Entry
Symbol
EPHX1
Name
microsomal epoxide hydrolase [EC:
3.3.2.9 ]
Pathway
map00980 Metabolism of xenobiotics by cytochrome P450
map05204 Chemical carcinogenesis - DNA adducts
map05207 Chemical carcinogenesis - receptor activation
map05208 Chemical carcinogenesis - reactive oxygen species
Reaction
R07013 (1R,2S)-naphthalene 1,2-oxide hydrolase
R07014 (1S,2R)-naphthalene 1,2-oxide hydrolase
R07027 1-nitronaphthalene-5,6-oxide hydrolase
R07071 bromobenzene-3,4-oxide hydrolase
R07072 bromobenzene-2,3-oxide hydrolase
R07082 benzo[a]pyrene-7,8-oxide hydrolase
R09417 microsomal epoxide hydrolase
R09443 microsomal epoxide hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
K01253 EPHX1; microsomal epoxide hydrolase
09150 Organismal Systems
09154 Digestive system
04976 Bile secretion
K01253 EPHX1; microsomal epoxide hydrolase
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
K01253 EPHX1; microsomal epoxide hydrolase
05207 Chemical carcinogenesis - receptor activation
K01253 EPHX1; microsomal epoxide hydrolase
05208 Chemical carcinogenesis - reactive oxygen species
K01253 EPHX1; microsomal epoxide hydrolase
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K01253 EPHX1; microsomal epoxide hydrolase
Enzymes [BR:ko01000 ]
3. Hydrolases
3.3 Acting on ether bonds
3.3.2 Ether hydrolases
3.3.2.9 microsomal epoxide hydrolase
K01253 EPHX1; microsomal epoxide hydrolase
Peptidases and inhibitors [BR:ko01002 ]
Serine peptidases
Family S33
K01253 EPHX1; microsomal epoxide hydrolase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
von Dippe P, Zhu QS, Levy D
Title
Cell surface expression and bile acid transport function of one topological form of m-epoxide hydrolase.
Journal
Reference
Authors
Decker M, Arand M, Cronin A
Title
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling.
Journal
Reference
Authors
Skoda RC, Demierre A, McBride OW, Gonzalez FJ, Meyer UA
Title
Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.
Journal
J Biol Chem 263:1549-54 (1988)
Sequence