KEGG ORTHOLOGY: K02089

ORTHOLOGY: K02089

Entry

K02089                      KO

Symbol

CDK4

Name

cyclin-dependent kinase 4 [EC:2.7.11.22]

Pathway

map01522

Endocrine resistance

map04110

Cell cycle

map04115

p53 signaling pathway

map04151

PI3K-Akt signaling pathway

map04218

Cellular senescence

map04530

Tight junction

map04660

T cell receptor signaling pathway

map04933

AGE-RAGE signaling pathway in diabetic complications

map04934

Cushing syndrome

map05160

Hepatitis C

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05212

Pancreatic cancer

map05214

Glioma

map05218

Melanoma

map05219

Bladder cancer

map05220

Chronic myeloid leukemia

map05222

Small cell lung cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

Disease

H00030

Cervical cancer

H00038

Melanoma

H00042

Glioma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02089  CDK4; cyclin-dependent kinase 4
   04115 p53 signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
   04218 Cellular senescence
    K02089  CDK4; cyclin-dependent kinase 4
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K02089  CDK4; cyclin-dependent kinase 4
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05203 Viral carcinogenesis
    K02089  CDK4; cyclin-dependent kinase 4
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05225 Hepatocellular carcinoma
    K02089  CDK4; cyclin-dependent kinase 4
   05214 Glioma
    K02089  CDK4; cyclin-dependent kinase 4
   05220 Chronic myeloid leukemia
    K02089  CDK4; cyclin-dependent kinase 4
   05218 Melanoma
    K02089  CDK4; cyclin-dependent kinase 4
   05219 Bladder cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05224 Breast cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05222 Small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05223 Non-small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02089  CDK4; cyclin-dependent kinase 4
   05160 Hepatitis C
    K02089  CDK4; cyclin-dependent kinase 4
   05164 Influenza A
    K02089  CDK4; cyclin-dependent kinase 4
   05162 Measles
    K02089  CDK4; cyclin-dependent kinase 4
   05163 Human cytomegalovirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05169 Epstein-Barr virus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05165 Human papillomavirus infection
    K02089  CDK4; cyclin-dependent kinase 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02089  CDK4; cyclin-dependent kinase 4
   04934 Cushing syndrome
    K02089  CDK4; cyclin-dependent kinase 4
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K02089  CDK4; cyclin-dependent kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02089  CDK4; cyclin-dependent kinase 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02089  CDK4; cyclin-dependent kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: CMGC group
  CDK family
   K02089  CDK4; cyclin-dependent kinase 4

Other DBs

GO:

0004693

Genes

HSA:	1019(CDK4)

PTR:	452025(CDK4)

PPS:	100976294(CDK4)

GGO:	101147065(CDK4)

PON:	100443314(CDK4)

PPYG:

129009437(CDK4)

NLE:	100594967(CDK4)

HMH:	116480850(CDK4)

SSYN:

129465288(CDK4)

MCC:	715650(CDK4)

MCF:	101925733(CDK4)

MTHB:

126930400

MNI:	105474081(CDK4)

CSAB:

103238589(CDK4)

CATY:

105587240(CDK4)

PANU:

101011004(CDK4)

TGE:	112634055(CDK4)

MLEU:

105545589(CDK4)

RRO:	104682344(CDK4)

RBB:	108524397(CDK4)

TFN:	117089862(CDK4)

PTEH:

111541790(CDK4)

CANG:

105500487(CDK4)

CJC:	100408304(CDK4)

SBQ:	101040767(CDK4)

CIMI:

108304334 108309741(CDK4) 108313247

ANAN:

105713363 105729110(CDK4)

CSYR:

103264423(CDK4)

MMUR:

105877995(CDK4)

LCAT:

123639589(CDK4)

PCOQ:

105816738(CDK4)

OGA:	100960589(CDK4)

MMU:	12567(Cdk4)

MCAL:

110303132(Cdk4)

MPAH:

110326196(Cdk4)

RNO:	94201(Cdk4)

MCOC:

116075684(Cdk4)

ANU:	117696408(Cdk4)

ASYL:

127670852(Cdk4)

MUN:	110561245(Cdk4)

CGE:	100760122(Cdk4)

MAUA:

101839492(Cdk4)

PROB:

127215685(Cdk4)

PLEU:

114704814(Cdk4)

MORG:

121461982 121463961(Cdk4)

MFOT:

126514774

AAMP:

119803317(Cdk4)

NGI:	103742900(Cdk4)

HGL:	101702608(Cdk4)

CPOC:

100717960(Cdk4)

CCAN:

109686224(Cdk4)

DORD:

105989896(Cdk4)

DSP:	122124085(Cdk4)

DMER:

138803510(Cdk4)

PLOP:

125362060(Cdk4)

NCAR:

124983907

MMMA:

107140113(Cdk4)

ITI:	101977768(Cdk4)

OCU:

100009039

OPI:	101530437(CDK4)

TUP:	102493291(CDK4)

GVR:	103609174(CDK4)

CFA:	481131(CDK4) 612475

CLUD:

112654545 112677962(CDK4)

VVP:	112922331(CDK4)

VLG:	121490703(CDK4)

NPO:	129511485(CDK4)

AML:	100481236(CDK4)

UMR:	103656694(CDK4)

UAH:	113256363(CDK4)

UAR:	123787201(CDK4)

ELK:

111160230

LLV:

125106397

MPUF:

101673063(CDK4)

MNP:	132019857(CDK4)

MLK:	131838541(CDK4)

NVS:	122892356(CDK4)

ORO:	101362330(CDK4)

EJU:	114214999(CDK4)

ZCA:	113921783(CDK4)

MLX:	118008659(CDK4)

NSU:	110577858(CDK4)

LWW:	102746891(CDK4)

FCA:	101097903(CDK4)

PYU:	121040857(CDK4)

PCOO:

112863780(CDK4)

PBG:	122473830(CDK4)

PVIV:

125170174(CDK4)

LRUF:

124501159

LGF:	123591923(CDK4)

AJU:

106975871

PTG:	102970281(CDK4)

PPAD:

109270390(CDK4)

PUC:

125919257

PLEZ:

122224752(CDK4)

HHV:	120248012(CDK4)

BTA:	510618(CDK4)

BOM:	102278545(CDK4)

BIU:	109559308(CDK4)

BBUB:

102412787(CDK4)

BBIS:

104988133(CDK4)

CHX:	102171306(CDK4)

OAS:	100144756(CDK4)

BTAX:

128047322(CDK4)

CSUM:

138077762(CDK4) 138081396

ODA:	120857506(CDK4)

CCAD:

122427215(CDK4)

MREE:

136167276(CDK4)

OVR:	110124902(CDK4)

MBEZ:

129536501(CDK4)

SSC:	100144492(CDK4)

CFR:	102522300(CDK4)

CBAI:

105062140(CDK4)

CDK:	105100330(CDK4)

VPC:	102532580(CDK4)

BACU:

103000540(CDK4) 103010593

BMUS:

118902505(CDK4)

LVE:	103084826(CDK4)

OOR:	101283760(CDK4)

LALB:

132529369(CDK4)

GMF:	115858543(CDK4)

DDP:	132433825(CDK4)

DLE:	111173824(CDK4)

PCAD:

102985179(CDK4)

PSIU:

116760381(CDK4)

PPHC:

136130395(CDK4)

NASI:

112394295(CDK4)

ECB:	100051005(CDK4)

EPZ:	103553644(CDK4)

EAI:	106833016(CDK4)

MYB:	102261527(CDK4)

MYD:	102758995(CDK4)

MMYO:

118651037(CDK4)

MLF:	102431798(CDK4)

MDT:	132227827(CDK4)

MYUM:

139006971(CDK4)

PKL:	118730275(CDK4)

EFUS:

103292479(CDK4)

MNA:	107546223(CDK4)

DRO:	112319119(CDK4)

SHON:

118975891(CDK4)

AJM:	119065244(CDK4)

PDIC:

114512697(CDK4)

PHAS:

123812897(CDK4)

MMF:	118624208(CDK4)

PPAM:

129075823(CDK4)

HAI:	109390747(CDK4)

RFQ:	117029166(CDK4)

PALE:

102894222(CDK4)

PGIG:

120604974(CDK4)

PVP:	105307393(CDK4)

RAY:	107501504(CDK4)

MJV:	108387631(CDK4)

TOD:	119248102(CDK4)

SARA:

101559274(CDK4)

SFUM:

130026983(CDK4)

SETR:

126022235(CDK4)

LAV:	104847103(CDK4)

TMU:

101355276

ETF:	101654378(CDK4)

DNM:	101416305(CDK4)

GAS:	123251284(CDK4)

SHR:	100932899(CDK4)

AFZ:

127538222

PCW:	110210989(CDK4)

TVP:	118828777 118851440(CDK4) 118857830

PBRV:

138155249(CDK4)

MLAO:

141515031(CDK4)

CJO:	107325825(CDK4)

ACYG:

125181066(CDK4)

PHI:	102103942(CDK4)

PMAJ:

107199280

ACOE:

138100094(CDK4)

SVG:	106862647(CDK4)

SATI:

136372859(CDK4)

CCIC:

134054832(CDK4)

TALA:

116960867 116963701(CDK4)

AGEN:

126037403

CBOY:

140644496(CDK4)

CNIC:

136000550(CDK4)

RTD:

128903864

AAM:

106492770

NPD:	112952245(CDK4)

DNE:	112983405(CDK4)

ASN:	102387479(CDK4)

AMJ:	102572556(CDK4)

CPOO:

109324458(CDK4)

CMY:	102945436(CDK4)

CCAY:

125627703(CDK4)

DCC:	119845815(CDK4)

CPIC:

101943854(CDK4)

TST:	117888590(CDK4)

CABI:

116828541(CDK4)

MRV:	120391006(CDK4)

ACS:	100559515(cdk4)

ASAO:

132767651(CDK4)

PVT:	110074435(CDK4)

SUND:

121920842(CDK4)

PBI:	103058869(CDK4)

PMUR:

107291540(CDK4)

CTIG:

120309963(CDK4)

TSR:	106540822(CDK4)

PGUT:

117662680(CDK4)

PCAE:

139310716(CDK4)

APRI:

131192160(CDK4)

PTEX:

113445556(CDK4)

NSS:	113418439(CDK4)

VKO:	123029774(CDK4)

PMUA:

114593035(CDK4)

PRAF:

128405821(CDK4)

ZVI:	118078968(CDK4)

HCG:	128347326(CDK4)

GJA:	107119665(CDK4)

EMC:	129346578(CDK4)

XLA:	379406(cdk4.S) 496334(cdk6.L)

XTR:	549496(cdk4)

NPR:	108795357(CDK4)

RTEM:

120929442(CDK4)

ACAT:

141121490 141127378(CDK4)

BBUF:

120996181(CDK4)

BGAR:

122932515(CDK4)

DTC:	141091286(CDK4)

PWL:	138292364(CDK4)

MUO:	115465825(CDK4)

GSH:	117357532(CDK4)

DRE:	777730(cdk4)

SRX:	107737134 107747701

SANH:

107684003 107701179

SGH:

107567936

CCAR:

109069976(cdk4) 109089968

CAUA:

113054912 113068151

CGIB:

127968260 128022703

PTET:

122353952 122354325(cdk4)

LROH:

127173464(cdk4)

GRF:	141293605(cdk4)

OMC:	131549489(cdk4)

PPRM:

120460707(cdk4)

RKG:	130086284(cdk4)

MAMB:

125256866(cdk4)

CIDE:

127522801

CERY:

137021810(cdk4)

MASI:

127425969

TROS:

130571158(cdk4)

TDW:	130410017(cdk4)

MANU:

129427530(cdk4)

PDAB:

135719313(cdk4)

IPU:

108255186

IFU:	128625273(cdk4)

PHYP:

113525662

SMEO:

124401943(cdk4)

TFD:	113639050(cdk4)

TVC:	132838231(cdk4)

CGAR:

128511614(cdk4)

NGRA:

132874257(cdk4)

TRN:	134301572(cdk4)

AMEX:

103034254(cdk4)

CMAO:

118799717(cdk4)

EEE:	113572459(cdk4)

CHAR:

105907246(cdk4)

SPIL:

134092555(cdk4)

TRU:	101063081(cdk4)

TFS:

130524612

TNG:	GSTEN00033818G001

LCO:	104929049(cdk4)

NCC:	104955917(cdk4)

TBEN:

117489719(cdk4)

CGOB:

115008789(cdk4)

PGEO:

117441083(cdk4)

GACU:

117534213(cdk4)

EMAC:

134883274(cdk4)

ELY:	117257485(cdk4)

EFO:	125893517(cdk4)

PLEP:

121953305(cdk4)

SLUC:

116066212(cdk4)

ECRA:

117942897(cdk4)

ESP:	116679825 116687243

PFLV:

114554047(cdk4)

GAT:	120835334(cdk4)

PPUG:

119194053(cdk4)

AFB:	129105372(cdk4)

CLUM:

117730594(cdk4)

PSWI:

130208515(cdk4)

CANA:

137796222(cdk4)

CVE:	137879550(cdk4)

MSAM:

119886384(cdk4)

SCHU:

122888471(cdk4)

CUD:	121507439(cdk4)

SPUL:

138605477(cdk4)

LMIX:

132977825(cdk4)

ALAT:

119020857(cdk4)

ASTR:

137595685(cdk4)

MZE:

101475315

ONL:	100710125(cdk4)

OAU:	116326635(cdk4)

OLA:	101172808(cdk4)

OML:	112145080(cdk4)

CSAI:

133448713(cdk4)

XMA:	102220323(cdk4)

XCO:	114135419(cdk4)

XHE:	116710170(cdk4)

PRET:

103465328(cdk4)

PFOR:

103129587(cdk4)

PLAI:

106961113

PMEI:

106923269

GAF:	122833741(cdk4)

PPRL:

129358305(cdk4)

CVG:	107082148(cdk4)

CTUL:

119795488(cdk4)

GMU:

124856981

NFU:	107385649(cdk4)

KMR:	108235797(cdk4)

ALIM:

106518078

NWH:	119412589(cdk4)

AOCE:

111587634(cdk4)

EJA:	138202137(cdk4)

BFRE:

138627170(cdk4)

MCEP:

125007293(cdk4)

CSEM:

103386052(cdk4)

POV:	109629352(cdk4)

SSEN:

122768740(cdk4)

SSOE:

131460614(cdk4)

HHIP:

117761425(cdk4)

HSP:	118104894(cdk4)

PPLT:

128454022(cdk4)

SMAU:

118309388(cdk4)

LCF:

108898964

SDU:	111221753(cdk4)

SLAL:

111667889(cdk4)

XGL:	120807598(cdk4)

HCQ:	109522590(cdk4)

SSCV:

125976797(cdk4)

SBIA:

133507496(cdk4)

PEE:	133408435(cdk4)

PTAO:

133483625(cdk4)

BPEC:

110171259(cdk4)

ENY:	140365258(cdk4)

MALB:

109956190(cdk4)

BSPL:

114855460(cdk4)

SJO:	128355116(cdk4)

SSCO:

133977555(cdk4)

GMH:

115557638

SASA:

106565448 106583286

STRU:

115150473 115207950

OTW:	112216345(cdk4) 112254694

OMY:	110494214 110528217

OGO:	124003111 124031204

ONE:	115140953 115143085

OKI:	109882619 109894658

OKE:	118388669 118400364

OMM:	135539878 135541845

OCLA:

139371003 139413598

SALP:

111965632 111970188 111970190

SNH:	120062000 120065264

CCLU:

121575165 121577842

ELS:	105016970(cdk4)

OEP:	134024501(cdk4)

SFM:	108918175(cdk4)

PKI:	111854375(cdk4) 111856032

AANG:

118210620(cdk4)

AROT:

135238423(cdk4)

CCOG:

133109516(cdk4)

LOC:	102686530(cdk4)

PSPA:

121308988(cdk4)

ARUT:

117401103 117962597

PSEX:

120524842(cdk4)

LCM:	102363370(CDK4)

CMK:	103191316(cdk4)

RTP:

109925336

CPLA:

122543277(cdk4)

HOC:	132805820(cdk4)

LERI:

129714770(cdk4)

HAKA:

140741307(cdk4)

LRJ:	133361523 133362026 133362062 133362134 133362705

AJC:

117108070

DME:	Dmel_CG5072(Cdk4)

DER:

6548425

DSE:

6609465

DSI:	Dsimw501_GD11207(Dsim_GD11207)

DYA:	Dyak_GE11805

DAN:

DSR:

DPO:

DPE:

DMN:	108158559 117191375 117191615 117191617

DWI:

6639792

DGR:

6559243

DMO:	Dmoj_GI20474

DAZ:

108615638

DNV:

108653601

DHE:

111593550

DVI:	6625181(Cdk4)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:	101892496 131801631

SCAC:

106086684

LCQ:

111675356

LSQ:

119603043

CVJ:	135960527(Cdk4)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015895

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

CCAL:

SOC:

MPHA:

AEC:

ACOC:

MZT:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

NVI:	100122192(Cdk4)

CSOL:

105361031

TPRE:

106648062

TCA:

663975

TMOL:

138123775(Cdk4)

DPA:

109545808

ESIM:

136410750(Cdk4)

EFOR:

136347934(Cdk4)

SOY:

115875203

AGRG:

126736132 126736532

ATD:	109601734 109602185

HAXR:

AGB:

LDC:

DVV:

NVL:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201733 KGM_201734

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137922781(Cdk4)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141443444(Cdk4)

CFEL:

113389462

HAMR:

139685711(Cdk4)

AFRA:

PJA:

PCLA:

CQD:

MRJ:

PORN:

ABRU:

UDV:	129217040 129235238

SDM:

118180084

CRQ:	GCK72_000989

LOA:	LOAG_17283

TSP:

Tsp_00762

CDET:

87951883(CDEST_15383) 87951981(CDEST_15481)

AOR:	AO090026000290

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Reference

PMID:18414028

Authors

Blain SW

Title

Switching cyclin D-Cdk4 kinase activity on and off.

Journal

Cell Cycle 7:892-8 (2008)
DOI:10.4161/cc.7.7.5637

Reference

PMID:7652577

Authors

Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH, Beach D

Title

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

Journal

Science 269:1281-4 (1995)
DOI:10.1126/science.7652577

Sequence

[hsa:1019]

All links

Ontology (1)   
   GO (1)   
Gene (273)   
   MGENES (54)   
   RefGene (209)   
   OC (10)   
All databases (274)   

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