KEGG ORTHOLOGY: K01906

ORTHOLOGY: K01906

Entry

K01906                      KO

Symbol

bioW

Name

6-carboxyhexanoate--CoA ligase [EC:6.2.1.14]

Pathway

map00780

Biotin metabolism

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Module

M00577

Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin

Reaction

R03209

6-carboxyhyxanoate:CoA ligase (AMP-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00780 Biotin metabolism
    K01906  bioW; 6-carboxyhexanoate--CoA ligase
Enzymes [BR:ko01000]
6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.14  6-carboxyhexanoate---CoA ligase
     K01906  bioW; 6-carboxyhexanoate--CoA ligase

Other DBs

COG:

COG1424

GO:

0042410

Genes

MALU:

KU6B_03740

GHC:	L9S41_06245

PCA:	Pcar_1666(bioW)

PACE:

A6070_06910

PEF:	A7E78_02755

DEU:	DBW_2418(bioW)

DVE:	DESUT3_28120(bioW)

DES:	DSOUD_1422

DDS:

Ddes_0424

DFI:	AXF13_07405

BSU:	BSU30240(bioW)

BSR:	I33_3078(bioW)

BSL:

A7A1_1652

BSH:	BSU6051_30240(bioW)

BSY:	I653_14475

BSUT:

BSUB_03213(bioW)

BSUL:

BSUA_03213(bioW)

BSUS:

Q433_16400

BSO:	BSNT_09444

BSN:	BSn5_05960

BSQ:	B657_30240(bioW)

BSX:	C663_2869(bioW)

BSP:	U712_15010

BSS:	BSUW23_14650(bioW)

BST:	GYO_3272(bioW)

BIT:	BIS30_04490

BLI:	BL02411(bioW)

BLD:	BLi00766(bioW)

BLH:	BaLi_c08640(bioW)

BAY:	RBAM_018290

BYA:	BANAU_1954(bioW)

BAMP:

B938_09460

BQY:	MUS_2183(bioW)

BAML:

BAM5036_1766(bioW)

BAMA:

RBAU_1804(bioW)

BAMN:

BASU_1784(bioW)

BAMB:

BAPNAU_1915(bioW)

BAMT:

AJ82_10390

BAMY:

V529_17990(bioW)

BMP:	NG74_01905(bioW)

BAO:	BAMF_1924(bioW)

BAZ:	BAMTA208_07885(bioW)

BQL:	LL3_02014(bioW)

BXH:	BAXH7_01606(bioW)

BAMI:

BAMC:

BAMF:

BSIA:

BAE:	BATR1942_12910

BVM:	B9C48_09335

BSON:

S101395_00961(bioW)

BHT:	DIC78_16480(bioW)

BMOJ:

HC660_28880(bioW)

BIQ:	AN935_15135

BSTR:

QI003_18320(bioW)

BGY:

BGLY_0780

BCAB:

EFK13_15365(bioW)

BRY:	M0696_15075(bioW)

BJS:

BACP:

BACB:

BACO:

BACY:

BACL:

BS34A_32880(bioW)

BALM:

BsLM_3008

BACS:

AUL54_01440

BACQ:

DOE78_13830(bioW)

BEO:

BEH_11230

BFX:	BC359_10250

BKW:	BkAM31D_02740(bioW)

BGI:	BGM20_09070

BPF:	BpOF4_16065(bioW)

LGY:	T479_02545

HSHI:

MUO14_17890(bioW)

VPN:	A21D_01033(bioW)

APAK:

AP3564_14135

PASA:

BAOM_1991

MSEM:

GMB29_11985(bioW)

ROSS:

V2W31_17285(bioW)

ALKL:

MM271_06855

DOM:	RRU94_17185(bioW)

SA2211

SAV:

SAV2423

SAW:

SAHV_2407

SAH:	SaurJH1_2497

SAJ:	SaurJH9_2449

SAM:

MW2346

SAS:

SAS2314

SAR:

SAR2513

SAC:	SACOL2424(bioW)

SAX:	USA300HOU_2407(bioW)

SAA:	SAUSA300_2369

SAO:	SAOUHSC_02712

SAE:	NWMN_2322(bioW)

SAD:	SAAV_2489(bioW)

SUU:	M013TW_2385

SUV:	SAVC_10990

SUE:	SAOV_2472c

SUJ:	SAA6159_02324

SUC:	ECTR2_2282

SUT:	SAT0131_02618

SUQ:	HMPREF0772_10764

SUZ:

MS7_2438

SUD:	ST398NM01_2476

SUX:	SAEMRSA15_23220

SUW:	SATW20_25530

SUG:

SAPIG2476

SUF:	SARLGA251_22050

SAUA:

SAAG_00250

SAUE:

RSAU_002262(bioW)

SAUN:

SAUS:

SAUU:

SAUG:

SAUZ:

SAUT:

SAI1T1_2017980(bioW)

SAUJ:

SAI2T2_1017990(bioW)

SAUK:

SAI3T3_1017980(bioW)

SAUQ:

SAI4T8_1017990(bioW)

SAUV:

SAI7S6_1017980(bioW)

SAUW:

SAI5S5_1017920(bioW)

SAUX:

SAI6T6_1017920(bioW)

SAUY:

SAI8T7_1017960(bioW)

SAUF:

X998_2409

SAB:

SAB2304c

SUY:	SA2981_2360

SAUB:

C248_2471

SAUM:

BN843_24650

SAUC:

CA347_2503

SAUR:

SABB_02993(bioW)

SAUI:

AZ30_12740

SAUD:

CH52_06865

SAMS:

NI36_12020

SUH:	SAMSHR1132_22520

SER:	SERP2393(bioW)

SEP:

SE_0182

SEPP:

SEB_00113

SEPS:

DP17_1279

SSD:	SPSINT_2336

SDT:	SPSE_0126(bioW)

SDP:	NCTC12225_00148(bioW)

SHU:	SHYC_01065(bioW)

SSCH:

SSCZ:

SAGQ:

SPET:

SLZ:	B5P37_05420

SFQ:	C7J90_03530

SCHR:

DWB92_00920

SSH:	NCTC13712_02374(bioW)

SSAC:

SRAI:

SCAQ:

SROT:

SFF:	FOB90_06765

ANX:	ACH33_05725

ASOC:

CB4_02730(bioW)

ATHE:

K3F53_13175

AUD:	PO771_10355(bioW)

ANEU:

PP175_00220(bioW)

TUM:	CBW65_01040

SPAE:

E2C16_15325(bioW)

SURL:

BI350_03175

FPEN:

KIW23_04250

CACE:

CACET_c13450(bioW)

CFM:	BJL90_12075

DOR:	Desor_2670

DKU:	Desku_2247

TFR:	BR63_04280

CTHM:

RTO:

PBIF:

PSOR:

RHOM:

TMY:	TEMA_34050(bioW)

TKI:	TKV_c07350(bioW)

HALS:

D7D81_09505

IFN:	GM661_06630

PHAR:

NCTC13077_01223(bioW)

PGK:	M9426_07060

CAD:	Curi_c25540(bioW)

VPR:

Vpar_1006

VAT:	B7L28_04875

VRM:	44547418_01018(bioW)

VDN:	NCTC11831_00891(bioW)

VNK:	VEIT17_08280(bioW)

VRG:	OKW85_04430

DHO:	Dia5BBH33_18170(bioW)

SSG:	Selsp_0126

SRI:	SELR_03060(bioWF)

MHG:

MFUN:

SGBI:

PUF:

PFT:	JBW_00789 JBW_04119

STED:

SPTER_12670(bioW)

PFAC:

PFJ30894_02090(bioW)

CDI:

DIP1381

CDP:	CD241_1323

CDH:	CDB402_1292

CDT:	CDHC01_1323

CDE:	CDHC02_1282

CDR:	CDHC03_1302

CDA:	CDHC04_1303

CDZ:	CD31A_1398

CDB:	CDBH8_1375

CDS:	CDC7B_1385

CDD:	CDCE8392_1298

CDW:	CDPW8_1371

CDV:	CDVA01_1266

CDIP:

ERS451417_01397(bioW)

CKP:	ckrop_1506(bioWF)

CPU:	CPFRC_05945

CPL:	Cp3995_1206(bioW)

CPG:	CP316_06095

CPP:	CpP54B96_1201(bioW)

CPK:	CP1002_07200

CPQ:	CPC231_05950

CPX:	CPI19_05570

CPZ:	CpPAT10_1177(bioW)

COR:	Cp267_1234(bioW)

COP:	CP31_06325

COD:	Cp106_1161(bioW)

COS:	Cp4202_1171(bioW)

COI:	CPCIP5297_06110

COE:	CP258_06110

COU:	CP162_05185

CPSE:

CPTA_01755

CPSU:

CPTB_02008

CPSF:

CPTC_01746

CUL:	CULC22_01291(bioW)

CUC:	CULC809_01277(bioW)

CUE:	CULC0102_1406(bioW)

CUN:	Cul210932_1345(bioW)

CUQ:	Cul210931_1242(bioW)

CUZ:	Cul05146_1318(bioW)

CUJ:	CUL131002_1273(bioW)

CUS:	CulFRC11_1258(bioW)

CVT:	B843_06145

CII:	CIMIT_09415

CUV:	CUREI_07155

COA:	DR71_1458(bioF)

CEI:	CEPID_09085

CLW:	CLAC_02085

CSP:

CPHO:

CSTR:

CSPH:

CMIN:

NCTC10288_01030(bioW)

CPEG:

CPELA_04945(bioW)

CGK:	CGERO_06225(bioW)

CRF:	FRC0190_01412

CPSO:

CPPEL_05150(bioW)

CKF:	I6I12_05810

CPRP:

CAMC:

CGLU:

CSIL:

CKW:	CKALI_03420(bioW)

CORY:

FQV43_04060

CMF:	GWO64_003750

CWK:	IA203_07480

CACC:

CACC_08710(bioW)

CHIN:

J5O04_10425

CPSP:

L9H27_04605

CMAS:

CMASS_00810(bioW)

CIHU:

CIHUM_06695(bioW)

CHAD:

CHAD_09610(bioW)

CFOU:

CFOUR_06755(bioW)

CFEU:

CFELI_06080(bioW)

CAFE:

CAFEL_06640(bioW)

CGOI:

CGOTT_09260(bioW)

CPYR:

CYJ47_07350

CIK:	H0194_06345

PAC:

PPA1866

PAK:	HMPREF0675_4919

PAV:	TIA2EST22_09135

PAX:	TIA2EST36_09115

PAZ:	TIA2EST2_09075

PAW:	PAZ_c19410(bioF)

PAD:	TIIST44_02135

PCN:	TIB1ST10_09540

PACC:

PACH:

PACN:

CACN:

PRA:	PALO_01675

PRL:	BCB70_09080

CGRN:

4412665_00276(bioW)

AAGG:

ETAA8_58000

TPI:	TREPR_3053(bioW)

TRI:	DYE50_09460

FSU:	Fisuc_2956

FSC:	FSU_0221(bioW)

AAE:	aq_1659(bioW)

HYA:	HY04AAS1_0813

HHO:	HydHO_0808

HYS:	HydSN_0825

HTH:	HTH_1774(bioW)

HTE:	Hydth_1756

TAL:

Thal_1538

TRD:	THERU_03735

SUL:	SYO3AOP1_1703

SAF:	SULAZ_1395(bioW)

PMX:	PERMA_1854(bioW)

TAM:	Theam_0831

DTE:	Dester_0730

TYE:	THEYE_A0810(bioW)

DTP:	JZK55_14060(bioW)

LFC:

LFE_0971

LFI:	LFML04_1509(bioW)

LFP:	Y981_07525

LEG:	ABH19_05580

MJA:

MJ_1297

MVU:	Metvu_0266

MFS:	MFS40622_0356

MIF:	Metin_0084

MJH:	JH146_0329

MESG:

MLAUSG7_1138(bioW)

MESA:

MLASG1_0637(bioW)

MIG:	Metig_1269

MMP:	MMP1575(bioW)

MMQ:	MmarC5_0001

MMX:	MmarC6_1095

MMZ:	MmarC7_0822

MMD:

GYY_08730

MMAK:

MMKA1_18050(bioW)

MMAO:

MMOS7_16870(bioW)

MMAD:

MMJJ_12610(bioW)

MAE:

Maeo_1420

MVN:	Mevan_0887

MVO:

Mvol_1143

MOK:	Metok_1553

METF:

CFE53_06525

MRU:	mru_2041(bioW)

MOL:

YLM1_1481

» show all

Reference

PMID:8763940

Authors

Bower S, Perkins JB, Yocum RR, Howitt CL, Rahaim P, Pero J

Title

Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon.

Journal

J Bacteriol 178:4122-30 (1996)
DOI:10.1128/JB.178.14.4122-4130.1996

Sequence

[bsu:BSU30240]

Reference

PMID:1445232

Authors

Ploux O, Soularue P, Marquet A, Gloeckler R, Lemoine Y

Title

Investigation of the first step of biotin biosynthesis in Bacillus sphaericus. Purification and characterization of the pimeloyl-CoA synthase, and uptake of pimelate.

Journal

Biochem J 287 ( Pt 3):685-90 (1992)
DOI:10.1042/bj2870685

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