KEGG   ORTHOLOGY: K01615
Entry
K01615                      KO                                     

Name
gcdA
Definition
glutaconyl-CoA decarboxylase subunit alpha [EC:7.2.4.5]
Pathway
ko00362  Benzoate degradation
ko00650  Butanoate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K01615  gcdA; glutaconyl-CoA decarboxylase subunit alpha
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K01615  gcdA; glutaconyl-CoA decarboxylase subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K01615  gcdA; glutaconyl-CoA decarboxylase subunit alpha
Enzymes [BR:ko01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.4  Linked to decarboxylation
    7.2.4.5  glutaconyl-CoA decarboxylase
     K01615  gcdA; glutaconyl-CoA decarboxylase subunit alpha
Transporters [BR:ko02000]
 Other transporters
  Primary active transporters
   K01615  gcdA; glutaconyl-CoA decarboxylase subunit alpha
Other DBs
RN: R03028
COG: COG4799
GO: 0018801
TC: 3.B.1.1.3
Genes
GBM: Gbem_1453(gcdA)
GEO: Geob_0238(gcdA)
GEM: GM21_2800
DML: Dmul_25060(gcdA)
DAT: HRM2_38510(gcdA1) HRM2_38640(gcdA2)
DTO: TOL2_C38230
DOV: DSCO28_25370 DSCO28_61390
DWD: DSCW_22800
DALK: DSCA_21110 DSCA_57350
SAT: SYN_00481
DBR: Deba_2446
CSO: CLS_16270
FAA: HMPREF0389_01471(gcdA)
OVA: OBV_10900
BPRS: CK3_23950
PED: ING2D1G_1422(gcdA)
PHAR: NCTC13077_00176(gcdA)
AIN: Acin_0318
FNU: FN0204
 » show all
Reference
  Authors
Braune A, Bendrat K, Rospert S, Buckel W
  Title
The sodium ion translocating glutaconyl-CoA decarboxylase from Acidaminococcus fermentans: cloning and function of the genes forming a second operon.
  Journal
Mol Microbiol 31:473-87 (1999)
DOI:10.1046/j.1365-2958.1999.01189.x
  Sequence

KEGG   ORTHOLOGY: K20509
Entry
K20509                      KO                                     

Name
madB, oadB, gcdB, mmdB
Definition
carboxybiotin decarboxylase [EC:7.2.4.1]
Pathway
ko00362  Benzoate degradation
ko00620  Pyruvate metabolism
ko00650  Butanoate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K20509  madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase
   00650 Butanoate metabolism
    K20509  madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K20509  madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K20509  madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase
Enzymes [BR:ko01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.4  Linked to decarboxylation
    7.2.4.1  carboxybiotin decarboxylase
     K20509  madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase
Transporters [BR:ko02000]
 Other transporters
  Primary active transporters
   K20509  madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase
Other DBs
RN: R03028 R09509 R12212
COG: COG1883
TC: 3.B.1.1
Genes
EFE: EFER_0028(oadB) EFER_3127
STY: STY0063(oadB) STY3531(oadB)
STT: t0056(oadB) t3266(oadB)
SEX: STBHUCCB_34540 STBHUCCB_650
SENT: TY21A_00290 TY21A_16565
STM: STM0054 STM0768(dcoB) STM3351(oadB)
SEO: STM14_0064 STM14_0892(dcoB) STM14_4043(oadB)
SEV: STMMW_00551 STMMW_08201 STMMW_33501
SEY: SL1344_0055 SL1344_0745(dcoB) SL1344_3323(oadB2)
SEM: STMDT12_C00550 STMDT12_C08210 STMDT12_C34090
SEF: UMN798_0061(oadB2) UMN798_0833(oadB2) UMN798_3643(oadB2)
SEND: DT104_00551(oadB2) DT104_07841(dcoB) DT104_33441
SPT: SPA0055(oadB) SPA3218(oadB)
SEI: SPC_0058(oadB) SPC_0764(oadB) SPC_3421(oadB)
SEC: SCH_0048(oadB) SCH_0766(oadB) SCH_3289(oadB)
SEG: SG0057 SG0746(oadB2) SG3241(oadB3)
KPU: KP1_4950(oadB)
KPP: A79E_0477
KPT: VK055_2545(oadB) VK055_3841(oadB2)
KPJ: N559_4403
KPX: PMK1_01144(oadB)
KPNU: LI86_22620
KPNK: BN49_0484(oadB_C) BN49_4310(oadB_N)
KPE: KPK_0485(oadB_2) KPK_4719(oadB_1)
EAR: CCG31803
CAMA: F384_01170
MINT: C7M51_04001(oadB)
MTHI: C7M52_03031(oadB)
HDU: HD_0782(oadB)
HPAZ: K756_01235
HSO: HS_0203(oadB)
HSM: HSM_0071
PMU: PM1423
PMV: PMCN06_1681(oadB)
PMP: Pmu_16740(oadB)
PMUL: DR93_277(oadB)
PDAG: 4362423_01743(oadB)
MSU: MS0038(oadB)
MHT: D648_4970
MHAT: B824_21790
MHX: MHH_c10410(oadB)
MHAE: F382_10330
MHAM: J450_09255
MHAO: J451_10550
MHAL: N220_02425
MHAQ: WC39_11425
MHAY: VK67_11430
MVI: X808_3670
MVG: X874_3760
APL: APL_1377(oadB)
APJ: APJL_1395(oadB)
APA: APP7_1428(oadB)
ASU: Asuc_0301
ALIG: NCTC10568_01712(oadB)
AAT: D11S_1381
AAN: D7S_00029
AACN: AANUM_1711
ASEG: NCTC10977_01471(oadB)
BTO: WQG_15840
BTRE: F542_6220
BTRH: F543_7400
BTRA: F544_16220
AVT: NCTC3438_00331(oadB)
RPNE: NCTC8284_00504(oadB)
PAET: NCTC13378_01917(oadB)
VCO: VC0395_A0086(oadB-1) VC0395_A0319(oadB-2)
VCR: VC395_0568(oadB-1) VC395_0809(oadB-2)
VCM: VCM66_0509(oadB-1) VCM66_0750(oadB-2)
VVU: VV1_1602
VVY: VV2798
VPA: VP2543
VPB: VPBB_2365
VAG: N646_1636
VSP: VS_2568
VNI: VIBNI_A0154(oadB2)
VAU: VANGNB10_cI0455(oadB-1) VANGNB10_cI1186(oadB-2)
VSC: VSVS12_02745(oadB)
VTA: A0111(oadB) B0177(oadB)
VFI: VF_0540(oadB)
PPR: PBPRA2299(T3266) PBPRA3050(T3266)
PMY: Pmen_2892
PMK: MDS_1765
PSA: PST_1378
PSTT: CH92_07865
PALL: UYA_08795
SFR: Sfri_1067
SAZ: Sama_1053
SBL: Sbal_1026
SLO: Shew_1221
SSE: Ssed_1322
SPL: Spea_1200
SHL: Shal_1237
SWP: swp_1380
SVO: SVI_3159(oadB)
SPSW: Sps_04082
SBK: SHEWBE_3815(oadB)
SKH: STH12_00600(gcdB)
ILO: IL1734(oadB)
CPS: CPS_1050(oadB)
PHA: PSHAa0540(oadB)
PTN: PTRA_a0612(oadB)
PAT: Patl_3011
PSM: PSM_A0587(oadB)
PSEO: OM33_13300
PEA: PESP_a0737(oadB)
PSPO: PSPO_a2228(oadB)
PART: PARC_a3300(oadB)
PTU: PTUN_a1102(oadB)
PNG: PNIG_a0652(oadB)
PTD: PTET_a0649(oadB)
PSEN: PNC201_12865(oadB)
PAGA: PAGA_a3166(oadB)
MAQ: Maqu_0972
MHC: MARHY2313
MAD: HP15_1332
MBS: MRBBS_1501(oadB)
MARJ: MARI_07630(oadB)
AMAL: I607_05280
AMAE: I876_05575
AMAO: I634_05600
AMAD: I636_05510
AMAI: I635_05475
AMAG: I533_05190
AMAC: MASE_05085
AAUS: EP12_05510
GNI: GNIT_2323(oadB)
GPS: C427_3629
SALH: HMF8227_02229(oadB)
PIN: Ping_3375
FBL: Fbal_0863
CJA: CJA_2758
SDE: Sde_1307
SAGA: M5M_00815
MICC: AUP74_02105(oadB)
MICT: FIU95_14075(oadB)
MCA: MCA2479(oadB)
METL: U737_10365
MAH: MEALZ_0543(oadB)
MMAI: sS8_1423
MEJ: Q7A_2132
MEC: Q7C_233
CYQ: Q91_0724
CZA: CYCME_1869(oadB)
HCH: HCH_05201
CSA: Csal_0694
HEL: HELO_3734(oadB)
HAM: HALO3828
HCO: LOKO_02895(oadB)
HBE: BEI_3145(oadB)
HSR: HSBAA_10760(oadB)
ABO: ABO_0845(oadB)
ADI: B5T_01561(oadB)
APAC: S7S_07075
AXE: P40_07280
KKO: Kkor_1246
TOL: TOL_2689
OAI: OLEAN_C28130(oadB)
TAU: Tola_0402
OCE: GU3_15045
RMA: Rmag_0847
VOK: COSY_0772(oadB)
EBH: BSEPE_1238(oadB)
ENM: EBS_1205(oadB)
RGE: RGE_11560
SUA: Saut_1374
SULC: CVO_03675
SULR: B649_01475
CPIN: CPIN18020_1008(oadB)
AELL: AELL_0302(oadB1) AELL_1495(oadB2)
AAQI: AAQM_0230(oadB1) AAQM_1291(oadB2)
AHS: AHALO_1371(oadB)
AMYT: AMYT_1453(oadB)
AMAR: AMRN_1363(oadB)
ACAA: ACAN_1416(oadB)
AMOL: AMOL_1432(oadB)
APAI: APAC_1406(oadB)
HBV: ABIV_1301(oadB1) ABIV_2120(oadB2)
HEBR: AEBR_1532(oadB)
PACO: AACT_0365(oadB1) AACT_1524(oadB2)
SDL: Sdel_0605
SMUL: SMUL_0790
SHAL: SHALO_0794
HYO: NNO_1527
SUN: SUN_1432
NIS: NIS_1302
NAM: NAMH_1020
GLO: Glov_1820
DHY: DESAM_20123(gcdB)
DPS: DP0687
DSF: UWK_01573
DOL: Dole_2282
DML: Dmul_03490(oadB1) Dmul_10450(oadB2) Dmul_25040(gcdB)
DAL: Dalk_1191
DAT: HRM2_06280(oadB1) HRM2_38530(oadB2) HRM2_38660(oadB3)
DTO: TOL2_C10000(oadB)
DALK: DSCA_41260
SFU: Sfum_3585
DBR: Deba_2621
RPB: RPB_3300
RPC: RPC_1055
BLAG: BLTE_21940
RCP: RCAP_rcp00132(oadB)
RSU: NHU_02470
RHC: RGUI_1051
MGRY: MSR1_01310(madB)
MAGQ: MGMAQ_2139
MGM: Mmc1_3197
SPYA: A20_0934(gcdB) A20_0940(gcdB)
SPS: SPs1031
STG: MGAS15252_0895(oadB.1) MGAS15252_0901(oadB.2)
STX: MGAS1882_0890(oadB.1) MGAS1882_0896(oadB.2)
SMU: SMU_1017(oadB)
SMC: SmuNN2025_1006(oadB)
SMJ: SMULJ23_1015(oadB)
SMUA: SMUFR_0887(oadB)
SEZ: Sez_0992(oadB)
SEQ: SZO_09780
SEZO: SeseC_01292(oadB)
SEQU: Q426_04240
SEU: SEQ_1203
SUB: SUB1591(gcdB)
SDS: SDEG_0989(oadB) SDEG_0996
SDC: SDSE_1018(oadB) SDSE_1025(gcdB)
STK: STP_0112(gcdB)
SIK: K710_0372
LSA: LCA_1229(oadB)
LCA: LSEI_1862
LCS: LCBD_2055
LCE: LC2W_2037
LCW: BN194_20360(gcdB)
LPAP: LBPC_1820
LCB: LCABL_20860(oadB)
LRH: LGG_01918(oadB)
LRG: LRHM_1841
LRL: LC705_01906(oadB)
LRA: LRHK_1906
EFA: EF3324
EFL: EF62_0383(oadD)
EFI: OG1RF_12569(gcdB)
EFD: EFD32_2875(oadD)
EFS: EFS1_2724(oadB)
EFN: DENG_03217(oadB)
EFQ: DR75_2041
ECAS: ECBG_03043
EMU: EMQU_1788(gcdB)
THL: TEH_07880
CRN: CAR_c13490(oadB)
CARC: NY10_724
JDA: BW727_101587(gcdB)
CACE: CACET_c36760(gcdB)
CCOH: SAMEA4530647_0549(gcdB)
AOE: Clos_0443
ASF: SFBM_1184
ASM: MOUSESFB_1096(oadB)
ASB: RATSFB_1016(oadB)
CTH: Cthe_0509
HSC: HVS_11090(gcdB2)
CSS: Cst_c06330(gcdB) Cst_c12080(oadB)
CSD: Clst_0601(oadB1) Clst_1166(oadB2)
ESR: ES1_14170
ESU: EUS_07390
RUM: CK1_07290
RUS: RBI_I01165(gcdB)
BPB: bpr_I1229
BFI: CIY_18060
BHU: bhn_I1151
RIX: RO1_15620
RIM: ROI_21890
COO: CCU_25780
CCT: CC1_18390
ROB: CK5_25600
BPRO: PMF13cell1_04189(gcdB)
CSCI: HDCHBGLK_03212(gcdB)
HSD: SD1D_0451 SD1D_1113(gcdB)
EHL: EHLA_2083
RTO: RTO_20160
EAC: EAL2_808p06910(gcdB)
CST: CLOST_0945(oadB)
OVA: OBV_10930
BPRM: CL3_29880
CBAR: PATL70BA_0283(oadB)
TTE: TTE0252(OadB) TTE1215(OadB2) TTE1798(OadB3)
THX: Thet_1086
TKI: TKV_c02030(gcdB)
CSC: Csac_2482
TSH: Tsac_2164
TAE: TepiRe1_1424(gcdB)
PED: ING2D1G_1321(gcdB1) ING2D1G_1425(gcdB3)
PHAR: NCTC13077_00173(gcdB)
VPR: Vpar_1240
VRM: 44547418_01322(gcdB)
VDN: NCTC11831_00635(gcdB)
MHG: MHY_07190
STED: SPTER_14190(gcdB)
AIN: Acin_0298(oadB)
PFAC: PFJ30894_00493(madB) PFJ30894_00913(gcdB_1) PFJ30894_00917(gcdB_2)
ERH: ERH_0758(oadB)
MGG: MPLG2_1841(gcdB)
RCA: Rcas_0953
ATM: ANT_05830(mmdB)
DFC: DFI_10225
OBG: Verru16b_01940(madB)
CAA: Caka_0796
AMU: Amuc_0204
AGL: PYTT_0610
IPA: Isop_1585
KST: KSMBR1_1801(mmdB)
PBU: L21SP3_02220(gcdB)
PBP: STSP1_01241(gcdB)
PBAS: SMSP2_02860(gcdB)
TPA: TP_0057
TPW: TPANIC_0057(oadB)
TPP: TPASS_0057(oadB)
TPU: TPADAL_0057(oadB)
TPO: TPAMA_0057(oadB)
TPC: TPECDC2_0057(oadB)
TPG: TPEGAU_0057(oadB)
TPM: TPESAMD_0057(oadB)
TPB: TPFB_0057(oadB)
TPL: TPCCA_0057(oadB)
TPED: TPE_1044
BIP: Bint_1369 Bint_2655(oadB)
FNU: FN0201
FSC: FSU_2086
BOA: Bovatus_01771(gcdB_1) Bovatus_01782(gcdB_2) Bovatus_04664(madB)
BCEL: BcellWH2_01306(gcdB_1) BcellWH2_03043(madB) BcellWH2_04425(gcdB_2)
PGI: PG_1608(mmdB)
PGN: PGN_0504
PGT: PGTDC60_0691(mmdB)
PCRE: NCTC12858_00696(gcdB)
PCAG: NCTC12856_00113(gcdB)
PMUC: ING2E5A_1041(oadB2-1) ING2E5A_1042(oadB2-2) ING2E5A_1825(oadB)
TFO: BFO_0962(oadB)
APS: CFPG_533
PRU: PRU_1644
AFD: Alfi_2937
BACC: BRDCF_p1211(gcdB)
BLQ: L21SP5_03928(gcdB)
MBAS: ALGA_0600
PPH: Ppha_0944
PAA: Paes_0917
PROC: Ptc2401_01012(gcdB)
CTS: Ctha_0175
IAL: IALB_1429(oadB)
MRO: MROS_0647
TMA: TM0880
TMW: THMA_0902
TMQ: THMB_0902
TMX: THMC_0902
TPT: Tpet_0047
TRQ: TRQ2_0047
TNA: CTN_1696
TNP: Tnap_0047
TLE: Tlet_0920
TME: Tmel_1898
TAF: THA_192
THER: Y592_01035
PMO: Pmob_1666
MARN: LN42_09035
DTN: DTL3_1241(oadB)
KOL: Kole_1742
MINF: MESINF_1656(gcdB) MESINF_2159(gcdB)
ASAC: ATHSA_1953
CEX: CSE_10380
CABY: Cabys_114
AFU: AF_2084
ABI: Aboo_1366
PFU: PF0674
PFI: PFC_02530
PHO: PH1283(PH1283)
PAB: PAB1772
PYN: PNA2_1857
PYS: Py04_0757
TKO: TK1625
TON: TON_0038
TGA: TGAM_2029(mmdB)
TSI: TSIB_1537
THE: GQS_05065
THA: TAM4_214
THM: CL1_0657
TLT: OCC_03162
THS: TES1_0182
TNU: BD01_2084
TEU: TEU_04770
PPAC: PAP_07985
SMR: Smar_1504
AG: AAC45399(madB) CAA05140(mmdB)
 » show all
Reference
PMID:9128730
  Authors
Berg M, Hilbi H, Dimroth P
  Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
  Journal
Eur J Biochem 245:103-15 (1997)
DOI:10.1111/j.1432-1033.1997.00103.x
  Sequence
Reference
PMID:1331067
  Authors
Woehlke G, Wifling K, Dimroth P
  Title
Sequence of the sodium ion pump oxaloacetate decarboxylase from Salmonella typhimurium.
  Journal
J Biol Chem 267:22798-803 (1992)
  Sequence
[stm:STM3351]
Reference
PMID:9428714
  Authors
Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P
  Title
Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.
  Journal
Eur J Biochem 250:590-9 (1997)
DOI:10.1111/j.1432-1033.1997.0590a.x
  Sequence
Reference
  Authors
Braune A, Bendrat K, Rospert S, Buckel W
  Title
The sodium ion translocating glutaconyl-CoA decarboxylase from Acidaminococcus fermentans: cloning and function of the genes forming a second operon.
  Journal
Mol Microbiol 31:473-87 (1999)
DOI:10.1046/j.1365-2958.1999.01189.x
  Sequence

KEGG   ORTHOLOGY: K23351
Entry
K23351                      KO                                     

Name
gcdC, mmdC
Definition
glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
Pathway
ko00362  Benzoate degradation
ko00650  Butanoate metabolism
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K23351  gcdC, mmdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K23351  gcdC, mmdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K23351  gcdC, mmdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
Transporters [BR:ko02000]
 Other transporters
  Primary active transporters
   K23351  gcdC, mmdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
Other DBs
RN: R03028
COG: COG0511 COG4770
TC: 3.B.1.1.2 3.B.1.1.3 3.B.1.1.5
Genes
HAXI: HAALTHF_39690n HAALTHF_52740n
CABA: SBC2_64950
RAC: RA876_12700
DUG: HH213_07215
RGE: RGE_11570
RBN: RBXJA2T_07315
DOE: DENOEST_0834
ACOM: CEW83_11075
APP: CAP2UW1_3916
GLO: Glov_1819
DSF: UWK_01574
DML: Dmul_03510(gcdC)
BVR: BVIR_2321
BLAG: BLTE_21960
RSU: NHU_02469
RHC: RGUI_1052
RRU: Rru_A0049
RRF: F11_00250
MGRY: MSR1_01300(cfiA)
MAGQ: MGMAQ_2138
SPYA: A20_0933(gcdC) A20_0939(oadG)
SMU: SMU_1016(bcc)
SMC: SmuNN2025_1007(bcc)
SMJ: SMULJ23_1016(bcc)
SMUA: SMUFR_0886
SEZ: Sez_0991(bcc)
SEQ: SZO_09790
SEZO: SeseC_01291(mmdC)
SEQU: Q426_04245
SEU: SEQ_1204
SUB: SUB1592
STK: STP_0111
SIK: K710_0371
LSA: LCA_1230(oadG)
LCA: LSEI_1863
LCS: LCBD_2056
LCE: LC2W_2038
LCW: BN194_20370(bcc)
LPAP: LBPC_1821
LCB: LCABL_20870(oadG)
LRH: LGG_01919(oadG)
LRL: LC705_01907(oadG)
LRA: LRHK_1907
EFA: EF3325
EFL: EF62_0384(oadH)
EFS: EFS1_2725
EFQ: DR75_2042
ENE: ENT_00470
ECAS: ECBG_03044
EMU: EMQU_1789
THL: TEH_07890
CRN: CAR_c13500(oadG)
CARC: NY10_725
JDA: BW727_101588(gcdC)
CCOH: SAMEA4530647_0550(gcdC)
AOE: Clos_0442
ASF: SFBM_1185
CTH: Cthe_0700
HSC: HVS_08285(gcdC)
CCE: Ccel_1737
CSD: Clst_1051
ESR: ES1_23260
ESU: EUS_17650
RCH: RUM_13650
RUM: CK1_07280
RUS: RBI_I01192(accB)
FPR: FP2_06010
FPA: FPR_30110
BPB: bpr_I1228
BFI: CIY_18050
BHU: bhn_I1150
RIX: RO1_15630
RIM: ROI_21880
COO: CCU_25770
CCT: CC1_18380
ROB: CK5_25590
BPRO: PMF13cell1_04190(gcdC)
CPY: Cphy_2435
CSCI: HDCHBGLK_03213(gcdC)
HSD: SD1D_1112
EHL: EHLA_2084
RTO: RTO_20150
ERT: EUR_12040
ERA: ERE_26960
CST: CLOST_0944(gcdC)
PTH: PTH_1366(MmcJ)
HMO: HM1_0379
OVA: OBV_10920
SAY: TPY_3499
CTHM: CFE_0665
TTE: TTE1222(AccB) TTE2383(AccB2)
THX: Thet_2117
TIT: Thit_2051
CHY: CHY_0919
MTA: Moth_1155
ATE: Athe_1318
TTM: Tthe_0369
TSH: Tsac_0945
TAE: TepiRe1_1423(gcdC)
PHAR: NCTC13077_00172(gcdC)
PIV: NCTC13079_00638(gcdC)
VPR: Vpar_1241
VRM: 44547418_01323(gcdC)
VDN: NCTC11831_00634(gcdC)
MED: MELS_1065
MANA: MAMMFC1_00401(gcdC)
STED: SPTER_14180(gcdC)
AIN: Acin_0297(mmdC)
PFAC: PFJ30894_00912(gcdC_1) PFJ30894_00916(gcdC_2)
ERH: ERH_0757
RCA: Rcas_0952
ATM: ANT_05820(mmdC)
DFC: DFI_10220
OTE: Oter_3309
OBG: Verru16b_01938(cfiA)
CAA: Caka_0797
AMU: Amuc_0203
AGL: PYTT_0609
IPA: Isop_1586
TPED: TPE_1043(oadB)
BHY: BHWA1_02044(accB)
BRM: Bmur_1757
BPO: BP951000_0992(accB)
BPJ: B2904_orf367(accB)
BPW: WESB_2320(accB)
BIP: Bint_2656(accB)
FNU: FN0200
TAI: Taci_0293
TLI: Tlie_0406
FSC: FSU_2085
BTH: BT_1688
BTHO: Btheta7330_01329(gcdC_1)
BFR: BF3291
BFS: BF9343_3044(bcc)
BFG: BF638R_3154(bcc)
BXY: BXY_46880
BOA: Bovatus_01770(gcdC_2)
BCEL: BcellWH2_04426(gcdC_1)
BVU: BVU_2489
PGI: PG_1609(mmdC)
PGN: PGN_0503
PGT: PGTDC60_0690(mmdC)
PCAG: NCTC12856_00114(gcdC)
PMUC: ING2E5A_1043(bcc)
PSAC: PSM36_2143
PDI: BDI_0161
TFO: BFO_0963
APS: CFPG_532
POC: NCTC13071_01597(accB)
AFD: Alfi_2936
ASH: AL1_03780
BACC: BRDCF_p1210(bccA)
DORI: FH5T_18410
BLQ: L21SP5_03929(gcdC_3)
MBAS: ALGA_0601
FLM: MY04_0933
CLI: Clim_0887
PVI: Cvib_1250
PLT: Plut_1433
PPH: Ppha_0945
CTS: Ctha_0176
IAL: IALB_1430(mmdC)
MRO: MROS_0646
TMA: TM0717
TMW: THMA_0733
TMQ: THMB_0733
TMX: THMC_0733
TPT: Tpet_0212
TRQ: TRQ2_0210
TNA: CTN_1867
TNP: Tnap_0515
TLE: Tlet_0175
TME: Tmel_0583
TAF: THA_1416
THER: Y592_06455
FNO: Fnod_1319
PMO: Pmob_0555
MARN: LN42_09880
DTN: DTL3_0602
KOL: Kole_1366
CEX: CSE_10390
CABY: Cabys_113
GAC: GACE_1316
GAH: GAH_00091
ABI: Aboo_1365
PFU: PF0673
PFI: PFC_02525
PHO: PH1284(PH1284)
PAB: PAB1771
PYN: PNA2_1858
PYS: Py04_0758
TKO: TK1624
TON: TON_0039
TGA: TGAM_2028(mmdC)
TSI: TSIB_1536
THE: GQS_05060
THA: TAM4_33
THM: CL1_0656
TLT: OCC_03157
THS: TES1_0181
TNU: BD01_2083
TEU: TEU_04765
PPAC: PAP_07990
AG: CAA05139(mmdC)
 » show all
Reference
  Authors
Braune A, Bendrat K, Rospert S, Buckel W
  Title
The sodium ion translocating glutaconyl-CoA decarboxylase from Acidaminococcus fermentans: cloning and function of the genes forming a second operon.
  Journal
Mol Microbiol 31:473-87 (1999)
DOI:10.1046/j.1365-2958.1999.01189.x
  Sequence
Reference
PMID:9428714
  Authors
Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P
  Title
Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.
  Journal
Eur J Biochem 250:590-9 (1997)
DOI:10.1111/j.1432-1033.1997.0590a.x
  Sequence
Reference
  Authors
Cohen GN, Barbe V, Flament D, Galperin M, Heilig R, Lecompte O, Poch O, Prieur D, Querellou J, Ripp R, Thierry JC, Van der Oost J, Weissenbach J, Zivanovic Y, Forterre P.
  Title
An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.
  Journal
Mol Microbiol 47:1495-512 (2003)
DOI:10.1046/j.1365-2958.2003.03381.x

KEGG   ORTHOLOGY: K23352
Entry
K23352                      KO                                     

Name
gcdD, mmdD
Definition
glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
Pathway
ko00362  Benzoate degradation
ko00650  Butanoate metabolism
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K23352  gcdD, mmdD; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K23352  gcdD, mmdD; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K23352  gcdD, mmdD; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
Transporters [BR:ko02000]
 Other transporters
  Primary active transporters
   K23352  gcdD, mmdD; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
Other DBs
RN: R03028
TC: 3.B.1.1.2 3.B.1.1.3 3.B.1.1.5
Genes
MCUN: NCTC10297_00469
KOA: H3L93_06520
ACOM: CEW83_11070
RHP: LPB142_12745
RSU: NHU_02468
RHM: B5V46_07285
RHC: RGUI_1053
RRU: Rru_A0050
RRF: F11_00255
RPM: RSPPHO_02677
CARC: NY10_726
AOE: Clos_0441
ASF: SFBM_1186
CTH: Cthe_1290
HSC: HVS_11085
CSD: Clst_0602(oadG)
ESR: ES1_14180
ESU: EUS_07400
RCH: RUM_16610
RUM: CK1_07270
FPR: FP2_05270
FPA: FPR_24530
BPB: bpr_I1227
BFI: CIY_18040
BHU: bhn_I1149
RIX: RO1_15640
RIM: ROI_21870
CCT: CC1_18370
ROB: CK5_25580
CPY: Cphy_2436
HSD: SD1D_1111
EHL: EHLA_2085
ERT: EUR_12030
ERA: ERE_26970
BPRM: CL3_21450
TIT: Thit_2052
VPR: Vpar_1243
MHG: MHY_07200
AIN: Acin_0296
ERH: ERH_0756(oadG)
ATM: ANT_05810(mmdD)
DFC: DFI_10215
OTE: Oter_3313
TPED: TPE_1042
BRM: Bmur_1758
BPW: WESB_2321
BIP: Bint_2657
FNU: FN0199
TAI: Taci_0292
TLI: Tlie_0405
SBR: SY1_11130
DORI: FH5T_18415
MBAS: ALGA_0602
FLM: MY04_0932
CLI: Clim_0888
PVI: Cvib_1249
PLT: Plut_1432
PPH: Ppha_0946
CTS: Ctha_0177
TMW: THMA_0732
TMQ: THMB_0732
TMX: THMC_0732
TPT: Tpet_0213
TRQ: TRQ2_0211
TNA: CTN_1868
TNP: Tnap_0514
TLE: Tlet_0176
TME: Tmel_0584
TAF: THA_1417
THER: Y592_06460
FNO: Fnod_1318
PMO: Pmob_0554
DTN: DTL3_0601
KOL: Kole_1367
PFU: PF0672
PFI: PFC_02520
PHO: PH1285(PH1285)
PAB: PAB1770
PYN: PNA2_1859
PYS: Py04_0759
TKO: TK1623
TON: TON_0040
TGA: TGAM_2027(mmdD)
TSI: TSIB_1535
THE: GQS_05055
THA: TAM4_386
THM: CL1_0655
TLT: OCC_03152
THS: TES1_0180
TNU: BD01_2082
TEU: TEU_04760
PPAC: PAP_07995
SMR: Smar_1503
AG: CAA05138(mmdD)
 » show all
Reference
  Authors
Braune A, Bendrat K, Rospert S, Buckel W
  Title
The sodium ion translocating glutaconyl-CoA decarboxylase from Acidaminococcus fermentans: cloning and function of the genes forming a second operon.
  Journal
Mol Microbiol 31:473-87 (1999)
DOI:10.1046/j.1365-2958.1999.01189.x
  Sequence
Reference
PMID:9428714
  Authors
Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P
  Title
Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.
  Journal
Eur J Biochem 250:590-9 (1997)
DOI:10.1111/j.1432-1033.1997.0590a.x
  Sequence
Reference
  Authors
Cohen GN, Barbe V, Flament D, Galperin M, Heilig R, Lecompte O, Poch O, Prieur D, Querellou J, Ripp R, Thierry JC, Van der Oost J, Weissenbach J, Zivanovic Y, Forterre P.
  Title
An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.
  Journal
Mol Microbiol 47:1495-512 (2003)
DOI:10.1046/j.1365-2958.2003.03381.x

KEGG   ENZYME: 7.2.4.5
Entry
EC 7.2.4.5                  Enzyme                                 

Name
glutaconyl-CoA decarboxylase;
glutaconyl coenzyme A decarboxylase;
pent-2-enoyl-CoA carboxy-lyase;
4-carboxybut-2-enoyl-CoA carboxy-lyase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
Sysname
(2E)-4-carboxybut-2-enoyl-CoA carboxy-lyase [(2E)-but-2-enoyl-CoA-forming]
Reaction(IUBMB)
(2E)-4-carboxybut-2-enoyl-CoA + Na+[side 1] = (2E)-but-2-enoyl-CoA + CO2 + Na+[side 2] [RN:R03028]
Reaction(KEGG)
R03028
Substrate
(2E)-4-carboxybut-2-enoyl-CoA [CPD:C02411];
Na+[side 1]
Product
(2E)-but-2-enoyl-CoA [CPD:C00877];
CO2 [CPD:C00011];
Na+[side 2]
Comment
The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
History
EC 7.2.4.5 created 1986 as EC 4.1.1.70, modified 2003, transferred 2019 to EC 7.2.4.5
Pathway
ec00362  Benzoate degradation
ec00650  Butanoate metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K01615  glutaconyl-CoA decarboxylase subunit alpha
Genes
GBM: Gbem_1453(gcdA)
GEO: Geob_0238(gcdA)
GEM: GM21_2800
DML: Dmul_25060(gcdA)
DAT: HRM2_38510(gcdA1) HRM2_38640(gcdA2)
DTO: TOL2_C38230
DOV: DSCO28_25370 DSCO28_61390
DWD: DSCW_22800
DALK: DSCA_21110 DSCA_57350
SAT: SYN_00481
DBR: Deba_2446
CSO: CLS_16270
FAA: HMPREF0389_01471(gcdA)
OVA: OBV_10900
BPRS: CK3_23950
PED: ING2D1G_1422(gcdA)
PHAR: NCTC13077_00176(gcdA)
AIN: Acin_0318
FNU: FN0204
 » show all
Reference
1  [PMID:6628393]
  Authors
Buckel W, Semmler R.
  Title
Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria.
  Journal
Eur J Biochem 136:427-34 (1983)
DOI:10.1111/j.1432-1033.1983.tb07760.x
Reference
2  [PMID:11248185]
  Authors
Buckel W.
  Title
Sodium ion-translocating decarboxylases.
  Journal
Biochim Biophys Acta 1505:15-27 (2001)
DOI:10.1016/S0005-2728(00)00273-5
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.5
IUBMB Enzyme Nomenclature: 7.2.4.5
ExPASy - ENZYME nomenclature database: 7.2.4.5
BRENDA, the Enzyme Database: 7.2.4.5
CAS: 84399-93-9

KEGG   REACTION: R03028
Entry
R03028                      Reaction                               

Name
glutaconyl-1-CoA carboxy-lyase;
4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)
Definition
Glutaconyl-1-CoA <=> Crotonoyl-CoA + CO2
Equation
Comment
following after R10074 (ec 1.3.8.6)
requires Na+ and acts as a sodium pump (ec 7.2.4.5)
Reaction class
RC00832  C00877_C02411
Enzyme
1.3.8.6         7.2.4.5
Pathway
rn00362  Benzoate degradation
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K01615  glutaconyl-CoA decarboxylase subunit alpha [EC:7.2.4.5]
K20509  carboxybiotin decarboxylase [EC:7.2.4.1]
K23351  glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
K23352  glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
Other DBs
RHEA: 23975

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