KEGG   ORTHOLOGY: K01852
Entry
K01852                      KO                                     

Name
LSS, ERG7
Definition
lanosterol synthase [EC:5.4.99.7]
Pathway
ko00100  Steroid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Disease
H01202  Cataract
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K01852  LSS, ERG7; lanosterol synthase
Enzymes [BR:ko01000]
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.99  Transferring other groups
    5.4.99.7  lanosterol synthase
     K01852  LSS, ERG7; lanosterol synthase
Other DBs
RN: R03199
COG: COG1657
GO: 0000250
Genes
HSA: 4047(LSS)
PTR: 474058(LSS)
PPS: 100974593(LSS)
GGO: 101124004(LSS)
PON: 100432375(LSS)
NLE: 100592843(LSS)
MCC: 709227(LSS)
MCF: 102137329(LSS)
CSAB: 103220328(LSS)
RRO: 104667600(LSS)
RBB: 108512153
CJC: 100409467(LSS)
SBQ: 101032145(LSS)
MMU: 16987(Lss)
MCAL: 110302909(Lss)
MPAH: 110326638(Lss)
RNO: 81681(Lss)
MUN: 110546351(Lss)
CGE: 100753498(Lss)
NGI: 103739961(Lss)
HGL: 101713900(Lss)
CCAN: 109695890(Lss)
OCU: 100359315(LSS)
TUP: 102473663(LSS)
CFA: 491611(LSS)
VVP: 112909549(LSS)
AML: 100482594(LSS)
UMR: 103680679(LSS)
UAH: 113258959(LSS)
ORO: 101375055(LSS)
ELK: 111155646
FCA: 101080651(LSS)
PTG: 102962591(LSS)
PPAD: 109258102(LSS)
AJU: 106987528(LSS)
BTA: 615906(LSS)
BOM: 102277039(LSS)
BIU: 109561307(LSS)
BBUB: 102395472(LSS)
CHX: 102175810(LSS)
OAS: 101106995(LSS)
SSC: 100625138(LSS)
CFR: 102516637(LSS)
CDK: 105090588(LSS)
BACU: 103005228(LSS)
LVE: 103077252(LSS)
OOR: 101289294(LSS)
DLE: 111186240(LSS)
ECB: 100055292(LSS)
EPZ: 103558417(LSS)
EAI: 106842988(LSS)
MYB: 102244769(LSS)
MYD: 102755441(LSS)
MNA: 107536230(LSS)
DRO: 112306546(LSS)
PALE: 102897618(LSS)
RAY: 107510225(LSS)
MJV: 108409563(LSS)
LAV: 100662429(LSS)
TMU: 101341011
SHR: 100933933(LSS)
PCW: 110198829(LSS)
OAA: 100083602(LSS)
GGA: 424037(LSS)
MGP: 100544500(LSS)
CJO: 107316378(LSS)
NMEL: 110399885(LSS)
APLA: 101801199(LSS)
ACYG: 106030113(LSS)
TGU: 100223318(LSS)
LSR: 110471683(LSS)
SCAN: 103814750(LSS)
GFR: 102037340(LSS)
FAB: 101809334(LSS)
PHI: 102113695(LSS)
CCAE: 111931893(LSS)
CCW: 104698254(LSS)
ETL: 114070053(LSS)
FPG: 101912237(LSS)
FCH: 102059359(LSS)
CLV: 102092351(LSS)
EGZ: 104133503(LSS)
NNI: 104013643(LSS)
ACUN: 113482095(LSS)
PADL: 103922915(LSS)
AAM: 106492318(LSS)
ASN: 102375533(LSS)
AMJ: 102568061(LSS)
CMY: 102946034(LSS)
ACS: 100558321(lss)
PVT: 110090934
PMUR: 107296168(LSS)
PMUA: 114582271(LSS)
XLA: 108703025(lss.S)
XTR: 733925(lss)
NPR: 108793617(LSS)
DRE: 795400(lss)
SGH: 107555930(lss)
CCAR: 109088812(lss)
IPU: 108266196(lss)
PHYP: 113526032(lss)
AMEX: 103022113(lss)
EEE: 113567698(lss)
TRU: 101062227(lss)
LCO: 104920782(lss)
MZE: 101485469(lss)
ONL: 100690152
OLA: 101157258 101157497(lss)
XMA: 102229476(lss)
XCO: 114148334(lss)
PRET: 103461854(lss)
CVG: 107086194(lss)
NFU: 107373714(lss)
KMR: 108247361
ALIM: 106529310(lss)
AOCE: 111582860(lss)
CSEM: 103392388(lss)
POV: 109644787(lss)
LCF: 108897198(lss)
SDU: 111218455(lss)
SLAL: 111667391(lss)
HCQ: 109517560(lss)
BPEC: 110167885(lss)
MALB: 109972638(lss)
SASA: 106581851(lss)
OTW: 112225134(lss)
SALP: 111959367(lss)
ELS: 105016172(lss)
SFM: 108924262(lss)
PKI: 111845428(lss)
LCM: 102361349(LSS)
CMK: 103188931(lss)
BFO: 118424025
SPU: 576764
ATH: AT3G45130(LAS1)
THJ: 104799632
SCE: YHR072W(ERG7)
ERC: Ecym_8182
KMX: KLMA_30341(ERG7)
NCS: NCAS_0H01640(NCAS0H01640)
NDI: NDAI_0C01970(NDAI0C01970)
TPF: TPHA_0E01120(TPHA0E01120)
TBL: TBLA_0A03120(TBLA0A03120)
TDL: TDEL_0E02760(TDEL0E02760)
KAF: KAFR_0D04670(KAFR0D04670)
PIC: PICST_77382(ERG7)
CAL: CAALFM_C202460WA(ERG7)
CDU: CD36_17130(ERG7)
SLB: AWJ20_3290(ERG7)
NCR: NCU01119
NTE: NEUTE1DRAFT127722(NEUTE1DRAFT_127722)
MGR: MGG_11702
MAW: MAC_04069
MAJ: MAA_01453
CMT: CCM_09526
MBE: MBM_02694
ANG: ANI_1_1064084(An09g01330) ANI_1_846084(An09g06490)
ABE: ARB_06777
TVE: TRV_05691
PTE: PTT_15458
SPO: SPAC13G7.01c(erg7)
CNE: CND02520
TASA: A1Q1_07921
ABP: AGABI1DRAFT55056(AGABI1DRAFT_55056)
ABV: AGABI2DRAFT206259(AGABI2DRAFT_206259)
MGL: MGL_1532
MRT: MRET_3825
DDI: DDB_G0269226(cas1)
 » show all
Reference
PMID:6027261
  Authors
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ
  Title
A soluble 2,3-oxidosqualene sterol cyclase.
  Journal
J Biol Chem 242:3014-5 (1967)
Reference
PMID:7639730
  Authors
Baker CH, Matsuda SP, Liu DR, Corey EJ
  Title
Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.
  Journal
Biochem Biophys Res Commun 213:154-60 (1995)
DOI:10.1006/bbrc.1995.2110
  Sequence
[hsa:4047]
Reference
PMID:8134375
  Authors
Corey EJ, Matsuda SP, Bartel B
  Title
Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase.
  Journal
Proc Natl Acad Sci U S A 91:2211-5 (1994)
DOI:10.1073/pnas.91.6.2211
  Sequence
[sce:YHR072W]
Reference
  Authors
Suzuki M, Xiang T, Ohyama K, Seki H, Saito K, Muranaka T, Hayashi H, Katsube Y, Kushiro T, Shibuya M, Ebizuka Y
  Title
Lanosterol synthase in dicotyledonous plants.
  Journal
Plant Cell Physiol 47:565-71 (2006)
DOI:10.1093/pcp/pcj031
  Sequence
[ath:AT3G45130]

KEGG   ENZYME: 5.4.99.7
Entry
EC 5.4.99.7                 Enzyme                                 

Name
lanosterol synthase;
2,3-epoxysqualene lanosterol cyclase;
squalene-2,3-oxide-lanosterol cyclase;
lanosterol 2,3-oxidosqualene cyclase;
squalene 2,3-epoxide:lanosterol cyclase;
2,3-oxidosqualene sterol cyclase;
oxidosqualene cyclase;
2,3-oxidosqualene cyclase;
2,3-oxidosqualene-lanosterol cyclase;
oxidosqualene-lanosterol cyclase;
squalene epoxidase-cyclase;
(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lanosterol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol [RN:R03199]
Reaction(KEGG)
R03199
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
lanosterol [CPD:C01724]
History
EC 5.4.99.7 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 5.4.99.7 rest to EC 1.14.99.7
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01852  lanosterol synthase
Genes
HSA: 4047(LSS)
PTR: 474058(LSS)
PPS: 100974593(LSS)
GGO: 101124004(LSS)
PON: 100432375(LSS)
NLE: 100592843(LSS)
MCC: 709227(LSS)
MCF: 102137329(LSS)
CSAB: 103220328(LSS)
RRO: 104667600(LSS)
RBB: 108512153
CJC: 100409467(LSS)
SBQ: 101032145(LSS)
MMU: 16987(Lss)
MCAL: 110302909(Lss)
MPAH: 110326638(Lss)
RNO: 81681(Lss)
MUN: 110546351(Lss)
CGE: 100753498(Lss)
NGI: 103739961(Lss)
HGL: 101713900(Lss)
CCAN: 109695890(Lss)
OCU: 100359315(LSS)
TUP: 102473663(LSS)
CFA: 491611(LSS)
VVP: 112909549(LSS)
AML: 100482594(LSS)
UMR: 103680679(LSS)
UAH: 113258959(LSS)
ORO: 101375055(LSS)
ELK: 111155646
FCA: 101080651(LSS)
PTG: 102962591(LSS)
PPAD: 109258102(LSS)
AJU: 106987528(LSS)
BTA: 615906(LSS)
BOM: 102277039(LSS)
BIU: 109561307(LSS)
BBUB: 102395472(LSS)
CHX: 102175810(LSS)
OAS: 101106995(LSS)
SSC: 100625138(LSS)
CFR: 102516637(LSS)
CDK: 105090588(LSS)
BACU: 103005228(LSS)
LVE: 103077252(LSS)
OOR: 101289294(LSS)
DLE: 111186240(LSS)
ECB: 100055292(LSS)
EPZ: 103558417(LSS)
EAI: 106842988(LSS)
MYB: 102244769(LSS)
MYD: 102755441(LSS)
MNA: 107536230(LSS)
DRO: 112306546(LSS)
PALE: 102897618(LSS)
RAY: 107510225(LSS)
MJV: 108409563(LSS)
LAV: 100662429(LSS)
TMU: 101341011
SHR: 100933933(LSS)
PCW: 110198829(LSS)
OAA: 100083602(LSS)
GGA: 424037(LSS)
MGP: 100544500(LSS)
CJO: 107316378(LSS)
NMEL: 110399885(LSS)
APLA: 101801199(LSS)
ACYG: 106030113(LSS)
TGU: 100223318(LSS)
LSR: 110471683(LSS)
SCAN: 103814750(LSS)
GFR: 102037340(LSS)
FAB: 101809334(LSS)
PHI: 102113695(LSS)
CCAE: 111931893(LSS)
CCW: 104698254(LSS)
ETL: 114070053(LSS)
FPG: 101912237(LSS)
FCH: 102059359(LSS)
CLV: 102092351(LSS)
EGZ: 104133503(LSS)
NNI: 104013643(LSS)
ACUN: 113482095(LSS)
PADL: 103922915(LSS)
AAM: 106492318(LSS)
ASN: 102375533(LSS)
AMJ: 102568061(LSS)
CMY: 102946034(LSS)
ACS: 100558321(lss)
PVT: 110090934
PMUR: 107296168(LSS)
PMUA: 114582271(LSS)
XLA: 108703025(lss.S)
XTR: 733925(lss)
NPR: 108793617(LSS)
DRE: 795400(lss)
SGH: 107555930(lss)
CCAR: 109088812(lss)
IPU: 108266196(lss)
PHYP: 113526032(lss)
AMEX: 103022113(lss)
EEE: 113567698(lss)
TRU: 101062227(lss)
LCO: 104920782(lss)
MZE: 101485469(lss)
ONL: 100690152
OLA: 101157258 101157497(lss)
XMA: 102229476(lss)
XCO: 114148334(lss)
PRET: 103461854(lss)
CVG: 107086194(lss)
NFU: 107373714(lss)
KMR: 108247361
ALIM: 106529310(lss)
AOCE: 111582860(lss)
CSEM: 103392388(lss)
POV: 109644787(lss)
LCF: 108897198(lss)
SDU: 111218455(lss)
SLAL: 111667391(lss)
HCQ: 109517560(lss)
BPEC: 110167885(lss)
MALB: 109972638(lss)
SASA: 106581851(lss)
OTW: 112225134(lss)
SALP: 111959367(lss)
ELS: 105016172(lss)
SFM: 108924262(lss)
PKI: 111845428(lss)
LCM: 102361349(LSS)
CMK: 103188931(lss)
BFO: 118424025
SPU: 576764
ATH: AT3G45130(LAS1)
THJ: 104799632
SCE: YHR072W(ERG7)
ERC: Ecym_8182
KMX: KLMA_30341(ERG7)
NCS: NCAS_0H01640(NCAS0H01640)
NDI: NDAI_0C01970(NDAI0C01970)
TPF: TPHA_0E01120(TPHA0E01120)
TBL: TBLA_0A03120(TBLA0A03120)
TDL: TDEL_0E02760(TDEL0E02760)
KAF: KAFR_0D04670(KAFR0D04670)
PIC: PICST_77382(ERG7)
CAL: CAALFM_C202460WA(ERG7)
CDU: CD36_17130(ERG7)
SLB: AWJ20_3290(ERG7)
NCR: NCU01119
NTE: NEUTE1DRAFT127722(NEUTE1DRAFT_127722)
MGR: MGG_11702
MAW: MAC_04069
MAJ: MAA_01453
CMT: CCM_09526
MBE: MBM_02694
ANG: ANI_1_1064084(An09g01330) ANI_1_846084(An09g06490)
ABE: ARB_06777
TVE: TRV_05691
PTE: PTT_15458
SPO: SPAC13G7.01c(erg7)
CNE: CND02520
TASA: A1Q1_07921
ABP: AGABI1DRAFT55056(AGABI1DRAFT_55056)
ABV: AGABI2DRAFT206259(AGABI2DRAFT_206259)
MGL: MGL_1532
MRT: MRET_3825
DDI: DDB_G0269226(cas1)
 » show all
Reference
1  [PMID:6027261]
  Authors
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ.
  Title
A soluble 2,3-oxidosqualene sterol cyclase.
  Journal
J Biol Chem 242:3014-5 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.7
IUBMB Enzyme Nomenclature: 5.4.99.7
ExPASy - ENZYME nomenclature database: 5.4.99.7
BRENDA, the Enzyme Database: 5.4.99.7
CAS: 9032-71-7

KEGG   REACTION: R03199
Entry
R03199                      Reaction                               

Name
(S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)
Definition
(S)-2,3-Epoxysqualene <=> Lanosterol
Equation
Reaction class
RC00874  C01054_C01724
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Orthology
K01852  lanosterol synthase [EC:5.4.99.7]
Other DBs
RHEA: 14624

DBGET integrated database retrieval system