)   
Protein sequence (102)   
   UniProt (80)   
   SWISS-PROT (2)   
   RefSeq(pep) (12)   
   PDBSTR (2)   
   PMD (6)   
DNA sequence (80)   
   RefSeq(nuc) (16)   
   GenBank (33)   
   EMBL (31)   
3D Structure (2)   
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Protein domain (5)   
   InterPro (4)   
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All databases (26993)   

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KEGG   REACTION: R07812
Entry
R07812                      Reaction                               

Name
L-iduronate-2-sulfate 2-sulfohydrolase
Definition
G13034 + H2O <=> G13035 + Sulfate
Equation
Enzyme
Pathway
rn00531  Glycosaminoglycan degradation
rn01100  Metabolic pathways
Module
M00078  Heparan sulfate degradation
Orthology
K01136  iduronate 2-sulfatase [EC:3.1.6.13]

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Ontology (1)   
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Pathway (5)   
   KEGG PATHWAY (4)   
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Chemical substance (4)   
   KEGG COMPOUND (2)   
   KEGG GLYCAN (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (750)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (749)   
All databases (761)   

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