KEGG   ORTHOLOGY: K01398
Entry
K01398                      KO                                     
Symbol
MMP2
Name
matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
Pathway
map01522  Endocrine resistance
map04670  Leukocyte transendothelial migration
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04926  Relaxin signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05219  Bladder cancer
map05415  Diabetic cardiomyopathy
map05418  Fluid shear stress and atherosclerosis
Disease
H00025  Penile cancer
H00028  Choriocarcinoma
H00472  Torg syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09152 Endocrine system
   04912 GnRH signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04915 Estrogen signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04926 Relaxin signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05205 Proteoglycans in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09162 Cancer: specific types
   05219 Bladder cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05415 Diabetic cardiomyopathy
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.24  gelatinase A
     K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M10
   K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Genes
HSA: 4313(MMP2)
PTR: 454094(MMP2)
PPS: 100970966(MMP2)
GGO: 101147102(MMP2)
PON: 100451667(MMP2)
PPYG: 129015390(MMP2)
NLE: 100597186(MMP2)
HMH: 116471259(MMP2)
SSYN: 129493287(MMP2)
MCC: 698478(MMP2)
MCF: 101865544(MMP2)
MTHB: 126945112
MNI: 105494081(MMP2)
CSAB: 103233007(MMP2)
CATY: 105588567(MMP2)
PANU: 101014166(MMP2)
TGE: 112613724(MMP2)
MLEU: 105533444(MMP2)
RRO: 104671481(MMP2)
RBB: 108531264(MMP2)
TFN: 117087797(MMP2)
PTEH: 111541252(MMP2)
CJC: 100387448(MMP2)
SBQ: 101042210(MMP2)
CIMI: 108305432(MMP2)
ANAN: 105714068(MMP2)
CSYR: 103272469(MMP2)
MMUR: 105866549(MMP2)
LCAT: 123625360(MMP2)
PCOQ: 105817042(MMP2)
OGA: 100965003(MMP2)
MMU: 17390(Mmp2)
MCAL: 110299708(Mmp2)
MPAH: 110337240(Mmp2)
RNO: 81686(Mmp2)
MCOC: 116069868(Mmp2)
ANU: 117701832 117723004(Mmp2)
MUN: 110545189(Mmp2)
CGE: 100774744(Mmp2)
MAUA: 101833614(Mmp2)
PROB: 127230005(Mmp2)
PLEU: 114694533(Mmp2)
MORG: 121446989(Mmp2)
MFOT: 126502468
AAMP: 119802075(Mmp2)
NGI: 103731682(Mmp2)
HGL: 101696977(Mmp2)
CPOC: 100719361(Mmp2)
CCAN: 109690723(Mmp2)
DORD: 105994417(Mmp2)
DSP: 122116321(Mmp2)
PLOP: 125358446(Mmp2)
NCAR: 124967289
MMMA: 107144864(Mmp2)
OCU: 100009000(MMP2)
OPI: 101522382(MMP2)
TUP: 102483061(MMP2)
GVR: 103610004 103610353
CFA: 403733(MMP2)
CLUD: 112659990(MMP2)
VVP: 112929621(MMP2)
VLG: 121498055(MMP2)
NPO: 129513683(MMP2)
AML: 100476183(MMP2)
UMR: 103673901(MMP2)
UAH: 113252249(MMP2)
UAR: 123798414(MMP2)
ELK: 111157340
LLV: 125089554
MPUF: 101675156(MMP2)
MNP: 132004844(MMP2)
MLK: 131818062(MMP2)
NVS: 122911443(MMP2)
ORO: 101378425(MMP2)
EJU: 114204089(MMP2)
ZCA: 113936159(MMP2)
MLX: 118023778(MMP2)
NSU: 110593361(MMP2)
LWW: 102726609(MMP2)
FCA: 101098838(MMP2)
PYU: 121045318(MMP2)
PCOO: 112857297(MMP2)
PBG: 122494216(MMP2)
PVIV: 125153390(MMP2)
LRUF: 124511320
PTG: 102956398(MMP2)
PPAD: 109270907(MMP2)
PUC: 125918162 125918164
AJU: 106973291
HHV: 120238088(MMP2)
BTA: 282872(MMP2)
BOM: 102269336(MMP2)
BIU: 109572595(MMP2)
BBUB: 102401701(MMP2)
BBIS: 105004336(MMP2)
CHX: 102184364(MMP2)
OAS: 443115(MMP2)
BTAX: 128062791(MMP2)
ODA: 120873204(MMP2)
CCAD: 122420084(MMP2)
MBEZ: 129547097(MMP2)
SSC: 397391(MMP2)
CFR: 102521167(MMP2)
CBAI: 105075731(MMP2)
CDK: 105097506(MMP2)
VPC: 102524948(MMP2)
BACU: 103016736(MMP2)
BMUS: 118885264(MMP2)
LVE: 103071760(MMP2)
OOR: 101275485(MMP2)
DLE: 111164984(MMP2)
PCAD: 102973920(MMP2)
PSIU: 116743436(MMP2)
NASI: 112401290(MMP2)
ECB: 100033948(MMP2)
EPZ: 103553197(MMP2)
EAI: 106822484(MMP2)
MYB: 102260608(MMP2)
MYD: 102767174(MMP2)
MMYO: 118674505(MMP2)
MLF: 102418715(MMP2)
MDT: 132217576(MMP2)
PKL: 118720617(MMP2)
EFUS: 103295886(MMP2)
MNA: 107543503(MMP2)
DRO: 112296673(MMP2)
SHON: 119001111(MMP2)
AJM: 119046441(MMP2)
PDIC: 114488295(MMP2)
PHAS: 123806069(MMP2)
MMF: 118639416(MMP2)
PPAM: 129068219(MMP2)
HAI: 109383663(MMP2)
RFQ: 117035241(MMP2)
PALE: 102883808(MMP2)
PGIG: 120617290(MMP2)
PVP: 105292047(MMP2)
RAY: 107499669(MMP2)
MJV: 108387896(MMP2)
TOD: 119248904(MMP2)
SARA: 101540694(MMP2)
SETR: 126027090(MMP2)
LAV: 100659450(MMP2)
TMU: 101358817
ETF: 101655753(MMP2)
DNM: 101442293(MMP2)
MDO: 100020585(MMP2)
GAS: 123235296(MMP2)
SHR: 100935012(MMP2)
AFZ: 127550719
PCW: 110207503(MMP2)
TVP: 118845035(MMP2)
OAA: 100077120(MMP2) 103166153
GGA: 386583(MMP2)
PCOC: 116243917(MMP2)
MGP: 100125331(MMP2)
CJO: 107319190(MMP2)
TPAI: 128082236(MMP2)
LMUT: 125699398(MMP2)
NMEL: 110404299(MMP2)
APLA: 101802059(MMP2)
ACYG: 106043076(MMP2)
CATA: 118246321(MMP2)
AFUL: 116493904(MMP2)
TGU: 100228546(MMP2)
LSR: 110484414(MMP2)
SCAN: 103816631(MMP2)
PMOA: 120508123(MMP2)
OTC: 121333988(MMP2)
PRUF: 121348910(MMP2)
GFR: 102040497(MMP2)
FAB: 101815345(MMP2)
OMA: 130257709(MMP2)
PHI: 102107059(MMP2)
PMAJ: 107209744(MMP2)
CCAE: 111934584(MMP2)
CCW: 104687474(MMP2)
CBRC: 103620188(MMP2)
ETL: 114060386(MMP2)
ZAB: 102062240(MMP2)
ZLE: 135452895(MMP2)
SVG: 106857180(MMP2)
MMEA: 130572734(MMP2)
HRT: 120757792(MMP2)
SATI: 136366636(MMP2)
FPG: 101924896(MMP2)
FCH: 102056005(MMP2)
CCRI: 104166870(MMP2)
NNT: 104409290(MMP2)
SHAB: 115600940(MMP2) 115619032
ACUN: 113484433(MMP2)
TALA: 104366500(MMP2)
ACHC: 115346374(MMP2)
HALD: 104318434(MMP2)
HLE: 104842482(MMP2)
AGEN: 126040514
GCL: 127021340
CSTI: 104554453
LDI: 104344620(MMP2)
MNB: 103775244(MMP2)
DPUB: 104298994(MMP2)
AVIT: 104279221(MMP2)
BRHI: 104500759(MMP2)
EGZ: 104125198(MMP2)
NNI: 104016354(MMP2)
PCRI: 104033146(MMP2)
PCAO: 104050385(MMP2)
PADL: 103914183(MMP2)
AFOR: 103896821(MMP2)
FGA: 104082041(MMP2)
GSTE: 104254084(MMP2)
CLV: 102092170(MMP2)
MUI: 104537531 104539090
PGUU: 104471839(MMP2)
PLET: 104620450(MMP2)
EHS: 104514040(MMP2)
CMAC: 104473655(MMP2)
CUCA: 104056804(MMP2)
TEO: 104371920(MMP2)
BREG: 104632882(MMP2)
OHA: 104333942(MMP2)
ACAR: 104531227(MMP2)
CPEA: 104388562(MMP2)
CVF: 104287626(MMP2)
RTD: 128908768(MMP2)
AAM: 106483196(MMP2)
AROW: 112967552(MMP2)
NPD: 112947679(MMP2)
TGT: 104568861(MMP2)
DNE: 112984295(MMP2)
SCAM: 104146313(MMP2)
ASN: 102372370(MMP2)
AMJ: 102562302(MMP2)
CPOO: 109310506(MMP2)
GGN: 109289618(MMP2)
PSS: 102463152(MMP2)
CMY: 102946066(MMP2)
CCAY: 125620722(MMP2)
DCC: 119841114(MMP2)
CPIC: 101941088(MMP2)
TST: 117886578(MMP2)
CABI: 116820815(MMP2)
MRV: 120384744(MMP2)
ACS: 100557569(mmp2)
ASAO: 132782909(MMP2)
PVT: 110082478(MMP2)
SUND: 121914771(MMP2)
PBI: 103055844(MMP2)
PMUR: 107295718(MMP2)
CTIG: 120312104(MMP2)
PGUT: 117670956(MMP2)
APRI: 131184179(MMP2)
PTEX: 113444987(MMP2)
NSS: 113424575(MMP2)
VKO: 123022290(MMP2)
PMUA: 114602200(MMP2)
PRAF: 128419434(MMP2)
ZVI: 118087109(MMP2)
HCG: 128334544(MMP2)
GJA: 107108344(MMP2)
STOW: 125443647(MMP2)
EMC: 129343948(MMP2)
XLA: 380389(mmp2.S)
XTR: 548506(mmp2)
NPR: 108797889(MMP2)
RTEM: 120917452(MMP2)
BBUF: 120980275(MMP2)
BGAR: 122920492(MMP2)
MUO: 115470786(MMP2)
GSH: 117359456(MMP2)
DRE: 337179(mmp2)
SRX: 107713064 107755129
SANH: 107657110(mmp2) 107696695
SGH: 107548946 107563472
CAUA: 113051472 113106043
CGIB: 127961268 128016865
PTET: 122348317(mmp2)
LROH: 127168284(mmp2)
OMC: 131544644(mmp2)
PPRM: 120491030(mmp2)
RKG: 130099619(mmp2)
MAMB: 125264833(mmp2)
CIDE: 127515393
CERY: 137031351(mmp2)
MASI: 127415980 127448392
TROS: 130558457(mmp2)
TDW: 130422583(mmp2)
MANU: 129444626(mmp2)
IPU: 108259638
IFU: 128602888(mmp2)
PHYP: 113540866(mmp2)
SMEO: 124379903(mmp2)
TFD: 113636780(mmp2)
TVC: 132838989(mmp2)
TRN: 134303902(mmp2)
AMEX: 125787173(mmp2)
CMAO: 118817379(mmp2)
EEE: 113590945(mmp2)
CHAR: 105899783(mmp2)
TRU: 653022(mmp2)
TFS: 130516082(mmp2)
TNG: GSTEN00012583G001
LCO: 104926945(mmp2)
NCC: 104964801(mmp2)
TBEN: 117496674(mmp2)
CGOB: 115028668(mmp2)
PGEO: 117440927(mmp2)
GACU: 117549196(mmp2)
EMAC: 134863115(mmp2)
ELY: 117258541(mmp2)
EFO: 125902484(mmp2)
PLEP: 121966899(mmp2)
SLUC: 116037572(mmp2)
ECRA: 117941776(mmp2)
ESP: 116689294(mmp2)
PFLV: 114549991(mmp2)
GAT: 120833716(mmp2)
PPUG: 119197235(mmp2)
AFB: 129099251(mmp2)
CLUM: 117728779(mmp2)
PSWI: 130193110(mmp2)
MSAM: 119890137(mmp2)
SCHU: 122877488(mmp2)
CUD: 121512707(mmp2)
ALAT: 119018443(mmp2)
MZE: 101472680(mmp2)
ONL: 100700606(mmp2)
OAU: 116325529(mmp2)
OLA: 100125419(mmp2)
OML: 112160915(mmp2)
CSAI: 133464007(mmp2)
XMA: 102226344(mmp2)
XCO: 114142975(mmp2)
XHE: 116718543(mmp2)
PRET: 103462668(mmp2)
PFOR: 103138100(mmp2)
PLAI: 106948460(mmp2)
PMEI: 106910952(mmp2)
GAF: 122840701(mmp2)
PPRL: 129364147(mmp2)
CVG: 107095465(mmp2)
CTUL: 119795137(mmp2)
GMU: 124867401(mmp2)
NFU: 107381256(mmp2)
KMR: 108240277(mmp2)
ALIM: 106517245(mmp2)
NWH: 119430131(mmp2)
AOCE: 111577723(mmp2)
MCEP: 125005339(mmp2)
CSEM: 103378988(mmp2)
POV: 109625153(mmp2)
SSEN: 122772468(mmp2)
HHIP: 117757506(mmp2)
HSP: 118106170(mmp2)
PPLT: 128438859(mmp2)
SMAU: 118302030(mmp2)
LCF: 108876984
SDU: 111218486(mmp2)
SLAL: 111649502(mmp2)
XGL: 120801953(mmp2)
HCQ: 109513920(mmp2)
SSCV: 125967271
SBIA: 133498146(mmp2)
PEE: 133397698(mmp2)
PTAO: 133474178(mmp2)
BPEC: 110175240(mmp2)
MALB: 109955873(mmp2)
BSPL: 114852189(mmp2)
SJO: 128358710(mmp2)
SASA: 100194903(mmp2) 106562416(MMP2)
STRU: 115167017 115203309
OTW: 112263861(mmp2)
OMY: 100135793 110526614
OGO: 124033574 124035551
ONE: 115121729(mmp2) 115125488
OKI: 109878791 109880637
OKE: 118376062 118381591
SALP: 112072490 112079849
SNH: 120025036 120039801
CCLU: 121580402(mmp2)
ELS: 105023458(mmp2)
SFM: 108926353 108928317
PKI: 111832721(mmp2) 111858175
AANG: 118215604 118228365
LOC: 102688130(mmp2)
PSPA: 121296334 121325662(mmp2)
ARUT: 117424448 117425416
PSEX: 120535223(mmp2)
LCM: 102350008(MMP2)
CMK: 103176101(mmp2)
RTP: 109921647(mmp2)
CPLA: 122558436(mmp2)
HOC: 132823964(mmp2)
LERI: 129705052(mmp2)
PMRN: 116956003 116956005
LRJ: 133358063(MMP2) 133358065
CIN: 100181993
SCLV: 120333349
LSM: 121128738
 » show all
Reference
PMID:2834383
  Authors
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI
  Title
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
  Journal
J Biol Chem 263:6579-87 (1988)
  Sequence
[hsa:4313]
Reference
PMID:19631700
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
PMID:18060181
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)

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