KEGG   ORTHOLOGY: K01283
Entry
K01283                      KO                                     

Name
ACE, CD143
Definition
peptidyl-dipeptidase A [EC:3.4.15.1]
Pathway
ko04614  Renin-angiotensin system
ko04924  Renin secretion
ko05142  Chagas disease
ko05171  Coronavirus disease - COVID-19
ko05410  Hypertrophic cardiomyopathy
ko05415  Diabetic cardiomyopathy
Disease
H00083  Allograft rejection
H00575  Renal tubular dysgenesis
H01456  Diabetic nephropathy
H01457  Diabetic retinopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    K01283  ACE, CD143; peptidyl-dipeptidase A
   04614 Renin-angiotensin system
    K01283  ACE, CD143; peptidyl-dipeptidase A
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01283  ACE, CD143; peptidyl-dipeptidase A
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K01283  ACE, CD143; peptidyl-dipeptidase A
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K01283  ACE, CD143; peptidyl-dipeptidase A
   05415 Diabetic cardiomyopathy
    K01283  ACE, CD143; peptidyl-dipeptidase A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01283  ACE, CD143; peptidyl-dipeptidase A
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01283  ACE, CD143; peptidyl-dipeptidase A
   04090 CD molecules
    K01283  ACE, CD143; peptidyl-dipeptidase A
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.15  Peptidyl-dipeptidases
    3.4.15.1  peptidyl-dipeptidase A
     K01283  ACE, CD143; peptidyl-dipeptidase A
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M2
   K01283  ACE, CD143; peptidyl-dipeptidase A
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01283  ACE, CD143; peptidyl-dipeptidase A
CD molecules [BR:ko04090]
 Proteins
  K01283  CD143, ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Genes
HSA: 1636(ACE)
PTR: 107969298 449567(ACE)
PPS: 100980711 100981368 103784926
GGO: 101139668 101145787
PON: 100453403(ACE) 100453767
NLE: 100592115 105737894
MCC: 100428661(ACE)
MCF: 102127700 102128376(ACE)
CSAB: 103243232 103243233
RRO: 104675473 104675505
CJC: 100408147(ACE)
SBQ: 101052117(ACE)
MMU: 11421(Ace) 217246(Ace3)
MCAL: 110304805(Ace) 110305195
MPAH: 110331687(Ace) 110332456
RNO: 24310(Ace) 498012(Ace3)
CGE: 100753209(Ace3) 103158533(Ace)
HGL: 101701835(Ace) 101703133
OCU: 100009274(ACE) 103351595
CFA: 100856208 610668(ACE)
UAH: 113265294(ACE) 113265295
FCA: 101083124 101094061(ACE)
BTA: 100295485(ACE3) 509484(ACE)
CHX: 102171917(ACE) 106503207
SSC: 100515049 613133(ACE)
LVE: 103087287
DLE: 111182603(ACE)
PCAD: 102985025(ACE) 102985307
ECB: 100064777 100064801(ACE)
EAI: 106835520(ACE) 106835568
MYB: 102243978(ACE)
MYD: 102756093(ACE)
MNA: 107531049(ACE)
HAI: 109380275 109380308(ACE)
DRO: 112316275(ACE)
PALE: 102880255 102890071(ACE)
MDO: 100025797(ACE)
OAA: 114815136(ACE)
GGA: 419953(ACE)
MGP: 100542100(ACE)
CJO: 107325232(ACE)
NMEL: 110388589(ACE)
APLA: 101802065(ACE)
ACYG: 106045989(ACE)
TGU: 100217841(ACE)
LSR: 110474830(ACE)
SCAN: 103821656(ACE)
GFR: 102032473(ACE)
FAB: 101819593(ACE)
PHI: 102111483(ACE)
PMAJ: 107215323(ACE)
CCAE: 111940103(ACE)
CCW: 104698643(ACE)
ETL: 114066935(ACE)
FPG: 101924109(ACE)
FCH: 102048145(ACE)
CLV: 102083877(ACE)
EGZ: 104134883(ACE)
NNI: 104009894(ACE)
ACUN: 113489137(ACE)
PADL: 103913868(ACE)
AAM: 106497416(ACE)
ASN: 102374457(ACE)
AMJ: 102573284(ACE)
PSS: 102443828(ACE)
CMY: 102933955(ACE)
CPIC: 101930790(ACE)
ACS: 100558092(ace)
PVT: 110080291(ACE)
PBI: 103067603(ACE)
PMUR: 107302404(ACE)
TSR: 106545809(ACE)
PMUA: 114581443(ACE)
GJA: 107125675(ACE)
XTR: 100144634(ace)
NPR: 108785994(ACE)
DRE: 565980(ace)
SRX: 107708876(ace) 107743967
SGH: 107557358(ace) 107598651
CCAR: 109060366(ace) 109099167
IPU: 108274082(ace)
PHYP: 113527416(ace)
AMEX: 103040258(ace)
EEE: 113584762(ace)
TRU: 101076790(ace)
LCO: 104923252(ace)
NCC: 104966409(ace)
MZE: 101470840(ace)
ONL: 100712518(ace)
XMA: 102221242(ace) 102238075
XCO: 114151374(ace) 114151607
PRET: 103481980(ace) 103482159
CVG: 107100492(ace)
KMR: 108237275(ace)
ALIM: 106517337(ace) 106535188
AOCE: 111570427(ace)
CSEM: 103382106(ace)
POV: 109626948(ace)
LCF: 108875837(ace)
SDU: 111220374(ace)
SLAL: 111672022(ace)
HCQ: 109515983(ace)
BPEC: 110159607(ace)
MALB: 109963664
ELS: 105024522(ace)
SFM: 108928079(ace)
PKI: 111848632(ace)
CMK: 103187713(ace)
RTP: 109937228
DME: Dmel_CG10142(Ance-5) Dmel_CG10593(Acer) Dmel_CG16869(Ance-2) Dmel_CG17988(Ance-3) Dmel_CG8196(Ance-4) Dmel_CG8827(Ance)
DSI: Dsimw501_GD10112(Dsim_GD10112) Dsimw501_GD23554(Dsim_GD23554) Dsimw501_GD23936(Dsim_Ance) Dsimw501_GD23937(Dsim_GD23937) Dsimw501_GD23939(Dsim_GD23939) Dsimw501_GD24910(Dsim_GD24910)
TUT: 107368139
CEL: CELE_C42D8.5(acn-1)
CBR: CBG14607(Cbr-acn-1)
BMY: Bm1_31085
TSP: Tsp_01435
CRG: 105337281(Ace) 109618257
XCC: XCC1116
XCB: XC_3130
XCP: XCR_1338
XCV: XCV1249
XAX: XACM_1192
XAC: XAC1217
XOM: XOO3345(XOO3345)
XOO: XOO3539
XOP: PXO_04473
XOR: XOC_1282
XAL: XALC_0887
SML: Smlt3574
SMT: Smal_2996
SMZ: SMD_3147
PSUW: WQ53_02775
PSD: DSC_06070
LAB: LA76x_3622(ace)
LCP: LC55x_3591(ace)
LEZ: GLE_1570
LEM: LEN_3391
DKO: I596_1523
SON: SO_2494
SDN: Sden_2117
SFR: Sfri_1887
SAZ: Sama_1817
SLO: Shew_2053
SSE: Ssed_2057
SPL: Spea_2340
SWD: Swoo_2544
SWP: swp_2383
SVO: SVI_2322
SPSW: Sps_01127
CPS: CPS_1585
PSEO: OM33_11595
PSPO: PSPO_a1844
PART: PARC_a2553
PAGA: PAGA_a2437
AMAL: I607_08070
AMAE: I876_08335
AMAO: I634_08440
AMAD: I636_08870
AMAI: I635_09140
AMAG: I533_08380
AMAC: MASE_07965
GNI: GNIT_1032
SAGA: M5M_17395
LLO: LLO_1982
KKO: Kkor_1388
KGE: TQ33_1115
ADE: Adeh_2024
MXA: MXAN_3581
HOH: Hoch_6422
PSF: PSE_0360
CAK: Caul_0184
PZU: PHZ_c0316
HNE: HNE_1947
HBA: Hbal_0598
SAL: Sala_0456
SPHP: LH20_16505
SMAZ: LH19_18700
SGI: SGRAN_3476(ace)
SPHU: SPPYR_0141
SWI: Swit_2667
SPHD: HY78_12175
SPHM: G432_00930
STAX: MC45_04745
SPHI: TS85_09285
SSAN: NX02_12980
SPKC: KC8_02095
SSY: SLG_23650
SPHR: BSY17_2968
BLAS: BSY18_285
SMIC: SmB9_12650
AAY: WYH_00229
ALB: AEB_P1567
ELI: ELI_07405
RXY: Rxyl_3178
GVI: gll3143
GLJ: GKIL_2224
FTJ: FTUN_6918
SACI: Sinac_2369
SUS: Acid_4844
THYD: TTHT_1108
GBA: J421_0092
HSW: Hsw_1814
FBU: UJ101_00896(ACE)
CABY: Cabys_1631
 » show all
Reference
PMID:2849100
  Authors
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P
  Title
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
  Journal
Proc Natl Acad Sci U S A 85:9386-90 (1988)
DOI:10.1073/pnas.85.24.9386
  Sequence
[hsa:1636]
Reference
PMID:1320019
  Authors
Wei L, Clauser E, Alhenc-Gelas F, Corvol P
  Title
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.
  Journal
J Biol Chem 267:13398-405 (1992)
Reference
PMID:8973330
  Authors
Taylor CA, Coates D, Shirras AD
  Title
The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue.
  Journal
Gene 181:191-7 (1996)
DOI:10.1016/S0378-1119(96)00503-3

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