KEGG ORTHOLOGY: K02090

ORTHOLOGY: K02090

Entry

K02090                      KO

Symbol

CDK5

Name

cyclin-dependent kinase 5 [EC:2.7.11.22]

Pathway

map04360

Axon guidance

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05030

Cocaine addiction

Disease

H00268

Lissencephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K02090  CDK5; cyclin-dependent kinase 5
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02090  CDK5; cyclin-dependent kinase 5
   05022 Pathways of neurodegeneration - multiple diseases
    K02090  CDK5; cyclin-dependent kinase 5
  09165 Substance dependence
   05030 Cocaine addiction
    K02090  CDK5; cyclin-dependent kinase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02090  CDK5; cyclin-dependent kinase 5
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K02090  CDK5; cyclin-dependent kinase 5
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02090  CDK5; cyclin-dependent kinase 5
Protein kinases [BR:ko01001]
Serine/threonine kinases: CMGC group
  CDK family
   K02090  CDK5; cyclin-dependent kinase 5
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K02090  CDK5; cyclin-dependent kinase 5

Other DBs

GO:

0004693

Genes

HSA:	1020(CDK5)

PTR:	463891(CDK5)

PPS:	100977790(CDK5)

GGO:	101149520(CDK5)

PON:	100442658(CDK5)

PPYG:

129040248(CDK5)

NLE:	100593355(CDK5)

HMH:	116813856 116814541(CDK5)

SSYN:

129485210(CDK5)

MCC:	714445(CDK5)

MCF:	101865873(CDK5)

MTHB:

126951617

MNI:	105474905(CDK5)

CSAB:

103227238(CDK5)

CATY:

105584739(CDK5)

PANU:

100999052(CDK5)

TGE:	112620084(CDK5)

MLEU:

105542703(CDK5)

RRO:	104675398(CDK5)

RBB:	108532531(CDK5)

TFN:	117072838(CDK5) 117082413 117088198

PTEH:

111551516(CDK5)

CANG:

105511330(CDK5)

CJC:	100411309(CDK5)

SBQ:	101037170(CDK5)

CIMI:

108297695(CDK5)

ANAN:

105710701(CDK5)

CSYR:

103275285(CDK5)

MMUR:

105883175(CDK5)

LCAT:

123647514(CDK5)

PCOQ:

105824605(CDK5)

OGA:	100955137(CDK5)

MMU:	12568(Cdk5)

MCAL:

110293885(Cdk5)

MPAH:

110315989(Cdk5)

RNO:	140908(Cdk5)

MCOC:

116097551(Cdk5)

ANU:	117720643(Cdk5)

ASYL:

127678224(Cdk5)

MUN:	110562558(Cdk5)

CGE:	100762907(Cdk5)

MAUA:

101836859(Cdk5)

PROB:

127235685(Cdk5)

PLEU:

114700086(Cdk5)

MORG:

121440026(Cdk5)

MFOT:

126489457

AAMP:

119806641(Cdk5)

NGI:	103745307(Cdk5)

HGL:	101708843(Cdk5)

CPOC:

100732840(Cdk5)

CCAN:

109694445(Cdk5)

DORD:

105993852(Cdk5)

DSP:	122105882(Cdk5)

DMER:

138809938(Cdk5)

PLOP:

125347322(Cdk5)

NCAR:

124990793

MMMA:

107148934(Cdk5)

ITI:	101977833(Cdk5)

OCU:	100352775 127488313

OPI:	101519803(CDK5)

TUP:	102497253(CDK5)

GVR:	103585103(CDK5)

CFA:	475537(CDK5)

CLUD:

112663900(CDK5)

VVP:	112916215(CDK5)

VLG:	121490120(CDK5)

NPO:	129515944(CDK5)

AML:	100483328(CDK5)

UMR:	103660955(CDK5)

UAH:	113241477(CDK5)

UAR:	123788779(CDK5)

ELK:

111154329

LLV:

125081339

MPUF:

101677047(CDK5)

MNP:	132014855(CDK5)

MLK:	131829947(CDK5)

NVS:	122904179(CDK5)

ORO:	101383507(CDK5)

EJU:	114197989(CDK5)

ZCA:	113911329(CDK5)

MLX:	118026782(CDK5)

NSU:	110582988(CDK5)

LWW:	102739787(CDK5)

FCA:	101097226(CDK5)

PYU:	121022910(CDK5)

PCOO:

112866624(CDK5)

PBG:	122488531(CDK5)

PVIV:

125160201(CDK5)

LRUF:

124523528

LGF:	123607119(CDK5)

AJU:

113596750

PTG:	102956209(CDK5)

PPAD:

109252371(CDK5)

PUC:

125930306

PLEZ:

122213596(CDK5)

HHV:	120230895(CDK5)

BTA:	281066(CDK5)

BOM:	102265949(CDK5)

BIU:	109557798(CDK5)

BBUB:

102390186(CDK5) 102399061

BBIS:

105001107(CDK5)

CHX:	102178040(CDK5)

OAS:	100190973(CDK5)

BTAX:

128046472(CDK5)

CSUM:

138080302(CDK5)

ODA:	120877914(CDK5)

MREE:

136170883(CDK5)

OVR:	110124632(CDK5)

MBEZ:

129552787(CDK5)

SSC:	733700(CDK5)

CFR:	102522591(CDK5)

CBAI:

105067013(CDK5)

CDK:	105105662(CDK5)

VPC:	102530037(CDK5)

BACU:

103018873(CDK5)

BMUS:

118901148(CDK5)

LVE:	103085591(CDK5)

OOR:	101281610(CDK5)

LALB:

132524065(CDK5)

GMF:	115851857(CDK5)

DDP:	132430821(CDK5)

DLE:	111176821(CDK5)

PCAD:

102986821(CDK5)

PSIU:

116759864(CDK5)

PPHC:

136128610(CDK5)

NASI:

112405887(CDK5)

ECB:	100063442(CDK5)

EPZ:	103564178(CDK5)

EAI:	106823329(CDK5)

MYB:	102255036(CDK5)

MYD:	102755674(CDK5)

MMYO:

118679406(CDK5)

MLF:	102434327(CDK5)

MDT:	132242618(CDK5)

MYUM:

139016683(CDK5)

PKL:	118704772(CDK5)

EFUS:

103301760(CDK5)

MNA:	107524907(CDK5)

DRO:	112308285(CDK5)

SHON:

118975530(CDK5)

AJM:	119039289(CDK5)

PDIC:

114507734(CDK5)

PHAS:

123817974(CDK5)

MMF:	118619839(CDK5)

PPAM:

129086762(CDK5)

HAI:	109389648(CDK5)

RFQ:	117018286(CDK5)

PALE:

102879023(CDK5)

PGIG:

120601504(CDK5)

PVP:	105303753(CDK5)

RAY:	107520296(CDK5)

MJV:	108391844(CDK5)

TOD:	119248750(CDK5)

SARA:

101557659(CDK5)

SFUM:

130042658(CDK5)

SETR:

126021881(CDK5)

LAV:	100671938(CDK5)

TMU:

101357699

ETF:	101660666(CDK5)

DNM:	101436006(CDK5)

MDO:	100015241(CDK5)

GAS:	123250574(CDK5)

SHR:	100914143(CDK5)

AFZ:	127538822 127557914

PCW:	110201934(CDK5)

TVP:	118849491(CDK5)

PBRV:

138157944(CDK5)

MLAO:

141492724(CDK5)

OAA:	100091902(CDK5)

TACU:

119936265(CDK5)

GGA:	100190948(CDK5)

PCOC:

116242828(CDK5)

MGP:	104916220(CDK5)

CJO:	107308706(CDK5)

TPAI:

128085812(CDK5)

LMUT:

125695858(CDK5)

NMEL:

110390738(CDK5)

APLA:

119715732(CDK5)

ACYG:

125180894(CDK5)

CATA:

118251738(CDK5)

AFUL:

116486005(CDK5)

TGU:	115493589(CDK5)

LSR:	110475089(CDK5)

PMOA:

120510565(CDK5)

OTC:	121334886(CDK5)

PRUF:

121356982(CDK5)

ATRC:

139605063(CDK5)

OMA:	130249119(CDK5)

PHI:	102111846(CDK5)

PMAJ:

107198231(CDK5)

CCW:	104684262(CDK5)

ACOE:

138106092(CDK5)

ETL:	114068008(CDK5)

ZLE:	135443474(CDK5)

SVG:	106861790(CDK5)

MMEA:

130574589(CDK5)

SATI:

136375591(CDK5)

CCIC:

134044022(CDK5)

FPG:	101913356(CDK5)

FCH:	102058220(CDK5)

NNT:	104409708(CDK5)

SHAB:

115610757(CDK5)

TALA:

122154322(CDK5)

ACHC:

115339893(CDK5)

HLE:	104829409(CDK5)

AGEN:

126037699

HHAR:

128152096(CDK5)

DPUB:

104298513(CDK5)

PPUS:

135185694(CDK5)

AFOR:

103897133(CDK5)

CBOY:

140648663(CDK5)

CLV:

102090553

CNIC:

135986215(CDK5)

CUCA:

128851205(CDK5)

RTD:	128904796(CDK5)

CRID:

134510944(CDK5)

AAM:	106491564(CDK5)

AROW:

112976161(CDK5)

DNE:	112987735(CDK5)

SCAM:

104144193(CDK5)

AMJ:	106740360(CDK5)

CMY:	102948311(CDK5)

CCAY:

125633037(CDK5)

DCC:	119850591(CDK5)

CPIC:

101952393(CDK5)

CABI:

116831904(CDK5)

MRV:	120397576(CDK5)

ASAO:

132779124(CDK5)

PVT:	110082556(CDK5)

SUND:

121935561(CDK5)

PBI:	103063081(CDK5)

PMUR:

107297802(CDK5)

CTIG:

120318317(CDK5)

TSR:

106550742

PGUT:

117669214(CDK5)

PCAE:

139317558(CDK5)

APRI:

131196550(CDK5)

VKO:	123019571(CDK5)

PMUA:

114607317(CDK5)

PRAF:

128424026(CDK5)

ZVI:	118092306(CDK5)

HCG:	128329362(CDK5)

GJA:	107108217(CDK5)

STOW:

125441255(CDK5)

EMC:	129337725(CDK5)

XLA:	399296(cdk5.L)

XTR:	780236(cdk5)

RTEM:

120941758(CDK5)

ACAT:

141145709(CDK5)

BBUF:

121000750(CDK5)

BGAR:

122938010(CDK5)

DTC:	141095855(CDK5)

PWL:	138261637(CDK5)

MUO:	115465141(CDK5)

GSH:	117354476(CDK5)

DRE:	65234(cdk5)

SRX:	107731788 107732074

SANH:

107677283 107690992

SGH:	107555551 107599666(cdk5)

CCAR:

109050000 109050139(cdk5)

CAUA:

113042631 113092791

CGIB:

127945825 128012870 128013316

PTET:

122330091(cdk5)

LROH:

127155975(cdk5)

GRF:	141300447(cdk5)

OMC:	131533524(cdk5)

PPRM:

120488006(cdk5)

RKG:	130084127(cdk5)

MAMB:

125258187(cdk5)

CIDE:

127506265

CERY:

137013557(cdk5)

MASI:

127432173 127434647

TROS:

130547008(cdk5)

TDW:	130413016(cdk5)

MANU:

129426169(cdk5)

PDAB:

135740337(cdk5)

IPU:	100528512(cdk5)

IFU:	128624156(cdk5)

PHYP:

113533817(cdk5)

SMEO:

124384903(cdk5)

TFD:	113651675(cdk5)

TVC:	132846351(cdk5)

CGAR:

128520106(cdk5)

NGRA:

132886402(cdk5)

TRN:	134310938(cdk5)

AMEX:

103032107(cdk5)

CMAO:

118822649(cdk5)

EEE:	113583777(cdk5)

CHAR:

105889514(cdk5)

SPIL:

134070821(cdk5)

TRU:	101063018(cdk5)

TFS:	130538560(cdk5)

TNG:	GSTEN00016158G001

LCO:	104917677(cdk5)

NCC:	104963881(cdk5)

TBEN:

117488909(cdk5)

CGOB:

115022461(cdk5)

PGEO:

117462414(cdk5)

GACU:

117558449(cdk5)

EMAC:

134866277(cdk5)

ELY:	117271442(cdk5)

EFO:	125901757(cdk5)

PLEP:

121951419(cdk5)

SLUC:

116045983(cdk5)

ECRA:

117954576(cdk5)

PFLV:

114565077

GAT:	120815976(cdk5)

PPUG:

119207145(cdk5)

AFB:	129111810(cdk5)

CLUM:

117746655(cdk5)

PSWI:

130198097(cdk5)

CANA:

137781394(cdk5)

CVE:	137866032(cdk5)

MSAM:

119901997(cdk5)

SCHU:

122886255(cdk5)

CUD:	121520307(cdk5)

SPUL:

138611350(cdk5)

LMIX:

132979250(cdk5)

ALAT:

119011844(cdk5)

ASTR:

137611995(cdk5)

MZE:	101470071(cdk5)

ONL:	100696050(cdk5)

OAU:	116318696(cdk5)

OLA:	101174461(cdk5)

OML:	112139614 112139625 112147472(cdk5)

CSAI:

133452829(cdk5)

XMA:	102234376(cdk5)

XCO:	114146448(cdk5)

XHE:	116721244(cdk5)

PRET:

103479697(cdk5)

PFOR:

103135762(cdk5)

PLAI:

106964296(cdk5)

PMEI:

106905666(cdk5)

GAF:	122841328(cdk5)

PPRL:

129361748(cdk5)

CVG:	107100454(cdk5)

CTUL:

119794182(cdk5)

GMU:	124870187(cdk5)

NFU:	107383863(cdk5)

KMR:	108241687(cdk5)

ALIM:

106533498(cdk5)

NWH:	119414660(cdk5)

AOCE:

111568626(cdk5)

EJA:	138203041(cdk5)

BFRE:

138617297(cdk5)

MCEP:

125011253(cdk5)

CSEM:

103396324(cdk5)

POV:	109646369(cdk5)

SSEN:

122772287(cdk5)

SSOE:

131469998(cdk5)

HHIP:

117778039(cdk5)

HSP:	118118243(cdk5)

PPLT:

128454900(cdk5)

SMAU:

118310367(cdk5)

LCF:

108883365

SDU:	111231009(cdk5)

SLAL:

111653275(cdk5)

XGL:	120799217(cdk5)

HCQ:	109526480(cdk5)

SSCV:

125984796(cdk5)

SBIA:

133510463(cdk5)

PEE:	133411192(cdk5)

PTAO:

133488546(cdk5)

BPEC:

110159635(cdk5)

ENY:	140356597(cdk5)

MALB:

109957746(cdk5)

BSPL:

114843870(cdk5)

SJO:	128368617(cdk5)

SSCO:

133990569(cdk5)

GMH:	115548290(cdk5)

SASA:

106569348 106599847

STRU:

115157187 115169592

OTW:	112226799 112260632

OMY:	110508586 110530478

OGO:	124009485 124041746

ONE:	115102955 115114561

OKI:	109871937 109875042

OKE:	118394808 118401965(cdk5)

OMM:	135512501 135558839

OCLA:

139376191 139387160

SALP:

111957139 111979362

SNH:	120020273 120055971

CCLU:

121535353 121581039

ELS:	105019653(cdk5)

OEP:	134036253(cdk5)

SFM:	108937758(cdk5)

PKI:	111845972(cdk5)

AANG:

118233742(cdk5)

AROT:

135261103(cdk5)

CCOG:

133137197(cdk5)

LOC:	102698957(cdk5)

PSPA:

121312832 121314320(cdk5)

ARUT:

117394786(cdk5) 117399411

PSEX:

120529452(cdk5)

LCM:	102359721(CDK5)

RTP:	109922947(cdk5)

CPLA:

122548793(cdk5)

HOC:	132815143(cdk5)

LERI:

129696379(cdk5)

HAKA:

140727630(cdk5)

PMRN:

116958541(CDK5)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918615 581028

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG8203(Cdk5)

DER:

6546598

DSE:

6609305

DSI:	Dsimw501_GD25609(Dsim_GD25609)

DYA:	Dyak_GE14145

DAN:

DSR:

DPO:

DPE:

DMN:	108158740 117188328

DWI:

6640325

DGR:

6559602

DMO:	Dmoj_GI19456

DAZ:

108615375

DNV:

108653292

DHE:

111593937

DVI:	6626353(Cdk5)

CCAT:

101449749

BOD:

106626444

BDR:

105233210

RZE:	108358407 108374494

AOQ:

129244442

ALUD:

128868608

TDA:	119679956 119685077

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135959750(Cdk5)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000065

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:	408325(Cdk5)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108723578(Cdk5)

CCOA:

108782322

VEM:

105555945

COBS:

139101614(Cdk5)

TLN:	139824042(Cdk5)

HST:

DQU:

CFO:

FEX:

PMEC:

138934715(Cdk5)

LHU:

PGC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100116531(Cdk5)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141530189(Cdk5)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124223864(Cdk5)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138125112(Cdk5)

DPA:

109543581

ESIM:

136410798(Cdk5)

EFOR:

136349707(Cdk5)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

135799299(Cdk5)

APLN:

PPYR:

OTU:

BMOR:

MSEX:

DPL:	KGM_211766

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137921281(Cdk5)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141434848(Cdk5)

CFEL:

113363184

CCRN:

123297899

API:	100160718(cdk5)

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106679346(Cdk5)

NLU:	111053534 111058816 111062275

HVI:	124365814 124371231

MQU:

129002517

PHU:	Phum_PHUM263550

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138701174(Cdk5)

SGRE:

126355822

BROR:

134536984

IEL:

124159314

HAMR:

139692259(Cdk5)

FCD:

110848364

DPX:	DAPPUDRAFT_118693 DAPPUDRAFT_299705 DAPPUDRAFT_5547

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123746993(Cdk5)

CQD:

PTRU:

ESN:

MNZ:

MRJ:	136828814(Cdk5)

PORN:

139764916(Cdk5)

HAZT:

108674536 108674537

EAF:

111695411

LSM:	121115327(Cdk5)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136985206(Cdk5)

PTEP:

ABRU:

UDV:

SDM:

PMEO:

CEL:	CELE_T27E9.3(cdk-5)

CBR:	CBG_21202(Cbr-cdk-5)

CRQ:	GCK72_008427

NAI:	NECAME_11256

BMY:	BM_BM6048(Bma-cdk-5)

LOA:	LOAG_07240

TSP:

Tsp_01982

HRO:	HELRODRAFT_68175

LGI:	LOTGIDRAFT_173111

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106160077 106173430

SMM:	Smp_073340

SHX:	MS3_00008566(CDK5)

OVI:	T265_03369

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114521212 114543370 114545125 114545128

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_49937

AQU:

100638364

AANS:

126804751

MBR:	MONBRDRAFT_25292(Cdk5)

DFA:

DFA_10177

TVA:	4752979(TVAGG3_0615140) 5468767(TVAGG3_0393250)

» show all

Reference

PMID:1639063

Authors

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH

Title

A family of human cdc2-related protein kinases.

Journal

EMBO J 11:2909-17 (1992)
DOI:10.1002/j.1460-2075.1992.tb05360.x

Sequence

[hsa:1020]

Reference

PMID:21600237

Authors

Zhu J, Li W, Mao Z

Title

Cdk5: mediator of neuronal development, death and the response to DNA damage.

Journal

Mech Ageing Dev 132:389-94 (2011)
DOI:10.1016/j.mad.2011.04.011

Sequence

[hsa:1020]

Reference

PMID:21473899

Authors

Lopes JP, Agostinho P

Title

Cdk5: multitasking between physiological and pathological conditions.

Journal

Prog Neurobiol 94:49-63 (2011)
DOI:10.1016/j.pneurobio.2011.03.006

Sequence

[hsa:1020]

All links

Ontology (1)   
   GO (1)   
Gene (1578)   
   MGENES (135)   
   RefGene (1437)   
   OC (6)   
All databases (1579)   

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