KEGG   ORTHOLOGY: K01457
Entry
K01457                      KO                                     

Name
atzF
Definition
allophanate hydrolase [EC:3.5.1.54]
Pathway
ko00220  Arginine biosynthesis
ko00791  Atrazine degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K01457  atzF; allophanate hydrolase
  09111 Xenobiotics biodegradation and metabolism
   00791 Atrazine degradation
    K01457  atzF; allophanate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.54  allophanate hydrolase
     K01457  atzF; allophanate hydrolase
Other DBs
RN: R00005
COG: COG0154
GO: 0004039
Genes
SEX: STBHUCCB_p2250
ENC: ECL_02193
ENL: A3UG_10155
ECLG: EC036_19680
ECLI: ECNIH5_22675
ECLA: ECNIH3_22195
EEC: EcWSU1_02003(gatA)
ELG: BH714_06310
EAS: Entas_1996
ENF: AKI40_2314
ESA: ESA_01767
CSK: ES15_1949
CTU: CTU_21870
KVA: Kvar_2573
KPE: KPK_2627(atzF)
KOX: KOX_20290
KOE: A225_2925
RAO: DSD31_13105(atzF)
RTG: NCTC13098_03736(gatA_1)
REE: electrica_02560(atzF)
CLAP: NCTC11466_02329(gatA_2)
KIE: NCTC12125_02717(gatA_2)
LEI: C2U54_15655(atzF)
LEE: DVA44_12680(atzF)
LER: GNG29_10500(atzF)
LEA: GNG26_10630(atzF)
BUF: D8682_02580(atzF)
AHN: NCTC12129_02474(gatA_1) NCTC12129_02475(gatA_2)
IZH: FEM41_17110(atzF)
EBF: D782_1860
EBC: C2U52_27945(atzF)
EBU: CUC76_02425(atzF)
PSTS: E05_21380
SMAR: SM39_0851
SPE: Spro_1418
SRL: SOD_c13040(atzF)
SPLY: Q5A_007110(atzF)
SMAF: D781_1327
SERF: L085_21510
SERA: Ser39006_007510(atzF)
SERQ: CWC46_07505(atzF)
SERM: CLM71_06500(atzF)
SQU: E4343_09065(atzF)
SFJ: SAMEA4384070_1467(gatA_2)
SOF: NCTC11214_05515(gatA_2)
RAA: Q7S_00370
ECA: ECA2141
PATR: EV46_10245
PATO: GZ59_24230
PCT: PC1_2164
PEC: W5S_2477
PPUJ: E2566_11350(atzF)
DFN: CVE23_17460(atzF)
DDQ: DDI_3235
DAQ: DAQ1742_03490(atzF)
DIC: Dpoa569_003026(atzF)
BRB: EH207_01615(atzF)
BNG: EH206_10075(atzF)
ETA: ETA_06890
EBI: EbC_06400
EGE: EM595_0657(atzF)
EPE: CI789_15265(atzF)
ERWI: GN242_17980(atzF)
PLF: PANA5342_3668(uahA)
PVA: Pvag_0053(uaha3)
PAGG: AL522_07250(atzF)
PSTW: DSJ_05900
PANS: FCN45_03070(atzF)
PEY: EE896_16310(atzF)
PDZ: HHA33_19485(atzF)
XAC: XAC4327(uahA)
XCI: XCAW_04699(gatA)
XPH: XppCFBP6546_12170(XppCFBP6546P_12170)
PSUW: WQ53_06105
PSD: DSC_01220
VAS: GT360_15585(atzF)
PMY: Pmen_0704
PMK: MDS_0789
PPSE: BN5_0595
PCQ: PcP3B5_39100(atzF)
PAMG: BKM19_008735(atzF)
PAVL: BKM03_07635(atzF) BKM03_23020(atzF)
PVD: CFBP1590__1310(atzF) CFBP1590__4583(atzF)
PMAN: OU5_2034
PSA: PST_2005
PLUL: FOB45_03030(atzF) FOB45_19205(atzF)
PKC: PKB_4202(DUR1)
PSES: PSCI_4771
PANR: A7J50_1569
PSET: THL1_5144
PSIL: PMA3_22625
PSED: DM292_09410(atzF)
ABY: ABAYE2422
ABN: AB57_1472
ABB: ABBFA_02215(atzF)
ABX: ABK1_1736
ABZ: ABZJ_01447(atzF)
ABH: M3Q_1659
ABAD: ABD1_13110
ABAZ: P795_10995
ABAU: IX87_04005
ASJ: AsACE_CH01428(atzF)
ADV: DJ533_13280(atzF)
ARJ: DOM24_03850(atzF)
AWU: BEN71_13110(atzF)
ACUM: C9E88_006630(atzF)
AGU: AS4_18550
AUG: URS_1953
ALW: FOB21_01785(atzF)
ADS: FPL17_04765(atzF)
MAD: HP15_2883
MARA: D0851_07775(atzF)
SALM: D0Y50_18905(atzF)
CJA: CJA_1244
CEK: D0B88_08830(atzF)
CEG: D0C16_22010(atzF)
SDE: Sde_1128
TTU: TERTU_3486(atzF)
MII: BTJ40_07685(atzF)
METL: U737_10840(atzF)
MPSY: CEK71_06110(atzF)
MMAI: sS8_4044
TCX: Tcr_1793
HTR: EPV75_09640(atzF)
THIG: FE785_04420(atzF)
HHA: Hhal_2362
TGR: Tgr7_3090
HAM: HALO3023
HHH: CLM76_17335(atzF)
HAF: C8233_04080(atzF)
ABO: ABO_2506
ADI: B5T_00741
AXE: P40_03485
KAK: Kalk_13745(atzF)
TOL: TOL_3578
BSAN: CHH28_05040(atzF)
BMAR: HF888_06895(atzF)
TAU: Tola_2898
SOK: D0B54_13695(atzF)
ACII: C4901_07815(atzF)
SALN: SALB1_0444
CGD: CR3_3919
BVE: AK36_5071(atzF)
BCJ: BCAS0273
BCEN: DM39_3455(atzF)
BCEW: DM40_5321(atzF)
BCEO: I35_7287
BCED: DM42_6768(atzF)
BDL: AK34_5499(atzF)
BCON: NL30_04575
BLAT: WK25_17275
BTEI: WS51_26370
BSEM: WJ12_17610
BPSL: WS57_06395
BMEC: WJ16_26385
BSTG: WT74_18120
BGO: BM43_112(atzF)
BUK: MYA_5127
BXB: DR64_6673(atzF) DR64_6690(atzF)
BPH: Bphy_3980
BFN: OI25_3648(atzF) OI25_7103(atzF)
PARB: CJU94_22270(atzF) CJU94_22355(atzF)
PHS: C2L64_19375(atzF)
PTER: C2L65_17250(atzF)
PGP: CUJ91_24580(atzF)
PCJ: CUJ87_29350(atzF)
PTS: CUJ90_03350(atzF)
PMEG: FNZ07_17710(atzF)
PAPI: SG18_19930
PLG: NCTC10937_01302(gatA_2)
BPT: Bpet0294(uahA)
BAV: BAV0804
BHO: D560_2863(atzF)
BHM: D558_2841(atzF)
BHZ: ACR54_01300(atzF)
AXY: AXYL_05233(atzF)
AXX: ERS451415_05059(gatA_8)
ASW: CVS48_12660(atzF)
ACHR: C2U31_28915(atzF)
ACHB: DVB37_22045(atzF)
ODI: ODI_R0885
PACR: FXN63_05835(atzF)
KGY: EHF36_12860(atzF)
PNA: Pnap_0035
POS: DT070_08280(atzF)
POO: F7R28_01140(atzF)
VEI: Veis_0832
VAM: C4F17_17475(atzF)
CTES: O987_22570
HYR: BSY239_964(atzF)
HYB: Q5W_18995
HPSE: HPF_00275(atzF2)
CBAA: SRAA_0220
MPT: Mpe_A0773
METP: C1M51_12985(atzF)
MMS: mma_3078(uahA)
HEE: hmeg3_06765(atzF)
HHF: E2K99_07100(atzF) E2K99_23520(atzF)
MUM: FCL38_08380(atzF)
LCH: Lcho_3031
THI: THI_3695
XYK: GT347_08300(atzF)
NLC: EBAPG3_006865(atzF)
MEH: M301_2217
MEP: MPQ_0993(gatA)
SLT: Slit_0081
GCA: Galf_0782
OTR: OTERR_09820(atzF)
DAR: Daro_0075
ACOM: CEW83_09345(atzF) CEW83_17195(atzF)
AZR: CJ010_24890(atzF)
WSU: WS1118(gatA)
AELL: AELL_1776
HEBR: AEBR_2021
ARC: ABLL_1819
SMUL: SMUL_2949
SHAL: SHALO_2738
SULJ: SJPD1_2632
SULT: FA592_05950(atzF)
MLO: mlr7070
NIY: FQ775_18970(atzF)
PLA: Plav_1893
RBS: RHODOSMS8_03365(atzF)
SFD: USDA257_c27410(gatA1)
ARA: Arad_10039(atzF) Arad_9881(atzF)
AVI: Avi_5649
AGC: BSY240_4746(atzF)
ALF: CFBP5473_16415(atzF)
RLG: Rleg_6104
RJG: CCGE525_31085(atzF)
RHR: CKA34_26525(atzF) CKA34_31170(atzF)
RGR: FZ934_06685(atzF)
RAD: CO657_33640(atzF)
BJA: bll1044
BRA: BRADO6814
AOL: S58_06490
BRK: CWS35_10045(atzF)
BOT: CIT37_09080(atzF)
BGQ: X265_34815(atzF)
BGZ: XH91_12440(atzF) XH91_33180(atzF)
BBET: F8237_13165(atzF)
RPC: RPC_1134
RPD: RPD_3802
RPE: RPE_1220
BOS: BSY19_3609(atzF)
BOF: FQV39_02780(atzF)
VGO: GJW-30_1_01656(atzF)
XAU: Xaut_4705
AZC: AZC_1523
SNO: Snov_3775
ANC: GBB76_12555(atzF)
APRA: G3A50_19730(atzF)
MEX: Mext_3721
MPO: Mpop_3899
MET: M446_3691
MOR: MOC_0456(atzF)
META: Y590_18470
MAQU: Maq22A_1p30070(gatA)
METD: C0214_24160(atzF)
METI: DK427_16785(atzF)
MMES: MMSR116_15635(atzF)
MSL: Msil_2607
MTUN: MTUNDRAET4_3061(atzF)
BBAR: RHAL1_02930(atzF)
PHL: KKY_843
DEI: C4375_10420(atzF)
BVR: BVIR_3167
BLAG: BLTE_06240
PLEO: OHA_1_04343(atzF) OHA_2_00069(atzF)
BRN: D1F64_10720(atzF)
HDI: HDIA_3341(atzF_1)
METG: HT051_05220(atzF)
RBM: TEF_15415
CCR: CC_1830
CAK: Caul_4450
RSP: RSP_3449
RLI: RLO149_c040170(atzF)
LABT: FIU93_19470(atzF)
LVS: LOKVESSMR4R_03018(atzF)
SAGU: CDO87_13225(atzF)
TAW: EI545_12460(atzF)
SALO: EF888_06020(atzF)
PPRU: FDP22_05810(atzF)
FAQ: G5B39_16905(atzF)
NAR: Saro_0605
NOV: TQ38_016735(atzF)
NOT: C7W88_10840(atzF)
NTD: EGO55_03485(atzF)
NOR: FA702_18560(atzF)
SPMI: K663_03325
SUFL: FIL70_22745(atzF)
SPHY: CHN51_14500(atzF)
BLAS: BSY18_2817(atzF)
EFV: CHH26_15250(atzF)
ALB: AEB_P3083
PHZ: CHX26_13140(atzF)
POT: E2E27_08300(atzF)
GOH: B932_3134
ACR: Acry_2726
KRE: GWK63_09720(atzF)
APK: APA386B_219(atzF)
ASZ: ASN_560(atzF)
APOM: CPF11_00700(atzF)
ATO: CIW82_09550(atzF)
ACET: DS739_06965(atzF)
SHUM: STHU_04720
RRU: Rru_A1505
MGRY: MSR1_01210(atzF)
AZL: AZL_a09070(gatA) AZL_b03880(gatA)
TMO: TMO_1197
MAGQ: MGMAQ_0576
NCB: C0V82_20995(atzF) C0V82_24165(atzF)
FER: FNB15_10000(atzF)
BMD: BMD_0981(atzF)
BMEG: BG04_3269(atzF)
BAG: Bcoa_0868
BACQ: DOE78_20235(atzF)
PPOL: X809_33795
PMW: B2K_03795
PDH: B9T62_31030(atzF)
PALB: EJC50_20935(atzF)
SACA: FFV09_11630(atzF)
AAC: Aaci_0767
AAD: TC41_0745
CTYK: CTK_C20910
RIX: RO1_30990
RIM: ROI_33670
SGY: Sgly_0808
MJL: Mjls_1822
MFJ: MFLOJ_05010(atzF)
MGRO: FZ046_15420(atzF)
MSM: MSMEG_2189(atzF)
MVQ: MYVA_0190(atzF)
MTHN: 4412656_02192(gatA_2)
MHAS: MHAS_01264(atzF)
MAB: MAB_1558c
MABB: MASS_1653
MCHE: BB28_08515
MSTE: MSTE_01559
MSAL: DSM43276_01421(atzF)
ASD: AS9A_0596
CEF: CE0710
NFA: NFA_22180
NFR: ERS450000_01879(gatA_2)
NOZ: DMB37_22760(atzF)
NOD: FOH10_00885(atzF)
RER: RER_15450
REY: O5Y_07340
ROP: ROP_18540
REQ: REQ_15710
RFA: A3L23_01648(atzF)
RHS: A3Q41_01706(atzF)
RRZ: CS378_09315(atzF)
RHU: A3Q40_01990(atzF)
RQI: C1M55_07820(atzF)
RRT: 4535765_03781(gatA_7)
RBY: CEJ39_20695(atzF)
GBR: Gbro_3887
GRU: GCWB2_19600(atzF)
GOM: D7316_00134(atzF_1) D7316_04837(atzF_2)
TPR: Tpau_1595
SRT: Srot_2307
DIT: C3V38_06980(atzF)
DIZ: CT688_00505(atzF)
SBH: SBI_01437
SHY: SHJG_1245
SALS: SLNWT_1829
SGE: DWG14_06846(atzF)
SDX: C4B68_32545(atzF)
KSK: KSE_50740
CMI: CMM_2824
CMS: CMS2365
CMC: CMN_02370
GRY: D7I44_06735(atzF)
ART: Arth_3670
ARN: CGK93_01130(atzF)
ARTH: C3B78_01320(atzF)
AAU: AAur_0186(atzF)
PSNI: NIBR502771_03895(atzF)
IDO: I598_2367(atzF)
CFL: Cfla_0711
CELH: GXP71_19670(atzF)
RAIN: Rai3103_05040(atzF)
ACTW: F7P10_17140(atzF)
FAL: FRAAL6407
NML: Namu_2026
KRA: Krad_0905
SACC: EYD13_13990(atzF)
AMD: AMED_2634(amiE)
AMN: RAM_13385
AMM: AMES_2606(amiE)
AMZ: B737_2607(amiE)
AMYY: YIM_35735(atzF2)
PSEH: XF36_01005
ALO: CRK57360
MICH: FJK98_13835(atzF)
ASE: ACPL_6107
AFS: AFR_34350
ACTS: ACWT_5975
CAI: Caci_3729
GVI: glr0961
GLJ: GKIL_0053(gatA)
VBH: CMV30_15915(atzF)
CAA: Caka_2068
ROO: G5S37_06905(atzF)
LUO: HHL09_03755(atzF)
VBS: EGM51_16875(atzF)
VBC: C5Q97_20565(atzF)
NAX: HC341_02810(atzF) HC341_03815(atzF)
AG: AAK50333(atzF)
 » show all
Reference
  Authors
Shapir N, Sadowsky MJ, Wackett LP
  Title
Purification and characterization of allophanate hydrolase (AtzF) from Pseudomonas sp. strain ADP.
  Journal
J Bacteriol 187:3731-8 (2005)
DOI:10.1128/JB.187.11.3731-3738.2005
  Sequence
Reference
  Authors
Kanamori T, Kanou N, Kusakabe S, Atomi H, Imanaka T
  Title
Allophanate hydrolase of Oleomonas sagaranensis involved in an ATP-dependent degradation pathway specific to urea.
  Journal
FEMS Microbiol Lett 245:61-5 (2005)
DOI:10.1016/j.femsle.2005.02.023

KEGG   ORTHOLOGY: K14541
Entry
K14541                      KO                                     

Name
DUR1
Definition
urea carboxylase / allophanate hydrolase [EC:6.3.4.6 3.5.1.54]
Pathway
ko00220  Arginine biosynthesis
ko00791  Atrazine degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K14541  DUR1; urea carboxylase / allophanate hydrolase
  09111 Xenobiotics biodegradation and metabolism
   00791 Atrazine degradation
    K14541  DUR1; urea carboxylase / allophanate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.54  allophanate hydrolase
     K14541  DUR1; urea carboxylase / allophanate hydrolase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.6  urea carboxylase
     K14541  DUR1; urea carboxylase / allophanate hydrolase
Other DBs
RN: R00005 R00774
COG: COG0154 COG0439 COG1984
GO: 0004847 0004039
Genes
SCE: YBR208C(DUR1)
AGO: AGOS_ADR051C
ERC: Ecym_1184
KLA: KLLA0_E08119g
KMX: KLMA_40362(DUR1)
LTH: KLTH0E12078g
VPO: Kpol_299p2
ZRO: ZYRO0F08976g
CGR: CAGL0M05533g
NCS: NCAS_0B02280(NCAS0B02280)
NDI: NDAI_0C05400(NDAI0C05400)
TPF: TPHA_0L01560(TPHA0L01560)
TDL: TDEL_0B03290(TDEL0B03290)
PIC: PICST_28452(DUR1)
CAL: CAALFM_C104660WA(DUR1)
SLB: AWJ20_5191(DUR1)
SMIN: v1.2.013193.t1(symbB.v1.2.013193.t1) v1.2.013193.t2(symbB.v1.2.013193.t2)
 » show all
Reference
PMID:3025621
  Authors
Genbauffe FS, Cooper TG
  Title
Induction and repression of the urea amidolyase gene in Saccharomyces cerevisiae.
  Journal
Mol Cell Biol 6:3954-64 (1986)
DOI:10.1128/MCB.6.11.3954
Reference
PMID:1802034
  Authors
Genbauffe FS, Cooper TG
  Title
The urea amidolyase (DUR1,2) gene of Saccharomyces cerevisiae.
  Journal
DNA Seq 2:19-32 (1991)
DOI:10.3109/10425179109008435
  Sequence
[sce:YBR208C]

KEGG   ENZYME: 3.5.1.54
Entry
EC 3.5.1.54                 Enzyme                                 

Name
allophanate hydrolase;
allophanate lyase;
AtzF;
TrzF
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
urea-1-carboxylate amidohydrolase
Reaction(IUBMB)
urea-1-carboxylate + H2O = 2 CO2 + 2 NH3 [RN:R00005]
Reaction(KEGG)
R00005
Substrate
urea-1-carboxylate [CPD:C01010];
H2O [CPD:C00001]
Product
CO2 [CPD:C00011];
NH3 [CPD:C00014]
Comment
Along with EC 3.5.2.15 (cyanuric acid amidohydrolase) and EC 3.5.1.84 (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6, urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate [6].
History
EC 3.5.1.54 created 1986, modified 2008
Pathway
ec00220  Arginine biosynthesis
ec00791  Atrazine degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01457  allophanate hydrolase
K14541  urea carboxylase / allophanate hydrolase
Genes
SCE: YBR208C(DUR1)
AGO: AGOS_ADR051C
ERC: Ecym_1184
KLA: KLLA0_E08119g
KMX: KLMA_40362(DUR1)
LTH: KLTH0E12078g
VPO: Kpol_299p2
ZRO: ZYRO0F08976g
CGR: CAGL0M05533g
NCS: NCAS_0B02280(NCAS0B02280)
NDI: NDAI_0C05400(NDAI0C05400)
TPF: TPHA_0L01560(TPHA0L01560)
TDL: TDEL_0B03290(TDEL0B03290)
PIC: PICST_28452(DUR1)
CAL: CAALFM_C104660WA(DUR1)
SLB: AWJ20_5191(DUR1)
SMIN: v1.2.013193.t1(symbB.v1.2.013193.t1) v1.2.013193.t2(symbB.v1.2.013193.t2)
ENC: ECL_02193
EEC: EcWSU1_02003(gatA)
ESA: ESA_01767
CSK: ES15_1949
CTU: CTU_21870
KVA: Kvar_2573
KPE: KPK_2627(atzF)
KOX: KOX_20290
KOE: A225_2925
RAO: DSD31_13105(atzF)
RTG: NCTC13098_03736(gatA_1)
REE: electrica_02560(atzF)
CLAP: NCTC11466_02329(gatA_2)
KIE: NCTC12125_02717(gatA_2)
LEI: C2U54_15655(atzF)
LEE: DVA44_12680(atzF)
LER: GNG29_10500(atzF)
LEA: GNG26_10630(atzF)
BUF: D8682_02580(atzF)
AHN: NCTC12129_02474(gatA_1) NCTC12129_02475(gatA_2)
IZH: FEM41_17110(atzF)
EBF: D782_1860
EBC: C2U52_27945(atzF)
EBU: CUC76_02425(atzF)
PSTS: E05_21380
SMAR: SM39_0851
SPE: Spro_1418
SRL: SOD_c13040(atzF)
SPLY: Q5A_007110(atzF)
SMAF: D781_1327
SERF: L085_21510
SERA: Ser39006_007510(atzF)
SERQ: CWC46_07505(atzF)
SERM: CLM71_06500(atzF)
SQU: E4343_09065(atzF)
SFJ: SAMEA4384070_1467(gatA_2)
SOF: NCTC11214_05515(gatA_2)
RAA: Q7S_00370
ECA: ECA2141
PATR: EV46_10245
PATO: GZ59_24230
PCT: PC1_2164
PEC: W5S_2477
PPUJ: E2566_11350(atzF)
DFN: CVE23_17460(atzF)
DDQ: DDI_3235
DAQ: DAQ1742_03490(atzF)
DIC: Dpoa569_003026(atzF)
BRB: EH207_01615(atzF)
BNG: EH206_10075(atzF)
ETA: ETA_06890
EBI: EbC_06400
EGE: EM595_0657(atzF)
EPE: CI789_15265(atzF)
ERWI: GN242_17980(atzF)
PLF: PANA5342_3668(uahA)
PVA: Pvag_0053(uaha3)
PAGG: AL522_07250(atzF)
PSTW: DSJ_05900
PANS: FCN45_03070(atzF)
PEY: EE896_16310(atzF)
PDZ: HHA33_19485(atzF)
XAC: XAC4327(uahA)
XCI: XCAW_04699(gatA)
XPH: XppCFBP6546_12170(XppCFBP6546P_12170)
PSUW: WQ53_06105
PSD: DSC_01220
VAS: GT360_15585(atzF)
PMY: Pmen_0704
PMK: MDS_0789
PPSE: BN5_0595
PCQ: PcP3B5_39100(atzF)
PAMG: BKM19_008735(atzF)
PAVL: BKM03_07635(atzF) BKM03_23020(atzF)
PVD: CFBP1590__1310(atzF) CFBP1590__4583(atzF)
PMAN: OU5_2034
PSA: PST_2005
PLUL: FOB45_03030(atzF) FOB45_19205(atzF)
PKC: PKB_4202(DUR1)
PSES: PSCI_4771
PANR: A7J50_1569
PSET: THL1_5144
PSIL: PMA3_22625
PSED: DM292_09410(atzF)
ABY: ABAYE2422
ABN: AB57_1472
ABB: ABBFA_02215(atzF)
ABX: ABK1_1736
ABZ: ABZJ_01447(atzF)
ABH: M3Q_1659
ABAD: ABD1_13110
ABAZ: P795_10995
ABAU: IX87_04005
ASJ: AsACE_CH01428(atzF)
ADV: DJ533_13280(atzF)
ARJ: DOM24_03850(atzF)
AWU: BEN71_13110(atzF)
ACUM: C9E88_006630(atzF)
AGU: AS4_18550
AUG: URS_1953
ALW: FOB21_01785(atzF)
ADS: FPL17_04765(atzF)
MAD: HP15_2883
MARA: D0851_07775(atzF)
SALM: D0Y50_18905(atzF)
CJA: CJA_1244
CEK: D0B88_08830(atzF)
CEG: D0C16_22010(atzF)
SDE: Sde_1128
TTU: TERTU_3486(atzF)
MII: BTJ40_07685(atzF)
METL: U737_10840(atzF)
MPSY: CEK71_06110(atzF)
MMAI: sS8_4044
TCX: Tcr_1793
HTR: EPV75_09640(atzF)
THIG: FE785_04420(atzF)
HHA: Hhal_2362
TGR: Tgr7_3090
HAM: HALO3023
HHH: CLM76_17335(atzF)
HAF: C8233_04080(atzF)
ABO: ABO_2506
ADI: B5T_00741
AXE: P40_03485
KAK: Kalk_13745(atzF)
TOL: TOL_3578
BSAN: CHH28_05040(atzF)
BMAR: HF888_06895(atzF)
TAU: Tola_2898
SOK: D0B54_13695(atzF)
ACII: C4901_07815(atzF)
SALN: SALB1_0444
CGD: CR3_3919
BVE: AK36_5071(atzF)
BCJ: BCAS0273
BCEN: DM39_3455(atzF)
BCEW: DM40_5321(atzF)
BCEO: I35_7287
BCED: DM42_6768(atzF)
BDL: AK34_5499(atzF)
BCON: NL30_04575
BLAT: WK25_17275
BTEI: WS51_26370
BSEM: WJ12_17610
BPSL: WS57_06395
BMEC: WJ16_26385
BSTG: WT74_18120
BGO: BM43_112(atzF)
BUK: MYA_5127
BXB: DR64_6673(atzF) DR64_6690(atzF)
BPH: Bphy_3980
BFN: OI25_3648(atzF) OI25_7103(atzF)
PARB: CJU94_22270(atzF) CJU94_22355(atzF)
PHS: C2L64_19375(atzF)
PTER: C2L65_17250(atzF)
PGP: CUJ91_24580(atzF)
PCJ: CUJ87_29350(atzF)
PTS: CUJ90_03350(atzF)
PMEG: FNZ07_17710(atzF)
PAPI: SG18_19930
PLG: NCTC10937_01302(gatA_2)
BPT: Bpet0294(uahA)
BAV: BAV0804
BHO: D560_2863(atzF)
BHM: D558_2841(atzF)
BHZ: ACR54_01300(atzF)
AXY: AXYL_05233(atzF)
AXX: ERS451415_05059(gatA_8)
ASW: CVS48_12660(atzF)
ACHR: C2U31_28915(atzF)
ACHB: DVB37_22045(atzF)
ODI: ODI_R0885
PACR: FXN63_05835(atzF)
KGY: EHF36_12860(atzF)
PNA: Pnap_0035
POS: DT070_08280(atzF)
POO: F7R28_01140(atzF)
VEI: Veis_0832
VAM: C4F17_17475(atzF)
CTES: O987_22570
HYR: BSY239_964(atzF)
HYB: Q5W_18995
HPSE: HPF_00275(atzF2)
CBAA: SRAA_0220
MPT: Mpe_A0773
METP: C1M51_12985(atzF)
MMS: mma_3078(uahA)
HEE: hmeg3_06765(atzF)
HHF: E2K99_07100(atzF) E2K99_23520(atzF)
MUM: FCL38_08380(atzF)
LCH: Lcho_3031
THI: THI_3695
XYK: GT347_08300(atzF)
NLC: EBAPG3_006865(atzF)
MEH: M301_2217
MEP: MPQ_0993(gatA)
SLT: Slit_0081
GCA: Galf_0782
OTR: OTERR_09820(atzF)
DAR: Daro_0075
ACOM: CEW83_09345(atzF) CEW83_17195(atzF)
AZR: CJ010_24890(atzF)
WSU: WS1118(gatA)
AELL: AELL_1776
HEBR: AEBR_2021
ARC: ABLL_1819
SMUL: SMUL_2949
SHAL: SHALO_2738
SULJ: SJPD1_2632
SULT: FA592_05950(atzF)
MLO: mlr7070
NIY: FQ775_18970(atzF)
PLA: Plav_1893
RBS: RHODOSMS8_03365(atzF)
SFD: USDA257_c27410(gatA1)
ARA: Arad_10039(atzF) Arad_9881(atzF)
AVI: Avi_5649
AGC: BSY240_4746(atzF)
ALF: CFBP5473_16415(atzF)
RLG: Rleg_6104
RJG: CCGE525_31085(atzF)
RHR: CKA34_26525(atzF) CKA34_31170(atzF)
RGR: FZ934_06685(atzF)
RAD: CO657_33640(atzF)
BJA: bll1044
BRA: BRADO6814
AOL: S58_06490
BRK: CWS35_10045(atzF)
BOT: CIT37_09080(atzF)
BGQ: X265_34815(atzF)
BGZ: XH91_12440(atzF) XH91_33180(atzF)
BBET: F8237_13165(atzF)
RPC: RPC_1134
RPD: RPD_3802
RPE: RPE_1220
BOS: BSY19_3609(atzF)
BOF: FQV39_02780(atzF)
VGO: GJW-30_1_01656(atzF)
XAU: Xaut_4705
AZC: AZC_1523
SNO: Snov_3775
ANC: GBB76_12555(atzF)
APRA: G3A50_19730(atzF)
MEX: Mext_3721
MPO: Mpop_3899
MET: M446_3691
MOR: MOC_0456(atzF)
META: Y590_18470
MAQU: Maq22A_1p30070(gatA)
METD: C0214_24160(atzF)
METI: DK427_16785(atzF)
MMES: MMSR116_15635(atzF)
MSL: Msil_2607
MTUN: MTUNDRAET4_3061(atzF)
BBAR: RHAL1_02930(atzF)
PHL: KKY_843
DEI: C4375_10420(atzF)
BVR: BVIR_3167
BLAG: BLTE_06240
PLEO: OHA_1_04343(atzF) OHA_2_00069(atzF)
BRN: D1F64_10720(atzF)
HDI: HDIA_3341(atzF_1)
METG: HT051_05220(atzF)
RBM: TEF_15415
CCR: CC_1830
CAK: Caul_4450
RSP: RSP_3449
RLI: RLO149_c040170(atzF)
LABT: FIU93_19470(atzF)
LVS: LOKVESSMR4R_03018(atzF)
SAGU: CDO87_13225(atzF)
TAW: EI545_12460(atzF)
SALO: EF888_06020(atzF)
PPRU: FDP22_05810(atzF)
FAQ: G5B39_16905(atzF)
NAR: Saro_0605
NOV: TQ38_016735(atzF)
NOT: C7W88_10840(atzF)
NTD: EGO55_03485(atzF)
NOR: FA702_18560(atzF)
SPMI: K663_03325
SUFL: FIL70_22745(atzF)
SPHY: CHN51_14500(atzF)
BLAS: BSY18_2817(atzF)
EFV: CHH26_15250(atzF)
ALB: AEB_P3083
PHZ: CHX26_13140(atzF)
POT: E2E27_08300(atzF)
GOH: B932_3134
ACR: Acry_2726
KRE: GWK63_09720(atzF)
APK: APA386B_219(atzF)
ASZ: ASN_560(atzF)
APOM: CPF11_00700(atzF)
ATO: CIW82_09550(atzF)
ACET: DS739_06965(atzF)
SHUM: STHU_04720
RRU: Rru_A1505
MGRY: MSR1_01210(atzF)
AZL: AZL_a09070(gatA) AZL_b03880(gatA)
TMO: TMO_1197
MAGQ: MGMAQ_0576
NCB: C0V82_20995(atzF) C0V82_24165(atzF)
FER: FNB15_10000(atzF)
BMD: BMD_0981(atzF)
BMEG: BG04_3269(atzF)
BAG: Bcoa_0868
BACQ: DOE78_20235(atzF)
PPOL: X809_33795
PMW: B2K_03795
PDH: B9T62_31030(atzF)
PALB: EJC50_20935(atzF)
SACA: FFV09_11630(atzF)
AAC: Aaci_0767
AAD: TC41_0745
CTYK: CTK_C20910
RIX: RO1_30990
RIM: ROI_33670
SGY: Sgly_0808
MJL: Mjls_1822
MFJ: MFLOJ_05010(atzF)
MGRO: FZ046_15420(atzF)
MSM: MSMEG_2189(atzF)
MVQ: MYVA_0190(atzF)
MTHN: 4412656_02192(gatA_2)
MHAS: MHAS_01264(atzF)
MAB: MAB_1558c
MABB: MASS_1653
MCHE: BB28_08515
MSTE: MSTE_01559
MSAL: DSM43276_01421(atzF)
ASD: AS9A_0596
CEF: CE0710
NFA: NFA_22180
NFR: ERS450000_01879(gatA_2)
NOZ: DMB37_22760(atzF)
NOD: FOH10_00885(atzF)
RER: RER_15450
REY: O5Y_07340
ROP: ROP_18540
REQ: REQ_15710
RFA: A3L23_01648(atzF)
RHS: A3Q41_01706(atzF)
RRZ: CS378_09315(atzF)
RHU: A3Q40_01990(atzF)
RQI: C1M55_07820(atzF)
RRT: 4535765_03781(gatA_7)
RBY: CEJ39_20695(atzF)
GBR: Gbro_3887
GRU: GCWB2_19600(atzF)
GOM: D7316_00134(atzF_1) D7316_04837(atzF_2)
TPR: Tpau_1595
SRT: Srot_2307
DIT: C3V38_06980(atzF)
DIZ: CT688_00505(atzF)
SBH: SBI_01437
SHY: SHJG_1245
SALS: SLNWT_1829
SGE: DWG14_06846(atzF)
SDX: C4B68_32545(atzF)
KSK: KSE_50740
CMI: CMM_2824
CMS: CMS2365
CMC: CMN_02370
GRY: D7I44_06735(atzF)
ART: Arth_3670
ARN: CGK93_01130(atzF)
ARTH: C3B78_01320(atzF)
AAU: AAur_0186(atzF)
PSNI: NIBR502771_03895(atzF)
IDO: I598_2367(atzF)
CFL: Cfla_0711
CELH: GXP71_19670(atzF)
RAIN: Rai3103_05040(atzF)
ACTW: F7P10_17140(atzF)
FAL: FRAAL6407
NML: Namu_2026
KRA: Krad_0905
SACC: EYD13_13990(atzF)
AMD: AMED_2634(amiE)
AMN: RAM_13385
AMM: AMES_2606(amiE)
AMZ: B737_2607(amiE)
AMYY: YIM_35735(atzF2)
PSEH: XF36_01005
ALO: CRK57360
MICH: FJK98_13835(atzF)
ASE: ACPL_6107
AFS: AFR_34350
ACTS: ACWT_5975
CAI: Caci_3729
GVI: glr0961
GLJ: GKIL_0053(gatA)
VBH: CMV30_15915(atzF)
CAA: Caka_2068
ROO: G5S37_06905(atzF)
LUO: HHL09_03755(atzF)
VBS: EGM51_16875(atzF)
VBC: C5Q97_20565(atzF)
NAX: HC341_02810(atzF) HC341_03815(atzF)
 » show all
Reference
1
  Authors
Maitz, G.S., Haas, E.M. and Castric, P.A.
  Title
Purification and properties of the allophanate hydrolase from Chlamydomonas reinhardii.
  Journal
Biochim Biophys Acta 714:486-491 (1982)
Reference
2  [PMID:4556303]
  Authors
Roon RJ, Levenberg B.
  Title
Urea amidolyase. I. Properties of the enzyme from Candida utilis.
  Journal
J Biol Chem 247:4107-13 (1972)
Reference
3  [PMID:6124544]
  Authors
Sumrada RA, Cooper TG.
  Title
Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast.
  Journal
J Biol Chem 257:9119-27 (1982)
Reference
4  [PMID:15796980]
  Authors
Kanamori T, Kanou N, Kusakabe S, Atomi H, Imanaka T.
  Title
Allophanate hydrolase of Oleomonas sagaranensis involved in an ATP-dependent degradation pathway specific to urea.
  Journal
FEMS Microbiol Lett 245:61-5 (2005)
DOI:10.1016/j.femsle.2005.02.023
Reference
5  [PMID:16085834]
  Authors
Cheng G, Shapir N, Sadowsky MJ, Wackett LP.
  Title
Allophanate hydrolase, not urease, functions in bacterial cyanuric acid metabolism.
  Journal
Appl Environ Microbiol 71:4437-45 (2005)
DOI:10.1128/AEM.71.8.4437-4445.2005
Reference
6  [PMID:15901697]
  Authors
Shapir N, Sadowsky MJ, Wackett LP.
  Title
Purification and characterization of allophanate hydrolase (AtzF) from Pseudomonas sp. strain ADP.
  Journal
J Bacteriol 187:3731-8 (2005)
DOI:10.1128/JB.187.11.3731-3738.2005
  Sequence
Reference
7  [PMID:16597948]
  Authors
Shapir N, Cheng G, Sadowsky MJ, Wackett LP.
  Title
Purification and characterization of TrzF: biuret hydrolysis by allophanate hydrolase supports growth.
  Journal
Appl Environ Microbiol 72:2491-5 (2006)
DOI:10.1128/AEM.72.4.2491-2495.2006
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.54
IUBMB Enzyme Nomenclature: 3.5.1.54
ExPASy - ENZYME nomenclature database: 3.5.1.54
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.54
BRENDA, the Enzyme Database: 3.5.1.54
CAS: 9076-72-6

KEGG   REACTION: R00005
Entry
R00005                      Reaction                               

Name
urea-1-carboxylate amidohydrolase
Definition
Urea-1-carboxylate + H2O <=> 2 CO2 + 2 Ammonia
Equation
C01010 + C00001 <=> 2 C00011 + 2 C00014
Comment
The yeast enzyme (but not that from green algae) also catalyses the
reaction of EC 6.3.4.6 urea carboxylase, thus bringing about the
hydrolysis of urea to CO2 and NH3 in the presence of ATP and
bicarbonate.
R00774 (6.3.4.6)
Reaction class
RC02756  C00011_C01010
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn00791  Atrazine degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K01457  allophanate hydrolase [EC:3.5.1.54]
K14541  urea carboxylase / allophanate hydrolase [EC:6.3.4.6 3.5.1.54]
Other DBs
RHEA: 19032

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