KEGG ORTHOLOGY: K02373

ORTHOLOGY: K02373

Entry

K02373                      KO

Symbol

FADD

Name

FAS-associated death domain protein

Pathway

map01524

Platinum drug resistance

map04210

Apoptosis

map04215

Apoptosis - multiple species

map04217

Necroptosis

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04624

Toll and Imd signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05142

Chagas disease

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Disease

H02525

Disorders of innate immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K02373  FADD; FAS-associated death domain protein
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02373  FADD; FAS-associated death domain protein
   04215 Apoptosis - multiple species
    K02373  FADD; FAS-associated death domain protein
   04217 Necroptosis
    K02373  FADD; FAS-associated death domain protein
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04624 Toll and Imd signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04621 NOD-like receptor signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04622 RIG-I-like receptor signaling pathway
    K02373  FADD; FAS-associated death domain protein
   04623 Cytosolic DNA-sensing pathway
    K02373  FADD; FAS-associated death domain protein
   04657 IL-17 signaling pathway
    K02373  FADD; FAS-associated death domain protein
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02373  FADD; FAS-associated death domain protein
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02373  FADD; FAS-associated death domain protein
   05161 Hepatitis B
    K02373  FADD; FAS-associated death domain protein
   05160 Hepatitis C
    K02373  FADD; FAS-associated death domain protein
   05164 Influenza A
    K02373  FADD; FAS-associated death domain protein
   05162 Measles
    K02373  FADD; FAS-associated death domain protein
   05168 Herpes simplex virus 1 infection
    K02373  FADD; FAS-associated death domain protein
   05163 Human cytomegalovirus infection
    K02373  FADD; FAS-associated death domain protein
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02373  FADD; FAS-associated death domain protein
   05169 Epstein-Barr virus infection
    K02373  FADD; FAS-associated death domain protein
   05165 Human papillomavirus infection
    K02373  FADD; FAS-associated death domain protein
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K02373  FADD; FAS-associated death domain protein
   05132 Salmonella infection
    K02373  FADD; FAS-associated death domain protein
   05152 Tuberculosis
    K02373  FADD; FAS-associated death domain protein
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K02373  FADD; FAS-associated death domain protein
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02373  FADD; FAS-associated death domain protein
   05022 Pathways of neurodegeneration - multiple diseases
    K02373  FADD; FAS-associated death domain protein
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K02373  FADD; FAS-associated death domain protein
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K02373  FADD; FAS-associated death domain protein

Genes

HSA:	8772(FADD)

PTR:	451389(FADD)

PPS:	100968673(FADD)

GGO:	101134274(FADD)

PON:	100439256(FADD)

PPYG:

129008452(FADD)

NLE:	100607557(FADD)

HMH:	116469121(FADD)

SSYN:

129478993(FADD)

MCC:	708606(FADD)

MCF:	101866285(FADD)

MTHB:

126935972

MNI:	105469733(FADD)

CSAB:

103245758(FADD)

CATY:

105577297(FADD)

PANU:

101017433(FADD)

TGE:	112606728(FADD)

MLEU:

105544509 105544531

RRO:	104677132(FADD)

RBB:	108538801(FADD)

TFN:	117079989(FADD)

PTEH:

111522332(FADD)

CANG:

105512314(FADD)

CJC:	100410616(FADD)

SBQ:	101046905(FADD)

CIMI:

108294124(FADD)

ANAN:

105717652(FADD)

CSYR:

103262441(FADD)

MMUR:

105867530(FADD)

LCAT:

123642797(FADD)

PCOQ:

105827473(FADD)

OGA:	100960309(FADD)

MMU:	14082(Fadd)

MCAL:

110298222(Fadd)

MPAH:

110333124(Fadd)

RNO:	266610(Fadd)

MCOC:

116103283(Fadd)

ANU:	117710030(Fadd)

MUN:	110546885(Fadd)

CGE:	100774599(Fadd)

MAUA:

101839512(Fadd)

PROB:

127228595(Fadd)

PLEU:

114694438(Fadd)

MORG:

121457709(Fadd)

MFOT:

126498470 126505976

AAMP:

119802203(Fadd)

NGI:	103751502(Fadd)

HGL:	101709972(Fadd)

CPOC:

100730628(Fadd)

CCAN:

109700274(Fadd)

DORD:

105989060(Fadd) 106002598

DSP:	122099877(Fadd)

PLOP:

125361339(Fadd)

NCAR:

124960510

MMMA:

107157044(Fadd)

OPI:	101521668(FADD)

TUP:	102489799(FADD)

GVR:	103605154(FADD)

CFA:	611694(FADD)

CLUD:

112663192(FADD)

VVP:	112924009(FADD)

VLG:	121471748(FADD)

NPO:	129503100(FADD)

AML:	100468003(FADD)

UMR:	103671072(FADD)

UAH:	113243978(FADD)

UAR:	123778464(FADD)

ELK:

111149616

LLV:

125079328

MPUF:

101671860(FADD)

MNP:	132017355(FADD)

MLK:	131817074(FADD)

NVS:	122913265(FADD)

ORO:	101385048(FADD)

EJU:	114220353(FADD)

ZCA:	113914747(FADD) 113931151

MLX:	118016168(FADD)

NSU:	110576065(FADD)

LWW:	102737084(FADD)

FCA:	101087871(FADD)

PYU:	121023867(FADD)

PCOO:

112851989(FADD)

PBG:	122484102(FADD)

PVIV:

125146980(FADD)

LRUF:

124505197

PPAD:

109246999(FADD)

PUC:

125929964

AJU:

106982870

HHV:	120233869(FADD)

BTA:	493720(FADD)

BOM:	102271962(FADD)

BIU:	109554562(FADD)

BBUB:

102397985(FADD)

BBIS:

104986928(FADD)

CHX:	102170760(FADD)

OAS:	101116783(FADD)

BTAX:

128068641(FADD)

ODA:	120874152(FADD)

CCAD:

122431085(FADD)

MBEZ:

129548659(FADD)

SSC:	595129(FADD)

CFR:	102519266(FADD)

CBAI:

105070436(FADD)

CDK:	105104389(FADD)

BACU:

103014148(FADD)

BMUS:

118899681(FADD)

LVE:	103080339(FADD)

OOR:	101272962(FADD)

DLE:	111183629(FADD)

PCAD:

102973514 112067437

PSIU:

116757390(FADD)

NASI:

112402377(FADD)

ECB:	100061802(FADD)

EPZ:	103566999(FADD)

EAI:	106822169(FADD)

MYD:	102756704(FADD)

MMYO:

118665178(FADD)

MLF:	111824600(FADD)

MDT:	132241296(FADD)

PKL:	118713371(FADD)

EFUS:

103291049(FADD)

MNA:	107542171(FADD)

DRO:	112317320(FADD)

SHON:

118998399(FADD)

AJM:	119041863(FADD)

PDIC:

114489990(FADD)

PHAS:

123829338(FADD)

MMF:	118628258(FADD)

PPAM:

129068522(FADD)

HAI:	109389315(FADD)

RFQ:	117030152(FADD)

PALE:

102892511(FADD)

PGIG:

120584707(FADD)

PVP:	105307475(FADD)

RAY:	107503382(FADD)

MJV:	108401442(FADD)

TOD:	119250504(FADD)

SARA:

101537769(FADD)

SETR:

126018803(FADD)

LAV:	100662633(FADD)

TMU:

101352734

DNM:	101415698(FADD)

MDO:	100031941(FADD)

GAS:	123256276(FADD)

SHR:	100925732(FADD)

AFZ:

127540264

PCW:	110197147(FADD)

TVP:	118852616(FADD)

OAA:	100075638(FADD)

GGA:	423146(FADD)

PCOC:

116229092(FADD)

MGP:	100540536(FADD)

CJO:	107314471(FADD)

TPAI:

128086469(FADD)

LMUT:

125695241(FADD)

NMEL:

110401719(FADD)

APLA:

101801863(FADD)

ACYG:

106044712(FADD)

CATA:

118250793(FADD)

AFUL:

116489918(FADD)

TGU:	100229649(FADD)

LSR:	110485062(FADD)

SCAN:

103822220(FADD)

PMOA:

120509904(FADD)

OTC:	121340228(FADD)

PRUF:

121349102(FADD)

GFR:	102042362(FADD)

FAB:	101806236(FADD)

OMA:	130254053(FADD)

PHI:	102102219(FADD)

PMAJ:

107205253(FADD)

CCAE:

111930654(FADD)

CCW:	104697634(FADD)

CBRC:

103614707(FADD)

ETL:	114070411(FADD)

ZAB:	102064080(FADD)

ZLE:	135449046(FADD)

ACHL:

103804464(FADD)

SVG:	106854799(FADD)

MMEA:

130577552(FADD)

HRT:	120754742(FADD)

SATI:

136362156(FADD)

FPG:	101918701(FADD)

FCH:	102055286(FADD)

CCRI:

104169344(FADD)

NNT:	104399843(FADD)

SHAB:

115607147(FADD)

ACUN:

113481356(FADD)

TALA:

104358040(FADD)

ACHC:

115351998(FADD)

HALD:

104324374(FADD)

HLE:	104829441(FADD)

AGEN:

126047517

GCL:

127017335

CSTI:

104560754(FADD)

LDI:	104341000(FADD)

MNB:	103776578(FADD)

DPUB:

104297557(FADD)

AVIT:

104277263(FADD)

BRHI:

104488312(FADD)

EGZ:	104124706(FADD)

NNI:	104009489(FADD)

PCRI:

104025288(FADD)

PCAO:

104041064(FADD)

PADL:

103925771(FADD)

AFOR:

103905128(FADD)

FGA:	104080225(FADD)

GSTE:

104251734(FADD)

CLV:	102085703(FADD)

MUI:	104543590(FADD)

PGUU:

104460901(FADD)

PLET:

104626095(FADD)

EHS:	104507013(FADD)

CMAC:

104476173(FADD)

CUCA:

104062504(FADD)

TEO:	104370986(FADD)

BREG:

104632863(FADD)

OHA:	104330757(FADD)

ACAR:

104520328(FADD)

CPEA:

104397483(FADD)

CVF:	104287571(FADD)

RTD:	128908383(FADD)

AAM:	106498371(FADD)

AROW:

112977257(FADD)

NPD:	112943547(FADD)

TGT:	104567940(FADD)

DNE:	112979977(FADD)

ASN:	102377608(FADD)

AMJ:	102572187(FADD)

CPOO:

109321492(FADD)

GGN:	109298988(FADD)

PSS:	102448271(FADD)

CMY:	102930159(FADD)

CCAY:

125638669(FADD)

DCC:	119857192(FADD)

CPIC:

101944927(FADD)

TST:	117877033(FADD)

CABI:

116822548(FADD)

MRV:	120402879(FADD)

ACS:	103279978(fadd)

ASAO:

132768935(FADD)

PVT:	110073515(FADD)

PBI:	103054174(FADD)

PMUR:

107287485(FADD)

CTIG:

120314118(FADD)

TSR:	106546194(FADD)

PGUT:

117665438(FADD)

APRI:

131188800(FADD)

PTEX:

113440349(FADD)

NSS:	113410258(FADD)

VKO:	123026823(FADD)

PMUA:

114596831(FADD)

PRAF:

128414015(FADD)

ZVI:	118085907(FADD)

HCG:	128350941(FADD)

GJA:	107118889(FADD)

STOW:

125427570(FADD)

EMC:	129323679(FADD) 129340065

XLA:	108713779(fadd.L) 496403(fadd.S)

XTR:	100379789(fadd)

NPR:	108785454(FADD)

RTEM:

120917101(FADD)

BBUF:

120980177(FADD)

BGAR:

122920804(FADD)

MUO:	115468770(FADD)

GSH:	117351958(FADD)

DRE:	562317(fadd)

SRX:	107727098 107730082

SANH:

107679720 107686825

SGH:	107559437 107594476

CCAR:

109047225(fadd)

CAUA:

113051795 113106512(fadd)

CGIB:

127961264 128016542

PTET:

122348403(fadd)

LROH:

127168898(fadd)

OMC:	131543697(fadd)

PPRM:

120492744(fadd)

RKG:	130097277(fadd)

MAMB:

125265402(fadd)

CIDE:

127516809

CERY:

137030077(fadd)

MASI:

127412107 127445671

TROS:

130562654(fadd)

TDW:	130411206(fadd)

MANU:

129451442(fadd)

IPU:	100305064(fadd)

IFU:	128613471(fadd)

PHYP:

113536458(fadd)

SMEO:

124391257(fadd)

TFD:	113646637(fadd)

TVC:	132856673(fadd)

TRN:	134331432(fadd)

AMEX:

103022073(fadd)

CMAO:

118819390(fadd)

EEE:	113578454(fadd)

CHAR:

105888982(fadd)

TRU:	101067067 115246498

TFS:	130521667(fadd)

LCO:

104933825

NCC:	104955074(fadd)

TBEN:

117491087(fadd)

CGOB:

115025685(fadd)

PGEO:

117463391(fadd)

GACU:

117534615(fadd)

EMAC:

134863816(fadd)

ELY:	117258051(fadd)

EFO:	125900496(fadd)

PLEP:

121964874

SLUC:

116045235(fadd)

ECRA:

117942648(fadd)

ESP:	116690512(fadd)

PFLV:

114558921(fadd)

GAT:	120832244(fadd)

PPUG:

119195422 119195515

AFB:	129099702(fadd)

CLUM:

117747456(fadd)

PSWI:

130192738(fadd)

MSAM:

119890367(fadd)

SCHU:

122876412(fadd)

CUD:	121512063(fadd)

ALAT:

119017669(fadd)

MZE:	101483780(fadd)

ONL:	100706963(fadd)

OAU:	116323704(fadd)

OLA:	100049399(fadd)

OML:	112160870(fadd)

CSAI:

133419352(fadd)

XMA:	102230597(fadd)

XCO:	114143134(fadd)

XHE:	116719102(fadd)

PRET:

103462317 108166171

PFOR:

103150957(fadd)

PLAI:

106943302(fadd)

PMEI:

106912590(fadd)

GAF:	122845769(fadd)

PPRL:

129353196(fadd)

CVG:

107101768

CTUL:

119772677(fadd)

GMU:	124867141(fadd)

NFU:

107372902

KMR:	108237856(fadd)

ALIM:

106526561

NWH:	119430211(fadd)

AOCE:

111583532(fadd)

MCEP:

125005173(fadD)

CSEM:

103378588(fadd)

POV:	109625113(fadd)

SSEN:

122772852(fadd)

HHIP:

117759449(fadd)

HSP:	118105702(fadd)

PPLT:

128455124(fadd)

SMAU:

118302382 118302662

LCF:	108880505(fadd)

SDU:	111218782(fadd)

SLAL:

111644206 111669290

XGL:	120800498(fadd)

HCQ:	109508026 109508027

SSCV:

125966915

SBIA:

133498558(fadd)

PEE:	133416408(fadd)

PTAO:

133469153(fadd)

BPEC:

110174542(fadd)

MALB:

109967863(fadd)

BSPL:

114852435(fadd)

SJO:	128358553(fadd)

SASA:

106561969(FADD) 106587129(FADD)

STRU:

115167502 115202892

OTW:	112249032(fadd) 112263517

OMY:	110506335 110526221(fadd)

OGO:	124033904(fadd) 124034867

ONE:	115112090 115112795

OKI:	109885763 109895028

OKE:	118393704(fadd)

SALP:

111969559 111974969

SNH:	120025030 120045951

CCLU:

121557680 121573323

ELS:	105017350(fadd)

SFM:	108941100(fadd)

PKI:	111851812(fadd)

AANG:

118226682(fadd)

LOC:	102690370(fadd)

PSPA:

121329520(fadd)

ARUT:

117431917(fadd) 117435159

PSEX:

120526028(fadd)

LCM:	102357786(FADD)

CMK:	103175018(fadd)

RTP:	109916874(fadd)

HOC:	132824517(fadd)

PMRN:

116956943

BFO:	118406213 118408956 118411461 118422230 118422514 118424980

BBEL:

109463572 109463573 109463897 109466708 109479421 109485753

SPU:	100887852 587131

LPIC:

129282291

APLC:

110977598 110982684 110982686

ARUN:

117292269 117303986

SKO:	100303599 100368353(fadd) 102807362 102807731

DME:	Dmel_CG12297(Fadd)

DER:

6555409

DSE:

6607373

DSI:	Dsimw501_GD20917(Dsim_GD20917)

DYA:	Dyak_GE10264

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12248

DAZ:

108614180

DNV:

108651126

DHE:	111595133 111595134

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009900

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105676271(Fadd)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

NFB:

NVG:

AROA:

TCA:	103312947(Fadd)

DPA:

SOY:

ATD:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207960

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CCRN:

FOC:

ZNE:

CSEC:

BROR:

IEL:

DMK:

CSCU:

PTEP:

ABRU:

LGI:	LOTGIDRAFT_68264

PVUL:

126810144

PCAN:

112577048

BGT:

106062358

GAE:	121372636 121378606 121381670

HRF:

124142312

HRJ:	124265832 124265833 124265843 124274168 124274796 124274805 124274806 124274860 124278680 124278697 124291715

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

117321177 117323156 117329240 117331032

MMER:

RPHI:

DPOL:

MAEA:

OBI:

LJP:	135475819 135478708

LAK:	106160250 106160410 106163499 106170519 106173228

LLON:

ATEN:

ADF:

PDAM:

SPIS:

DGT:

XEN:	124435808 124453671

HMG:	100206003 100208118 105845101

HSY:

130630638

TAD:	TRIADDRAFT_59576

AQU:

100633090

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Reference

PMID:7538907

Authors

Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM

Title

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.

Journal

Cell 81:505-12 (1995)
DOI:10.1016/0092-8674(95)90071-3

Sequence

[hsa:8772]

Reference

PMID:21109225

Authors

Bolze A, Byun M, McDonald D, Morgan NV, Abhyankar A, Premkumar L, Puel A, Bacon CM, Rieux-Laucat F, Pang K, Britland A, Abel L, Cant A, Maher ER, Riedl SJ, Hambleton S, Casanova JL

Title

Whole-exome-sequencing-based discovery of human FADD deficiency.

Journal

Am J Hum Genet 87:873-81 (2010)
DOI:10.1016/j.ajhg.2010.10.028

Sequence

[hsa:8772]

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Gene (673)   
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