| Entry |
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| Name |
alpha-N-acetylgalactosaminidase;
alpha-acetylgalactosaminidase;
N-acetyl-alpha-D-galactosaminidase;
N-acetyl-alpha-galactosaminidase;
alpha-NAGAL;
alpha-NAGA;
alpha-GalNAcase
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
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| Sysname |
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
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| Reaction(IUBMB) |
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids
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| Reaction(KEGG) |
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| Comment |
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
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| History |
EC 3.2.1.49 created 1972, modified 2011
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| Pathway |
| ec00603 | Glycosphingolipid biosynthesis - globo and isoglobo series |
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| Orthology |
| K01204 | alpha-N-acetylgalactosaminidase |
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| Genes |
» show all
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| Reference |
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| Authors |
Asfaw B, Schindler D, Ledvinova J, Cerny B, Smid F, Conzelmann E |
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| Title |
Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts. |
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| Journal |
J Lipid Res 39:1768-80 (1998) |
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| Sequence |
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| Reference |
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| Authors |
Zhu A, Monahan C, Wang ZK, Goldstein J |
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| Title |
Expression, purification, and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris. |
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| Journal |
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| Reference |
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| Authors |
Clark NE, Garman SC |
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| Title |
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hoskins LC, Boulding ET, Larson G |
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| Title |
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70. |
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| Journal |
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| Reference |
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| Authors |
Harun-Or-Rashid M, Matsuzawa T, Satoh Y, Shiraishi T, Ando M, Sadik G, Uda Y |
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| Title |
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis. |
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| Journal |
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| Reference |
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| Authors |
Weignerova L, Filipi T, Manglova D, Kren V |
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| Title |
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus Niger. |
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| Journal |
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| Reference |
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| Authors |
Ashida H, Tamaki H, Fujimoto T, Yamamoto K, Kumagai H |
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| Title |
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.2.1.49 |
| ExPASy - ENZYME nomenclature database: | 3.2.1.49 |
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