KEGG ORTHOLOGY: K01392

ORTHOLOGY: K01392

Entry

K01392                      KO

Symbol

THOP1

Name

thimet oligopeptidase [EC:3.4.24.15]

Pathway

map04614

Renin-angiotensin system

map05143

African trypanosomiasis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    K01392  THOP1; thimet oligopeptidase
09160 Human Diseases
  09174 Infectious disease: parasitic
   05143 African trypanosomiasis
    K01392  THOP1; thimet oligopeptidase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01392  THOP1; thimet oligopeptidase
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.15  thimet oligopeptidase
     K01392  THOP1; thimet oligopeptidase
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M3
   K01392  THOP1; thimet oligopeptidase

Genes

HSA:	7064(THOP1)

PTR:	750162(THOP1)

PPS:	100985112(THOP1)

GGO:	101143234(THOP1)

PON:	100455971(THOP1)

PPYG:

129020261(THOP1)

NLE:	100583449(THOP1)

HMH:	116483102(THOP1)

SSYN:

129465293(THOP1)

MCC:	721578(THOP1)

MCF:	102117812(THOP1)

MTHB:

126942541

MNI:	105485733(THOP1)

CSAB:

103233658(THOP1)

CATY:

105591760(THOP1)

PANU:

101016285(THOP1)

TGE:	112613114(THOP1)

MLEU:

105551973(THOP1)

RRO:	104665465(THOP1)

RBB:	108537535(THOP1)

TFN:	117074290(THOP1)

PTEH:

111520680(THOP1)

CANG:

105527655(THOP1)

CJC:	100385317(THOP1)

SBQ:	101028985(THOP1)

CIMI:

108288502(THOP1)

ANAN:

105706088(THOP1)

CSYR:

103265974(THOP1)

MMUR:

105873975(THOP1)

LCAT:

123633237(THOP1)

PCOQ:

105811943(THOP1)

OGA:	100947655(THOP1)

MMU:	50492(Thop1)

MCAL:

110303835(Thop1)

MPAH:

110326403(Thop1)

RNO:	64517(Thop1)

MCOC:

116076209(Thop1)

ANU:	117696806(Thop1)

MUN:	110555611(Thop1)

CGE:	100764672(Thop1)

MAUA:

101823587(Thop1)

PROB:

127216546(Thop1)

PLEU:

114688124(Thop1)

MORG:

121459922(Thop1)

MFOT:

126489301

AAMP:

119800920(Thop1)

NGI:	103737278(Thop1)

HGL:	101714143(Thop1)

CPOC:

100731879(Thop1)

CCAN:

109691048(Thop1) 109702423

DORD:

105990473(Thop1)

DSP:	122099291(Thop1)

PLOP:

125348632(Thop1)

NCAR:

124969480

MMMA:

107157425(Thop1)

OPI:	101521830(THOP1)

TUP:	102500342(THOP1)

GVR:	103605472(THOP1)

CFA:	476748(THOP1)

CLUD:

112666240(THOP1)

VVP:	112935469(THOP1)

VLG:	121494789(THOP1)

NPO:	129521739(THOP1)

AML:	100471700(THOP1)

UMR:	103681807(THOP1)

UAH:	113242770(THOP1)

UAR:	123793979(THOP1)

ELK:

111161713

LLV:

125086980

MPUF:

101675322(THOP1)

MNP:	132010756(THOP1)

MLK:	131823254(THOP1)

NVS:	122909904(THOP1)

ORO:	101362401(THOP1)

EJU:	114226166(THOP1)

ZCA:	113916363(THOP1)

MLX:	118005518(THOP1)

NSU:	110593679(THOP1)

LWW:	102733859(THOP1)

FCA:	101083746(THOP1)

PYU:	121021304(THOP1)

PBG:	122486659(THOP1)

PVIV:

125160661(THOP1)

LRUF:

124524840

PTG:	102964477(THOP1)

PPAD:

109260811(THOP1)

PUC:

125930507

AJU:

106982145

HHV:	120242394(THOP1)

BTA:	510889(THOP1)

BOM:	102265369(THOP1)

BIU:	109561783(THOP1)

BBUB:

102413536(THOP1)

BBIS:

105005586(THOP1)

CHX:	102178165(THOP1)

OAS:	101119557(THOP1)

BTAX:

128050814(THOP1)

ODA:	120864781(THOP1)

CCAD:

122440188(THOP1)

MBEZ:

129559136(THOP1)

SSC:	397442(THOP1)

CFR:	102508107(THOP1)

CBAI:

105078170(THOP1)

CDK:	105106052(THOP1)

VPC:	102539590(THOP1)

BACU:

103019210(THOP1)

BMUS:

118892444(THOP1) 118892597

LVE:	103090843(THOP1)

OOR:	101287363(THOP1)

DLE:	111170481(THOP1)

PCAD:

102992430(THOP1)

PSIU:

116751758(THOP1) 116761195

NASI:

112396373(THOP1)

ECB:	100059667(THOP1)

EPZ:	103540477(THOP1)

EAI:	106834154(THOP1)

MYB:	102262534(THOP1)

MYD:	102774039(THOP1)

MMYO:

118658947(THOP1)

MLF:	102426538(THOP1)

MDT:	132235224(THOP1)

PKL:	118731308(THOP1)

EFUS:

103294259(THOP1)

MNA:	107534611(THOP1)

DRO:	112312636(THOP1)

SHON:

118984464(THOP1)

AJM:	119063770(THOP1)

PDIC:

114502924(THOP1)

PHAS:

123814089(THOP1)

MMF:	118615985(THOP1)

PPAM:

129081319(THOP1)

HAI:	109390675(THOP1)

RFQ:	117038291(THOP1)

PALE:

102886786(THOP1)

PGIG:

120583743(THOP1)

PVP:	105300464(THOP1)

RAY:	107520132(THOP1)

MJV:

108393267

TOD:	119240546(THOP1)

SARA:

101543766(THOP1)

SETR:

126031140(THOP1)

LAV:

100665776

TMU:

101346830

ETF:	101649445(THOP1)

DNM:	101436326(THOP1)

MDO:	100020499(THOP1)

GAS:	123256779(THOP1)

SHR:	100924623(THOP1)

AFZ:

127545129

PCW:	110223381(THOP1)

TVP:	118846412(THOP1)

OAA:	100076730(THOP1)

GGA:	426398(THOP1)

PCOC:

116235780(THOP1)

MGP:	100545913(THOP1)

CJO:	107325439(THOP1)

TPAI:

128088932(THOP1)

LMUT:

125685058(THOP1)

NMEL:

110388975(THOP1)

APLA:

101804753(THOP1)

ACYG:

106048201(THOP1)

CATA:

118260844(THOP1)

AFUL:

116499110(THOP1)

TGU:	100231983(THOP1)

LSR:	110483736(THOP1)

SCAN:

103822058(THOP1)

PMOA:

120513634(THOP1)

OTC:	121342122(THOP1)

PRUF:

121360908

GFR:	102032301(THOP1)

FAB:	101805763(THOP1)

OMA:	130264551(THOP1)

PHI:	102110662(THOP1)

PMAJ:

107215455(THOP1)

CCAE:

111940251(THOP1)

CCW:	104697073(THOP1)

CBRC:

103622198

ETL:	114066386(THOP1)

ZAB:	102062983(THOP1)

ZLE:	135458833(THOP1)

ACHL:

103804792(THOP1)

SVG:	106857154(THOP1)

MMEA:

130580196(THOP1)

SATI:

136371853(THOP1)

FPG:	101913462(THOP1)

FCH:	102053721(THOP1)

CCRI:

104165370(THOP1)

NNT:	104413388(THOP1)

SHAB:

115618044(THOP1)

ACUN:

113489333(THOP1)

TALA:

104363459(THOP1)

ACHC:

115348846(THOP1)

HALD:

104319119

HLE:	104829105(THOP1)

AGEN:

GCL:

CSTI:

LDI:

MNB:	103780001(THOP1)

DPUB:

104299056(THOP1)

AVIT:

104279925(THOP1)

EGZ:	104132299(THOP1)

NNI:	104016288(THOP1)

PCRI:

104035619(THOP1)

PCAO:

104042347(THOP1)

PADL:

103925937(THOP1)

AFOR:

103899398(THOP1)

FGA:	104084170(THOP1)

GSTE:

104260085(THOP1)

CLV:	102095097(THOP1)

MUI:	104539560(THOP1)

PGUU:

104471466(THOP1)

PLET:

104621712(THOP1)

EHS:	104513053(THOP1)

CMAC:

104474322(THOP1)

CUCA:

104065758(THOP1)

TEO:	104378215(THOP1)

BREG:

104641176(THOP1)

OHA:	104327957(THOP1)

ACAR:

104523453

CPEA:

104395609(THOP1)

CVF:	104285119(THOP1)

RTD:	128900752(THOP1)

AAM:	106486695(THOP1)

AROW:

112965657(THOP1)

NPD:	112946888(THOP1)

TGT:	104568357(THOP1)

DNE:	112992759(THOP1)

SCAM:

104139383(THOP1)

ASN:	102383675(THOP1)

AMJ:	102558370(THOP1)

CPOO:

109312321(THOP1)

GGN:	109294955(THOP1)

PSS:	102457370(THOP1)

CMY:	102940710(THOP1)

CCAY:

125627075(THOP1)

DCC:	119848370(THOP1)

CPIC:

101943510(THOP1)

TST:	117868787(THOP1)

CABI:

116831649(THOP1)

MRV:	120391749(THOP1)

ASAO:

132780866(THOP1)

PVT:	110079254(THOP1)

SUND:

121936693(THOP1)

PBI:	103051765(THOP1)

PMUR:

107296844(THOP1)

CTIG:

120299507(THOP1)

TSR:	106544855(THOP1)

PGUT:

117670577(THOP1)

APRI:

131188456(THOP1)

PTEX:

113451175(THOP1)

NSS:	113426270(THOP1)

VKO:

123017592

PMUA:

114588367(THOP1)

PRAF:

128405630(THOP1)

ZVI:	118087077(THOP1)

HCG:	128344541(THOP1)

GJA:	107105512(THOP1)

STOW:

125433653(THOP1)

EMC:	129330744(THOP1)

XLA:	108706839(thop1.S) 397806(thop1.L)

XTR:	779863(thop1)

NPR:

108802730

RTEM:

120912800(THOP1)

BBUF:

120989474(THOP1)

BGAR:

122919913(THOP1)

MUO:	115480489(THOP1)

GSH:	117365613(THOP1)

DRE:	436628(thop1)

SRX:	107726548 107730481 107751012

SANH:

107658499

SGH:	107568058 107592556

CCAR:

109087313

CAUA:

113054995 113069380

CGIB:

127968090 128022613

PTET:

122354205(thop1)

LROH:

127173375(thop1)

OMC:	131549863(thop1)

PPRM:

120464244(thop1)

RKG:	130100915(thop1)

MAMB:

125256422(thop1)

CIDE:

127522016

CERY:

137021698(thop1)

MASI:

127426443 127427641

TROS:

130571149(thop1)

TDW:	130410790(thop1)

MANU:

129427250(thop1)

IPU:

108271294

IFU:	128614035(thop1)

PHYP:

113535897(thop1)

SMEO:

124391613(thop1)

TFD:	113657854(thop1)

TVC:	132851924(thop1)

TRN:	134331189(thop1)

AMEX:

103038939(thop1)

CMAO:

118819360(thop1)

EEE:	113568245(thop1)

CHAR:

105896439(thop1)

TRU:

101069017

TFS:	130528297(thop1)

TNG:	GSTEN00006269G001

LCO:	104935746(thop1)

TBEN:

117491064(thop1)

CGOB:

115006745(thop1)

PGEO:

117445633(thop1)

GACU:

117534328(thop1)

EMAC:

134869686(thop1)

ELY:	117254224(thop1)

EFO:	125895982(thop1)

PLEP:

121941066(thop1)

SLUC:

116066747(thop1)

ESP:

116679471

PFLV:

114552158(thop1)

GAT:	120823858(thop1)

PPUG:

119216330(thop1)

AFB:	129094302(thop1)

CLUM:

117730033(thop1)

PSWI:

130193560(thop1)

MSAM:

119888385 119888386

SCHU:

122877413(thop1)

CUD:	121511696(thop1)

ALAT:

119029193(thop1)

MZE:	101464999(thop1)

ONL:

100703187

OAU:	116323245(thop1)

OLA:	101157763(thop1)

OML:	112136800(thop1)

CSAI:

133458331(thop1)

XMA:	102222331(thop1)

XCO:	114141368(thop1)

XHE:

116725751

PRET:

103463257(thop1)

PFOR:

103155047(thop1)

PLAI:

106941416(thop1)

PMEI:

106927773(thop1)

GAF:	122838058(thop1)

PPRL:

129378906(thop1)

CVG:	107085901(thop1)

CTUL:

119791252(thop1)

GMU:	124873733(thop1)

NFU:	107395897(thop1)

KMR:	108228871(thop1)

ALIM:

106532164

NWH:	119430462(thop1)

AOCE:

111563975(thop1)

MCEP:

125009784(thop1)

CSEM:

103396631(thop1)

POV:

109642545

SSEN:

122780778(thop1)

HHIP:

117760170(thop1)

HSP:	118121258(thop1)

PPLT:

128447974(thop1)

SMAU:

118318066(thop1)

LCF:	108882357(thop1) 108892667

SDU:	111231825(thop1)

SLAL:

111671759(thop1)

XGL:	120790957(thop1)

HCQ:	109506833(thop1)

SSCV:

125975091

SBIA:

133503286(thop1)

PEE:	133406741(thop1)

PTAO:

133481261(thop1)

BPEC:

110167856(thop1)

MALB:

109965204(thop1)

BSPL:

114854329

SJO:	128362053(thop1)

SASA:

100194867(mepd) 106613599(MEPD)

STRU:

115151639 115158073

OTW:	112250709 112252097

OMY:	110489937 110524109

OGO:	123997264(thop1) 123997863

ONE:	115108147 115109114

OKI:	109889094 109902350

OKE:	118387838 118401487

SALP:

111952854 111975950

SNH:	120053694 120054667

CCLU:

121533688 121576477(thop1)

ELS:	105011365(thop1)

SFM:

108935234

PKI:

111840410

AANG:

118225034(thop1)

LOC:

102698056

PSPA:

121300806

ARUT:

117401455 117966344

PSEX:

120537589(thop1)

LCM:	102357708(THOP1)

CMK:

103181955

RTP:

109912733

CPLA:

122557939 122565420

HOC:	132821387 132828857

LERI:

129711114(thop1)

PMRN:

116942290(THOP1)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

BCOO:

FCD:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

CSCU:

111634737 111637553 111642625

CVS:

PTEP:

ABRU:

UDV:

SDM:	118187678 118200824

LPOL:

106458305

LGI:	LOTGIDRAFT_178669

PVUL:

126819247

PCAN:

112573585

BGT:

106064971

GAE:	121376297 121376298

HRF:

124113096

HRJ:

124258522

CRG:	105326160 117684168

CANU:

128164619

CVN:	111117774 111122414

OED:	125668093 125668094

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_029470 Smp_029500

SHX:	MS3_00004895(THOP1_1) MS3_00004897(THOP1_2)

OVI:	T265_02526

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

RES:

TAD:	TRIADDRAFT_22587

ATH:

AT1G67690

ALY:

9324680

CRB:

17894312

CSAT:

104704713 104750568 104787784

EUS:	EUTSA_v10018203mg

BRP:	103831014 103831191

BNA:	106353963 106410390 106436805 106454291

BOE:	106300211 106300276

RSZ:	108817546 108817732

THJ:

104825527

CPAP:

110811640

CIT:

102612794

CIC:	CICLE_v10033657mg

PVY:

MINC:

TCC:

GRA:

GHI:	107886507 107909759

GAB:

HSYR:

DZI:

EGR:

GMX:	100793518 100796889

GSJ:

114394812

PVU:	PHAVU_001G258500g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131661506 131661518

LJA:

130724453

ADU:

107468942

AIP:

107623713

AHF:	112715069 112783859

LANG:

109327233

PCIN:

129293194

QSA:	O6P43_023901

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103450130 103452091

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107776157 107805230

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110710335 110712431

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119269828 119277834

TAES:

123062821 123071663 123080010

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122041905 122046429

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_113618 SELMODRAFT_164651

PPP:	112295568 112295983

MNG:	MNEG_12125

OLU:	OSTLU_46518

OTA:	OT_ostta09g02980

BPG:	Bathy10g01530

CME:	CYME_CMS446C

ZTR:	MYCGRDRAFT_107351

MBR:	MONBRDRAFT_25656

SRE:	PTSG_13259

DDI:	DDB_G0292362

DPP:	DICPUDRAFT_54379

DFA:

DFA_04384

AAF:	AURANDRAFT_72404

PIF:	PITG_08599

PSOJ:

PHYSODRAFT_329905

SPAR:

SPRG_12685

GTT:	GUITHDRAFT_166948

TBR:	Tb927.7.190

TBG:	TbgDal_VII70

TCR:	506411.10 511237.10

LMA:	LMJF_26_1570

LIF:	LINJ_26_1550

LDO:	LDBPK_261550

LMI:	LMXM_26_1570

LMAT:

92514198(LSCM1_04165)

LBZ:	LBRM_26_1590

LPAN:

LPMP_261550

NGR:	NAEGRDRAFT_36811

» show all

Reference

PMID:2261476

Authors

Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL

Title

Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.

Journal

Biochemistry 29:10323-9 (1990)
DOI:10.1021/bi00497a006

Sequence

[rno:64517]

Reference

PMID:8869556

Authors

Vincent B, Vincent JP, Checler F

Title

Purification and characterization of human endopeptidase 3.4.24.16. Comparison with the porcine counterpart indicates a unique cleavage site on neurotensin.

Journal

Brain Res 709:51-8 (1996)
DOI:10.1016/0006-8993(95)01260-5

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (6368)   
   KEGG GENES (700)   
   KEGG MGENES (1967)   
   RefGene (3666)   
   OC (35)   
Literature (2)   
   PubMed (2)   
All databases (6378)   

Download RDF

DBGET integrated database retrieval system