KEGG ORTHOLOGY: K01371

ORTHOLOGY: K01371

Entry

K01371                      KO

Symbol

CTSK

Name

cathepsin K [EC:3.4.22.38]

Pathway

map04142

Lysosome

map04210

Apoptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map05323

Rheumatoid arthritis

Disease

H00273

Pycnodysostosis

H00425

Lysosomal cysteine protease deficiencies

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01371  CTSK; cathepsin K
  09143 Cell growth and death
   04210 Apoptosis
    K01371  CTSK; cathepsin K
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K01371  CTSK; cathepsin K
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K01371  CTSK; cathepsin K
09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K01371  CTSK; cathepsin K
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01371  CTSK; cathepsin K
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01371  CTSK; cathepsin K
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     K01371  CTSK; cathepsin K
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C1: papain family
   K01371  CTSK; cathepsin K
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Papain family
   K01371  CTSK; cathepsin K

Genes

HSA:	1513(CTSK)

PTR:	457278(CTSK)

PPS:	100974656(CTSK)

GGO:	101145486(CTSK)

PON:	100432447(CTSK)

PPYG:

129029729(CTSK)

NLE:	100580351(CTSK)

HMH:	116469475(CTSK)

SSYN:

134734261(CTSK)

MCC:	574112(CTSK)

MCF:	102120416(CTSK)

MTHB:

126932254

MNI:	105497819(CTSK)

CSAB:

103247207(CTSK)

CATY:

105590201(CTSK)

PANU:

101022150(CTSK)

TGE:	112620351(CTSK)

MLEU:

105534753(CTSK)

RRO:	104681068(CTSK)

RBB:	108533261(CTSK)

TFN:	117075082(CTSK)

PTEH:

111543623(CTSK)

CANG:

105508848(CTSK)

CJC:	100410169(CTSK)

SBQ:	101045222(CTSK)

CIMI:

108316465(CTSK)

ANAN:

105724217(CTSK)

CSYR:

103251387(CTSK)

MMUR:

105873002(CTSK)

LCAT:

123633926(CTSK)

PCOQ:

105821962(CTSK)

OGA:	100950359(CTSK)

MMU:	13038(Ctsk)

MCAL:

110291053(Ctsk)

MPAH:

110320301(Ctsk)

RNO:	29175(Ctsk)

MCOC:

116093414(Ctsk)

ANU:	117707493(Ctsk)

MUN:	110541001(Ctsk)

CGE:	100765407(Ctsk)

MAUA:

101827712(Ctsk)

PROB:

127232730(Ctsk)

PLEU:

114682409(Ctsk)

MORG:

121437982 121450816

MFOT:

126489972

AAMP:

119801328(Ctsk)

NGI:	103729102(Ctsk)

HGL:	101716993(Ctsk)

CPOC:

100718267(Ctsk)

CCAN:

109681204(Ctsk)

DORD:

105984894(Ctsk)

DSP:	122109759(Ctsk)

PLOP:

125360056(Ctsk)

NCAR:

124977877

MMMA:

107156833(Ctsk)

OCU:	100009334(CTSK)

OPI:	101525281(CTSK)

TUP:	102469152(CTSK)

GVR:

103600563

CFA:	608843(CTSK)

CLUD:

112663999(CTSK)

VVP:	112907784(CTSK)

VLG:	121490825(CTSK)

NPO:	129501301(CTSK)

AML:	100483004(CTSK)

UMR:	103667534(CTSK)

UAH:	113246211(CTSK)

UAR:	123787737(CTSK)

ELK:

111161944

LLV:

125096877

MPUF:

101682378(CTSK)

MNP:	132001450(CTSK)

MLK:	131810361(CTSK)

NVS:	122900432(CTSK)

ORO:	101371209(CTSK)

EJU:	114197248(CTSK)

ZCA:	113915477(CTSK)

MLX:	118000314(CTSK)

NSU:	110578599(CTSK)

LWW:	102747919(CTSK)

FCA:	101093379(CTSK)

PYU:	121021051(CTSK)

PCOO:

112871757(CTSK)

PBG:	122481133(CTSK)

PVIV:

125159462(CTSK)

LRUF:

124516160

PTG:	102968588(CTSK)

PPAD:

109257023(CTSK)

PUC:

125912125

AJU:

106979872

HHV:	120241249(CTSK)

BTA:	513038(CTSK)

BOM:	102287709(CTSK)

BIU:	109555331(CTSK)

BBUB:

102407535(CTSK)

BBIS:

104987657(CTSK)

CHX:	102183473(CTSK)

OAS:	101108972(CTSK)

BTAX:

128044625(CTSK)

ODA:	120855928(CTSK)

CCAD:

122434369(CTSK)

MBEZ:

129540299(CTSK)

SSC:	397569(CTSK)

CFR:	102511322(CTSK)

CBAI:

105071740(CTSK)

CDK:	105103193(CTSK)

VPC:	102545171(CTSK)

BACU:

103008252(CTSK)

BMUS:

118902912(CTSK)

LVE:	103075087(CTSK)

OOR:	101270188(CTSK)

DLE:	111169765(CTSK)

PCAD:

102980378(CTSK)

PSIU:

116750388(CTSK)

NASI:

112411616(CTSK)

ECB:	100054991(CTSK)

EPZ:	103547638(CTSK)

EAI:	106846533(CTSK)

MYB:	102259503(CTSK)

MYD:	102771486(CTSK)

MMYO:

118672754(CTSK)

MLF:	102440408(CTSK)

MDT:	132220677(CTSK)

PKL:	118727475(CTSK)

EFUS:

103298978(CTSK)

MNA:	107539127(CTSK)

DRO:	112313792(CTSK)

AJM:	119034729(CTSK)

PDIC:

114489030(CTSK)

PHAS:

123804409(CTSK)

MMF:	118637271(CTSK)

PPAM:

129076823(CTSK) 129076831

HAI:	109372279(CTSK)

RFQ:	117014590(CTSK)

PALE:

102885198(CTSK)

PGIG:

120585212(CTSK)

PVP:	105303821(CTSK)

RAY:	107498992(CTSK)

MJV:	108408263(CTSK)

TOD:	119235951(CTSK)

SARA:

101553291(CTSK)

SETR:

125997497(CTSK)

LAV:	100673950(CTSK)

TMU:

101349596

ETF:	101656870(CTSK)

DNM:	101441026(CTSK)

MDO:	100017449(CTSK)

GAS:	123244279(CTSK)

SHR:	100917440(CTSK)

AFZ:

127559104

PCW:	110220566(CTSK)

TVP:	118858513(CTSK)

OAA:	100088286(CTSK)

GGA:	395818(CTSK)

PCOC:

116238446(CTSK)

MGP:	104914440(CTSK)

TPAI:

128071928(CTSK)

LMUT:

125685749(CTSK)

APLA:

101794155(CTSK)

ACYG:

106049270(CTSK)

CATA:

118260436(CTSK)

AFUL:

116499629(CTSK)

TGU:	101233119(CTSK)

LSR:	110476861(CTSK)

SCAN:

103824024(CTSK)

PMOA:

120502594(CTSK)

OTC:	121335614(CTSK)

PRUF:

121353488(CTSK)

GFR:	102031691(CTSK)

OMA:	130263422(CTSK)

PHI:	102102166(CTSK)

PMAJ:

107214633(CTSK)

CCAE:

111939475(CTSK)

CBRC:

103619626(CTSK)

ZAB:	102060957(CTSK)

ZLE:

135457673

ACHL:

103798515(CTSK)

SVG:	106862381(CTSK)

MMEA:

130586602

HRT:	120764214(CTSK)

SATI:

136372936(CTSK)

FPG:	101919682(CTSK)

FCH:	102049655(CTSK)

NNT:	104409362(CTSK)

SHAB:

115602670(CTSK)

TALA:

116959555 122152483

ACHC:

115345553(CTSK)

HLE:	104830533(CTSK)

AGEN:

126040213

GCL:

127027057

LDI:	104348855(CTSK)

NNI:	104014432(CTSK)

AFOR:

103900499(CTSK)

CLV:	102096035(CTSK)

CMAC:

104479610(CTSK)

CUCA:

104066026(CTSK)

TEO:

104382293

BREG:

104632109

ACAR:

104527988

CPEA:

104385234(CTSK)

CVF:	104285440(CTSK)

RTD:	128900891(CTSK)

AAM:	106495413(CTSK)

AROW:

112972480(CTSK)

NPD:	112952963(CTSK)

DNE:	112990056(CTSK)

SCAM:

104139546(CTSK)

ASN:	112547876(CTSK)

AMJ:	109281035(CTSK)

CPOO:

109324822(CTSK)

GGN:	109305208(CTSK)

PSS:	102447447 102459334

CMY:	102937600 102948156(CTSK)

CCAY:

125625610(CTSK) 125625765

DCC:	119847720 119847843

CPIC:

101953906 101954188

TST:

117869790

CABI:

116817633 116817658(CTSK)

MRV:	120390078(CTSK) 120390507

ACS:	100561728(ctsk)

ASAO:

132764182(CTSK)

PVT:	110081453(CTSK)

SUND:

121916255(CTSK)

PBI:	103053602(CTSK)

PMUR:

107292918(CTSK)

CTIG:

120317161(CTSK)

TSR:

106554193

PGUT:

117670136(CTSK)

APRI:

131186544(CTSK)

PTEX:

113449215(CTSK)

NSS:	113425696(CTSK)

VKO:	123032931(CTSK)

PMUA:

114586294(CTSK)

PRAF:

128403645(CTSK)

ZVI:	118076335(CTSK)

HCG:	128337698(CTSK)

GJA:	107120548(CTSK)

STOW:

125436656 125436704 125444042

EMC:	129328519(CTSK)

XLA:	100127265(ctsk.L) 108699348 108699349 108700337

XTR:	100490139 100492634 448216(ctsk) 779889(ctsk)

NPR:	108789812 108789813

RTEM:

120921060 120921061

BBUF:

120981857 120982069

BGAR:

122923215 122923216(CTSK)

MUO:	115458068 115458069

GSH:	117350538 117350800

DRE:	550475(ctsk)

SRX:	107717769 107741754

SANH:

107663458 107689854

SGH:	107576564 107587836

CCAR:

109056407 109084523

CAUA:

113059151 113116115

CGIB:

127975145 128030028

PTET:

122359891(ctsk)

LROH:

127178601(ctsk)

OMC:	131521346(ctsk)

PPRM:

120484668(ctsk)

RKG:	130069294(ctsk)

MAMB:

125243547(ctsk)

CIDE:

127496726

CERY:

137034431(ctsk)

MASI:

127452790 127454028

TROS:

130558316(ctsk)

TDW:	130432744(ctsk) 130433069

MANU:

129448131(ctsk)

IPU:	100528180(ctsk) 108274827(ctss1)

IFU:	128610336(ctsk) 128618188 128618285

PHYP:

113525378 113533989

SMEO:

124384142(ctsk) 124392178(ctss1) 124392838 124392839

TFD:	113644778(ctsk)

TVC:	132845888(ctsk)

TRN:	134310793(ctsk)

AMEX:

103044235(ctsk)

CMAO:

118812790(ctss1) 118817493(ctsk)

EEE:	113575274 113585755

CHAR:

105891723 105891891(ctsk) 105891894 105902966 105902972 116221019

TRU:

101066261

TFS:	130518781(ctss1) 130532154(ctsk)

TNG:	GSTEN00011686G001

LCO:

104923938

NCC:	104944927 104955931

TBEN:

117478362(ctss1) 117494853(ctsk)

CGOB:

115015607 115021678

PGEO:

117460845(ctsk)

GACU:

117563199(ctsk)

EMAC:

134862311(ctsk) 134874960(ctss1)

ELY:	117263942 117266432(ctsk)

EFO:	125892610(ctsk) 125904819

PLEP:

121945418(ctsk)

SLUC:

116047396 116049094(ctsk)

ECRA:

117946035(ctsk)

ESP:

116690790

PFLV:

114556731 114567830

GAT:	120810482(ctsk)

PPUG:

119197583(ctsk) 119219160(ctss1)

AFB:	129097575(ctss1) 129110242(ctsk)

CLUM:

117745145(ctsk)

PSWI:

130187951(ctsk)

MSAM:

119882211 119897014(ctsk)

SCHU:

122864988 122882285(ctsk)

CUD:	121513705(ctsk) 121523315

ALAT:

119005465(ctsk) 119016605

MZE:	101486434 106675288

ONL:	102080361(ctsk) 109204084

OAU:	116333437(ctsk)

OLA:	101160005 101164922

OML:	112136686(ctsk) 112137541

CSAI:

133440252(ctsk) 133461475

XMA:

102230067

XCO:

114142267

XHE:	116717364 116731588

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122831312(ctsk) 122844185(ctss1)

PPRL:

129371013(ctsk) 129375187(ctss1)

CVG:	107086845 107088362

CTUL:

119781875(ctsk) 119784812

GMU:	124865442(ctsk) 124879804

NFU:

107379225

KMR:	108243181(ctsk)

ALIM:

106524066

NWH:	119409271(ctsk)

AOCE:

111569218 111571631

MCEP:

125016158(ctsK) 125020404

CSEM:

103388696

POV:

109633525

SSEN:

122775141(ctsk) 122786639

HHIP:

117770320 117770321 117776445(ctsk)

HSP:	118114030(ctsk) 124855045 124855046

PPLT:

128448909(ctsk) 128461960(ctss1)

SMAU:

118285187(ctsk) 118292023

LCF:	108883173 108884675

SDU:	111222414 111234098

SLAL:

111644723 111668412 111668430 111669222

XGL:	120784603(ctsk)

HCQ:

109512208

SSCV:

125974680

SBIA:

133500961(ctsk)

PEE:	133401554(ctsk)

PTAO:

133479666(ctsk)

BPEC:

110170731

MALB:

109968905 109968961

BSPL:

114843460(ctsk) 114845304 114845306 114845307 114846125 114865357(ctss1)

SJO:	128365726 128366917 128373690

SASA:

100195370(catk) 106580864

STRU:

115176788 115178886

OTW:	112222948(ctsk) 112229285

OMY:	100136757(ctsk) 110514697

OGO:	123997752(ctsk) 124006230

ONE:	115103964 115141061

OKI:	109902021 109908581

OKE:	118364447(ctsk) 118367492

SALP:

111959001

SNH:	120031339 120048416(ctsk)

CCLU:

121543125 123486200

ELS:	105009269(ctsk)

SFM:	108930421 108941878

PKI:	111838383 111853517 111853532 111860671

AANG:

118213555(ctsk) 118233651 118233652 118233656 118233658 118233659 118233660 118234219 118234220

LOC:	102682459 102683074 102692644

PSPA:

121309883

ARUT:

117395492 117971318

PSEX:

120527418

LCM:	102352136(CTSK)

RTP:

109919200

CPLA:

122547102 122565168

LERI:

129711259

DME:	Dmel_CG4847(CtsK2)

DYA:	Dyak_GE11675

DGR:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

SCAC:

LSQ:	119608035 119615828

GFS:

119641177

ECOE:

129945757

HIS:	119654852 119655276 119655781

BCOO:

AEC:

ACEP:

DQU:

CFO:

OBO:

PCF:

TCA:	658343 660669

SOY:	115877905 115879668

AGRG:

126735916

CSET:

123316309 123316315 123318474

LDC:	111502369 111511108 111511781

DVV:	114324171 114335561 126892061 126893277

CFEL:

BTAB:

HVI:

FCD:

DPX:	DAPPUDRAFT_306050 DAPPUDRAFT_312319 DAPPUDRAFT_315184 DAPPUDRAFT_320635 DAPPUDRAFT_47691 DAPPUDRAFT_8167

DMK:	116919999 116920002 116920003 116932093

TUT:	107367640 107371849 112538500

DPTE:

113792611

DFR:

124499318

PTEP:

107450796

LOA:	LOAG_18685

LGI:	LOTGIDRAFT_116870 LOTGIDRAFT_161642 LOTGIDRAFT_172091

GAE:

121381730

HRF:	124135182 124135263 124135264

CRG:

105345948

OED:	125651393 130052272

MMER:

123533619 123533940 123534315 123556631

RPHI:

132744918

DPOL:

127837684 127837686 127838417 127839807 127840581 127865030

MAEA:

128208897 128211880 128217606 128218990

LAK:

EGL:

NAU:

DFA:

EIV:	EIN_325530

TPV:

TP02_0140

PTM:	GSPATT00008837001 GSPATT00009853001

CFUS:

CYFUS_004023

PSER:

ABRG53_3160

HHY:	Halhy_1431

SLI:

Slin_5291

RUN:	DR864_07255

ZPR:

ZPR_4593

WIN:

WPG_0559

FBE:	FF125_17725

» show all

Reference

PMID:18239127

Authors

Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H

Title

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

Journal

Science 319:624-7 (2008)
DOI:10.1126/science.1150110

Reference

PMID:8703060

Authors

Gelb BD, Shi GP, Chapman HA, Desnick RJ

Title

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.

Journal

Science 273:1236-8 (1996)
DOI:10.1126/science.273.5279.1236

Reference

PMID:11082042

Authors

Tepel C, Bromme D, Herzog V, Brix K

Title

Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.

Journal

J Cell Sci 113 Pt 24:4487-98 (2000)

Sequence

[mmu:13038]

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Disease (2)   
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Gene (1795)   
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   KEGG MGENES (123)   
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