KEGG   ORTHOLOGY: K01860Help
Entry
K01860                      KO                                     

Name
E5.5.1.7
Definition
chloromuconate cycloisomerase [EC:5.5.1.7]
Pathway
ko00361  Chlorocyclohexane and chlorobenzene degradation
ko00364  Fluorobenzoate degradation
ko00623  Toluene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00364 Fluorobenzoate degradation
    K01860  E5.5.1.7; chloromuconate cycloisomerase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K01860  E5.5.1.7; chloromuconate cycloisomerase
   00623 Toluene degradation
    K01860  E5.5.1.7; chloromuconate cycloisomerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.7  chloromuconate cycloisomerase
     K01860  E5.5.1.7; chloromuconate cycloisomerase
BRITE hierarchy
Other DBs
RN: R04259 R05392 R06834 R06840 R08119 R09135 R09215 R09217 R09221
GO: 0018850
Genes
PKC: PKB_3274(clcb1) PKB_3623(clcb3)
REU: Reut_D6465 Reut_D6474
BXE: Bxe_A1129(clcB)
BXB: DR64_3289(tcbD)
BPT: Bpet1535(catB2) Bpet3749(catB5)
AXY: AXYL_06560(clcB)
SJP: SJA_C1-21130(tfdD)
AG: AAD13626(tcbD)
TaxonomyKoalaUniProt
Reference
  Authors
Kajander T, Lehtio L, Schlomann M, Goldman A
  Title
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function.
  Journal
Protein Sci 12:1855-64 (2003)
DOI:10.1110/ps.0388503
  Sequence

KEGG   ENZYME: 5.5.1.7Help
Entry
EC 5.5.1.7                  Enzyme                                 

Name
chloromuconate cycloisomerase;
muconate cycloisomerase II;
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing);
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Reaction(IUBMB)
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate [RN:R04259]
Reaction(KEGG)
Substrate
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04522]
Product
3-chloro-cis,cis-muconate [CPD:C03585]
Comment
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).
History
EC 5.5.1.7 created 1983
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00364  Fluorobenzoate degradation
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01860  chloromuconate cycloisomerase
Genes
PKC: PKB_3274(clcb1) PKB_3623(clcb3)
REU: Reut_D6465 Reut_D6474
BXE: Bxe_A1129(clcB)
BXB: DR64_3289(tcbD)
BPT: Bpet1535(catB2) Bpet3749(catB5)
AXY: AXYL_06560(clcB)
SJP: SJA_C1-21130(tfdD)
Taxonomy
Reference
1  [PMID:7305906]
  Authors
Schmidt E, Knackmuss HJ.
  Title
Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid.
  Journal
Biochem J 192:339-47 (1980)
Reference
2  [PMID:11443090]
  Authors
Kaulmann U, Kaschabek SR, Schlomann M
  Title
Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A.
  Journal
J Bacteriol 183:4551-61 (2001)
DOI:10.1128/JB.183.15.4551-4561.2001
Reference
3  [PMID:12930985]
  Authors
Kajander T, Lehtio L, Schlomann M, Goldman A
  Title
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of  structure and dynamics with the dehalogenation function.
  Journal
Protein Sci 12:1855-64 (2003)
DOI:10.1110/ps.0388503
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.7
IUBMB Enzyme Nomenclature: 5.5.1.7
ExPASy - ENZYME nomenclature database: 5.5.1.7
UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.7
BRENDA, the Enzyme Database: 5.5.1.7
CAS: 95990-33-3

KEGG   REACTION: R09221Help
Entry
R09221                      Reaction                               

Name
chloromuconate cycloisomerase
Definition
3,5-Dichloro-2-methylmuconate <=> 2-Chloro-5-methyl-cis-dienelactone + Hydrochloric acid
Equation
Reaction class
RC01687  C18303_C18304
Enzyme
Pathway
rn00623  Toluene degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K01860  chloromuconate cycloisomerase [EC:5.5.1.7]

DBGET integrated database retrieval system