ORTHOLOGY: K07514 Help
Entry
Symbol
EHHADH
Name
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:
4.2.1.17 1.1.1.35 5.3.3.8 ]
Pathway
map00280 Valine, leucine and isoleucine degradation
map01110 Biosynthesis of secondary metabolites
map01120 Microbial metabolism in diverse environments
Module
M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Reaction
R01975 (S)-3-hydroxybutanoyl-CoA:NAD+ oxidoreductase
R03026 (S)-3-hydroxybutanoyl-CoA hydro-lyase
R03045 3-hydroxypropionyl-CoA hydro-lyase
R04137 3-hydroxyisovaleryl-CoA hydro-lyase
R04170 (S)-3-hydroxydodecanoyl-CoA hydro-lyase
R04203 (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
R04204 (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase
R04224 (S)-3-hydroxyisobutyryl-CoA hydro-lyase
R04737 (S)-3-hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase
R04738 (S)-3-hydroxyhexadecanoyl-CoA hydro-lyase
R04739 (S)-3-hydroxytetradecanoyl-CoA:NAD+ oxidoreductase
R04740 (S)-3-hydroxytetradecanoyl-CoA hydro-lyase
R04741 (S)-3-hydroxydodecanoyl-CoA:NAD+ oxidoreductase
R04743 (S)-hydroxydecanoyl-CoA:NAD+ oxidoreductase
R04744 (S)-hydroxydecanoyl-CoA hydro-lyase
R04745 (S)-hydroxyoctanoyl-CoA:NAD+ oxidoreductase
R04746 (S)-hydroxyoctanoyl-CoA hydro-lyase
R04748 (S)-hydroxyhexanoyl-CoA:NAD+ oxidoreductase
R04749 (S)-hydroxyhexanoyl-CoA hydro-lyase
R04756 cis,cis-3,6-dodecadienoyl-CoA delta3-cis-delta2-trans-isomerase
R06941 (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
R06942 (3S)-3-hydroxyacyl-CoA hydro-lyase
Disease
H01198 Fanconi renotubular syndrome
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
00650 Butanoate metabolism
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09103 Lipid metabolism
00071 Fatty acid degradation
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
00310 Lysine degradation
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
00380 Tryptophan metabolism
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09106 Metabolism of other amino acids
00410 beta-Alanine metabolism
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09111 Xenobiotics biodegradation and metabolism
00627 Aminobenzoate degradation
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
00930 Caprolactam degradation
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
09150 Organismal Systems
09152 Endocrine system
03320 PPAR signaling pathway
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.17 enoyl-CoA hydratase
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.8 Delta3-Delta2-enoyl-CoA isomerase
K07514 EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
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Taxonomy UniProt
Reference
Authors
Hoefler G, Forstner M, McGuinness MC, Hulla W, Hiden M, Krisper P, Kenner L, Ried T, Lengauer C, Zechner R, et al.
Title
cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.
Journal
Sequence
Reference
Authors
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL
Title
Regulation of cellular metabolism by protein lysine acetylation.
Journal