KEGG   ORTHOLOGY: K02090
Entry
K02090                      KO                                     

Symbol
CDK5
Name
cyclin-dependent kinase 5 [EC:2.7.11.22]
Pathway
map04360  Axon guidance
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05030  Cocaine addiction
Disease
H00268  Lissencephaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K02090  CDK5; cyclin-dependent kinase 5
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02090  CDK5; cyclin-dependent kinase 5
   05022 Pathways of neurodegeneration - multiple diseases
    K02090  CDK5; cyclin-dependent kinase 5
  09165 Substance dependence
   05030 Cocaine addiction
    K02090  CDK5; cyclin-dependent kinase 5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02090  CDK5; cyclin-dependent kinase 5
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K02090  CDK5; cyclin-dependent kinase 5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02090  CDK5; cyclin-dependent kinase 5
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02090  CDK5; cyclin-dependent kinase 5
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K02090  CDK5; cyclin-dependent kinase 5
Other DBs
GO: 0004693
Genes
HSA: 1020(CDK5)
PTR: 463891(CDK5)
PPS: 100977790(CDK5)
GGO: 101149520(CDK5)
PON: 100442658(CDK5)
NLE: 100593355(CDK5)
MCC: 714445(CDK5)
MCF: 101865873(CDK5)
CSAB: 103227238(CDK5)
CATY: 105584739(CDK5)
PANU: 100999052(CDK5)
RRO: 104675398(CDK5)
RBB: 108532531(CDK5)
TFN: 117072838(CDK5) 117082413 117088198
PTEH: 111551516(CDK5)
CJC: 100411309(CDK5)
SBQ: 101037170(CDK5)
MMUR: 105883175(CDK5)
MMU: 12568(Cdk5)
MCAL: 110293885(Cdk5)
MPAH: 110315989(Cdk5)
RNO: 140908(Cdk5)
MCOC: 116097551(Cdk5)
MUN: 110562558(Cdk5)
CGE: 100762907(Cdk5)
PLEU: 114700086(Cdk5)
NGI: 103745307(Cdk5)
HGL: 101708843(Cdk5)
CPOC: 100732840(Cdk5)
CCAN: 109694445(Cdk5)
OCU: 100352775(CDK5)
OPI: 101519803(CDK5)
TUP: 102497253(CDK5)
CFA: 475537(CDK5)
VVP: 112916215(CDK5)
VLG: 121490120(CDK5)
AML: 100483328(CDK5)
UMR: 103660955(CDK5)
UAH: 113241477(CDK5)
ORO: 101383507(CDK5)
ELK: 111154329
MPUF: 101677047(CDK5)
EJU: 114197989(CDK5)
MLX: 118026782(CDK5)
FCA: 101097226(CDK5)
PYU: 121022910(CDK5)
PBG: 122488531(CDK5)
PTG: 102956209(CDK5)
PPAD: 109252371(CDK5)
AJU: 113596750(CDK5)
HHV: 120230895(CDK5)
BTA: 281066(CDK5)
BOM: 102265949(CDK5)
BIU: 109557798(CDK5)
BBUB: 102390186(CDK5)
CHX: 102178040(CDK5)
OAS: 100190973(CDK5)
ODA: 120877914(CDK5)
SSC: 733700(CDK5)
CFR: 102522591(CDK5)
CBAI: 105067013(CDK5)
CDK: 105105662(CDK5)
BACU: 103018873(CDK5)
LVE: 103085591(CDK5)
OOR: 101281610(CDK5)
DLE: 111176821(CDK5)
PCAD: 102986821(CDK5)
PSIU: 116759864(CDK5)
ECB: 100063442(CDK5)
EPZ: 103564178(CDK5)
EAI: 106823329(CDK5)
MYB: 102255036(CDK5)
MYD: 102755674(CDK5)
MMYO: 118679406(CDK5)
MLF: 102434327(CDK5)
MNA: 107524907(CDK5)
PKL: 118704772(CDK5)
HAI: 109389648(CDK5)
DRO: 112308285(CDK5)
SHON: 118975530(CDK5)
AJM: 119039289(CDK5)
PDIC: 114507734(CDK5)
MMF: 118619839(CDK5)
RFQ: 117018286(CDK5)
PALE: 102879023(CDK5)
PGIG: 120601504(CDK5)
RAY: 107520296(CDK5)
MJV: 108391844(CDK5)
TOD: 119248750(CDK5)
LAV: 100671938(CDK5)
TMU: 101357699
MDO: 100015241(CDK5)
GAS: 123250574(CDK5)
SHR: 100914143(CDK5)
PCW: 110201934(CDK5)
OAA: 100091902(CDK5)
GGA: 100190948(CDK5)
PCOC: 116242828(CDK5)
MGP: 104916220(CDK5)
CJO: 107308706(CDK5)
NMEL: 110390738(CDK5)
TGU: 115493589(CDK5)
LSR: 110475089(CDK5)
PMOA: 120510565(CDK5)
OTC: 121334886(CDK5)
PRUF: 121356982(CDK5)
PHI: 102111846(CDK5)
PMAJ: 107198231(CDK5)
CCW: 104684262(CDK5)
ETL: 114068008(CDK5)
FPG: 101913356(CDK5)
FCH: 102058220(CDK5)
CLV: 102090553
AAM: 106491564(CDK5)
AROW: 112976161(CDK5)
DNE: 112987735(CDK5)
AMJ: 106740360(CDK5)
CMY: 102948311(CDK5)
CPIC: 101952393(CDK5)
CABI: 116831904(CDK5)
MRV: 120397576(CDK5)
PVT: 110082556(CDK5)
SUND: 121935561(CDK5)
PBI: 103063081(CDK5)
PMUR: 107297802(CDK5)
TSR: 106550742
PGUT: 117669214(CDK5)
VKO: 123019571(CDK5)
PMUA: 114607317(CDK5)
ZVI: 118092306(CDK5)
GJA: 107108217(CDK5)
XLA: 399296(cdk5.L)
XTR: 780236(cdk5)
DRE: 65234(cdk5)
SRX: 107731788 107732074
SANH: 107677283 107690992
SGH: 107555551 107599666(cdk5)
CCAR: 109050000(cdk5) 109050139
CAUA: 113042631 113092791
IPU: 100528512(cdk5)
PHYP: 113533817(cdk5)
AMEX: 103032107(cdk5)
EEE: 113583777(cdk5)
TRU: 101063018(cdk5)
TNG: GSTEN00016158G001
LCO: 104917677(cdk5)
NCC: 104963881(cdk5)
CGOB: 115022461(cdk5)
ELY: 117271442(cdk5)
PLEP: 121951419(cdk5)
SLUC: 116045983(cdk5)
ECRA: 117954576(cdk5)
PFLV: 114565077
GAT: 120815976(cdk5)
PPUG: 119207145(cdk5)
MSAM: 119901997(cdk5)
CUD: 121520307(cdk5)
MZE: 101470071(cdk5)
ONL: 100696050(cdk5)
OAU: 116318696(cdk5)
OLA: 101174461(cdk5)
OML: 112139614 112139625 112147472(cdk5)
XMA: 102234376(cdk5)
XCO: 114146448(cdk5)
XHE: 116721244(cdk5)
PRET: 103479697(cdk5)
GAF: 122841328(cdk5)
CVG: 107100454(cdk5)
CTUL: 119794182(cdk5)
NFU: 107383863(cdk5)
KMR: 108241687(cdk5)
ALIM: 106533498(cdk5)
AOCE: 111568626(cdk5)
CSEM: 103396324(cdk5)
POV: 109646369(cdk5)
SSEN: 122772287(cdk5)
HHIP: 117778039(cdk5)
LCF: 108883365(cdk5)
SDU: 111231009(cdk5)
SLAL: 111653275(cdk5)
XGL: 120799217(cdk5)
HCQ: 109526480(cdk5)
BPEC: 110159635(cdk5)
MALB: 109957746(cdk5)
SASA: 106569348 106599847
OTW: 112226799 112260632
OMY: 110508586 110530478
SALP: 111957139 111979362
SNH: 120020273 120055971
ELS: 105019653(cdk5)
SFM: 108937758(cdk5)
PKI: 111845972(cdk5)
AANG: 118233742(cdk5)
LOC: 102698957(cdk5)
PSPA: 121312832 121314320(cdk5)
ARUT: 117394786(cdk5) 117399411
LCM: 102359721(CDK5)
RTP: 109922947(cdk5)
BFO: 118424258
BBEL: 109488304
CIN: 100181289
SCLV: 120342731
SPU: 115918615 581028
APLC: 110973569
SKO: 100369508
DME: Dmel_CG8203(Cdk5)
DER: 6546598
DSE: 6609305
DSI: Dsimw501_GD25609(Dsim_GD25609)
DYA: Dyak_GE14145
DAN: 6505282
DSR: 110178355
DPO: Dpse_GA20894
DPE: 6590340
DMN: 108158740 117188328
DWI: 6640325
DGR: 6559602
DMO: Dmoj_GI19456
DAZ: 108615375
DNV: 108653292
DHE: 111593937
DVI: 6626353
CCAT: 101449749
BOD: 106626444
MDE: 101901726
SCAC: 106084624
LCQ: 111678128
AGA: AgaP_AGAP005772
ACOZ: 120953850
AARA: 120898337
AAG: 5570866
AALB: 109411096
CQU: CpipJ_CPIJ000065
CPII: 120431057 120431063
AME: 408325(Cdk5)
ACER: 107995526
BIM: 105680799
BBIF: 117214069
BVK: 117236406
BVAN: 117153146
BTER: 100644730
BPYO: 122573041
CCAL: 108624906
OBB: 114875986
MGEN: 117229975
NMEA: 116428359
CGIG: 122397101
SOC: 105193774
MPHA: 105828515
AEC: 105150872
ACEP: 105627216
VEM: 105555945
HST: 105186563
DQU: 106747541
CFO: 105248046
FEX: 115243605
LHU: 105673938
PGC: 109852002
PCF: 106786265
PFUC: 122525376
VPS: 122633522
NVI: 100116531(Cdk5)
CSOL: 105364446
TPRE: 106653017
MDL: 103569778
CGLO: 123267410
FAS: 105270356
DAM: 107045133
AGIF: 122855179
CCIN: 107266722
TCA: 661807
DPA: 109543581
ATD: 109594827
AGB: 108907563
LDC: 111507149
NVL: 108568514
APLN: 108739458
PPYR: 116159523
OTU: 111421388
BMOR: 100316861
MSEX: 115444228 119189494
DPL: KGM_211766
BANY: 112042924
PMAC: 106716624
PPOT: 106102176
PXU: 106114063
PRAP: 110995770
ZCE: 119831861
HAW: 110371274
TNL: 113494727
PXY: 105383321 105397219
API: 100160718(cdk5)
DNX: 107168281
AGS: 114122571
RMD: 113552236
BTAB: 109030687
DCI: 103512112
CLEC: 106672918
HHAL: 106679346
NLU: 111053534 111058816 111062275
PHU: Phum_PHUM263550
FOC: 113208745
ZNE: 110830702
CSEC: 111874018
FCD: 110848364
DPX: DAPPUDRAFT_118693 DAPPUDRAFT_299705 DAPPUDRAFT_5547
PVM: 113826004
PJA: 122266632
HAME: 121863791
HAZT: 108674536 108674537
EAF: 111695411
ISC: IscW_ISCW021518
DSV: 119442331
RSAN: 119387220
RMP: 119159578
VDE: 111245929
VJA: 111265248
TUT: 107371333
DPTE: 113792262
CSCU: 111629032
PTEP: 107451100
SDM: 118188642
CEL: CELE_T27E9.3(cdk-5)
CBR: CBG_21202(Cbr-cdk-5)
BMY: BM_BM6048(Bma-cdk-5)
LOA: LOAG_07240
NAI: NECAME_11256
TSP: Tsp_01982
HRO: HELRODRAFT_68175
LGI: LOTGIDRAFT_173111
PCAN: 112564382
BGT: 106076847
GAE: 121367465
CRG: 105344147
MYI: 110443310
PMAX: 117343526
OBI: 106880362
OSN: 115216414
LAK: 106160077 106173430
SMM: Smp_073340
OVI: T265_03369
EGL: EGR_05289
NVE: 5521700
EPA: 110250749
ATEN: 116298309
ADF: 107331947
AMIL: 114961499
PDAM: 113672325
SPIS: 111323585
DGT: 114521212 114543370 114545125 114545128
HMG: 100197614
TAD: TRIADDRAFT_49937
AQU: 100638364
MBR: MONBRDRAFT_25292(Cdk5)
DFA: DFA_10177
TVA: TVAG_185150 TVAG_336270
 » show all
Reference
PMID:1639063
  Authors
Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH
  Title
A family of human cdc2-related protein kinases.
  Journal
EMBO J 11:2909-17 (1992)
DOI:10.1002/j.1460-2075.1992.tb05360.x
  Sequence
[hsa:1020]
Reference
  Authors
Zhu J, Li W, Mao Z
  Title
Cdk5: mediator of neuronal development, death and the response to DNA damage.
  Journal
Mech Ageing Dev 132:389-94 (2011)
DOI:10.1016/j.mad.2011.04.011
  Sequence
[hsa:1020]
Reference
  Authors
Lopes JP, Agostinho P
  Title
Cdk5: multitasking between physiological and pathological conditions.
  Journal
Prog Neurobiol 94:49-63 (2011)
DOI:10.1016/j.pneurobio.2011.03.006
  Sequence
[hsa:1020]

  All links  
Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1975)   
   KEGG GENES (384)   
   KEGG MGENES (148)   
   RefGene (1437)   
   OC (6)   
Literature (3)   
   PubMed (3)   
All databases (1994)   

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