KEGG   ORTHOLOGY: K01228
Entry
K01228                      KO                                     

Name
MOGS
Definition
mannosyl-oligosaccharide glucosidase [EC:3.2.1.106]
Pathway
ko00510  N-Glycan biosynthesis
ko01100  Metabolic pathways
ko04141  Protein processing in endoplasmic reticulum
Module
M00073  N-glycan precursor trimming
Disease
H00119  Congenital disorders of glycosylation type II
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K01228  MOGS; mannosyl-oligosaccharide glucosidase
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K01228  MOGS; mannosyl-oligosaccharide glucosidase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01228  MOGS; mannosyl-oligosaccharide glucosidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.106  mannosyl-oligosaccharide glucosidase
     K01228  MOGS; mannosyl-oligosaccharide glucosidase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01228  MOGS; mannosyl-oligosaccharide glucosidase
Other DBs
RN: R05979
GO: 0004573
Genes
HSA: 7841(MOGS)
PTR: 740472(MOGS)
PPS: 100989540(MOGS)
GGO: 101148967(MOGS)
PON: 100456318(MOGS)
NLE: 100587064(MOGS)
MCC: 708913(MOGS)
MCF: 102131903(MOGS)
CSAB: 103220027(MOGS)
RRO: 104674816(MOGS)
RBB: 108531677(MOGS)
CJC: 100399857(MOGS)
SBQ: 101050054(MOGS)
MMU: 57377(Mogs)
MCAL: 110296892(Mogs)
MPAH: 110316001(Mogs)
RNO: 103692171 78947(Gcs1)
MUN: 110559323(Mogs) 110559328
CGE: 100689098(Mogs)
NGI: 103726994(Mogs)
HGL: 101699668(Mogs)
CCAN: 109692434(Mogs)
OCU: 100349132(MOGS)
TUP: 102469724(MOGS)
CFA: 483104(MOGS)
VVP: 112916713(MOGS)
AML: 100473274(MOGS)
UMR: 103671412(MOGS)
UAH: 113243493(MOGS)
ORO: 101380088(MOGS)
ELK: 111148165
FCA: 101086221(MOGS)
PTG: 102965884(MOGS)
PPAD: 109263071(MOGS)
AJU: 106988593(MOGS)
BTA: 516155(MOGS)
BOM: 102271661(MOGS)
BIU: 109565909
BBUB: 102393218(MOGS)
CHX: 102171985(MOGS)
OAS: 101118003(MOGS)
SSC: 100513204(MOGS)
CFR: 102503430(MOGS)
CDK: 105105961(MOGS)
BACU: 102999832(MOGS)
LVE: 103084054(MOGS)
OOR: 101274685(MOGS)
DLE: 111169093(MOGS)
PCAD: 102973351(MOGS)
ECB: 100069105(MOGS)
EPZ: 103557690(MOGS)
EAI: 106823842(MOGS)
MYB: 102262392(MOGS)
MYD: 102775421(MOGS)
MNA: 107529255(MOGS)
HAI: 109371217(MOGS)
DRO: 112303069(MOGS)
PALE: 102887551(MOGS)
RAY: 107502936(MOGS)
MJV: 108402288(MOGS)
LAV: 100657938(MOGS)
TMU: 101345839
MDO: 100017334(MOGS)
SHR: 100925812(MOGS)
PCW: 110221002(MOGS)
OAA: 114811204(MOGS)
GGA: 107049491(MOGS)
MGP: 104916406(MOGS)
CJO: 107306839(MOGS)
TGU: 115494857(MOGS)
LSR: 110468700(MOGS)
PHI: 102101442(MOGS)
PMAJ: 107203112(MOGS)
ETL: 114068886(MOGS)
FPG: 101910764(MOGS)
ASN: 112548011(MOGS)
AMJ: 102576397(MOGS)
CMY: 102941231(MOGS)
CPIC: 101939841(MOGS)
ACS: 100558509(mogs)
PVT: 110079822(MOGS)
PBI: 103067986(MOGS)
PMUR: 107292508(MOGS)
TSR: 106538914(MOGS)
PMUA: 114604469(MOGS)
GJA: 107114281(MOGS)
XLA: 100158418(mogs.L)
XTR: 619362(mogs)
NPR: 108796278 108803080(MOGS)
DRE: 567913(mogs)
IPU: 108260492 108260493(Mogs)
AMEX: 103032841(mogs)
EEE: 113578999(mogs)
TRU: 101061971(mogs)
LCO: 104926976(mogs)
NCC: 104951177(mogs)
MZE: 101475138(mogs)
ONL: 100708454(mogs)
OLA: 101164458(mogs)
XMA: 102226259(mogs)
XCO: 114144736(mogs)
PRET: 103466387(mogs)
CVG: 107091135(mogs)
NFU: 107375288(mogs)
KMR: 108231066(mogs)
ALIM: 106517046(mogs)
AOCE: 111575465(mogs)
CSEM: 103383539(mogs)
POV: 109638361(mogs)
LCF: 108896565(mogs)
SDU: 111236637(mogs)
SLAL: 111670425(mogs)
HCQ: 109511469(mogs)
BPEC: 110165316(mogs)
MALB: 109961400(mogs)
OTW: 112231722(mogs)
ELS: 105029335(mogs)
SFM: 108924334(mogs)
PKI: 111837272(mogs)
LCM: 102359377(MOGS)
CMK: 103172295(mogs)
RTP: 109934039(mogs)
CIN: 100183132
SPU: 115924219 591837(mogs)
APLC: 110981262
SKO: 100372636
DME: Dmel_CG1597(GCS1)
DER: 6551432
DSE: 6617655
DSI: Dsimw501_GD15993(Dsim_GD15993)
DAN: 6504477
DSR: 110181677
DPE: 6602679
DMN: 108152970
DWI: 6648708
DAZ: 108619758
DNV: 115565244
DHE: 111603188
DVI: 6632177
MDE: 101894492
LCQ: 111674816
AAG: 5576381
AME: 411730
BIM: 100745926
BTER: 100642977
CCAL: 108631859
OBB: 114876763
SOC: 105201295
MPHA: 105838053
AEC: 105151670
ACEP: 105621167
PBAR: 105428250
VEM: 105561383
HST: 105189509
DQU: 106745826
CFO: 105249065
LHU: 105674772
PGC: 109853555
OBO: 105275198
PCF: 106788557
NVI: 100119845
CSOL: 105365662
MDL: 103570799
TCA: 661492
DPA: 109543454
ATD: 109597104
NVL: 108567459
BMOR: 101742535
BMAN: 114243551
PMAC: 106710507
PRAP: 110996650
HAW: 110380113
TNL: 113492303
API: 100159015
DNX: 107161371
AGS: 114118986
RMD: 113559408
BTAB: 109030234
CLEC: 106670041
ZNE: 110837085
PVM: 113810984
TUT: 107359578
DPTE: 113789944
CSCU: 111619659
PTEP: 107441175
CEL: CELE_F13H10.4(mogs-1)
CBR: CBG05981
BMY: Bm1_40265
PCAN: 112564864
CRG: 105331294
MYI: 110460508
OBI: 106869785
LAK: 106158814
EGL: EGR_08968
NVE: 5511507
EPA: 110250425
ADF: 107327751
AMIL: 114960255
PDAM: 113667488
SPIS: 111320660
DGT: 114538040
HMG: 100204917
ATH: AT1G24320 AT1G67490(GCS1)
THJ: 104807884
CPAP: 110815960
CIT: 102626422
TCC: 18609047
GRA: 105785861
GAB: 108467160
EGR: 104433660
LJA: Lj4g3v2539160.1(Lj4g3v2539160.1) Lj4g3v2949800.1(Lj4g3v2949800.1)
ADU: 107482112
AIP: 107632002
FVE: 101304833
RCN: 112200307
CSV: 101210818
CMO: 103488898
MCHA: 111019700
CMAX: 111492274
CMOS: 111458598
CPEP: 111801444
RCU: 8286815
JCU: 105636116
MESC: 110629359
POP: 7477030
PEU: 105137467
JRE: 109003148
VVI: 100264375
SLY: 101267114
SPEN: 107020771
SOT: 102580572
NSY: 104228399
NAU: 109244799
INI: 109172062
SIND: 105168395
HAN: 110926203
LSV: 111881539
CCAV: 112527654
BVG: 104897586
SOE: 110794228
NNU: 104591694
OSA: 4327748
DOSA: Os01t0921200-01(Os01g0921200)
BDI: 100822845
ATS: 109778661(LOC109778661)
SBI: 8059369
ZMA: 103652327
PDA: 103706515
EGU: 105051156
MUS: 103987628
DCT: 110097965
PEQ: 110032801
AOF: 109823842
ATR: 18438178
PPP: 112289032
MNG: MNEG_6941
APRO: F751_4830
SCE: YGL027C(CWH41)
ERC: Ecym_1427
KMX: KLMA_20048(CWH41)
NCS: NCAS_0A01760(NCAS0A01760)
NDI: NDAI_0D03690(NDAI0D03690)
TPF: TPHA_0K01720(TPHA0K01720)
TBL: TBLA_0A08950(TBLA0A08950)
TDL: TDEL_0F02570(TDEL0F02570)
KAF: KAFR_0F03510(KAFR0F03510)
PIC: PICST_39865(CWH41)
SPAA: SPAPADRAFT_146978(CWH41)
CAL: CAALFM_C406100WA(CWH41)
CDU: CD36_45640(CWH41)
SLB: AWJ20_2073(CWH41)
NCR: NCU03657(gh63-1)
NTE: NEUTE1DRAFT35029(NEUTE1DRAFT_35029)
SSCK: SPSK_05967
MAW: MAC_03939
MAJ: MAA_01473
CMT: CCM_07809
MBE: MBM_05686
ANI: AN6606.2
ANG: ANI_1_240134(An15g01420)
CIM: CIMG_13554(CIMG10187)
ABE: ARB_07582
TVE: TRV_07006
ABP: AGABI1DRAFT53637(AGABI1DRAFT_53637)
ABV: AGABI2DRAFT217075(AGABI2DRAFT_217075)
MGL: MGL_1071
MRT: MRET_3083
DFA: DFA_05938
SMIN: v1.2.029725.t1(symbB.v1.2.029725.t1)
SPAR: SPRG_06895
 » show all
Reference
  Authors
De Praeter CM, Gerwig GJ, Bause E, Nuytinck LK, Vliegenthart JF, Breuer W, Kamerling JP, Espeel MF, Martin JJ, De Paepe AM, Chan NW, Dacremont GA, Van Coster RN
  Title
A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency.
  Journal
Am J Hum Genet 66:1744-56 (2000)
DOI:10.1086/302948
  Sequence
[hsa:7841]
Reference
  Authors
Ruddock LW, Molinari M
  Title
N-glycan processing in ER quality control.
  Journal
J Cell Sci 119:4373-80 (2006)
DOI:10.1242/jcs.03225

KEGG   ENZYME: 3.2.1.106
Entry
EC 3.2.1.106                Enzyme                                 

Name
mannosyl-oligosaccharide glucosidase;
Glc3Man9NAc2 oligosaccharide glucosidase;
trimming glucosidase I;
CWH41 (gene name);
MOGS (gene name);
mannosyl-oligosaccharide glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting)
Reaction(IUBMB)
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose [RN:R05979]
Reaction(KEGG)
R05979(G)
Substrate
Glc3Man9GlcNAc2-[protein];
H2O [CPD:C00001]
Product
Glc2Man9GlcNAc2-[protein];
beta-D-glucopyranose [CPD:C00221]
Comment
This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.
History
EC 3.2.1.106 created 1984, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01228  mannosyl-oligosaccharide glucosidase
Genes
HSA: 7841(MOGS)
PTR: 740472(MOGS)
PPS: 100989540(MOGS)
GGO: 101148967(MOGS)
PON: 100456318(MOGS)
NLE: 100587064(MOGS)
MCC: 708913(MOGS)
MCF: 102131903(MOGS)
CSAB: 103220027(MOGS)
RRO: 104674816(MOGS)
RBB: 108531677(MOGS)
CJC: 100399857(MOGS)
SBQ: 101050054(MOGS)
MMU: 57377(Mogs)
MCAL: 110296892(Mogs)
MPAH: 110316001(Mogs)
RNO: 103692171 78947(Gcs1)
MUN: 110559323(Mogs) 110559328
CGE: 100689098(Mogs)
NGI: 103726994(Mogs)
HGL: 101699668(Mogs)
CCAN: 109692434(Mogs)
OCU: 100349132(MOGS)
TUP: 102469724(MOGS)
CFA: 483104(MOGS)
VVP: 112916713(MOGS)
AML: 100473274(MOGS)
UMR: 103671412(MOGS)
UAH: 113243493(MOGS)
ORO: 101380088(MOGS)
ELK: 111148165
FCA: 101086221(MOGS)
PTG: 102965884(MOGS)
PPAD: 109263071(MOGS)
AJU: 106988593(MOGS)
BTA: 516155(MOGS)
BOM: 102271661(MOGS)
BIU: 109565909
BBUB: 102393218(MOGS)
CHX: 102171985(MOGS)
OAS: 101118003(MOGS)
SSC: 100513204(MOGS)
CFR: 102503430(MOGS)
CDK: 105105961(MOGS)
BACU: 102999832(MOGS)
LVE: 103084054(MOGS)
OOR: 101274685(MOGS)
DLE: 111169093(MOGS)
PCAD: 102973351(MOGS)
ECB: 100069105(MOGS)
EPZ: 103557690(MOGS)
EAI: 106823842(MOGS)
MYB: 102262392(MOGS)
MYD: 102775421(MOGS)
MNA: 107529255(MOGS)
HAI: 109371217(MOGS)
DRO: 112303069(MOGS)
PALE: 102887551(MOGS)
RAY: 107502936(MOGS)
MJV: 108402288(MOGS)
LAV: 100657938(MOGS)
TMU: 101345839
MDO: 100017334(MOGS)
SHR: 100925812(MOGS)
PCW: 110221002(MOGS)
OAA: 114811204(MOGS)
GGA: 107049491(MOGS)
MGP: 104916406(MOGS)
CJO: 107306839(MOGS)
TGU: 115494857(MOGS)
LSR: 110468700(MOGS)
PHI: 102101442(MOGS)
PMAJ: 107203112(MOGS)
ETL: 114068886(MOGS)
FPG: 101910764(MOGS)
ASN: 112548011(MOGS)
AMJ: 102576397(MOGS)
CMY: 102941231(MOGS)
CPIC: 101939841(MOGS)
ACS: 100558509(mogs)
PVT: 110079822(MOGS)
PBI: 103067986(MOGS)
PMUR: 107292508(MOGS)
TSR: 106538914(MOGS)
PMUA: 114604469(MOGS)
GJA: 107114281(MOGS)
XLA: 100158418(mogs.L)
XTR: 619362(mogs)
NPR: 108796278 108803080(MOGS)
DRE: 567913(mogs)
IPU: 108260492 108260493(Mogs)
AMEX: 103032841(mogs)
EEE: 113578999(mogs)
TRU: 101061971(mogs)
LCO: 104926976(mogs)
NCC: 104951177(mogs)
MZE: 101475138(mogs)
ONL: 100708454(mogs)
OLA: 101164458(mogs)
XMA: 102226259(mogs)
XCO: 114144736(mogs)
PRET: 103466387(mogs)
CVG: 107091135(mogs)
NFU: 107375288(mogs)
KMR: 108231066(mogs)
ALIM: 106517046(mogs)
AOCE: 111575465(mogs)
CSEM: 103383539(mogs)
POV: 109638361(mogs)
LCF: 108896565(mogs)
SDU: 111236637(mogs)
SLAL: 111670425(mogs)
HCQ: 109511469(mogs)
BPEC: 110165316(mogs)
MALB: 109961400(mogs)
OTW: 112231722(mogs)
ELS: 105029335(mogs)
SFM: 108924334(mogs)
PKI: 111837272(mogs)
LCM: 102359377(MOGS)
CMK: 103172295(mogs)
RTP: 109934039(mogs)
CIN: 100183132
SPU: 115924219 591837(mogs)
APLC: 110981262
SKO: 100372636
DME: Dmel_CG1597(GCS1)
DER: 6551432
DSE: 6617655
DSI: Dsimw501_GD15993(Dsim_GD15993)
DAN: 6504477
DSR: 110181677
DPE: 6602679
DMN: 108152970
DWI: 6648708
DAZ: 108619758
DNV: 115565244
DHE: 111603188
DVI: 6632177
MDE: 101894492
LCQ: 111674816
AAG: 5576381
AME: 411730
BIM: 100745926
BTER: 100642977
CCAL: 108631859
OBB: 114876763
SOC: 105201295
MPHA: 105838053
AEC: 105151670
ACEP: 105621167
PBAR: 105428250
VEM: 105561383
HST: 105189509
DQU: 106745826
CFO: 105249065
LHU: 105674772
PGC: 109853555
OBO: 105275198
PCF: 106788557
NVI: 100119845
CSOL: 105365662
MDL: 103570799
TCA: 661492
DPA: 109543454
ATD: 109597104
NVL: 108567459
BMOR: 101742535
BMAN: 114243551
PMAC: 106710507
PRAP: 110996650
HAW: 110380113
TNL: 113492303
API: 100159015
DNX: 107161371
AGS: 114118986
RMD: 113559408
BTAB: 109030234
CLEC: 106670041
ZNE: 110837085
PVM: 113810984
TUT: 107359578
DPTE: 113789944
CSCU: 111619659
PTEP: 107441175
CEL: CELE_F13H10.4(mogs-1)
CBR: CBG05981
BMY: Bm1_40265
PCAN: 112564864
CRG: 105331294
MYI: 110460508
OBI: 106869785
LAK: 106158814
EGL: EGR_08968
NVE: 5511507
EPA: 110250425
ADF: 107327751
AMIL: 114960255
PDAM: 113667488
SPIS: 111320660
DGT: 114538040
HMG: 100204917
ATH: AT1G24320 AT1G67490(GCS1)
THJ: 104807884
CPAP: 110815960
CIT: 102626422
TCC: 18609047
GRA: 105785861
GAB: 108467160
EGR: 104433660
LJA: Lj4g3v2539160.1(Lj4g3v2539160.1) Lj4g3v2949800.1(Lj4g3v2949800.1)
ADU: 107482112
AIP: 107632002
FVE: 101304833
RCN: 112200307
CSV: 101210818
CMO: 103488898
MCHA: 111019700
CMAX: 111492274
CMOS: 111458598
CPEP: 111801444
RCU: 8286815
JCU: 105636116
MESC: 110629359
POP: 7477030
PEU: 105137467
JRE: 109003148
VVI: 100264375
SLY: 101267114
SPEN: 107020771
SOT: 102580572
NSY: 104228399
NAU: 109244799
INI: 109172062
SIND: 105168395
HAN: 110926203
LSV: 111881539
CCAV: 112527654
BVG: 104897586
SOE: 110794228
NNU: 104591694
OSA: 4327748
DOSA: Os01t0921200-01(Os01g0921200)
BDI: 100822845
ATS: 109778661(LOC109778661)
SBI: 8059369
ZMA: 103652327
PDA: 103706515
EGU: 105051156
MUS: 103987628
DCT: 110097965
PEQ: 110032801
AOF: 109823842
ATR: 18438178
PPP: 112289032
MNG: MNEG_6941
APRO: F751_4830
SCE: YGL027C(CWH41)
ERC: Ecym_1427
KMX: KLMA_20048(CWH41)
NCS: NCAS_0A01760(NCAS0A01760)
NDI: NDAI_0D03690(NDAI0D03690)
TPF: TPHA_0K01720(TPHA0K01720)
TBL: TBLA_0A08950(TBLA0A08950)
TDL: TDEL_0F02570(TDEL0F02570)
KAF: KAFR_0F03510(KAFR0F03510)
PIC: PICST_39865(CWH41)
SPAA: SPAPADRAFT_146978(CWH41)
CAL: CAALFM_C406100WA(CWH41)
CDU: CD36_45640(CWH41)
SLB: AWJ20_2073(CWH41)
NCR: NCU03657(gh63-1)
NTE: NEUTE1DRAFT35029(NEUTE1DRAFT_35029)
SSCK: SPSK_05967
MAW: MAC_03939
MAJ: MAA_01473
CMT: CCM_07809
MBE: MBM_05686
ANI: AN6606.2
ANG: ANI_1_240134(An15g01420)
CIM: CIMG_13554(CIMG10187)
ABE: ARB_07582
TVE: TRV_07006
ABP: AGABI1DRAFT53637(AGABI1DRAFT_53637)
ABV: AGABI2DRAFT217075(AGABI2DRAFT_217075)
MGL: MGL_1071
MRT: MRET_3083
DFA: DFA_05938
SMIN: v1.2.029725.t1(symbB.v1.2.029725.t1)
SPAR: SPRG_06895
 » show all
Reference
1  [PMID:7358674]
  Authors
Elting JJ, Chen WW, Lennarz WJ.
  Title
Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.
  Journal
J Biol Chem 255:2325-31 (1980)
Reference
2  [PMID:479161]
  Authors
Grinna LS, Robbins PW.
  Title
Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.
  Journal
J Biol Chem 254:8814-8 (1979)
Reference
3  [PMID:7014569]
  Authors
Kilker RD Jr, Saunier B, Tkacz JS, Herscovics A.
  Title
Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.
  Journal
J Biol Chem 256:5299-603 (1981)
Reference
4  [PMID:7358666]
  Authors
Grinna LS, Robbins PW.
  Title
Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.
  Journal
J Biol Chem 255:2255-8 (1980)
Reference
5  [PMID:7356331]
  Authors
Michael JM, Kornfeld S.
  Title
Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
  Journal
Arch Biochem Biophys 199:249-58 (1980)
DOI:10.1016/0003-9861(80)90278-7
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.106
IUBMB Enzyme Nomenclature: 3.2.1.106
ExPASy - ENZYME nomenclature database: 3.2.1.106
BRENDA, the Enzyme Database: 3.2.1.106
CAS: 78413-07-7

KEGG   REACTION: R05979
Entry
R05979                      Reaction                               

Definition
H2O + G00009 <=> beta-D-Glucose + G00171
Equation
Enzyme
Pathway
rn00510  N-Glycan biosynthesis
rn01100  Metabolic pathways
Module
M00073  N-glycan precursor trimming
Orthology
K01228  mannosyl-oligosaccharide glucosidase [EC:3.2.1.106]

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