KEGG   ORTHOLOGY: K01253
Entry
K01253                      KO                                     
Symbol
EPHX1
Name
microsomal epoxide hydrolase [EC:3.3.2.9]
Pathway
map00980  Metabolism of xenobiotics by cytochrome P450
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Disease
H01935  Familial hypercholanemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K01253  EPHX1; microsomal epoxide hydrolase
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K01253  EPHX1; microsomal epoxide hydrolase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K01253  EPHX1; microsomal epoxide hydrolase
   05207 Chemical carcinogenesis - receptor activation
    K01253  EPHX1; microsomal epoxide hydrolase
   05208 Chemical carcinogenesis - reactive oxygen species
    K01253  EPHX1; microsomal epoxide hydrolase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01253  EPHX1; microsomal epoxide hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.9  microsomal epoxide hydrolase
     K01253  EPHX1; microsomal epoxide hydrolase
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S33
   K01253  EPHX1; microsomal epoxide hydrolase
Other DBs
RN: R07013 R07014 R07027 R07071 R07072 R07082 R09410 R09417 R09443
COG: COG0596
GO: 0004301
Genes
HSA: 2052(EPHX1)
PTR: 457777(EPHX1)
PPS: 100995858(EPHX1)
GGO: 101130068(EPHX1)
PON: 100173792(EPHX1) 100437687
NLE: 100592261(EPHX1)
MCC: 700180(EPHX1)
MCF: 101866419(EPHX1)
MTHB: 126937150
MNI: 105478502(EPHX1)
CSAB: 103230002(EPHX1)
CATY: 105576938(EPHX1)
PANU: 101012773(EPHX1)
TGE: 112623225(EPHX1)
RRO: 104660094(EPHX1)
RBB: 108538734(EPHX1)
TFN: 117074936(EPHX1)
PTEH: 111537082(EPHX1)
CANG: 105516681(EPHX1)
CJC: 100409580(EPHX1)
SBQ: 101029266(EPHX1)
CSYR: 103269955(EPHX1)
MMUR: 105863794(EPHX1)
LCAT: 123627522(EPHX1)
PCOQ: 105810378(EPHX1)
OGA: 100943654(EPHX1)
MMU: 13849(Ephx1)
MCAL: 110290857(Ephx1)
MPAH: 110321688(Ephx1)
RNO: 25315(Ephx1)
MCOC: 116096986(Ephx1)
MUN: 110559921(Ephx1)
CGE: 100750792(Ephx1) 100758590
PLEU: 114686406
HGL: 101725522(Ephx1)
CPOC: 100721931(Ephx1)
DORD: 106001117
DSP: 122102745(Ephx1)
NCAR: 124961084
OCU: 100009104(EPHX1)
OPI: 101530165(EPHX1)
TUP: 102495357(EPHX1)
GVR: 103600115(EPHX1)
CFA: 480113(EPHX1)
CLUD: 112648822(EPHX1)
VVP: 112923564(EPHX1)
VLG: 121486260(EPHX1)
AML: 100477671(EPHX1)
UMR: 103669061(EPHX1)
UAH: 113262914(EPHX1)
UAR: 123791844(EPHX1)
ELK: 111150921
LLV: 125085943
MPUF: 106003316(EPHX1)
NVS: 122918688(EPHX1)
ORO: 101368385(EPHX1)
EJU: 114215601(EPHX1)
ZCA: 113933305(EPHX1)
MLX: 118013009(EPHX1)
NSU: 110571396(EPHX1) 123323815
LWW: 102745377(EPHX1)
FCA: 101085519(EPHX1)
PYU: 121015164(EPHX1)
PBG: 122476210(EPHX1)
LRUF: 124510305
PTG: 102949568(EPHX1)
PPAD: 109250808(EPHX1)
AJU: 106968617(EPHX1)
HHV: 120234147(EPHX1)
BTA: 535293(EPHX1)
BOM: 102267623(EPHX1)
BIU: 109570425(EPHX1)
BBUB: 102409402(EPHX1)
BBIS: 104997889(EPHX1)
CHX: 100860945(EPHX1)
OAS: 101111038(EPHX1)
ODA: 120880347(EPHX1)
CCAD: 122451836(EPHX1)
SSC: 397639(EPHX1)
CFR: 102519415(EPHX1)
CBAI: 105083879(EPHX1)
CDK: 105099693(EPHX1)
VPC: 102527697(EPHX1)
BACU: 103003233(EPHX1)
LVE: 103074317(EPHX1)
OOR: 101288139(EPHX1)
DLE: 111177519(EPHX1)
PCAD: 102984566(EPHX1)
PSIU: 116748723(EPHX1)
ECB: 100054269(EPHX1)
EPZ: 103543505(EPHX1)
EAI: 106844729(EPHX1)
MYB: 102263401(EPHX1)
MYD: 102767193(EPHX1)
MMYO: 118678977(EPHX1)
MNA: 107543604(EPHX1)
PKL: 118727632(EPHX1)
HAI: 109391461(EPHX1)
DRO: 112318922(EPHX1)
SHON: 119003202(EPHX1)
AJM: 119044442(EPHX1)
PDIC: 114512342(EPHX1)
PHAS: 123832837(EPHX1)
MMF: 118640564(EPHX1)
RFQ: 117018666(EPHX1)
PALE: 102883919(EPHX1)
PGIG: 120619125(EPHX1)
PVP: 105292584(EPHX1)
RAY: 107517097(EPHX1)
MJV: 108408993(EPHX1)
TOD: 119244568(EPHX1)
SARA: 101537100(EPHX1)
LAV: 100673770(EPHX1)
TMU: 101360751
ETF: 101652159(EPHX1)
DNM: 101418215(EPHX1)
MDO: 100025778(EPHX1)
GAS: 123245662(EPHX1)
SHR: 100925093(EPHX1)
PCW: 110205523(EPHX1)
OAA: 100081956(EPHX1)
GGA: 421321(EPHX1) 421447(EPHX1L)
PCOC: 116229249 116231009(EPHX1)
MGP: 100539493 100545721(EPHX1)
CJO: 107311037(EPHX1) 107311272
NMEL: 110395399(EPHX1) 110396838
APLA: 101790722 101801005(EPHX1)
ACYG: 106031535(EPHX1)
AFUL: 116487216(EPHX1) 116487912
TGU: 100222959(EPHX1) 100227392
LSR: 110477509(EPHX1) 110477916
SCAN: 103817382 103819288(EPHX1)
PMOA: 120505979(EPHX1) 120506812
OTC: 121335741 121346931(EPHX1)
PRUF: 121357056(EPHX1) 121358526
GFR: 102041759(EPHX1) 102042334
FAB: 101806940(EPHX1) 101814529
PHI: 102100615 102109472(EPHX1)
PMAJ: 107201686 107201817(EPHX1)
CCAE: 111926266(EPHX1) 111926954
CCW: 104684354 104685565(EPHX1)
CBRC: 103612689(EPHX1) 103624121
ETL: 114059335 114073697(EPHX1)
ZAB: 102060438 102070896(EPHX1)
ACHL: 103799966(EPHX1)
FPG: 101912868 101914944(EPHX1)
FCH: 102050687 102059804(EPHX1)
CLV: 102085632(EPHX1) 102092641
EGZ: 104134609(EPHX1)
NNI: 104019274(EPHX1)
PLET: 104618973(EPHX1) 104619723
PCRI: 104024981 104031194(EPHX1)
PCAO: 104043305(EPHX1) 104050640
ACUN: 113478105(EPHX1)
TALA: 104363663 104368663(EPHX1)
PADL: 103925015(EPHX1)
AFOR: 103898883(EPHX1) 103902677
ACHC: 115349892(EPHX1) 115350316
HALD: 104314305 104325460(EPHX1)
HLE: 104838144(EPHX1) 104840322
CCRI: 104161930(EPHX1) 104164844
CSTI: 104553225(EPHX1) 104557585
CMAC: 104481879(EPHX1) 104486566
MUI: 104547407
FGA: 104070751 104073957(EPHX1)
GSTE: 104259295(EPHX1)
LDI: 104348936(EPHX1) 104350292
MNB: 103775848 103777511(EPHX1)
OHA: 104329296 104331963(EPHX1)
NNT: 104405042(EPHX1) 104406829
DPUB: 104299949 104300896(EPHX1)
PGUU: 104458493(EPHX1) 104459025
CPEA: 104386207(EPHX1) 104396428
AVIT: 104267999(EPHX1) 104268224
CVF: 104282324 104294655(EPHX1)
CUCA: 104056265 104067037(EPHX1)
TEO: 104370184(EPHX1) 104373427
BRHI: 104491536(EPHX1)
AAM: 106482713(EPHX1) 106485556
AROW: 112963396(EPHX1) 112973398
NPD: 112942790(EPHX1) 112957521
TGT: 104578955(EPHX1)
DNE: 112980038(EPHX1) 112997146
SCAM: 104151569(EPHX1) 104151692
ASN: 102368835(EPHX1) 102386213
AMJ: 102571832 102577262(EPHX1)
CPOO: 109319775(EPHX1) 109319862
GGN: 109296897(EPHX1)
PSS: 102456152 102457257(EPHX1)
CMY: 102934448(EPHX1) 102942209
CPIC: 101936865(EPHX1) 101949762
TST: 117874510(EPHX1) 117874592
CABI: 116819064 116823869(EPHX1)
MRV: 120400560(EPHX1) 120400786
ACS: 100554472 100555586(ephx1)
PVT: 110075401(EPHX1)
SUND: 121915364(EPHX1) 121934079
PBI: 103058096(EPHX1)
PMUR: 107289275(EPHX1)
CTIG: 120307226(EPHX1) 120307716
TSR: 106541570 106542798(EPHX1)
PGUT: 117671761(EPHX1) 117671857
VKO: 123025614(EPHX1) 123032030
PMUA: 114594523 114594618(EPHX1)
ZVI: 118081778 118083220(EPHX1)
GJA: 107119060(EPHX1)
STOW: 125425855 125437417(EPHX1)
XLA: 108716563 432100(ephx1.L)
XTR: 100158543(ephx1) 105946059
NPR: 108787057(EPHX1) 108802126
DRE: 394043(ephx1)
SRX: 107732537
SANH: 107690044(ephx1)
CCAR: 109080243
PPRM: 120493268(ephx1)
MAMB: 125278271(ephx1)
IPU: 108263372(ephx5)
PHYP: 113542048(ephx1)
SMEO: 124376972(ephx1)
TFD: 113647581(ephx1)
AMEX: 103040834(ephx1)
EEE: 113587098(ephx1)
TRU: 101066103(ephx1)
LCO: 104918259 104918311(ephx1)
NCC: 104963447(ephx1)
CGOB: 115003531(ephx1) 115020096
ELY: 117248410(ephx5) 117271285(ephx1)
EFO: 125897156(ephx1) 125903794(ephx5)
PLEP: 121954425(ephx5) 121955668(ephx1) 121964048
SLUC: 116051469(ephx5) 116065557(ephx1)
ECRA: 117960017(ephx5) 117961646(ephx1)
ESP: 116705706 116705884(ephx1)
PFLV: 114571843 114573297(ephx1)
GAT: 120807746(ephx1) 120820603(ephx5)
PPUG: 119194870(ephx1) 119214299(ephx5)
MSAM: 119909018(ephx1) 119916924(ephx5) 119918272
MZE: 101463752 101487605(ephx1)
OAU: 116314224(ephx1) 116318528
OLA: 101166982 101172051(ephx1)
OML: 112141000(ephx1) 112161741(ephx5)
XMA: 102229129 102230310(ephx1)
XCO: 114138263 114158698(ephx1)
XHE: 116713645 116734282(ephx1)
PRET: 103477226
PFOR: 103134161(ephx1)
PLAI: 106961696(ephx1)
PMEI: 106930043(ephx1)
GAF: 122824815(ephx1) 122842946(ephx5)
CVG: 107093270(ephx1)
CTUL: 119797626(ephx5) 119797636(ephx1)
GMU: 124859323(ephx5) 124881512(ephx1)
NFU: 107375461
KMR: 108233942(ephx5) 108246518(ephx1)
ALIM: 106515907 106532950(ephx1)
NWH: 119417756(ephx5) 119417998(ephx1)
AOCE: 111583489(ephx1) 111585235
MCEP: 124999376(ephx1) 125019156(ephx5)
CSEM: 103380678(ephx1)
POV: 109632306(ephx1)
SSEN: 122784166(ephx1)
HHIP: 117758195(ephx1)
HSP: 118099717(ephx1)
LCF: 108877099(ephx5) 108901766
SDU: 111220582 111239530(ephx1)
SLAL: 111661516(ephx1)
XGL: 120788741(ephx1) 120796290(ephx5)
BPEC: 110154206(ephx1)
MALB: 109958771(ephx1)
BSPL: 114870553(ephx5)
OTW: 112250359(ephx1) 112261919
ELS: 105017773(ephx1)
SFM: 108925178(ephx1)
PKI: 111854029(ephx1)
AANG: 118217958(ephx5) 118230719(ephx1)
LOC: 102682886(ephx1) 102687913
ARUT: 117402351(ephx5) 117402598
PSEX: 120516512(ephx5)
LCM: 102353239(EPHX1)
CMK: 103181611
RTP: 109925374(ephx1)
CIN: 100176449
SCLV: 120335264
SPU: 588166
APLC: 110978249
SKO: 100371948
RZE: 108357011
VPS: 122631147
HHAL: 106691877
SGRE: 126293680
DMK: 116921463
PVM: 113814676
HAME: 121867766
PCLA: 123770507
PTRU: 123501561
HAZT: 108672100
DSV: 119461825
VDE: 111248235
VJA: 111259854
TUT: 107364002
CSCU: 111622807
PTEP: 107446491
SDM: 118180616
CEL: CELE_W01A11.1(W01A11.1)
CBR: CBG_18950
TSP: Tsp_04403
LAK: 106154062
NVE: 5500949
EPA: 110242247
ADF: 107344265
PDAM: 113677512
SPIS: 111325313
XEN: 124459167
QSU: 112010208
NCR: NCU08783
NTE: NEUTE1DRAFT122640(NEUTE1DRAFT_122640)
MGR: MGG_14882
SSCK: SPSK_07616
MAW: MAC_05449
MAJ: MAA_09463
CMT: CCM_05222
MBE: MBM_02500
ANI: AN3017.2
ANG: ANI_1_1072104(An12g08930) ANI_1_312144(An16g02170)
PTE: PTT_15786
CNE: CNN02220
CNB: CNBN2260
TASA: A1Q1_01368
PUB: SAR11_0803(ephX1)
BCL: ABC1387
 » show all
Reference
  Authors
von Dippe P, Zhu QS, Levy D
  Title
Cell surface expression and bile acid transport function of one topological form of m-epoxide hydrolase.
  Journal
Biochem Biophys Res Commun 309:804-9 (2003)
DOI:10.1016/j.bbrc.2003.08.074
Reference
  Authors
Decker M, Arand M, Cronin A
  Title
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling.
  Journal
Arch Toxicol 83:297-318 (2009)
DOI:10.1007/s00204-009-0416-0
Reference
PMID:2891713
  Authors
Skoda RC, Demierre A, McBride OW, Gonzalez FJ, Meyer UA
  Title
Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.
  Journal
J Biol Chem 263:1549-54 (1988)
  Sequence
[hsa:2052]

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