KEGG   ORTHOLOGY: K01648
Entry
K01648                      KO                                     

Name
ACLY
Definition
ATP citrate (pro-S)-lyase [EC:2.3.3.8]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K01648  ACLY; ATP citrate (pro-S)-lyase
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K01648  ACLY; ATP citrate (pro-S)-lyase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01648  ACLY; ATP citrate (pro-S)-lyase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8  ATP citrate synthase
     K01648  ACLY; ATP citrate (pro-S)-lyase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01648  ACLY; ATP citrate (pro-S)-lyase
  Exosomal proteins of bladder cancer cells
   K01648  ACLY; ATP citrate (pro-S)-lyase
  Exosomal proteins of melanoma cells
   K01648  ACLY; ATP citrate (pro-S)-lyase
Other DBs
RN: R00352
GO: 0003878
Genes
HSA: 47(ACLY)
PTR: 454672(ACLY)
PPS: 100981849(ACLY)
GGO: 101132535(ACLY)
PON: 100439535(ACLY)
NLE: 100601132(ACLY)
MCC: 708501(ACLY)
MCF: 102139439(ACLY)
CSAB: 103243859(ACLY)
RRO: 104680455(ACLY) 115894939 115894954
RBB: 108518356 108534726(ACLY)
CJC: 100405725(ACLY)
SBQ: 101051906(ACLY)
MMU: 104112(Acly)
MCAL: 110304306(Acly)
MPAH: 110332696(Acly)
RNO: 24159(Acly)
MUN: 110540730(Acly)
CGE: 100773325(Acly)
NGI: 103735876(Acly)
HGL: 101700349(Acly)
CCAN: 109695762(Acly)
OCU: 100346747(ACLY)
TUP: 102487454(ACLY)
CFA: 607852(ACLY)
VVP: 112910827(ACLY)
AML: 100467494(ACLY)
UMR: 103672560(ACLY)
UAH: 113265439(ACLY)
ORO: 101368080(ACLY)
ELK: 111151216
FCA: 100422779(ACLY)
PTG: 102954566(ACLY)
PPAD: 109258552(ACLY)
AJU: 106972598(ACLY)
BTA: 511135(ACLY)
BOM: 102287054(ACLY)
BIU: 109573634(ACLY)
BBUB: 102393057(ACLY)
CHX: 102181894(ACLY)
OAS: 654404(ACLY)
SSC: 100125957(ACLY)
CFR: 102508520(ACLY)
CDK: 105090445(ACLY)
LVE: 103077497(ACLY)
OOR: 101277148(ACLY)
DLE: 111166237(ACLY)
ECB: 100053195(ACLY)
EPZ: 103550376(ACLY)
EAI: 106826361(ACLY)
MYB: 102246873(ACLY)
MYD: 102759921(ACLY)
MNA: 107538758(ACLY)
HAI: 109395729(ACLY)
DRO: 112298553(ACLY)
PALE: 102888049(ACLY)
RAY: 107513807(ACLY)
MJV: 108397138(ACLY)
LAV: 100667233(ACLY)
TMU: 101346806
MDO: 100011977(ACLY)
SHR: 100924578(ACLY)
PCW: 110198389(ACLY)
OAA: 100089333(ACLY)
GGA: 395373(ACLY)
MGP: 100544111(ACLY)
CJO: 107325118(ACLY)
NMEL: 110388478(ACLY)
APLA: 101793308(ACLY)
ACYG: 106048017(ACLY)
TGU: 100221719(ACLY)
LSR: 110471854(ACLY)
SCAN: 103821599(ACLY)
GFR: 102034815(ACLY)
FAB: 101805819(ACLY)
PHI: 102099293(ACLY)
PMAJ: 107215114(ACLY)
CCAE: 111939941(ACLY)
CCW: 104697755(ACLY)
ETL: 114063634(ACLY)
FPG: 101918381(ACLY)
FCH: 102047351(ACLY)
CLV: 102097494(ACLY)
EGZ: 104131387(ACLY)
NNI: 104009868(ACLY)
ACUN: 113489156(ACLY)
PADL: 103919491(ACLY)
AAM: 106487628(ACLY)
ASN: 102386616(ACLY)
AMJ: 102572777(ACLY)
PSS: 102444696(ACLY)
CMY: 102930695(ACLY)
CPIC: 101941763(ACLY)
ACS: 100557175(acly)
PVT: 110088988(ACLY)
PBI: 103067911(ACLY)
PMUR: 107303043(ACLY)
TSR: 106538254(ACLY)
PMUA: 114581513(ACLY)
GJA: 107116244(ACLY)
XLA: 495086(acly.S) 495316
XTR: 493390(acly)
NPR: 108788936(ACLY)
DRE: 436922(aclya) 794259(aclyb)
IPU: 108258521(acly) 108273769
PHYP: 113528283(acly) 113535056
AMEX: 103023371 103042216(acly)
EEE: 113581553 113592331(acly)
TRU: 101069651 101072240(acly)
NCC: 104949162(acly) 104967624
MZE: 101483257 101485070(acly)
ONL: 100690537(acly) 100706997
XMA: 102224554(acly) 102228484
XCO: 114152045 114159617(acly)
PRET: 103469414(acly) 103481260
CVG: 107099611(acly) 107099763
NFU: 107387857 107395298(acly)
KMR: 108243751(acly) 108249058
ALIM: 106516978 106527937(acly)
AOCE: 111566731 111584364(acly)
CSEM: 103381466 103393105(acly)
LCF: 108901343(acly) 108901721
SDU: 111217495(acly) 111220212
SLAL: 111652814(acly) 111657113
BPEC: 110154214 110161819(acly)
MALB: 109963029 109964230(acly)
ELS: 105013338(acly)
SFM: 108919709 108941823(acly)
PKI: 111842517 111855971(acly)
LCM: 102364563(ACLY)
CMK: 103185738(acly)
RTP: 109918067(acly)
BFO: 118424959
CIN: 445783(acl)
SKO: 100377487
DME: Dmel_CG8322(ATPCL)
DER: 6548754
DSE: 6609355
DSI: Dsimw501_GD25577(Dsim_GD25577)
DAN: 6496171
DSR: 110178519
DPE: 6601350
DWI: 6637856
DAZ: 108615968
DNV: 108654447
DHE: 111594006
DVI: 6627274
MDE: 101891858
LCQ: 111680485
AAG: 5564509
AALB: 109425132
AME: 550686
BIM: 100745478
BTER: 100650219
CCAL: 108627768
OBB: 114876334
MPHA: 105839063
AEC: 105143187
ACEP: 105622935
PBAR: 105429784
VEM: 105560699
HST: 105188186
DQU: 106743343
CFO: 105250699
LHU: 105675266
PGC: 109855528
OBO: 105285413
PCF: 106788484
NVI: 100119651
CSOL: 105361316
MDL: 103568760
TCA: 656728
DPA: 109541269
NVL: 108569619
BMAN: 114247106
PMAC: 106711742
PRAP: 111001964
HAW: 110382034
TNL: 113505697
PXY: 105380677
API: 100165099(Atpcl)
DNX: 107173542
AGS: 114119839
RMD: 113557292
BTAB: 109033027
CLEC: 106665077
ZNE: 110839946
FCD: 110847723
PVM: 113820574
TUT: 107362563
DPTE: 113791137
CSCU: 111628825
PTEP: 107443062
CEL: CELE_B0365.1(acly-2) CELE_D1005.1(acly-1)
BMY: Bm1_26245
TSP: Tsp_01728
PCAN: 112564404
CRG: 105335901
MYI: 110465532
OBI: 106879485
SHX: MS3_06938
NVE: 5509100
EPA: 110250736
AMIL: 114957318
PDAM: 113678655
SPIS: 111328982
DGT: 114530732
HMG: 100201862
AQU: 100640666
ATH: AT1G09430(ACLA-3) AT1G10670(ACLA-1) AT1G60810(ACLA-2) AT3G06650(ACLB-1) AT5G49460(ACLB-2)
LJA: Lj0g3v0068209.1(Lj0g3v0068209.1) Lj1g3v4804050.1(Lj1g3v4804050.1) Lj1g3v4804050.2(Lj1g3v4804050.2) Lj2g3v1415070.1(Lj2g3v1415070.1) Lj3g3v0937850.1(Lj3g3v0937850.1) Lj4g3v2265020.1(Lj4g3v2265020.1) Lj4g3v2266260.1(Lj4g3v2266260.1) Lj6g3v1915820.1(Lj6g3v1915820.1) Lj6g3v1915820.2(Lj6g3v1915820.2)
DOSA: Os01t0300200-01(Os01g0300200) Os11t0693800-01(Os11g0693800) Os11t0696200-01(Os11g0696200) Os12t0566300-01(Os12g0566300)
ATS: 109750159(LOC109750159) 109752526(LOC109752526) 109778001(LOC109778001) 109782165(LOC109782165)
ZMA: 100273868(cl718_1(752)) 100282948(pco080711) 100381760(pco065117) 103635086
SLB: AWJ20_2117(LSC1)
NTE: NEUTE1DRAFT117451(NEUTE1DRAFT_117451) NEUTE1DRAFT123184(NEUTE1DRAFT_123184)
SMP: SMAC_06774(acl2) SMAC_06775(acl1)
BFU: BCIN_13g02430(CND16) BCIN_13g02440(CND6)
ANG: ANI_1_76094(An11g00510) ANI_1_78094(An11g00530)
CNE: CNJ00800
CNB: CNBJ2710
TASA: A1Q1_06527
ABP: AGABI1DRAFT115583(AGABI1DRAFT_115583)
ABV: AGABI2DRAFT194501(AGABI2DRAFT_194501)
DFA: DFA_04229 DFA_09735(acly)
SMIN: v1.2.003200.t1(symbB.v1.2.003200.t1) v1.2.026551.t1(symbB.v1.2.026551.t1) v1.2.028198.t1(symbB.v1.2.028198.t1) v1.2.030373.t1(symbB.v1.2.030373.t1)
PTI: PHATRDRAFT_54477(ACL)
SPAR: SPRG_01813
BANA: BARAN1_0736(aclA)
PSYT: DSAG12_02466(sucD_2)
 » show all
Reference
PMID:1371749
  Authors
Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS
  Title
Cloning and expression of a human ATP-citrate lyase cDNA.
  Journal
Eur J Biochem 204:491-9 (1992)
DOI:10.1111/j.1432-1033.1992.tb16659.x
  Sequence
[hsa:47]
Reference
  Authors
Beckner ME, Fellows-Mayle W, Zhang Z, Agostino NR, Kant JA, Day BW, Pollack IF
  Title
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
  Journal
Int J Cancer 126:2282-95 (2010)
DOI:10.1002/ijc.24918

KEGG   ORTHOLOGY: K15230
Entry
K15230                      KO                                     

Name
aclA
Definition
ATP-citrate lyase alpha-subunit [EC:2.3.3.8]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K15230  aclA; ATP-citrate lyase alpha-subunit
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K15230  aclA; ATP-citrate lyase alpha-subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8  ATP citrate synthase
     K15230  aclA; ATP-citrate lyase alpha-subunit
Other DBs
RN: R00352
GO: 0003878
Genes
TDN: Suden_0571
SUA: Saut_1577
SULN: FJR47_02470
SULG: FJR48_02400
SULC: CVO_07030
SKU: Sulku_0667
SULR: B649_03335
SMUL: SMUL_0067(aclB)
HYO: NNO_1443
NSA: Nitsa_0577
SUN: SUN_0542
NIS: NIS_0653
NAM: NAMH_0714
CTE: CT1088
CPC: Cpar_1009
CCH: Cag_0797
CLI: Clim_1231
PVI: Cvib_0866
PLT: Plut_1062
PPH: Ppha_1393
PAA: Paes_1090
PROC: Ptc2401_01123(sucD_2)
CTS: Ctha_2552
NDE: NIDE0835(aclA)
NMV: NITMOv2_0691(aclA)
NIO: NITINOP_0227(aclA)
NJA: NSJP_1800(aclA)
MHI: Mhar_1526
 » show all
Reference
  Authors
Aoshima M, Ishii M, Igarashi Y
  Title
A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:763-70 (2004)
DOI:10.1111/j.1365-2958.2004.04010.x

KEGG   ORTHOLOGY: K15231
Entry
K15231                      KO                                     

Name
aclB
Definition
ATP-citrate lyase beta-subunit [EC:2.3.3.8]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K15231  aclB; ATP-citrate lyase beta-subunit
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K15231  aclB; ATP-citrate lyase beta-subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8  ATP citrate synthase
     K15231  aclB; ATP-citrate lyase beta-subunit
Other DBs
RN: R00352
GO: 0003878
Genes
TDN: Suden_0570
SUA: Saut_1578
SULN: FJR47_02465
SULG: FJR48_02395
SULC: CVO_07035
SKU: Sulku_0666
SULR: B649_03330
SMUL: SMUL_0066(aclA)
HYO: NNO_1444
NSA: Nitsa_0576
SUN: SUN_0541
NIS: NIS_0652
NAM: NAMH_0713
CTE: CT1089
CPC: Cpar_1008
CCH: Cag_0796
CLI: Clim_1232
PVI: Cvib_0867
PLT: Plut_1061
PPH: Ppha_1392
PAA: Paes_1089
PROC: Ptc2401_01122(sucC_1)
CTS: Ctha_2553
NDE: NIDE0834(aclB)
NMV: NITMOv2_0690(aclB)
NIO: NITINOP_0228(aclB)
NJA: NSJP_1799(aclB)
BANA: BARAN1_0735(aclB)
MHI: Mhar_1527
LOKI: Lokiarch_34550(sucC_1)
 » show all
Reference
  Authors
Aoshima M, Ishii M, Igarashi Y
  Title
A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:763-70 (2004)
DOI:10.1111/j.1365-2958.2004.04010.x

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