KEGG   ORTHOLOGY: K01666
Entry
K01666                      KO                                     

Name
mhpE
Definition
4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
Pathway
ko00360  Phenylalanine metabolism
ko00362  Benzoate degradation
ko00621  Dioxin degradation
ko00622  Xylene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
   00622 Xylene degradation
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
   00621 Dioxin degradation
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
Other DBs
RN: R00750
COG: COG0119
GO: 0008701
Genes
ECO: b0352(mhpE)
ECJ: JW0343(mhpE)
EBW: BWG_0241(mhpE)
ECOK: ECMDS42_0274(mhpE)
ECE: Z0452(mhpE)
ECS: ECs0407
ECF: ECH74115_0427(mhpE)
ETW: ECSP_0416(mhpE)
ELX: CDCO157_0395
EOI: ECO111_0388(mhpE)
EOJ: ECO26_0388(mhpE)
EOH: ECO103_0334(mhpE)
ECOO: ECRM13514_0494(mhpE)
ECOH: ECRM13516_0332(mhpE)
ESL: O3K_19715
ESO: O3O_05580
ESM: O3M_19700
ECK: EC55989_0359(mhpE)
EOK: G2583_0465(mhpE)
ELH: ETEC_0408
ECW: EcE24377A_0376(mhpE)
EUN: UMNK88_402(mhpE)
ENA: ECNA114_0335(mhpE)
ECOS: EC958_0496
ECX: EcHS_A0416(mhpE)
ECM: EcSMS35_0383(mhpE)
ECY: ECSE_0377
ECR: ECIAI1_0353(mhpE)
ECQ: ECED1_0380(mhpE)
EUM: ECUMN_0395(mhpE)
ECT: ECIAI39_0326(mhpE)
EOC: CE10_0320(mhpE)
EBR: ECB_00306(mhpE)
EBL: ECD_00306(mhpE)
EBE: B21_00310(mhpE)
EBD: ECBD_3305
ELO: EC042_0389(mhpE)
ESE: ECSF_0323
EKF: KO11_21820(mhpE)
EDJ: ECDH1ME8569_0339(mhpE)
ELW: ECW_m0430(mhpE)
ELL: WFL_02115(mhpE)
ELP: P12B_c0312(mhpE) P12B_c0370(mhpE)
ECOJ: P423_01850
EMA: C1192_10895(dmpG)
ESZ: FEM44_16335(dmpG)
SSN: SSON_0331(mhpE)
KPN: KPN_02117(mhpE)
KPU: KP1_3212(mhpE)
KPP: A79E_2127
KPT: VK055_0344(dmpG)
KPR: KPR_2662(mhpE)
KPJ: N559_2173
KPX: PMK1_04481(mhpE)
KPNU: LI86_10795
KPNK: BN49_3222(mhpE)
KVA: Kvar_2158
KPE: KPK_2206(mhpE)
KOX: KOX_22670
KOE: A225_3411
KQV: B8P98_11815(dmpG)
KLW: DA718_12110(dmpG)
CWE: CO701_16970(dmpG)
CYO: CD187_18570(dmpG)
CPOT: FOB25_06035(dmpG)
CFQ: C2U38_05270(dmpG)
CIF: AL515_06460(dmpG)
CIE: AN232_24605(dmpG)
CPAR: CUC49_01495(dmpG)
EBT: EBL_c19990(mhpE)
RAO: DSD31_10730(dmpG)
REE: electrica_02140(mhpE)
EBF: D782_1987
EBU: CUC76_00405(dmpG)
SPE: Spro_3025
SERA: Ser39006_017380(dmpG)
SERQ: CWC46_17380(dmpG)
SQU: E4343_00890(dmpG)
ECA: ECA1429(nahM)
PATR: EV46_07235
PATO: GZ59_14680(nahM)
EPY: EpC_04020
PLU: plu4081
XNE: XNC1_0240
XNM: XNC2_0241
LRI: NCTC12151_03194(mhpE)
VAG: N646_2394
PAEP: PA1S_20450
PAEG: AI22_13500
PCQ: PcP3B5_23500(mhpE) PcP3B5_25720(dmpG)
PPU: PP_1791
PPT: PPS_1433
PPX: T1E_4258(cmtG) T1E_4274(tobH)
PPUH: B479_25865
PPUT: L483_06510
PSB: Psyr_3072
PEN: PSEEN0975
PSTT: CH92_19040
PKC: PKB_1193 PKB_3256(amng1) PKB_3604(amng3)
PSES: PSCI_2058(xylK)
PSOS: POS17_2261
PSET: THL1_490
PSIL: PMA3_18060
PKE: DLD99_14425(dmpG) DLD99_14495(dmpG)
AVN: Avin_08740(xylK) Avin_15130(mphE) Avin_42120
AVL: AvCA_08740(xylK) AvCA_15130(mphE) AvCA_42120
ACX: Achr_27750(mphE) Achr_32700(xylK)
ADV: DJ533_01780(dmpG)
ADS: FPL17_05445(dmpG)
SDN: Sden_2668
PTN: PTRA_a0482(mhpE)
MHC: MARHY0649
KIM: G3T16_05375(dmpG)
LPN: lpg2681
LPH: LPV_3027
LPO: LPO_2962
LPM: LP6_2713
LPF: lpl2608
LPP: lpp2735
LPC: LPC_0455
LPA: lpa_03915
LPE: lp12_2674
LLO: LLO_0366
LFA: LFA_0384
LHA: LHA_2302
LLG: 44548918_00735(bphI)
LJR: NCTC11533_00845(mhpE)
LCJ: NCTC11976_00245(mhpE)
LWA: SAMEA4504053_3185(bphI)
TMC: LMI_2790
HMAR: HVMH_0576
MEJ: Q7A_1101
HALK: CUU95_03820(dmpG)
HVN: EI420_02110(dmpG)
SOK: D0B54_04235(dmpG)
SINI: GT972_13755(dmpG)
CHRO: CXB49_03860(dmpG)
CRZ: D1345_11515(dmpG)
CHAE: CH06BL_23600(mhpE)
AQS: DKK66_07210(dmpG)
RSO: RSp0895(dmpG)
RSM: CMR15_mp10879(mhpE)
RSE: F504_4322
RPU: CDC45_22090(dmpG)
REH: H16_A1807(mhpE2) H16_B0552(mhpE1)
RME: Rmet_5209(mhpE)
COX: E0W60_03755(dmpG) E0W60_07650(dmpG) E0W60_07795(dmpG)
BPS: BPSS1807(mhpE)
BPM: BURPS1710b_A0890(mhpE)
BPD: BURPS668_A2590(mhpE)
BPSE: BDL_5207(dmpG)
BPSM: BBQ_4325(dmpG)
BPSU: BBN_5270(dmpG)
BPSD: BBX_4373(dmpG)
BPZ: BP1026B_II1937(mhpE)
BPK: BBK_4537(dmpG)
BPSH: DR55_5932(dmpG)
BPSA: BBU_4207(dmpG)
BPSO: X996_5729(dmpG)
BUT: X994_5292(dmpG)
BTE: BTH_II0570(mhpE)
BTQ: BTQ_3864(dmpG)
BTJ: BTJ_4896(dmpG)
BTZ: BTL_5690(dmpG)
BTD: BTI_5186(dmpG)
BTV: BTHA_4520(dmpG)
BTHE: BTN_5352(dmpG)
BTHM: BTRA_5626(dmpG)
BTHA: DR62_5490
BTHL: BG87_5697(dmpG)
BOK: DM82_6079(dmpG)
BOC: BG90_4586(dmpG)
BVE: AK36_3502(dmpG)
BCJ: BCAM2121
BCEN: DM39_1991(dmpG) DM39_4966(dmpG)
BCEW: DM40_5000(dmpG)
BCEO: I35_6003
BMUL: NP80_3434(dmpG) NP80_3873(dmpG)
BCON: NL30_34160
BLAT: WK25_27480
BSEM: WJ12_26060
BMEC: WJ16_20010
BGU: KS03_3374(dmpG) KS03_5342
BGO: BM43_7072(dmpG)
BUK: MYA_5002
BUL: BW21_2671(dmpG) BW21_4722(dmpG)
BXB: DR64_1245(dmpG) DR64_3311(dmpG) DR64_4657(dmpG)
BFN: OI25_255(dmpG)
PARB: CJU94_31730(dmpG)
PHS: C2L64_35640(dmpG)
PTER: C2L65_38855(dmpG)
PGP: CUJ91_31740(dmpG)
PPNM: LV28_21850
PPUL: RO07_16240
PSPU: NA29_20920
PAPI: SG18_00060
PAND: DRB87_06760(dmpG)
PFIB: PI93_020350(dmpG)
BAV: BAV0600(bphF)
BHZ: ACR54_00829(mhpE)
ACHR: C2U31_03430(dmpG)
PUT: PT7_2460
PUD: G9Q38_01255(dmpG) G9Q38_15010(dmpG)
AFQ: AFA_13960(dmpG)
AAQU: D3M96_14820(dmpG)
PIG: EGT29_26650(dmpG)
KGY: EHF36_03355(dmpG)
POL: Bpro_5136
ACK: C380_15915(bphF)
VBO: CKY39_22055(dmpG)
CTES: O987_08265
HPSE: HPF_15300(mhpE)
DIH: G7047_22420(dmpG)
SIMP: C6571_19090(dmpG)
JAG: GJA_232(dmpG)
HEE: hmeg3_19565(dmpG)
DAR: Daro_3238
CCF: YSQ_01790
ABU: Abu_1489
ABT: ABED_1386
ATP: ATR_1318
AELL: AELL_1860
AAQI: AAQM_1697
ACIB: ACBT_1008
AMAR: AMRN_1917
APAI: APAC_0989
HBV: ABIV_1064
HEBR: AEBR_1328
PACO: AACT_1972
ARC: ABLL_1976
SHAL: SHALO_2223
SUN: SUN_2142
GLO: Glov_0787
DMA: DMR_24610(nahM)
DPI: BN4_11362(nahM)
HOH: Hoch_1083
PCAY: FRD00_17515(dmpG)
RBT: NOVO_02090(leuA)
ARA: Arad_7255
ABAW: D5400_20370(dmpG)
BTR: BT_2080
XAU: Xaut_0938
MSL: Msil_1479
MTUN: MTUNDRAET4_3892(mhpE)
MMED: Mame_00137(mhpE)
PHP: PhaeoP97_04061(leuA_2)
PPIC: PhaeoP14_03833(leuA_2)
OCT: FTO60_10560(dmpG)
CEH: CEW89_11445(dmpG)
THAA: CFI11_19395(dmpG)
MON: G8E03_15165(dmpG)
NOV: TQ38_027305(dmpG)
NOT: C7W88_20915(dmpG)
NTD: EGO55_02910(dmpG) EGO55_13670(dmpG)
NOG: GKE62_05085(dmpG)
SGI: SGRAN_1422(mhpE2)
SPHO: C3E99_03975(dmpG)
SPHU: SPPYR_1439(mhpE)
SPHM: G432_01975
SPHF: DM480_04890(dmpG)
SPHA: D3Y57_15225(dmpG)
SPHB: EP837_03396(mhpE)
SUFL: FIL70_18670(dmpG)
SPHY: CHN51_06975(dmpG) CHN51_18315(dmpG)
RDI: CMV14_04950(dmpG)
PALG: HFP57_16675(dmpG)
ERK: CD351_08255(dmpG)
PHZ: CHX26_05330(dmpG)
TMO: TMO_3169(mhpE) TMO_b0123
MAGQ: MGMAQ_0651
BSS: BSUW23_00995(rhiG)
BCA: BCE_2157
BCX: BCA_2155(dmpG)
BCF: bcf_10215
BCER: BCK_24220
BTL: BALH_1844
BMYC: DJ92_4638(dmpG)
BTRO: FJR70_09220(dmpG)
BMQ: BMQ_1728 BMQ_3587(dmpG)
BMD: BMD_1715 BMD_3572(dmpG)
BMEG: BG04_4046 BG04_461(dmpG)
BACO: OXB_2503
BEO: BEH_08655
BFD: NCTC4823_00793(dmpG)
BKO: CKF48_08550(dmpG)
GTN: GTNG_3151(nbaI)
LYB: C3943_22675(dmpG)
LYZ: DCE79_01755(dmpG)
LYG: C1N55_08075(dmpG)
LPAK: GDS87_20230(dmpG)
PRD: F7984_08685(dmpG) F7984_12025(dmpG)
RUE: DT065_12685(dmpG) DT065_13790(dmpG) DT065_15115(dmpG) DT065_15205(dmpG)
SALE: EPH95_15040(dmpG)
PMW: B2K_02290
PRI: PRIO_1606
PSWU: SY83_12875
ASOC: CB4_02452
AAC: Aaci_1619
AAD: TC41_1515(mhpE)
SIV: SSIL_0066(nbaI) SSIL_3690
SOB: CSE16_14630(dmpG)
KUR: ASO14_173
KZO: NCTC404_01743(mhpE)
SPAE: E2C16_04460(dmpG) E2C16_12280(dmpG)
ESR: ES1_22750
ESU: EUS_17010
COO: CCU_13650
CSO: CLS_02690
DSY: DSY3306
PTH: PTH_0483(LeuA)
TFR: BR63_18625(dmpG)
TMR: Tmar_1781
SAY: TPY_0642(mhpE)
BPRS: CK3_33700
CHY: CHY_1280(mhpE)
MTA: Moth_1775
SPOA: EQM13_05625(dmpG)
LPIL: LIP_2173
MTU: Rv3469c(mhpE) Rv3534c(hsaF)
MTC: MT3575(bphI-1) MT3638(bphI-2)
MRA: MRA_3509(mhpE) MRA_3573(bphI)
MTD: UDA_3469c(mhpE) UDA_3534c
MBO: BQ2027_MB3498C(mhpE) BQ2027_MB3564C(hsaf)
MBB: BCG_3534c(mhpE) BCG_3598c
MBT: JTY_3534(mhpE) JTY_3599
MAF: MAF_34840(mhpE) MAF_35460
MPA: MAP_0533
MAO: MAP4_3334
MAVI: RC58_16535
MAVU: RE97_16570
MAV: MAV_0627
MID: MIP_00991
MYO: OEM_05440
MIR: OCQ_05520
MMAL: CKJ54_02610(dmpG)
MLP: MLM_0772
MMM: W7S_02630
MSHG: MSG_03538(mhpE) MSG_04519(bphI-2)
MFJ: MFLOJ_23740 MFLOJ_41030(bphI-2)
MGRO: FZ046_02630(dmpG) FZ046_24415(dmpG)
MSG: MSMEI_4052 MSMEI_5778(bphI-2)
MGI: Mflv_1522
MVQ: MYVA_5129
MTHN: 4412656_04050(bphI)
MHAS: MHAS_03727 MHAS_04021(mhpE)
MDU: MDUV_49660(bphI-2)
MCHT: MCHIJ_19800(bphI-2)
MABB: MASS_0596
MCHE: BB28_03000
MSTE: MSTE_00585
MTER: 4434518_03651(bphI)
MMIN: MMIN_05360(mhpE) MMIN_06630(bphI-2_1) MMIN_12010(bphI-2_2)
MKR: MKOR_35810(bphI-2) MKOR_36590
CDR: CDHC03_1949(mhpE)
CAMG: CAMM_02595
NFR: ERS450000_00749(dmpG_1) ERS450000_01014(dmpG_2) ERS450000_03770(mhpE)
NCY: NOCYR_0495(mhpE)
NSR: NS506_01252(mhpE)
NOZ: DMB37_23575(dmpG)
NOD: FOH10_28770(dmpG)
NAH: F5544_02620(dmpG)
NAD: NCTC11293_01237(mhpE_1) NCTC11293_04251(mhpE_2) NCTC11293_04415(mhpE_3)
REQ: REQ_42060
RHS: A3Q41_02907(mhpE)
RRZ: CS378_11835(dmpG) CS378_19560(dmpG) CS378_23185(dmpG) CS378_24200(dmpG)
RQI: C1M55_04085(dmpG) C1M55_29425(dmpG)
RRT: 4535765_04741(mhpE)
RBY: CEJ39_02110(dmpG) CEJ39_23375(dmpG)
RCR: NCTC10994_02788(dmpG)
GPO: GPOL_c41170(hsaF)
GOR: KTR9_0812(hsaF)
GOC: CXX93_11335(dmpG)
GIT: C6V83_12290(dmpG)
GAV: C5O27_00905(dmpG) C5O27_10800(dmpG)
GOD: GKZ92_03925(dmpG) GKZ92_16330(dmpG)
TPR: Tpau_3800
DIT: C3V38_09240(dmpG)
DIZ: CT688_01915(dmpG) CT688_03155(dmpG)
TOY: FO059_00405(dmpG)
SGR: SGR_564
SCB: SCAB_15191 SCAB_2071(mhpE)
SALU: DC74_7440
SALL: SAZ_38405
STRM: M444_14905
SLE: sle_57500(sle_57500)
SGE: DWG14_08257(mhpE)
SKY: D0C37_31235(dmpG)
SDX: C4B68_37440(dmpG)
KSK: KSE_23710
SALC: C2138_13080(dmpG)
SALD: FVA74_01595(dmpG)
LTR: EVS81_03260(dmpG)
HEA: HL652_17945(dmpG)
ARTP: E5206_04525(dmpG) E5206_14565(dmpG)
JLI: EXU32_15360(dmpG)
JME: EEW87_015415(dmpG)
RAIN: Rai3103_00290(dmpG)
PRV: G7070_02140(dmpG)
NDK: I601_0557(mhpE) I601_3471
NBE: Back2_27170(bphI-2)
AEZ: C3E78_16535(dmpG)
AEB: C6I20_03245(dmpG)
NDA: Ndas_2258
ACTW: F7P10_01800(dmpG)
SRO: Sros_9113
FAL: FRAAL4663
NML: Namu_4081
SACE: GIY23_13345(dmpG)
AMD: AMED_4220(mhpE)
AMN: RAM_21495
AMM: AMES_4170(mhpE)
AMZ: B737_4170(mhpE)
AOI: AORI_3691(mhpE)
AMQ: AMETH_2976(mhpE)
AMYC: CU254_20390(dmpG)
AMYY: YIM_27900
PDX: Psed_4179
PAUT: Pdca_38540(mhpE)
MIL: ML5_3357
MTUA: CSH63_33400(dmpG)
MTEM: GCE86_19385(dmpG)
MCAB: HXZ27_12170(dmpG)
AFS: AFR_23745
PLK: CIK06_08080(dmpG) CIK06_17415(dmpG)
ERZ: ER308_02425(dmpG)
SYW: SYNW0424
RCA: Rcas_2410
CAU: Caur_1351
CAG: Cagg_2034
TRO: trd_1392
KBS: EPA93_11945(dmpG)
TTJ: TTHB246
TSC: TSC_c11570(dmpG)
TTF: THTE_4184
TPI: TREPR_1324(dmpG)
BRM: Bmur_0128
BIP: Bint_1446
FSC: FSU_2557
GFL: GRFL_0092
MARM: YQ22_08335
NDO: DDD_3546
CTS: Ctha_2137
MARC: AR505_0545
MLA: Mlab_0987
HLM: DV707_09475(dmpG)
NMR: Nmar_0140
AG: CAA43227(dmpG)
 » show all
Reference
  Authors
Lee SJ, Ko JH, Kang HY, Lee Y
  Title
Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli.
  Journal
Biochem Biophys Res Commun 346:1009-15 (2006)
DOI:10.1016/j.bbrc.2006.06.009
  Sequence
[eco:b0352]
Reference
PMID:22316175 (EC:4.1.3.39 4.1.3.43)
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a
  Sequence
[ttj:TTHB246]

KEGG   ORTHOLOGY: K18365
Entry
K18365                      KO                                     

Name
bphI, xylK, nahM, tesG
Definition
4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
Pathway
ko00362  Benzoate degradation
ko00621  Dioxin degradation
ko00622  Xylene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00622 Xylene degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00621 Dioxin degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
    4.1.3.43  4-hydroxy-2-oxohexanoate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Other DBs
RN: R00750 R05298
COG: COG0119
GO: 0008701
Genes
PSD: DSC_09375
RGL: CS053_01770(dmpG)
RBD: ALSL_0877 ALSL_1082
VAF: D1115_22440(dmpG)
PRE: PCA10_13840
PPI: ND084(nahM)
PPUT: L483_14055
PPUN: PP4_27280(mhpE)
PVR: PverR02_11585 PverR02_14710
PSC: A458_06510
PPUU: PputUW4_01662(mhpE)
PKC: PKB_4237(nahM)
PSET: THL1_1435
PSIL: PMA3_11725
PKE: DLD99_14740(dmpG)
AVN: Avin_30570(lapG)
AVL: AvCA_30570(lapG)
AVD: AvCA6_30570(lapG)
ASJ: AsACE_CH00352(nahM)
ADV: DJ533_16960(dmpG)
ARJ: DOM24_01575(dmpG)
AWU: BEN71_02690(dmpG)
ACUM: C9E88_006015(dmpG)
ALW: FOB21_11710(dmpG)
SPL: Spea_2116
SHL: Shal_2088
SWD: Swoo_1390
CBER: B5D82_11260(dmpG)
THT: E2K93_11210(dmpG)
PHA: PSHAa2143(mhpE)
PTN: PTRA_a2596(bphI)
PNG: PNIG_a2790(bphI)
MARJ: MARI_05460(bphI)
SALH: HMF8227_02732(bphI)
TTU: TERTU_1283(dmpG)
HALC: EY643_13285(dmpG)
CYQ: Q91_0510 Q91_1491(lapG)
CZA: CYCME_0969(lapG) CYCME_2101(dmpG)
CYY: CPC19_05395(dmpG) CPC19_10505(dmpG)
BLEP: AL038_01290(dmpG)
THIS: HZT40_10615(dmpG)
AEH: Mlg_2462
KAK: Kalk_07865(dmpG)
MPRI: MP3633_3149(mhpE)
NCU: F0U83_03055(dmpG)
NIK: F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)
SOK: D0B54_06190(dmpG)
SINI: GT972_14660(dmpG)
TBN: TBH_C0930
GPB: HDN1F_27070(tesG)
NZO: SAMEA4504057_0444(bphI)
RPI: Rpic_4617
REH: H16_B0595(bpHI)
CNC: CNE_2c05400(bpHI)
RME: Rmet_1319(bphI)
CTI: RALTA_B0399(mhpE)
COX: E0W60_08015(dmpG)
BCJ: BCAM1615(bphI)
BCEN: DM39_3381(dmpG) DM39_4832(dmpG)
BCEO: I35_5475(bphI)
BCED: DM42_4991(dmpG) DM42_6343(dmpG)
BMEC: WJ16_26800
BXE: Bxe_C1187(bphI)
BXB: DR64_8618(dmpG)
BFN: OI25_4591(dmpG)
PARB: CJU94_37880(dmpG) CJU94_38125(dmpG)
PMEG: FNZ07_21155(dmpG)
CABA: SBC2_49000(bphI)
LIMN: HKT17_03830(dmpG)
AXY: AXYL_04307(dmpG)
RFR: Rfer_0454
PNA: Pnap_4142
AJS: Ajs_0224
VEI: Veis_2781
VBO: CKY39_28495(dmpG)
CTES: O987_07730
COF: FOZ74_08315(dmpG)
HPSE: HPF_01850(bphI)
HYN: F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)
DIH: G7047_09695(dmpG)
SIMP: C6571_13625(dmpG)
MELA: C6568_07850(dmpG)
METP: C1M51_06440(dmpG) C1M51_16320(dmpG)
JAJ: EKL02_01800(dmpG) EKL02_13150(dmpG)
LCH: Lcho_3340
SNN: EWH46_19310(dmpG)
DEY: HYN24_14110(dmpG) HYN24_14200(dmpG)
AZO: azo1857(lapG) azo1972(mhpE) azo2431(nahM)
ACOM: CEW83_03610(dmpG)
AZD: CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)
AZR: CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)
AZQ: G3580_00550(dmpG) G3580_08280(dmpG)
THK: CCZ27_04605(dmpG) CCZ27_10750(dmpG)
AAQI: AAQM_0982(dmpG)
ACIB: ACBT_0259(dmpG)
AFC: AFAEC_1844(dmpG)
ARC: ABLL_2442
SHZ: shn_33310
CID: P73_1382
SGI: SGRAN_1579(mhpE)
SJP: SJA_C1-11910(mhpE_xylK)
SINB: SIDU_08310
SHYD: CJD35_06515(dmpG)
SFLA: SPHFLASMR4Y_02366(bphI)
TXI: TH3_21418
HTL: HPTL_0047
GGH: GHH_c14840(pheE)
AAD: TC41_0802(mhpE)
BTS: Btus_0969
KYR: CVV65_10345(dmpG) CVV65_11290(dmpG)
DHD: Dhaf_1245
TOC: Toce_0378
 » show all
Reference
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence

KEGG   ENZYME: 4.1.3.39
Entry
EC 4.1.3.39                 Enzyme                                 

Name
4-hydroxy-2-oxovalerate aldolase;
4-hydroxy-2-ketovalerate aldolase;
HOA;
DmpG;
4-hydroxy-2-oxovalerate pyruvate-lyase;
4-hydroxy-2-oxopentanoate pyruvate-lyase;
BphI;
4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(S)-4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
Reaction(IUBMB)
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
Reaction(KEGG)
(other) R00750
Substrate
(S)-4-hydroxy-2-oxopentanoate
Product
acetaldehyde [CPD:C00084];
pyruvate [CPD:C00022]
Comment
Requires Mn2+ for maximal activity [1]. The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH [1]. In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5].
History
EC 4.1.3.39 created 2006, modified 2011
Pathway
ec00360  Phenylalanine metabolism
ec00362  Benzoate degradation
ec00621  Dioxin degradation
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01666  4-hydroxy 2-oxovalerate aldolase
K18365  4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Genes
ECO: b0352(mhpE)
ECJ: JW0343(mhpE)
EBW: BWG_0241(mhpE)
ECOK: ECMDS42_0274(mhpE)
ECE: Z0452(mhpE)
ECS: ECs0407
ECF: ECH74115_0427(mhpE)
ETW: ECSP_0416(mhpE)
ELX: CDCO157_0395
EOI: ECO111_0388(mhpE)
EOJ: ECO26_0388(mhpE)
EOH: ECO103_0334(mhpE)
ECOO: ECRM13514_0494(mhpE)
ECOH: ECRM13516_0332(mhpE)
ESL: O3K_19715
ESO: O3O_05580
ESM: O3M_19700
ECK: EC55989_0359(mhpE)
EOK: G2583_0465(mhpE)
ELH: ETEC_0408
ECW: EcE24377A_0376(mhpE)
EUN: UMNK88_402(mhpE)
ENA: ECNA114_0335(mhpE)
ECOS: EC958_0496
ECX: EcHS_A0416(mhpE)
ECM: EcSMS35_0383(mhpE)
ECY: ECSE_0377
ECR: ECIAI1_0353(mhpE)
ECQ: ECED1_0380(mhpE)
EUM: ECUMN_0395(mhpE)
ECT: ECIAI39_0326(mhpE)
EOC: CE10_0320(mhpE)
EBR: ECB_00306(mhpE)
EBL: ECD_00306(mhpE)
EBE: B21_00310(mhpE)
EBD: ECBD_3305
ELO: EC042_0389(mhpE)
ESE: ECSF_0323
EKF: KO11_21820(mhpE)
EDJ: ECDH1ME8569_0339(mhpE)
ELW: ECW_m0430(mhpE)
ELL: WFL_02115(mhpE)
ELP: P12B_c0312(mhpE) P12B_c0370(mhpE)
ECOJ: P423_01850
EMA: C1192_10895(dmpG)
ESZ: FEM44_16335(dmpG)
SSN: SSON_0331(mhpE)
KPN: KPN_02117(mhpE)
KPU: KP1_3212(mhpE)
KPP: A79E_2127
KPT: VK055_0344(dmpG)
KPR: KPR_2662(mhpE)
KPJ: N559_2173
KPX: PMK1_04481(mhpE)
KPNU: LI86_10795
KPNK: BN49_3222(mhpE)
KVA: Kvar_2158
KPE: KPK_2206(mhpE)
KOX: KOX_22670
KOE: A225_3411
KQV: B8P98_11815(dmpG)
KLW: DA718_12110(dmpG)
CWE: CO701_16970(dmpG)
CYO: CD187_18570(dmpG)
CPOT: FOB25_06035(dmpG)
CFQ: C2U38_05270(dmpG)
CIF: AL515_06460(dmpG)
CIE: AN232_24605(dmpG)
CPAR: CUC49_01495(dmpG)
EBT: EBL_c19990(mhpE)
RAO: DSD31_10730(dmpG)
REE: electrica_02140(mhpE)
EBF: D782_1987
EBU: CUC76_00405(dmpG)
SPE: Spro_3025
SERA: Ser39006_017380(dmpG)
SERQ: CWC46_17380(dmpG)
SQU: E4343_00890(dmpG)
ECA: ECA1429(nahM)
PATR: EV46_07235
PATO: GZ59_14680(nahM)
EPY: EpC_04020
PLU: plu4081
XNE: XNC1_0240
XNM: XNC2_0241
LRI: NCTC12151_03194(mhpE)
PSD: DSC_09375
RGL: CS053_01770(dmpG)
VAG: N646_2394
VAF: D1115_22440(dmpG)
PAEP: PA1S_20450
PAEG: AI22_13500
PCQ: PcP3B5_23500(mhpE) PcP3B5_25720(dmpG)
PPU: PP_1791
PPT: PPS_1433
PPI: ND084(nahM)
PPX: T1E_4258(cmtG) T1E_4274(tobH)
PPUH: B479_25865
PPUN: PP4_27280(mhpE)
PSB: Psyr_3072
PEN: PSEEN0975
PSTT: CH92_19040
PPUU: PputUW4_01662(mhpE)
PKC: PKB_1193 PKB_3256(amng1) PKB_3604(amng3) PKB_4237(nahM)
PSES: PSCI_2058(xylK)
PSOS: POS17_2261
PKE: DLD99_14425(dmpG) DLD99_14495(dmpG) DLD99_14740(dmpG)
AVN: Avin_08740(xylK) Avin_15130(mphE) Avin_30570(lapG) Avin_42120
AVL: AvCA_08740(xylK) AvCA_15130(mphE) AvCA_30570(lapG) AvCA_42120
ACX: Achr_27750(mphE) Achr_32700(xylK)
ASJ: AsACE_CH00352(nahM)
ADV: DJ533_01780(dmpG) DJ533_16960(dmpG)
ARJ: DOM24_01575(dmpG)
AWU: BEN71_02690(dmpG)
ACUM: C9E88_006015(dmpG)
ALW: FOB21_11710(dmpG)
ADS: FPL17_05445(dmpG)
SDN: Sden_2668
SPL: Spea_2116
SHL: Shal_2088
SWD: Swoo_1390
CBER: B5D82_11260(dmpG)
THT: E2K93_11210(dmpG)
PHA: PSHAa2143(mhpE)
PTN: PTRA_a0482(mhpE) PTRA_a2596(bphI)
PNG: PNIG_a2790(bphI)
MHC: MARHY0649
MARJ: MARI_05460(bphI)
SALH: HMF8227_02732(bphI)
TTU: TERTU_1283(dmpG)
HALC: EY643_13285(dmpG)
KIM: G3T16_05375(dmpG)
LPN: lpg2681
LPH: LPV_3027
LPO: LPO_2962
LPM: LP6_2713
LPF: lpl2608
LPP: lpp2735
LPC: LPC_0455
LPA: lpa_03915
LPE: lp12_2674
LLO: LLO_0366
LFA: LFA_0384
LHA: LHA_2302
LLG: 44548918_00735(bphI)
LJR: NCTC11533_00845(mhpE)
LCJ: NCTC11976_00245(mhpE)
LWA: SAMEA4504053_3185(bphI)
TMC: LMI_2790
HMAR: HVMH_0576
MEJ: Q7A_1101
CYQ: Q91_0510 Q91_1491(lapG)
CZA: CYCME_0969(lapG) CYCME_2101(dmpG)
CYY: CPC19_05395(dmpG) CPC19_10505(dmpG)
BLEP: AL038_01290(dmpG)
THIS: HZT40_10615(dmpG)
AEH: Mlg_2462
HALK: CUU95_03820(dmpG)
HVN: EI420_02110(dmpG)
KAK: Kalk_07865(dmpG)
MPRI: MP3633_3149(mhpE)
NCU: F0U83_03055(dmpG)
NIK: F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)
SOK: D0B54_04235(dmpG) D0B54_06190(dmpG)
SINI: GT972_13755(dmpG) GT972_14660(dmpG)
TBN: TBH_C0930
GPB: HDN1F_27070(tesG)
NZO: SAMEA4504057_0444(bphI)
CHRO: CXB49_03860(dmpG)
CRZ: D1345_11515(dmpG)
CHAE: CH06BL_23600(mhpE)
AQS: DKK66_07210(dmpG)
RSO: RSp0895(dmpG)
RSM: CMR15_mp10879(mhpE)
RSE: F504_4322
RPI: Rpic_4617
RPU: CDC45_22090(dmpG)
REH: H16_A1807(mhpE2) H16_B0552(mhpE1) H16_B0595(bpHI)
RME: Rmet_1319(bphI) Rmet_5209(mhpE)
CTI: RALTA_B0399(mhpE)
COX: E0W60_03755(dmpG) E0W60_07650(dmpG) E0W60_07795(dmpG) E0W60_08015(dmpG)
BPS: BPSS1807(mhpE)
BPM: BURPS1710b_A0890(mhpE)
BPD: BURPS668_A2590(mhpE)
BPSE: BDL_5207(dmpG)
BPSM: BBQ_4325(dmpG)
BPSU: BBN_5270(dmpG)
BPSD: BBX_4373(dmpG)
BPZ: BP1026B_II1937(mhpE)
BPK: BBK_4537(dmpG)
BPSH: DR55_5932(dmpG)
BPSA: BBU_4207(dmpG)
BPSO: X996_5729(dmpG)
BUT: X994_5292(dmpG)
BTE: BTH_II0570(mhpE)
BTQ: BTQ_3864(dmpG)
BTJ: BTJ_4896(dmpG)
BTZ: BTL_5690(dmpG)
BTD: BTI_5186(dmpG)
BTV: BTHA_4520(dmpG)
BTHE: BTN_5352(dmpG)
BTHM: BTRA_5626(dmpG)
BTHA: DR62_5490
BTHL: BG87_5697(dmpG)
BOK: DM82_6079(dmpG)
BOC: BG90_4586(dmpG)
BVE: AK36_3502(dmpG)
BCJ: BCAM1615(bphI) BCAM2121
BCEN: DM39_1991(dmpG) DM39_3381(dmpG) DM39_4832(dmpG) DM39_4966(dmpG)
BCEW: DM40_5000(dmpG)
BCEO: I35_5475(bphI) I35_6003
BMUL: NP80_3434(dmpG) NP80_3873(dmpG)
BCED: DM42_4991(dmpG) DM42_6343(dmpG)
BLAT: WK25_27480
BSEM: WJ12_26060
BGU: KS03_3374(dmpG) KS03_5342
BGO: BM43_7072(dmpG)
BUK: MYA_5002
BUL: BW21_2671(dmpG) BW21_4722(dmpG)
BXB: DR64_1245(dmpG) DR64_3311(dmpG) DR64_4657(dmpG) DR64_8618(dmpG)
BFN: OI25_255(dmpG) OI25_4591(dmpG)
PARB: CJU94_31730(dmpG) CJU94_37880(dmpG) CJU94_38125(dmpG)
PHS: C2L64_35640(dmpG)
PTER: C2L65_38855(dmpG)
PGP: CUJ91_31740(dmpG)
PMEG: FNZ07_21155(dmpG)
PPNM: LV28_21850
PPUL: RO07_16240
PSPU: NA29_20920
PAPI: SG18_00060
PAND: DRB87_06760(dmpG)
PFIB: PI93_020350(dmpG)
CABA: SBC2_49000(bphI)
LIMN: HKT17_03830(dmpG)
BAV: BAV0600(bphF)
BHZ: ACR54_00829(mhpE)
AXY: AXYL_04307(dmpG)
ACHR: C2U31_03430(dmpG)
PUT: PT7_2460
PUD: G9Q38_01255(dmpG) G9Q38_15010(dmpG)
AFQ: AFA_13960(dmpG)
AAQU: D3M96_14820(dmpG)
PIG: EGT29_26650(dmpG)
KGY: EHF36_03355(dmpG)
RFR: Rfer_0454
POL: Bpro_5136
PNA: Pnap_4142
AJS: Ajs_0224
ACK: C380_15915(bphF)
VEI: Veis_2781
VBO: CKY39_22055(dmpG) CKY39_28495(dmpG)
COF: FOZ74_08315(dmpG)
HPSE: HPF_01850(bphI) HPF_15300(mhpE)
HYN: F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)
DIH: G7047_09695(dmpG) G7047_22420(dmpG)
SIMP: C6571_13625(dmpG) C6571_19090(dmpG)
MELA: C6568_07850(dmpG)
METP: C1M51_06440(dmpG) C1M51_16320(dmpG)
JAG: GJA_232(dmpG)
JAJ: EKL02_01800(dmpG) EKL02_13150(dmpG)
HEE: hmeg3_19565(dmpG)
LCH: Lcho_3340
SNN: EWH46_19310(dmpG)
DEY: HYN24_14110(dmpG) HYN24_14200(dmpG)
AZO: azo1857(lapG) azo1972(mhpE) azo2431(nahM)
ACOM: CEW83_03610(dmpG)
AZD: CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)
AZR: CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)
AZQ: G3580_00550(dmpG) G3580_08280(dmpG)
THK: CCZ27_04605(dmpG) CCZ27_10750(dmpG)
CCF: YSQ_01790
ABU: Abu_1489
ABT: ABED_1386
ATP: ATR_1318
AELL: AELL_1860
AAQI: AAQM_0982(dmpG) AAQM_1697
ACIB: ACBT_0259(dmpG) ACBT_1008
AMAR: AMRN_1917
APAI: APAC_0989
HBV: ABIV_1064
HEBR: AEBR_1328
PACO: AACT_1972
SHAL: SHALO_2223
SUN: SUN_2142
GLO: Glov_0787
DMA: DMR_24610(nahM)
DPI: BN4_11362(nahM)
HOH: Hoch_1083
PCAY: FRD00_17515(dmpG)
RBT: NOVO_02090(leuA)
ARA: Arad_7255
SHZ: shn_33310
ABAW: D5400_20370(dmpG)
BTR: BT_2080
XAU: Xaut_0938
MSL: Msil_1479
MTUN: MTUNDRAET4_3892(mhpE)
MMED: Mame_00137(mhpE)
PHP: PhaeoP97_04061(leuA_2)
PPIC: PhaeoP14_03833(leuA_2)
OCT: FTO60_10560(dmpG)
CID: P73_1382
CEH: CEW89_11445(dmpG)
THAA: CFI11_19395(dmpG)
MON: G8E03_15165(dmpG)
NOV: TQ38_027305(dmpG)
NOT: C7W88_20915(dmpG)
NTD: EGO55_02910(dmpG) EGO55_13670(dmpG)
NOG: GKE62_05085(dmpG)
SGI: SGRAN_1422(mhpE2) SGRAN_1579(mhpE)
SPHO: C3E99_03975(dmpG)
SPHU: SPPYR_1439(mhpE)
SPHM: G432_01975
SPHF: DM480_04890(dmpG)
SPHA: D3Y57_15225(dmpG)
SJP: SJA_C1-11910(mhpE_xylK)
SPHB: EP837_03396(mhpE)
SINB: SIDU_08310
SHYD: CJD35_06515(dmpG)
SUFL: FIL70_18670(dmpG)
SFLA: SPHFLASMR4Y_02366(bphI)
SPHY: CHN51_06975(dmpG) CHN51_18315(dmpG)
RDI: CMV14_04950(dmpG)
PALG: HFP57_16675(dmpG)
ERK: CD351_08255(dmpG)
PHZ: CHX26_05330(dmpG)
TMO: TMO_3169(mhpE) TMO_b0123
TXI: TH3_21418
MAGQ: MGMAQ_0651
HTL: HPTL_0047
BSS: BSUW23_00995(rhiG)
BCA: BCE_2157
BCX: BCA_2155(dmpG)
BCF: bcf_10215
BCER: BCK_24220
BTL: BALH_1844
BMYC: DJ92_4638(dmpG)
BTRO: FJR70_09220(dmpG)
BMQ: BMQ_1728 BMQ_3587(dmpG)
BMD: BMD_1715 BMD_3572(dmpG)
BMEG: BG04_4046 BG04_461(dmpG)
BACO: OXB_2503
BEO: BEH_08655
BFD: NCTC4823_00793(dmpG)
BKO: CKF48_08550(dmpG)
GTN: GTNG_3151(nbaI)
GGH: GHH_c14840(pheE)
LYB: C3943_22675(dmpG)
LYZ: DCE79_01755(dmpG)
LYG: C1N55_08075(dmpG)
LPAK: GDS87_20230(dmpG)
PRD: F7984_08685(dmpG) F7984_12025(dmpG)
RUE: DT065_12685(dmpG) DT065_13790(dmpG) DT065_15115(dmpG) DT065_15205(dmpG)
SALE: EPH95_15040(dmpG)
PMW: B2K_02290
PRI: PRIO_1606
PSWU: SY83_12875
ASOC: CB4_02452
AAC: Aaci_1619
AAD: TC41_0802(mhpE) TC41_1515(mhpE)
BTS: Btus_0969
KYR: CVV65_10345(dmpG) CVV65_11290(dmpG)
SIV: SSIL_0066(nbaI) SSIL_3690
SOB: CSE16_14630(dmpG)
KUR: ASO14_173
KZO: NCTC404_01743(mhpE)
SPAE: E2C16_04460(dmpG) E2C16_12280(dmpG)
ESR: ES1_22750
ESU: EUS_17010
COO: CCU_13650
CSO: CLS_02690
DSY: DSY3306
DHD: Dhaf_1245
PTH: PTH_0483(LeuA)
TFR: BR63_18625(dmpG)
TMR: Tmar_1781
SAY: TPY_0642(mhpE)
BPRS: CK3_33700
CHY: CHY_1280(mhpE)
MTA: Moth_1775
TOC: Toce_0378
SPOA: EQM13_05625(dmpG)
LPIL: LIP_2173
MTU: Rv3469c(mhpE) Rv3534c(hsaF)
MTC: MT3575(bphI-1) MT3638(bphI-2)
MRA: MRA_3509(mhpE) MRA_3573(bphI)
MTD: UDA_3469c(mhpE) UDA_3534c
MBO: BQ2027_MB3498C(mhpE) BQ2027_MB3564C(hsaf)
MBB: BCG_3534c(mhpE) BCG_3598c
MBT: JTY_3534(mhpE) JTY_3599
MAF: MAF_34840(mhpE) MAF_35460
MPA: MAP_0533
MAO: MAP4_3334
MAVI: RC58_16535
MAVU: RE97_16570
MAV: MAV_0627
MID: MIP_00991
MYO: OEM_05440
MIR: OCQ_05520
MMAL: CKJ54_02610(dmpG)
MLP: MLM_0772
MMM: W7S_02630
MSHG: MSG_03538(mhpE) MSG_04519(bphI-2)
MFJ: MFLOJ_23740 MFLOJ_41030(bphI-2)
MGRO: FZ046_02630(dmpG) FZ046_24415(dmpG)
MSG: MSMEI_4052 MSMEI_5778(bphI-2)
MGI: Mflv_1522
MVQ: MYVA_5129
MTHN: 4412656_04050(bphI)
MHAS: MHAS_03727 MHAS_04021(mhpE)
MDU: MDUV_49660(bphI-2)
MCHT: MCHIJ_19800(bphI-2)
MABB: MASS_0596
MCHE: BB28_03000
MSTE: MSTE_00585
MTER: 4434518_03651(bphI)
MMIN: MMIN_05360(mhpE) MMIN_06630(bphI-2_1) MMIN_12010(bphI-2_2)
MKR: MKOR_35810(bphI-2) MKOR_36590
CDR: CDHC03_1949(mhpE)
CAMG: CAMM_02595
NFR: ERS450000_00749(dmpG_1) ERS450000_01014(dmpG_2) ERS450000_03770(mhpE)
NCY: NOCYR_0495(mhpE)
NSR: NS506_01252(mhpE)
NOZ: DMB37_23575(dmpG)
NOD: FOH10_28770(dmpG)
NAH: F5544_02620(dmpG)
NAD: NCTC11293_01237(mhpE_1) NCTC11293_04251(mhpE_2) NCTC11293_04415(mhpE_3)
REQ: REQ_42060
RHS: A3Q41_02907(mhpE)
RRZ: CS378_11835(dmpG) CS378_19560(dmpG) CS378_23185(dmpG) CS378_24200(dmpG)
RQI: C1M55_04085(dmpG) C1M55_29425(dmpG)
RRT: 4535765_04741(mhpE)
RBY: CEJ39_02110(dmpG) CEJ39_23375(dmpG)
RCR: NCTC10994_02788(dmpG)
GPO: GPOL_c41170(hsaF)
GOR: KTR9_0812(hsaF)
GOC: CXX93_11335(dmpG)
GIT: C6V83_12290(dmpG)
GAV: C5O27_00905(dmpG) C5O27_10800(dmpG)
GOD: GKZ92_03925(dmpG) GKZ92_16330(dmpG)
TPR: Tpau_3800
DIT: C3V38_09240(dmpG)
DIZ: CT688_01915(dmpG) CT688_03155(dmpG)
TOY: FO059_00405(dmpG)
SGR: SGR_564
SCB: SCAB_15191 SCAB_2071(mhpE)
SALU: DC74_7440
SALL: SAZ_38405
STRM: M444_14905
SLE: sle_57500(sle_57500)
SGE: DWG14_08257(mhpE)
SKY: D0C37_31235(dmpG)
SDX: C4B68_37440(dmpG)
KSK: KSE_23710
SALC: C2138_13080(dmpG)
SALD: FVA74_01595(dmpG)
LTR: EVS81_03260(dmpG)
HEA: HL652_17945(dmpG)
ARTP: E5206_04525(dmpG) E5206_14565(dmpG)
JLI: EXU32_15360(dmpG)
JME: EEW87_015415(dmpG)
RAIN: Rai3103_00290(dmpG)
PRV: G7070_02140(dmpG)
NDK: I601_0557(mhpE) I601_3471
NBE: Back2_27170(bphI-2)
AEZ: C3E78_16535(dmpG)
AEB: C6I20_03245(dmpG)
NDA: Ndas_2258
ACTW: F7P10_01800(dmpG)
SRO: Sros_9113
FAL: FRAAL4663
NML: Namu_4081
SACE: GIY23_13345(dmpG)
AMD: AMED_4220(mhpE)
AMN: RAM_21495
AMM: AMES_4170(mhpE)
AMZ: B737_4170(mhpE)
AOI: AORI_3691(mhpE)
AMQ: AMETH_2976(mhpE)
AMYC: CU254_20390(dmpG)
AMYY: YIM_27900
PDX: Psed_4179
PAUT: Pdca_38540(mhpE)
MIL: ML5_3357
MTUA: CSH63_33400(dmpG)
MTEM: GCE86_19385(dmpG)
MCAB: HXZ27_12170(dmpG)
AFS: AFR_23745
PLK: CIK06_08080(dmpG) CIK06_17415(dmpG)
ERZ: ER308_02425(dmpG)
SYW: SYNW0424
RCA: Rcas_2410
CAU: Caur_1351
CAG: Cagg_2034
TRO: trd_1392
KBS: EPA93_11945(dmpG)
TTJ: TTHB246
TSC: TSC_c11570(dmpG)
TTF: THTE_4184
TPI: TREPR_1324(dmpG)
BRM: Bmur_0128
BIP: Bint_1446
FSC: FSU_2557
GFL: GRFL_0092
MARM: YQ22_08335
NDO: DDD_3546
CTS: Ctha_2137
MARC: AR505_0545
MLA: Mlab_0987
HLM: DV707_09475(dmpG)
NMR: Nmar_0140
 » show all
Reference
1  [PMID:12764229]
  Authors
Manjasetty BA, Powlowski J, Vrielink A.
  Title
Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate.
  Journal
Proc Natl Acad Sci U S A 100:6992-7 (2003)
DOI:10.1073/pnas.1236794100
  Sequence
Reference
2  [PMID:8419288]
  Authors
Powlowski J, Sahlman L, Shingler V.
  Title
Purification and properties of the physically associated meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 175:377-85 (1993)
DOI:10.1128/JB.175.2.377-385.1993
  Sequence
Reference
3  [PMID:11264589]
  Authors
Manjasetty BA, Croteau N, Powlowski J, Vrielink A.
  Title
Crystallization and preliminary X-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase--aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600.
  Journal
Acta Crystallogr D Biol Crystallogr 57:582-5 (2001)
DOI:10.1107/S0907444901000439
Reference
4  [PMID:21425833]
  Authors
Baker P, Carere J, Seah SY
  Title
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI.
  Journal
Biochemistry 50:3559-69 (2011)
DOI:10.1021/bi101947g
  Sequence
[bxe:Bxe_C1187]
Reference
5  [PMID:22316175]
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a
  Sequence
[ttj:TTHB246]
Reference
6  [PMID:22081904]
  Authors
Baker P, Seah SY
  Title
Rational design of stereoselectivity in the class II pyruvate aldolase BphI.
  Journal
J Am Chem Soc 134:507-13 (2012)
DOI:10.1021/ja208754r
  Sequence
[bxe:Bxe_C1187]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.39
IUBMB Enzyme Nomenclature: 4.1.3.39
ExPASy - ENZYME nomenclature database: 4.1.3.39
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.3.39
BRENDA, the Enzyme Database: 4.1.3.39
CAS: 37325-52-3

KEGG   REACTION: R00750
Entry
R00750                      Reaction                               

Name
4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
Definition
Acetaldehyde + Pyruvate <=> 4-Hydroxy-2-oxopentanoate
Equation
Reaction class
RC00307  C00022_C03589
RC00371  C00084_C03589
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00621  Dioxin degradation
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Orthology
K01666  4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K18365  4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
Other DBs
RHEA: 22627

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