KEGG   ORTHOLOGY: K01499
Entry
K01499                      KO                                     

Name
mch
Definition
methenyltetrahydromethanopterin cyclohydrolase [EC:3.5.4.27]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K01499  mch; methenyltetrahydromethanopterin cyclohydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.27  methenyltetrahydromethanopterin cyclohydrolase
     K01499  mch; methenyltetrahydromethanopterin cyclohydrolase
Other DBs
RN: R03464
COG: COG3252
GO: 0018759
Genes
MCA: MCA2863
METU: GNH96_03530(mch)
MMT: Metme_2265
MDN: JT25_019335
MDH: AYM39_08540
MKO: MKLM6_1778
METL: U737_14820
MAH: MEALZ_2425(mch)
MBUR: EQU24_09125
MPSY: CEK71_15610
MMAI: sS8_3394
MEJ: Q7A_44
MEC: Q7C_1772
NHL: Nhal_3876
BXE: Bxe_B2433(mch)
BXB: DR64_4761(mch)
VPD: VAPA_1c31460(mch)
MPT: Mpe_A2609
LCH: Lcho_3150
RGE: RGE_40250(mch)
METR: BSY238_3292(mch)
MFA: Mfla_1658
MMB: Mmol_1344
MEH: M301_1554
MEP: MPQ_1565
MBAC: BN1209_0747(mch)
SPLB: SFPGR_25980(mch)
RGA: RGR602_PC01568(mch)
XAU: Xaut_1788
SNO: Snov_0750
MEA: Mex_1p1763(mch)
MDI: METDI2515(mch)
MEX: Mext_1831
MCH: Mchl_2166
MPO: Mpop_1782
MET: M446_5780
MNO: Mnod_6004
MOR: MOC_0685(mch)
META: Y590_08770
MAQU: Maq22A_c16475(mch)
MSL: Msil_2387
MTUN: MTUNDRAET4_2723(mch)
HDN: Hden_1477
HMC: HYPMC_1627(mch)
FIL: BN1229_v1_0586(mch)
FIY: BN1229_v1_0588(mch)
MSC: BN69_1353
PLEO: OHA_1_01035(mch)
MCG: GL4_1786
HDI: HDIA_2312(mch)
ALI: AZOLI_p10687(mch1) AZOLI_p10889(mch2)
ABS: AZOBR_p270082(mch)
CBT: CLH_1638(mch)
CAP: CLDAP_00590(mch)
RBA: RB6759(mch)
PSL: Psta_3184
PIR: VN12_11975(mch)
RUL: UC8_55600(mch)
MFF: MFFC18_17580(mch)
ROL: CA51_33360(mch)
AHEL: Q31a_62590(mch)
LCRE: Pla8534_46610(mch)
AMUC: Pan181_44380(mch)
PND: Pla175_40180(mch)
PLM: Plim_2586
PEH: Spb1_33570(mch)
PLS: VT03_28970(mch)
PLH: VT85_05465(mch)
FMR: Fuma_00366(mch)
GMR: GmarT_12110(mch)
BVO: Pan97_33090(mch)
MRI: Mal4_29800(mch)
SDYN: Mal52_18780(mch)
PLON: Pla110_19000(mch)
GES: VT84_09780(mch)
GOG: C1280_06325(mch)
LRS: PX52LOC_02773(mch)
FTJ: FTUN_8522
IPA: Isop_0325
SACI: Sinac_1236
PBOR: BSF38_00163(mch)
AGV: OJF2_59280(mch)
MOX: DAMO_0461(mch)
MJA: MJ_1636
MMP: MMP1191(mch)
MMD: GYY_06780
MMAK: MMKA1_13660(mch)
MMAO: MMOS7_12990(mch)
MMAD: MMJJ_16540(mch)
MAE: Maeo_0441
MVO: Mvol_0378
METF: CFE53_06735(mch)
MTH: MTH_773
MMG: MTBMA_c11690(mch)
METC: MTCT_0692
MWO: MWSIV6_1147(mch)
METE: tca_00740(mch)
METK: FVF72_07680(mch)
MTHM: FZP57_05450(mch)
MST: Msp_1238(mch)
MRU: mru_1619(mch)
MSI: Msm_1723
MEB: Abm4_1203(mch)
MMIL: sm9_1330(mch)
MEYE: TL18_04360
MOL: YLM1_1103
METH: MBMB1_0537(mch)
MFC: BRM9_1751(mch)
MFI: DSM1535_2390(mch)
MCUB: MCBB_0462(mch)
METT: CIT01_01545(mch)
METO: CIT02_04240(mch)
MFV: Mfer_0254
MKA: MK0625(mch)
AFU: AF_1935
FPL: Ferp_0606
GAC: GACE_0343
GAH: GAH_01155
MBAR: MSBR2_0727
MBAK: MSBR3_0457
MAC: MA_1710(mch)
MMA: MM_2653
MMAC: MSMAC_1059
METM: MSMTP_2066
MTHR: MSTHT_0435
MTHE: MSTHC_0286
MHOR: MSHOH_2598
MFZ: AOB57_000035(mch)
MBU: Mbur_0653(mch)
MMET: MCMEM_0808
MMH: Mmah_1138
MPY: Mpsy_3012
MZI: HWN40_06075(mch)
MTP: Mthe_0252
MCJ: MCON_1290(mch)
MHI: Mhar_2174
MLA: Mlab_0399
MBG: BN140_0141(mch1) BN140_1778(mch3)
MEMA: MMAB1_2292(mch)
MPI: Mpet_0065
MBN: Mboo_0680
MPL: Mpal_2022
MPD: MCP_1132(mch-1) MCP_1888(mch-2)
MEZ: Mtc_1063(mch-1) Mtc_1978(mch-2)
RCI: LRC191(mch-1) RCIX2742(mch-2)
HAL: VNG_1686G(mch)
HSL: OE_3383R(mch)
HHB: Hhub_3179(mch)
HALH: HTSR_0323
HHSR: HSR6_0309(mch)
HMA: rrnAC1616(mch)
HHI: HAH_2159(mch)
NPH: NP_2634A(mch)
NMO: Nmlp_2018(mch)
HUT: Huta_1145
HTI: HTIA_1038
HMU: Hmuk_1816
HALL: LC1Hm_1117(mch)
HWA: HQ_2798A(mch)
HWC: Hqrw_3170(mch)
HVO: HVO_2573
HME: HFX_2599
HLA: Hlac_1693
HDF: AArcSl_1968(mch)
HTU: Htur_2210
NMG: Nmag_0205(mch)
NAT: NJ7G_2078
SALI: L593_12155
BARC: AOA65_2050(mch)
LOKI: Lokiarch_00580(mch_1) Lokiarch_17800(mch_2)
 » show all
Reference
  Authors
Vorholt JA, Chistoserdova L, Stolyar SM, Thauer RK, Lidstrom ME
  Title
Distribution of tetrahydromethanopterin-dependent enzymes in methylotrophic bacteria and phylogeny of methenyl tetrahydromethanopterin cyclohydrolases.
  Journal
J Bacteriol 181:5750-7 (1999)
DOI:10.1128/JB.181.18.5750-5757.1999
  Sequence
[xau:Xaut_1788]

KEGG   ENZYME: 3.5.4.27
Entry
EC 3.5.4.27                 Enzyme                                 

Name
methenyltetrahydromethanopterin cyclohydrolase;
5,10-methenyltetrahydromethanopterin cyclohydrolase;
N5,N10-methenyltetrahydromethanopterin cyclohydrolase;
methenyl-H4MPT cyclohydrolase;
5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
5,10-methenyltetrahydromethanopterin 10-hydrolase (ring-opening)
Reaction(IUBMB)
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin [RN:R03464]
Reaction(KEGG)
R03464
Substrate
5,10-methenyl-5,6,7,8-tetrahydromethanopterin [CPD:C04330];
H2O [CPD:C00001]
Product
5-formyl-5,6,7,8-tetrahydromethanopterin [CPD:C01274]
Comment
Methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.
History
EC 3.5.4.27 created 1989
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01499  methenyltetrahydromethanopterin cyclohydrolase
Genes
MCA: MCA2863
METU: GNH96_03530(mch)
MMT: Metme_2265
MDN: JT25_019335
MDH: AYM39_08540
MKO: MKLM6_1778
METL: U737_14820
MAH: MEALZ_2425(mch)
MBUR: EQU24_09125
MPSY: CEK71_15610
MMAI: sS8_3394
MEJ: Q7A_44
MEC: Q7C_1772
NHL: Nhal_3876
BXE: Bxe_B2433(mch)
BXB: DR64_4761(mch)
VPD: VAPA_1c31460(mch)
MPT: Mpe_A2609
LCH: Lcho_3150
RGE: RGE_40250(mch)
METR: BSY238_3292(mch)
MFA: Mfla_1658
MMB: Mmol_1344
MEH: M301_1554
MEP: MPQ_1565
MBAC: BN1209_0747(mch)
SPLB: SFPGR_25980(mch)
RGA: RGR602_PC01568(mch)
XAU: Xaut_1788
SNO: Snov_0750
MEA: Mex_1p1763(mch)
MDI: METDI2515(mch)
MEX: Mext_1831
MCH: Mchl_2166
MPO: Mpop_1782
MET: M446_5780
MNO: Mnod_6004
MOR: MOC_0685(mch)
META: Y590_08770
MAQU: Maq22A_c16475(mch)
MSL: Msil_2387
MTUN: MTUNDRAET4_2723(mch)
HDN: Hden_1477
HMC: HYPMC_1627(mch)
FIL: BN1229_v1_0586(mch)
FIY: BN1229_v1_0588(mch)
MSC: BN69_1353
PLEO: OHA_1_01035(mch)
MCG: GL4_1786
HDI: HDIA_2312(mch)
ALI: AZOLI_p10687(mch1) AZOLI_p10889(mch2)
ABS: AZOBR_p270082(mch)
CBT: CLH_1638(mch)
CAP: CLDAP_00590(mch)
RBA: RB6759(mch)
PSL: Psta_3184
PIR: VN12_11975(mch)
RUL: UC8_55600(mch)
MFF: MFFC18_17580(mch)
ROL: CA51_33360(mch)
AHEL: Q31a_62590(mch)
LCRE: Pla8534_46610(mch)
AMUC: Pan181_44380(mch)
PND: Pla175_40180(mch)
PLM: Plim_2586
PEH: Spb1_33570(mch)
PLS: VT03_28970(mch)
PLH: VT85_05465(mch)
FMR: Fuma_00366(mch)
GMR: GmarT_12110(mch)
BVO: Pan97_33090(mch)
MRI: Mal4_29800(mch)
SDYN: Mal52_18780(mch)
PLON: Pla110_19000(mch)
GES: VT84_09780(mch)
GOG: C1280_06325(mch)
LRS: PX52LOC_02773(mch)
FTJ: FTUN_8522
IPA: Isop_0325
SACI: Sinac_1236
PBOR: BSF38_00163(mch)
AGV: OJF2_59280(mch)
MOX: DAMO_0461(mch)
MJA: MJ_1636
MMP: MMP1191(mch)
MMD: GYY_06780
MMAK: MMKA1_13660(mch)
MMAO: MMOS7_12990(mch)
MMAD: MMJJ_16540(mch)
MAE: Maeo_0441
MVO: Mvol_0378
METF: CFE53_06735(mch)
MTH: MTH_773
MMG: MTBMA_c11690(mch)
METC: MTCT_0692
MWO: MWSIV6_1147(mch)
METE: tca_00740(mch)
METK: FVF72_07680(mch)
MTHM: FZP57_05450(mch)
MST: Msp_1238(mch)
MRU: mru_1619(mch)
MSI: Msm_1723
MEB: Abm4_1203(mch)
MMIL: sm9_1330(mch)
MEYE: TL18_04360
MOL: YLM1_1103
METH: MBMB1_0537(mch)
MFC: BRM9_1751(mch)
MFI: DSM1535_2390(mch)
MCUB: MCBB_0462(mch)
METT: CIT01_01545(mch)
METO: CIT02_04240(mch)
MFV: Mfer_0254
MKA: MK0625(mch)
AFU: AF_1935
FPL: Ferp_0606
GAC: GACE_0343
GAH: GAH_01155
MBAR: MSBR2_0727
MBAK: MSBR3_0457
MAC: MA_1710(mch)
MMA: MM_2653
MMAC: MSMAC_1059
METM: MSMTP_2066
MTHR: MSTHT_0435
MTHE: MSTHC_0286
MHOR: MSHOH_2598
MFZ: AOB57_000035(mch)
MBU: Mbur_0653(mch)
MMET: MCMEM_0808
MMH: Mmah_1138
MPY: Mpsy_3012
MZI: HWN40_06075(mch)
MTP: Mthe_0252
MCJ: MCON_1290(mch)
MHI: Mhar_2174
MLA: Mlab_0399
MBG: BN140_0141(mch1) BN140_1778(mch3)
MEMA: MMAB1_2292(mch)
MPI: Mpet_0065
MBN: Mboo_0680
MPL: Mpal_2022
MPD: MCP_1132(mch-1) MCP_1888(mch-2)
MEZ: Mtc_1063(mch-1) Mtc_1978(mch-2)
RCI: LRC191(mch-1) RCIX2742(mch-2)
HAL: VNG_1686G(mch)
HSL: OE_3383R(mch)
HHB: Hhub_3179(mch)
HALH: HTSR_0323
HHSR: HSR6_0309(mch)
HMA: rrnAC1616(mch)
HHI: HAH_2159(mch)
NPH: NP_2634A(mch)
NMO: Nmlp_2018(mch)
HUT: Huta_1145
HTI: HTIA_1038
HMU: Hmuk_1816
HALL: LC1Hm_1117(mch)
HWA: HQ_2798A(mch)
HWC: Hqrw_3170(mch)
HVO: HVO_2573
HME: HFX_2599
HLA: Hlac_1693
HDF: AArcSl_1968(mch)
HTU: Htur_2210
NMG: Nmag_0205(mch)
NAT: NJ7G_2078
SALI: L593_12155
BARC: AOA65_2050(mch)
LOKI: Lokiarch_00580(mch_1) Lokiarch_17800(mch_2)
 » show all
Reference
1  [PMID:4062290]
  Authors
Donnelly MI, Escalante-Semerena JC, Rinehart KL Jr, Wolfe RS.
  Title
Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of Methanobacterium.
  Journal
Arch Biochem Biophys 242:430-9 (1985)
DOI:10.1016/0003-9861(85)90227-9
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.27
IUBMB Enzyme Nomenclature: 3.5.4.27
ExPASy - ENZYME nomenclature database: 3.5.4.27
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.4.27
BRENDA, the Enzyme Database: 3.5.4.27
CAS: 99533-50-3

KEGG   REACTION: R03464
Entry
R03464                      Reaction                               

Name
5,10-Methenyltetrahydromethanopterin 10-hydrolase (decyclizing)
Definition
5,10-Methenyltetrahydromethanopterin + H2O <=> 5-Formyl-5,6,7,8-tetrahydromethanopterin + H+
Equation
Reaction class
RC01870  C01274_C04330
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00567  Methanogenesis, CO2 => methane
Orthology
K01499  methenyltetrahydromethanopterin cyclohydrolase [EC:3.5.4.27]
Other DBs
RHEA: 19056

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