KEGG   ORTHOLOGY: K01539
Entry
K01539                      KO                                     

Name
ATP1A
Definition
sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04911  Insulin secretion
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04960  Aldosterone-regulated sodium reabsorption
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04964  Proximal tubule bicarbonate reclamation
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04973  Carbohydrate digestion and absorption
ko04974  Protein digestion and absorption
ko04976  Bile secretion
ko04978  Mineral absorption
Disease
H00775  Hemiplegic migraine
H00831  Primary dystonia
H00998  Alternating hemiplegia of childhood
H01603  Primary aldosteronism
H02272  CAPOS syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04022 cGMP-PKG signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04918 Thyroid hormone synthesis
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04919 Thyroid hormone signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04925 Aldosterone synthesis and secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04261 Adrenergic signaling in cardiomyocytes
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  09154 Digestive system
   04970 Salivary secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04971 Gastric acid secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04972 Pancreatic secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04976 Bile secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04973 Carbohydrate digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04974 Protein digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04978 Mineral absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04964 Proximal tubule bicarbonate reclamation
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Enzymes [BR:ko01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.13  Na+/K+-exchanging ATPase
     K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of colorectal cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of bladder cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Other DBs
COG: COG0474
GO: 0005391
TC: 3.A.3.1
Genes
HSA: 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
RRO: 104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
RBB: 108524039(ATP1A4) 108524041(ATP1A2) 108528132(ATP1A1)
CJC: 100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3)
MMU: 11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
MCAL: 110290752(Atp1a1) 110291780(Atp1a4) 110296540 110297290(Atp1a3)
MPAH: 110319913(Atp1a1) 110321177(Atp1a4) 110322617 110337068(Atp1a3)
RNO: 24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
NGI: 103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CCAN: 109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4)
TUP: 102475448(ATP1A3) 102483255(ATP1A2) 102483994(ATP1A1)
CFA: 403992(ATP1A1) 488636 612463(ATP1A3)
VVP: 112910077 112910081 112916773(ATP1A1) 112931443(ATP1A3)
AML: 100477585(ATP1A3) 100477989(ATP1A1) 100480641 100480890(ATP1A4)
UMR: 103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
UAH: 113243247(ATP1A3) 113244381(ATP1A1) 113246653(ATP1A4) 113246737
ORO: 101366083(ATP1A1) 101376936(ATP1A3) 101379349(ATP1A2) 101379646(ATP1A4)
FCA: 101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785
PTG: 102954810 102955336(ATP1A3) 102955398 102971148(ATP1A1)
PPAD: 109257219 109257221(ATP1A2) 109257944(ATP1A3) 109272127(ATP1A1)
AJU: 106969643(ATP1A1) 106978517(ATP1A4) 106985576 106987698(ATP1A3)
BTA: 282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
BBUB: 102396896(ATP1A3) 102404308(ATP1A1) 102405290 102405960(ATP1A4)
CHX: 102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 101103751(ATP1A3) 101118148(ATP1A2) 101118398 443381(ATP1A1)
SSC: 100157711 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
CDK: 105089616(ATP1A1) 105090227(ATP1A3) 105100141(ATP1A2) 116147050(ATP1A4)
BACU: 102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
OOR: 101279507(ATP1A1) 101280223(ATP1A3) 101288540(ATP1A4) 101288792(ATP1A2)
DLE: 111166986 111166987 111179983(ATP1A1) 111180802(ATP1A3)
PCAD: 102981487 102982135 102983659(ATP1A1) 102985775(ATP1A3)
ECB: 100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
EPZ: 103543741 103547749(ATP1A1) 103551135(ATP1A4) 103551139(ATP1A2)
EAI: 106835689(ATP1A1) 106835754(ATP1A4) 106835755(ATP1A2) 106847933(ATP1A3)
MYB: 102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2)
MYD: 102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
MNA: 107534181(ATP1A3) 107538456 107545330(ATP1A1)
HAI: 109374464(ATP1A3) 109386501(ATP1A2) 109392813(ATP1A1)
DRO: 112313776(ATP1A1) 112315807 112317734(ATP1A2) 112320186(ATP1A3)
PALE: 102884868(ATP1A4) 102885125 102888359(ATP1A1) 102893697(ATP1A3)
RAY: 107499819(ATP1A1) 107502600(ATP1A3) 107507949(ATP1A2) 107507966(ATP1A4)
MJV: 108390973(ATP1A1) 108393642(ATP1A3) 108402828 108402834
LAV: 100661428(ATP1A1) 100667801 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 100029754(ATP1A4) 100029759(ATP1A2)
SHR: 100914130(ATP1A2) 100918637 100922123(ATP1A3) 100928210(ATP1A1)
PCW: 110203112(ATP1A2) 110203115 110219354(ATP1A1) 110220180(ATP1A3)
OAA: 100083795 100088125(ATP1A3) 100088592(ATP1A1) 103166927
GGA: 396530(ATP1A1)
MGP: 100303690(ATP1A1) 104915899
NMEL: 110399227(ATP1A1)
APLA: 101801864(ATP1A1)
ACYG: 106029333 106037472(ATP1A1)
TGU: 100190719(ATP1A1) 105760330
SCAN: 103827109(ATP1A1)
GFR: 102036467(ATP1A1)
FAB: 101813002(ATP1A1) 101813385
PHI: 102104980 102106372(ATP1A1) 102107817(ATP1A2)
PMAJ: 107207264(ATP1A1)
CCAE: 111938980(ATP1A1)
CCW: 104687046(ATP1A1)
ETL: 114055106(ATP1A1)
FPG: 101914787(ATP1A1) 101915017(ATP1A2)
FCH: 102050259(ATP1A1) 102059303(ATP1A2)
CLV: 102092496(ATP1A1) 102093141
EGZ: 104126505(ATP1A1)
NNI: 104008633(ATP1A1) 104012600(ATP1A2)
ACUN: 113485715
PADL: 103921389(ATP1A1)
AAM: 106490649(ATP1A1) 106500059(ATP1A2)
AMJ: 102567591(ATP1A1) 102575084(ATP1A2) 106737151
CMY: 102936217(ATP1A1) 102938341(ATP1A2)
CPIC: 101931556(ATP1A3) 101933418(ATP1A1) 101950302(ATP1A2)
PMUR: 107289344(ATP1A1) 107298220 107299011(ATP1A3)
PMUA: 114585062 114586449 114587332(ATP1A1) 114603364(ATP1A3)
XLA: 108697760 108699431 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 245703(atp1a1a.5) 64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64613(atp1a1a.2) 64614(atp1a1a.3) 64615(atp1a1a.4) 64616(atp1a1b)
LCM: 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
BFO: 118424338
APLC: 110976714
SKO: 100370816(ATP1A1)
DME: Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DSI: Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
DAN: 6500777
DVI: 6632311
MDE: 101893028
LCQ: 111678276
AAG: 5575790
NVI: 100116320
CLEC: 106667156
ZNE: 110827645
CEL: CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: CBG01656 CBG08751(Cbr-catp-1) CBG09434(Cbr-eat-6) CBG19651
CRG: 105338008
MYI: 110459295
OBI: 106880261
EGL: EGR_08003
ADF: 107343492
DGT: 114524594
AQU: 100634317
QSU: 111989924
PIC: PICST_60178(PMR2)
CAL: CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
SLB: AWJ20_4150(PMR1)
MBE: MBM_04409
ANI: AN8941.2
ANG: ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
PTE: PTT_00480
TASA: A1Q1_02917
SMIN: v1.2.028598.t1(symbB.v1.2.028598.t1)
METL: U737_16210
MMAI: sS8_5209
TCX: Tcr_1065
HMAR: HVMH_1068
CYQ: Q91_1618
TAU: Tola_1844
PSE: NH8B_2287
SLT: Slit_1198
GCA: Galf_2615
SLAC: SKTS_18720
DAR: Daro_1851
AZA: AZKH_2708
SULR: B649_05270
GUR: Gura_3300
GEO: Geob_1849
PCA: Pcar_2279
PPD: Ppro_1564
SAT: SYN_02485
MGRY: MSR1_15930
MAGX: XM1_2567
MAGN: WV31_04655
LBF: LBF_2665
ABAC: LuPra_03991(yloB_2)
NDE: NIDE3786
CTHI: THC_0765
MOX: DAMO_0992
MBAR: MSBR2_3266
MBAK: MSBR3_3261
MAC: MA_4378
MMA: MM_1069
MMAC: MSMAC_0238
METM: MSMTP_0268
MHOR: MSHOH_0294
MBU: Mbur_0431
MPY: Mpsy_0778
 » show all
Reference
PMID:2540956
  Authors
Lebovitz RM, Takeyasu K, Fambrough DM
  Title
Molecular characterization and expression of the (Na+ + K+)-ATPase alpha-subunit in Drosophila melanogaster.
  Journal
EMBO J 8:193-202 (1989)
DOI:10.1002/j.1460-2075.1989.tb03364.x
  Sequence
Reference
PMID:1328175
  Authors
Lingrel JB
  Title
Na,K-ATPase: isoform structure, function, and expression.
  Journal
J Bioenerg Biomembr 24:263-70 (1992)
DOI:10.1007/BF00768847
Reference
  Authors
Morth JP, Poulsen H, Toustrup-Jensen MS, Schack VR, Egebjerg J, Andersen JP, Vilsen B, Nissen P
  Title
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:217-27 (2009)
DOI:10.1098/rstb.2008.0201

KEGG   ORTHOLOGY: K01540
Entry
K01540                      KO                                     

Name
ATP1B, CD298
Definition
sodium/potassium-transporting ATPase subunit beta
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04911  Insulin secretion
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04960  Aldosterone-regulated sodium reabsorption
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04964  Proximal tubule bicarbonate reclamation
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04973  Carbohydrate digestion and absorption
ko04974  Protein digestion and absorption
ko04976  Bile secretion
ko04978  Mineral absorption
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04022 cGMP-PKG signaling pathway
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04918 Thyroid hormone synthesis
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04919 Thyroid hormone signaling pathway
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04925 Aldosterone synthesis and secretion
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04261 Adrenergic signaling in cardiomyocytes
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
  09154 Digestive system
   04970 Salivary secretion
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04971 Gastric acid secretion
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04972 Pancreatic secretion
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04976 Bile secretion
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04973 Carbohydrate digestion and absorption
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04974 Protein digestion and absorption
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04978 Mineral absorption
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
   04964 Proximal tubule bicarbonate reclamation
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K01540  ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
CD molecules [BR:ko04090]
 Proteins
  K01540  CD298, ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide
Other DBs
TC: 3.A.3.1
Genes
HSA: 23439(ATP1B4) 481(ATP1B1) 482(ATP1B2) 483(ATP1B3)
PTR: 457497(ATP1B1) 738390(ATP1B4) 746692(ATP1B3) 749043(ATP1B2)
PPS: 100972401(ATP1B4) 100974727(ATP1B2) 100977407(ATP1B3) 100981350(ATP1B1)
GGO: 101133872(ATP1B2) 101140721(ATP1B3) 101145254(ATP1B1) 101150859(ATP1B4)
PON: 100173011(ATP1B1) 100434842(ATP1B2) 100440451(ATP1B4) 100447776(ATP1B3)
NLE: 100579331(ATP1B1) 100582993(ATP1B2) 100591621(ATP1B4) 100600591(ATP1B3)
MCC: 696160(ATP1B4) 700443(ATP1B1) 716093(ATP1B2) 716682(ATP1B3)
MCF: 101865296(ATP1B3) 101866484(ATP1B1) 102119097(ATP1B4) 102135605(ATP1B2)
CSAB: 103230624(ATP1B1) 103241560(ATP1B3) 103242319(ATP1B2) 103247357(ATP1B4)
RRO: 104661660(ATP1B2) 104663105(ATP1B4) 104668956(ATP1B1) 104674060(ATP1B3)
RBB: 108514361(ATP1B2) 108522426(ATP1B3) 108527281(ATP1B1) 108535342(ATP1B4)
CJC: 100392174(ATP1B2) 100412553(ATP1B3) 100414358(ATP1B1) 103794919(ATP1B4)
SBQ: 101028686(ATP1B3) 101044391(ATP1B2) 101053320(ATP1B1) 101053553 101053863(ATP1B4)
MMU: 11931(Atp1b1) 11932(Atp1b2) 11933(Atp1b3) 67821(Atp1b4)
MCAL: 110287115(Atp1b4) 110290643(Atp1b1) 110301197(Atp1b3) 110304973(Atp1b2)
MPAH: 110313906(Atp1b4) 110321497(Atp1b1) 110327684(Atp1b3) 110331574(Atp1b2)
RNO: 24214(Atp1b2) 25390(Atp1b3) 25650(Atp1b1) 84396(Atp1b4)
MUN: 110542156(Atp1b4) 110549938(Atp1b1) 110555146(Atp1b2) 110555290(Atp1b3)
CGE: 100757379(Atp1b2) 100760718(Atp1b1) 100762833(Atp1b4) 100765669(Atp1b3)
NGI: 103727107(Atp1b1) 103728423(Atp1b3) 103734865(Atp1b4) 103752117(Atp1b2)
HGL: 101697891(Atp1b3) 101701102(Atp1b1) 101701421(Atp1b2) 101709990(Atp1b4)
CCAN: 109674190(Atp1b2) 109687402(Atp1b1) 109698509(Atp1b4) 109699815(Atp1b3)
OCU: 100008749(ATP1B1) 100008788(ATP1B3) 100009577(ATP1B2) 100350113(ATP1B4)
TUP: 102467892(ATP1B2) 102474656(ATP1B4) 102481090(ATP1B1) 102486693(ATP1B3) 102493344
CFA: 403966(ATP1B1) 477098(ATP1B3) 481036(ATP1B4) 489479(ATP1B2)
VVP: 112923490(ATP1B1) 112924852(ATP1B2) 112934460(ATP1B4) 112934973(ATP1B3)
AML: 100468266(ATP1B2) 100469080(ATP1B1) 100481012(ATP1B4) 100484596(ATP1B3)
UMR: 103660367(ATP1B2) 103669178(ATP1B1) 103678432(ATP1B3) 103680217(ATP1B4)
UAH: 113254012(ATP1B3) 113262865(ATP1B1) 113270910(ATP1B4) 113271155(ATP1B2)
ORO: 101362729(ATP1B2) 101368218(ATP1B3) 101376641(ATP1B4) 101377129(ATP1B1)
FCA: 101081858(ATP1B1) 101087210(ATP1B4) 101097586(ATP1B3) 101100258(ATP1B2)
PTG: 102950345(ATP1B1) 102951098(ATP1B3) 102966509(ATP1B4) 102972397(ATP1B2)
PPAD: 109245933(ATP1B2) 109250740(ATP1B4) 109251996(ATP1B1) 109260258(ATP1B3)
AJU: 106966210(ATP1B1) 106972503(ATP1B2) 106981973(ATP1B3) 106986116(ATP1B4)
BTA: 282562(ATP1B2) 510026(ATP1B4) 519758(ATP1B1) 532844(ATP1B3)
BOM: 102270497(ATP1B1) 102270637(ATP1B3) 102272087(ATP1B2) 102282617(ATP1B4)
BIU: 109555144(ATP1B4) 109559642(ATP1B3) 109570324(ATP1B1) 109574423(ATP1B2)
BBUB: 102389327(ATP1B3) 102391404(ATP1B1) 102393025(ATP1B4) 102401420(ATP1B2)
CHX: 102168373(ATP1B1) 102183405(ATP1B4) 102188357(ATP1B3) 102191649(ATP1B2) 108633809
OAS: 101103490(ATP1B2) 101107568(ATP1B3) 101113044(ATP1B4) 114117869 443384(ATP1B1)
SSC: 100514493(ATP1B3) 100522212(ATP1B2) 396898(ATP1B1) 397245(ATP1B4)
CFR: 102505216(ATP1B1) 102508164(ATP1B2) 102517415(ATP1B3) 102520577(ATP1B4)
CDK: 105086324(ATP1B3) 105092738(ATP1B1) 105098894(ATP1B4) 105103012(ATP1B2)
BACU: 103001473(ATP1B4) 103004536(ATP1B2) 103009756(ATP1B1) 103014131(ATP1B3)
LVE: 103068907(ATP1B1) 103084463(ATP1B3) 103089387(ATP1B4) 103089616(ATP1B2)
OOR: 101277459(ATP1B3) 101286190(ATP1B1) 101286264(ATP1B2) 101286948(ATP1B4)
DLE: 111167389(ATP1B1) 111168235(ATP1B4) 111179257(ATP1B3) 111185833(ATP1B2)
PCAD: 102981290(ATP1B3) 102985944(ATP1B2) 102988537(ATP1B1) 102988723(ATP1B4)
ECB: 100033968(ATP1B1) 100055231(ATP1B4) 100062895(ATP1B3) 100073014(ATP1B2)
EPZ: 103540766(ATP1B4) 103557126(ATP1B3) 103557709(ATP1B2) 103560615(ATP1B1)
EAI: 106824855(ATP1B4) 106838143(ATP1B3) 106841565(ATP1B1) 106844216(ATP1B2)
MYB: 102243046(ATP1B4) 102244043(ATP1B3) 102245478(ATP1B1)
MYD: 102760424(ATP1B3) 102761222(ATP1B4) 102762820(ATP1B1)
MNA: 107529056(ATP1B1) 107534499 107534704(ATP1B3) 107537932(ATP1B4) 107544529(ATP1B2)
HAI: 109377058(ATP1B4) 109384530(ATP1B3) 109385316(ATP1B1) 109385672 109394700(ATP1B2)
DRO: 112298654(ATP1B1) 112301115(ATP1B3) 112308526(ATP1B2) 112310823(ATP1B4)
PALE: 102889357(ATP1B2) 102891547(ATP1B4) 102894054(ATP1B1) 102896850(ATP1B3)
RAY: 107498709(ATP1B4) 107509410(ATP1B3) 107512755(ATP1B1) 107515690(ATP1B2)
MJV: 108396363(ATP1B4) 108399443(ATP1B1) 108404279(ATP1B2) 108404924(ATP1B3)
LAV: 100655666(ATP1B3) 100660792(ATP1B4) 100668753(ATP1B2) 100676526(ATP1B1)
MDO: 100015422(ATP1B2) 100019139(ATP1B1) 100020118(ATP1B4) 100618619(ATP1B3)
SHR: 100915285(ATP1B4) 100915426(ATP1B2) 100915602(ATP1B1) 100935132(ATP1B3)
PCW: 110194460(ATP1B2) 110197228(ATP1B3) 110199765(ATP1B1) 110200046(ATP1B4)
OAA: 100078595(ATP1B3) 100079079(ATP1B4) 100083662(ATP1B1) 114808215(ATP1B2)
GGA: 107050378 396529(ATP1B1) 396549(ATP1B3) 422365(ATP1B4)
MGP: 100540826(ATP1B1) 100542023(ATP1B3) 100544093(ATP1B4)
CJO: 107307581 107312918(ATP1B4) 107318078(ATP1B3) 107319960(ATP1B1)
NMEL: 110391327(ATP1B2) 110397597(ATP1B3) 110399938(ATP1B1) 110403150(ATP1B4)
APLA: 101795008(ATP1B4) 101796786(ATP1B3) 101803145(ATP1B1)
ACYG: 106029401 106037081(ATP1B1) 106038542(ATP1B4)
TGU: 100225314(ATP1B4) 100228265(ATP1B3) 100229364(ATP1B1)
LSR: 110473943(ATP1B3) 110480315(ATP1B2) 110480503(ATP1B4) 110480769(ATP1B1)
SCAN: 103812425(ATP1B1) 103815419(ATP1B3) 103816394(ATP1B4)
GFR: 102031729(ATP1B3) 102031771(ATP1B1) 102038722(ATP1B4)
FAB: 101806172(ATP1B4) 101807834(ATP1B3) 101813667(ATP1B1)
PHI: 102101305(ATP1B2) 102108945(ATP1B3) 102113006(ATP1B4) 102113748(ATP1B1)
PMAJ: 107200323(ATP1B1) 107203644(ATP1B4) 107208713(ATP1B3)
CCAE: 111928664(ATP1B4) 111933514(ATP1B3) 111943265(ATP1B1)
CCW: 104687204(ATP1B1) 104693497(ATP1B3) 104694435(ATP1B4)
ETL: 114064576(ATP1B1) 114064932(ATP1B4) 114068736(ATP1B3)
FPG: 101910692(ATP1B1) 101913219(ATP1B4) 101917737 101924346(ATP1B3)
FCH: 102048230(ATP1B1) 102050299(ATP1B3) 102053971(ATP1B4)
CLV: 102085627(ATP1B3) 102089443(ATP1B4) 102097960(ATP1B1)
EGZ: 104124072(ATP1B4) 104126041(ATP1B1) 104127108(ATP1B3)
NNI: 104014150(ATP1B1) 104016486(ATP1B3) 104019090(ATP1B4)
ACUN: 113479214(ATP1B1) 113479906(ATP1B4) 113483519(ATP1B3)
PADL: 103917878(ATP1B3) 103922451(ATP1B1) 103922692(ATP1B4)
AAM: 106485899(ATP1B3) 106487548(ATP1B4) 106490663(ATP1B1)
ASN: 102372900(ATP1B4) 102376847(ATP1B2) 102378959(ATP1B3) 102382652(ATP1B1)
AMJ: 102559077(ATP1B3) 102565782(ATP1B4) 102570388(ATP1B2) 102573901(ATP1B1)
PSS: 102448519(ATP1B2) 102452713(ATP1B4) 102458081(ATP1B1) 102460753(ATP1B3)
CMY: 102942386(ATP1B4) 102943638(ATP1B1) 102948106(ATP1B3)
CPIC: 101937457(ATP1B1) 101939870(ATP1B4) 101942568(ATP1B2) 101943960(ATP1B3)
ACS: 100556957(atp1b3) 100557723(atp1b4) 100557885(atp1b1) 100562654(atp1b2)
PVT: 110074597(ATP1B1) 110078437(ATP1B3) 110087764(ATP1B2) 110089991(ATP1B4)
PBI: 103049667(ATP1B3) 103054021(ATP1B4) 103061200(ATP1B1) 103062796(ATP1B2)
PMUR: 107287477(ATP1B1) 107292033(ATP1B3) 107299048(ATP1B2) 107302749(ATP1B4)
TSR: 106541869(ATP1B3) 106546521(ATP1B1)
PMUA: 114595854(ATP1B1) 114597835(ATP1B3) 114608088(ATP1B2)
GJA: 107110300(ATP1B1) 107112362(ATP1B3) 107121089(ATP1B2) 107123739(ATP1B4)
XLA: 108700091 108708208(atp1b1.L) 379345(atp1b3.L) 379920(atp1b1.S) 380054(atp1b2) 397733(atp1b3.S) 444626(atp1b2.S) 735041(atp1b4.L)
XTR: 100490400(atp1b4) 394667(atp1b2) 394687(atp1b3) 548592(atp1b1)
NPR: 108787690(ATP1B1) 108789924(ATP1B4) 108790160(ATP1B3) 108803618
DRE: 100037383(atp1b4) 114457(atp1b2b) 30468(atp1b3a) 64267(atp1b1a) 64269(atp1b2a) 64272(atp1b3b) 64273(atp1b1b)
IPU: 100528881(atp1b1) 108258321(atnb233) 108260403 108269189(atp1b4) 108275701(atp1b2) 108277440
OLA: 101157248(atp1b3) 101161164(atp1b4) 101164636 101166353 101166489(atp1b2)
ALIM: 106514674(atp1b4) 106516378(atp1b2) 106528001(atp1b1) 106535133 106535838(atp1b3) 106536098 106536099
AOCE: 111563202 111568143 111568840 111570111(atp1b4) 111577662(atp1b2) 111582633(atp1b1) 111585502(atp1b3)
LCF: 108878854(atp1b1) 108882205 108883733(atp1b3) 108893737(atp1b2) 108895404(atp1b4) 108902546 108902943
HCQ: 109512378(atp1b2) 109514758 109516540 109518812(atp1b4) 109520624(atp1b3) 109532355(atp1b1)
MALB: 109951970(atp1b3) 109952758 109956392(atp1b4) 109959553(atp1b2) 109965735
LCM: 102349197(ATP1B3) 102354768(ATP1B1) 102363213(ATP1B2) 102363784(ATP1B4)
CMK: 103177442(atp1b1) 103178537(atp1b4) 103178677(atp1b3)
RTP: 109912303(atp1b4) 109917977 109925522(atp1b2) 109932517(atp1b1) 109938314
BFO: 118427323
CIN: 100175072
SPU: 579450
DME: Dmel_CG8663(nrv3) Dmel_CG9258(nrv1) Dmel_CG9261(nrv2)
DSI: Dsimw501_GD22540(Dsim_GD22540) Dsimw501_GD22541(Dsim_GD22541) Dsimw501_GD26934(Dsim_GD26934)
TUT: 107369869
CEL: CELE_C17E4.9(nkb-1) CELE_F55F3.3(nkb-3)
TSP: Tsp_04025
NVE: 5503335
EPA: 110242033
ADF: 107333663
AMIL: 114957006
PDAM: 113675291
SPIS: 111320717
DGT: 114524599
AQU: 109586231
 » show all
Reference
PMID:8798450
  Authors
Malik N, Canfield VA, Beckers MC, Gros P, Levenson R
  Title
Identification of the mammalian Na,K-ATPase 3 subunit.
  Journal
J Biol Chem 271:22754-8 (1996)
DOI:10.1074/jbc.271.37.22754
  Sequence
[hsa:483]
Reference
PMID:1328175
  Authors
Lingrel JB
  Title
Na,K-ATPase: isoform structure, function, and expression.
  Journal
J Bioenerg Biomembr 24:263-70 (1992)
DOI:10.1007/BF00768847

KEGG   ORTHOLOGY: K01538
Entry
K01538                      KO                                     

Name
FXYD2, ATP1G1
Definition
sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04911  Insulin secretion
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04960  Aldosterone-regulated sodium reabsorption
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04964  Proximal tubule bicarbonate reclamation
ko04970  Salivary secretion
ko04972  Pancreatic secretion
ko04973  Carbohydrate digestion and absorption
ko04974  Protein digestion and absorption
ko04976  Bile secretion
ko04978  Mineral absorption
Disease
H01210  Hypomagnesemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04022 cGMP-PKG signaling pathway
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04918 Thyroid hormone synthesis
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04919 Thyroid hormone signaling pathway
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04261 Adrenergic signaling in cardiomyocytes
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
  09154 Digestive system
   04970 Salivary secretion
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04972 Pancreatic secretion
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04976 Bile secretion
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04973 Carbohydrate digestion and absorption
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04974 Protein digestion and absorption
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04978 Mineral absorption
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04964 Proximal tubule bicarbonate reclamation
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
   04147 Exosome
    K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
Other DBs
GO: 0005391 0017080
TC: 1.A.27.2 3.A.3.1
Genes
HSA: 486(FXYD2)
PTR: 466793
PPS: 103786316(FXYD2)
GGO: 109023060
PON: 103891919
NLE: 105737519
MCC: 704049
MCF: 102123177(FXYD2)
CSAB: 103248564(FXYD2)
RRO: 104665560
RBB: 108536391(FXYD2)
CJC: 103796045(FXYD2)
SBQ: 104650672(FXYD2)
MMU: 11936(Fxyd2)
MCAL: 110302161(Fxyd2)
MPAH: 110327737(Fxyd2)
RNO: 29639(Fxyd2)
MUN: 110549094
CGE: 100771061(Fxyd2)
NGI: 103748311(Fxyd2)
HGL: 101704851(Fxyd2)
CCAN: 109697518(Fxyd2)
OCU: 103349229(FXYD2)
TUP: 102481218(FXYD2)
CFA: 608594(FXYD2)
VVP: 112920357(FXYD2)
AML: 100469796
UMR: 103662511(FXYD2)
UAH: 113260011(FXYD2)
ORO: 101382690(FXYD2)
ELK: 111153819
FCA: 101087093(FXYD2)
PTG: 102948994(FXYD2)
PPAD: 109278582(FXYD2)
AJU: 106966269
BTA: 281773(FXYD2)
BOM: 102275041(FXYD2)
BIU: 109569778(FXYD2)
BBUB: 102394926(FXYD2)
CHX: 102187334(FXYD2)
OAS: 114118392(FXYD2)
SSC: 541593(FXYD2)
CDK: 105090183(FXYD2)
BACU: 102999896(FXYD2)
DLE: 111166927(FXYD2)
PCAD: 102974454(FXYD2)
ECB: 100629801(FXYD2)
EPZ: 103548764(FXYD2)
EAI: 106840265(FXYD2)
MNA: 107530783(FXYD2)
HAI: 109385315(FXYD2)
DRO: 112314310(FXYD2)
PALE: 102891289(FXYD2)
RAY: 107505043(FXYD2)
MJV: 108402725(FXYD2)
LAV: 111752838(FXYD2)
TMU: 111822243
MDO: 107652422(FXYD2)
SHR: 100929307(FXYD2)
PCW: 110210628(FXYD2)
GGA: 419770(FXYD2)
MGP: 104914364(FXYD2)
CJO: 107324264(FXYD2)
NMEL: 110387608(FXYD2)
ACYG: 106039828(FXYD2)
TGU: 101233455(FXYD2)
LSR: 110470412(FXYD2)
SCAN: 108963268(FXYD2)
GFR: 106631970(FXYD2)
PHI: 106628608(FXYD2)
PMAJ: 107214483(FXYD2)
CCAE: 111939269(FXYD2)
CCW: 104692063(FXYD2)
ETL: 114056283(FXYD2)
FCH: 114015464(FXYD2)
CLV: 106146134(FXYD2)
NNI: 104008754(FXYD2)
ASN: 102383329(FXYD2)
AMJ: 102573878(FXYD2)
CMY: 102939296(FXYD2)
CPIC: 103305909(FXYD2)
ACS: 103281397(fxyd2)
PMUA: 114585187(FXYD2)
XLA: 397916(fxyd2.S)
XTR: 100038171(fxyd2)
DRE: 794522(fxyd2)
SGH: 107596205
IPU: 108260287
PHYP: 113531243(fxyd2)
AMEX: 103022524(fxyd2)
EEE: 113589137(fxyd2)
ALIM: 106515427
CMK: 103173409
 » show all
Reference
PMID:9048881
  Authors
Kim JW, Lee Y, Lee IA, Kang HB, Choe YK, Choe IS
  Title
Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit.
  Journal
Biochim Biophys Acta 1350:133-5 (1997)
DOI:10.1016/S0167-4781(96)00219-9
  Sequence
[hsa:486]

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