KEGG   ORTHOLOGY: K01136
Entry
K01136                      KO                                     

Name
IDS
Definition
iduronate 2-sulfatase [EC:3.1.6.13]
Pathway
ko00531  Glycosaminoglycan degradation
ko01100  Metabolic pathways
ko04142  Lysosome
Module
M00076  Dermatan sulfate degradation
M00078  Heparan sulfate degradation
Disease
H00129  Mucopolysaccharidosis type II
H00421  Mucopolysaccharidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00531 Glycosaminoglycan degradation
    K01136  IDS; iduronate 2-sulfatase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01136  IDS; iduronate 2-sulfatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.6  Sulfuric-ester hydrolases
    3.1.6.13  iduronate-2-sulfatase
     K01136  IDS; iduronate 2-sulfatase
Other DBs
RN: R07812 R07821
GO: 0004423
Genes
HSA: 3423(IDS)
PTR: 465896(IDS)
PPS: 100981796(IDS)
GGO: 101148217(IDS)
PON: 100435640(IDS)
NLE: 100581849(IDS)
MCC: 700892(IDS)
MCF: 102137236(IDS)
CSAB: 103232717(IDS)
RRO: 104657812(IDS)
RBB: 108539780(IDS)
CJC: 100415225(IDS)
SBQ: 101027610(IDS)
MMU: 15931(Ids)
MCAL: 110286776(Ids)
MPAH: 110313631(Ids)
RNO: 363513(Ids)
MUN: 110540175(Ids)
CGE: 100763345(Ids)
NGI: 103737443(Ids)
HGL: 101710577(Ids)
CCAN: 109695031(Ids)
OCU: 100356659(IDS)
TUP: 102483402(IDS)
CFA: 492194(IDS)
VVP: 112927657(IDS)
AML: 100469837(IDS)
UMR: 103662556(IDS)
UAH: 113241894(IDS)
ORO: 101382674(IDS)
ELK: 111158976
FCA: 101081450(IDS)
PTG: 102968319(IDS)
PPAD: 109258697(IDS)
AJU: 106988547(IDS)
BTA: 541272(IDS)
BOM: 102286693(IDS)
BIU: 109554785(IDS)
BBUB: 102410975(IDS)
CHX: 102189563(IDS)
OAS: 101116540(IDS)
SSC: 100512880(IDS)
CFR: 102510249(IDS)
CDK: 105104103(IDS)
BACU: 103018480(IDS)
LVE: 103078281(IDS)
OOR: 101289790(IDS)
DLE: 111167853(IDS)
PCAD: 102983735
ECB: 111771607(IDS)
EPZ: 103540044(IDS)
EAI: 106842534(IDS)
MYB: 102251234(IDS)
MYD: 102771465(IDS)
MNA: 107530067(IDS)
HAI: 109388991(IDS)
DRO: 112296325(IDS)
PALE: 102893087(IDS)
MJV: 108405651(IDS)
LAV: 100668951(IDS)
TMU: 101348522
MDO: 100025173(IDS)
SHR: 100932918(IDS)
PCW: 110199816(IDS)
OAA: 100081812(IDS)
GGA: 422392(IDS)
MGP: 100548552(IDS)
CJO: 107312964(IDS)
NMEL: 110403286(IDS)
APLA: 101805206(IDS)
ACYG: 106037727(IDS)
TGU: 100231299(IDS)
LSR: 110480065(IDS)
SCAN: 103816359(IDS)
GFR: 102044849(IDS)
FAB: 101817405(IDS)
PHI: 102102287(IDS)
PMAJ: 107204060(IDS)
CCAE: 111928496(IDS)
CCW: 104691675(IDS)
ETL: 114056735(IDS)
FPG: 101917991(IDS)
FCH: 102056477(IDS)
CLV: 102095548(IDS)
EGZ: 104124077(IDS)
NNI: 104019072(IDS)
ACUN: 113480248(IDS)
PADL: 103922912(IDS)
AAM: 106487578(IDS)
ASN: 102375700(IDS)
AMJ: 102571433(IDS)
PSS: 102447899(IDS)
CMY: 102931008(IDS)
CPIC: 101944748(IDS)
ACS: 100565846(ids)
PVT: 110082990(IDS)
PBI: 103053966(IDS)
PMUR: 107291666(IDS)
TSR: 106549285(IDS)
PMUA: 114589233(IDS)
GJA: 107107996(IDS)
XLA: 108698425
XTR: 100135738(ids)
NPR: 108783898(IDS)
DRE: 559959(ids)
SANH: 107703646
SGH: 107588358
CCAR: 109108298(ids)
IPU: 108268807(ids)
PHYP: 113542945(ids)
AMEX: 103032782(ids)
EEE: 113572503(ids)
LCO: 104932265(ids)
NCC: 104948380(ids)
MZE: 101484170(ids)
ONL: 100701301(ids)
OLA: 101158287(ids)
XMA: 102223507(ids)
XCO: 114139558(ids)
PRET: 103471071(ids)
CVG: 107093837(ids)
NFU: 107382373(ids)
KMR: 108240015(ids)
ALIM: 106533195(ids)
AOCE: 111582599(ids)
CSEM: 103391272(ids)
POV: 109627356(ids)
LCF: 108878945(ids)
SDU: 111226708(ids)
SLAL: 111646415(ids)
HCQ: 109524284(ids)
BPEC: 110172172(ids)
MALB: 109957582(ids)
SASA: 106611990(ids)
OTW: 112256025
SALP: 111965339 112070437(ids)
ELS: 105027395(ids)
SFM: 108922862(ids)
PKI: 111848144(ids)
LCM: 102348043(IDS)
CMK: 103178266(ids)
RTP: 109937925
CIN: 100185385
DME: Dmel_CG12014(Ids)
DER: 6546473
DSE: 6610634
DSI: Dsimw501_GD13763(Dsim_GD13763)
DAN: 6506843
DSR: 110177559
DPE: 6601698
DMN: 108152850
DWI: 6645875
DAZ: 108614650
DNV: 108650413
DHE: 111601084
DVI: 6623790
MDE: 101896463
LCQ: 111690708
AAG: 5572289
AALB: 109431614
AME: 724550
BIM: 100747349
BTER: 100647993
CCAL: 108622260
SOC: 105193763
MPHA: 105837418
AEC: 105147376
ACEP: 105624958
PBAR: 105426620
VEM: 105557423
HST: 105185301
DQU: 106749424
CFO: 105253432
LHU: 105673528
PGC: 109860994
OBO: 105283280
PCF: 106787197
NVI: 100119376
CSOL: 105365576
MDL: 103570322
TCA: 655669
DPA: 109540804
ATD: 109598542
NVL: 108560267
BMOR: 101744799
BMAN: 114241742
PMAC: 106715653
PRAP: 111001403
HAW: 110370991
TNL: 113507089
BTAB: 109038066
CLEC: 106670417
ZNE: 110832438
PVM: 113824470
CSCU: 111634598
MYI: 110456562
OBI: 106871045
NVE: 5506756
EPA: 110243498
ADF: 107340223
AMIL: 114970454
SPIS: 111326384
NGD: NGA_0701900(IDS)
PAT: Patl_0891
SPHU: SPPYR_0445
SSAN: NX02_06250
ADO: A6F68_00793(betC_2) A6F68_01095(betC_7)
PIR: VN12_09385 VN12_21255(betC_6) VN12_22170(betC_7)
RUL: UC8_11930 UC8_17290(betC_4) UC8_25850 UC8_36630(betC_8) UC8_53680(betC_12)
PEH: Spb1_00530(betC_1) Spb1_14370(betC_2) Spb1_39310(betC_6)
PLS: VT03_16380(betC_4) VT03_26185(betC_5)
GMR: GmarT_16040(betC_3) GmarT_33550(betC_6) GmarT_39170(betC_9) GmarT_51320(betC_11) GmarT_52750(betC_12) GmarT_56780(betC_15) GmarT_56970(betC_16)
ALUS: STSP2_00836(betC_2)
VBL: L21SP4_00397(betC_1) L21SP4_01487 L21SP4_01919(betC_8)
ABAC: LuPra_00139(betC_1)
BVU: BVU_1771
PSAC: PSM36_3070
BACC: BRDCF_p1883(betC)
SDJ: NCTC13534_02722(betC_2)
DFE: Dfer_2051
MARM: YQ22_02090
ZGA: ZOBELLIA_181(idsA1) ZOBELLIA_2730(idsA2) ZOBELLIA_3146(idsA3) ZOBELLIA_3526(idsA4)
TJE: TJEJU_2924(idsA)
 » show all
Reference
  Authors
Coronado-Pons I, Novials A, Casas S, Clark A, Gomis R
  Title
Identification of iduronate-2-sulfatase in mouse pancreatic islets.
  Journal
Am J Physiol Endocrinol Metab 287:E983-90 (2004)
DOI:10.1152/ajpendo.00528.2003
  Sequence
[mmu:15931]

KEGG   ENZYME: 3.1.6.13
Entry
EC 3.1.6.13                 Enzyme                                 

Name
iduronate-2-sulfatase;
chondroitinsulfatase;
idurono-2-sulfatase;
iduronide-2-sulfate sulfatase;
L-iduronosulfatase;
L-idurono sulfate sulfatase;
iduronate sulfatase;
sulfo-L-iduronate sulfatase;
L-iduronate 2-sulfate sulfatase;
sulfoiduronate sulfohydrolase;
2-sulfo-L-iduronate 2-sulfatase;
iduronate-2-sulfate sulfatase;
iduronate sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
L-iduronate-2-sulfate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821]
Reaction(KEGG)
R07812(G) R07821(G)
History
EC 3.1.6.13 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01136  iduronate 2-sulfatase
Genes
HSA: 3423(IDS)
PTR: 465896(IDS)
PPS: 100981796(IDS)
GGO: 101148217(IDS)
PON: 100435640(IDS)
NLE: 100581849(IDS)
MCC: 700892(IDS)
MCF: 102137236(IDS)
CSAB: 103232717(IDS)
RRO: 104657812(IDS)
RBB: 108539780(IDS)
CJC: 100415225(IDS)
SBQ: 101027610(IDS)
MMU: 15931(Ids)
MCAL: 110286776(Ids)
MPAH: 110313631(Ids)
RNO: 363513(Ids)
MUN: 110540175(Ids)
CGE: 100763345(Ids)
NGI: 103737443(Ids)
HGL: 101710577(Ids)
CCAN: 109695031(Ids)
OCU: 100356659(IDS)
TUP: 102483402(IDS)
CFA: 492194(IDS)
VVP: 112927657(IDS)
AML: 100469837(IDS)
UMR: 103662556(IDS)
UAH: 113241894(IDS)
ORO: 101382674(IDS)
ELK: 111158976
FCA: 101081450(IDS)
PTG: 102968319(IDS)
PPAD: 109258697(IDS)
AJU: 106988547(IDS)
BTA: 541272(IDS)
BOM: 102286693(IDS)
BIU: 109554785(IDS)
BBUB: 102410975(IDS)
CHX: 102189563(IDS)
OAS: 101116540(IDS)
SSC: 100512880(IDS)
CFR: 102510249(IDS)
CDK: 105104103(IDS)
BACU: 103018480(IDS)
LVE: 103078281(IDS)
OOR: 101289790(IDS)
DLE: 111167853(IDS)
PCAD: 102983735
ECB: 111771607(IDS)
EPZ: 103540044(IDS)
EAI: 106842534(IDS)
MYB: 102251234(IDS)
MYD: 102771465(IDS)
MNA: 107530067(IDS)
HAI: 109388991(IDS)
DRO: 112296325(IDS)
PALE: 102893087(IDS)
MJV: 108405651(IDS)
LAV: 100668951(IDS)
TMU: 101348522
MDO: 100025173(IDS)
SHR: 100932918(IDS)
PCW: 110199816(IDS)
OAA: 100081812(IDS)
GGA: 422392(IDS)
MGP: 100548552(IDS)
CJO: 107312964(IDS)
NMEL: 110403286(IDS)
APLA: 101805206(IDS)
ACYG: 106037727(IDS)
TGU: 100231299(IDS)
LSR: 110480065(IDS)
SCAN: 103816359(IDS)
GFR: 102044849(IDS)
FAB: 101817405(IDS)
PHI: 102102287(IDS)
PMAJ: 107204060(IDS)
CCAE: 111928496(IDS)
CCW: 104691675(IDS)
ETL: 114056735(IDS)
FPG: 101917991(IDS)
FCH: 102056477(IDS)
CLV: 102095548(IDS)
EGZ: 104124077(IDS)
NNI: 104019072(IDS)
ACUN: 113480248(IDS)
PADL: 103922912(IDS)
AAM: 106487578(IDS)
ASN: 102375700(IDS)
AMJ: 102571433(IDS)
PSS: 102447899(IDS)
CMY: 102931008(IDS)
CPIC: 101944748(IDS)
ACS: 100565846(ids)
PVT: 110082990(IDS)
PBI: 103053966(IDS)
PMUR: 107291666(IDS)
TSR: 106549285(IDS)
PMUA: 114589233(IDS)
GJA: 107107996(IDS)
XLA: 108698425
XTR: 100135738(ids)
NPR: 108783898(IDS)
DRE: 559959(ids)
SANH: 107703646
SGH: 107588358
CCAR: 109108298(ids)
IPU: 108268807(ids)
PHYP: 113542945(ids)
AMEX: 103032782(ids)
EEE: 113572503(ids)
LCO: 104932265(ids)
NCC: 104948380(ids)
MZE: 101484170(ids)
ONL: 100701301(ids)
OLA: 101158287(ids)
XMA: 102223507(ids)
XCO: 114139558(ids)
PRET: 103471071(ids)
CVG: 107093837(ids)
NFU: 107382373(ids)
KMR: 108240015(ids)
ALIM: 106533195(ids)
AOCE: 111582599(ids)
CSEM: 103391272(ids)
POV: 109627356(ids)
LCF: 108878945(ids)
SDU: 111226708(ids)
SLAL: 111646415(ids)
HCQ: 109524284(ids)
BPEC: 110172172(ids)
MALB: 109957582(ids)
SASA: 106611990(ids)
OTW: 112256025
SALP: 111965339 112070437(ids)
ELS: 105027395(ids)
SFM: 108922862(ids)
PKI: 111848144(ids)
LCM: 102348043(IDS)
CMK: 103178266(ids)
RTP: 109937925
CIN: 100185385
DME: Dmel_CG12014(Ids)
DER: 6546473
DSE: 6610634
DSI: Dsimw501_GD13763(Dsim_GD13763)
DAN: 6506843
DSR: 110177559
DPE: 6601698
DMN: 108152850
DWI: 6645875
DAZ: 108614650
DNV: 108650413
DHE: 111601084
DVI: 6623790
MDE: 101896463
LCQ: 111690708
AAG: 5572289
AALB: 109431614
AME: 724550
BIM: 100747349
BTER: 100647993
CCAL: 108622260
SOC: 105193763
MPHA: 105837418
AEC: 105147376
ACEP: 105624958
PBAR: 105426620
VEM: 105557423
HST: 105185301
DQU: 106749424
CFO: 105253432
LHU: 105673528
PGC: 109860994
OBO: 105283280
PCF: 106787197
NVI: 100119376
CSOL: 105365576
MDL: 103570322
TCA: 655669
DPA: 109540804
ATD: 109598542
NVL: 108560267
BMOR: 101744799
BMAN: 114241742
PMAC: 106715653
PRAP: 111001403
HAW: 110370991
TNL: 113507089
BTAB: 109038066
CLEC: 106670417
ZNE: 110832438
PVM: 113824470
CSCU: 111634598
MYI: 110456562
OBI: 106871045
NVE: 5506756
EPA: 110243498
ADF: 107340223
AMIL: 114970454
SPIS: 111326384
NGD: NGA_0701900(IDS)
PAT: Patl_0891
SPHU: SPPYR_0445
SSAN: NX02_06250
ADO: A6F68_00793(betC_2) A6F68_01095(betC_7)
PIR: VN12_09385 VN12_21255(betC_6) VN12_22170(betC_7)
RUL: UC8_11930 UC8_17290(betC_4) UC8_25850 UC8_36630(betC_8) UC8_53680(betC_12)
PEH: Spb1_00530(betC_1) Spb1_14370(betC_2) Spb1_39310(betC_6)
PLS: VT03_16380(betC_4) VT03_26185(betC_5)
GMR: GmarT_16040(betC_3) GmarT_33550(betC_6) GmarT_39170(betC_9) GmarT_51320(betC_11) GmarT_52750(betC_12) GmarT_56780(betC_15) GmarT_56970(betC_16)
ALUS: STSP2_00836(betC_2)
VBL: L21SP4_00397(betC_1) L21SP4_01487 L21SP4_01919(betC_8)
ABAC: LuPra_00139(betC_1)
BVU: BVU_1771
PSAC: PSM36_3070
BACC: BRDCF_p1883(betC)
SDJ: NCTC13534_02722(betC_2)
DFE: Dfer_2051
MARM: YQ22_02090
ZGA: ZOBELLIA_181(idsA1) ZOBELLIA_2730(idsA2) ZOBELLIA_3146(idsA3) ZOBELLIA_3526(idsA4)
TJE: TJEJU_2924(idsA)
 » show all
Reference
1  [PMID:6816283]
  Authors
Archer IM, Harper PS, Wusteman FS.
  Title
Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids.
  Journal
Biochim Biophys Acta 708:134-40 (1982)
DOI:10.1016/0167-4838(82)90213-8
Reference
2  [PMID:4269173]
  Authors
Bach G, Eisenberg F Jr, Cantz M, Neufeld EF.
  Title
The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase.
  Journal
Proc Natl Acad Sci U S A 70:2134-8 (1973)
DOI:10.1073/pnas.70.7.2134
Reference
3  [PMID:6945876]
  Authors
Di Natale P, Ronsisvalle L.
  Title
Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta.
  Journal
Biochim Biophys Acta 661:106-11 (1981)
DOI:10.1016/0005-2744(81)90088-7
Reference
4  [PMID:6950934]
  Authors
Yutaka T, Fluharty AL, Stevens RL, Kihara H.
  Title
Purification and some properties of human liver iduronate sulfatase.
  Journal
J Biochem (Tokyo) 91:433-41 (1982)
DOI:10.1093/oxfordjournals.jbchem.a133715
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.13
IUBMB Enzyme Nomenclature: 3.1.6.13
ExPASy - ENZYME nomenclature database: 3.1.6.13
BRENDA, the Enzyme Database: 3.1.6.13
CAS: 50936-59-9

KEGG   REACTION: R07821
Entry
R07821                      Reaction                               

Name
L-iduronate-2-sulfate 2-sulfohydrolase
Definition
G13041 + H2O <=> G13042 + Sulfate
Equation
Enzyme
Pathway
rn00531  Glycosaminoglycan degradation
rn01100  Metabolic pathways
Module
M00076  Dermatan sulfate degradation
Orthology
K01136  iduronate 2-sulfatase [EC:3.1.6.13]

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